8HYL
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![BU of 8hyl by Molmil](/molmil-images/mine/8hyl) | Crystal structure of DO1 Fv-clasp fragment | Descriptor: | VH-SARAH, VL-SARAH | Authors: | Anan, Y, Lu, P, Nagata, K, Itakura, M, Uchida, K. | Deposit date: | 2023-01-06 | Release date: | 2024-02-14 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Molecular and structural basis of anti-DNA antibody specificity for pyrrolated proteins. Commun Biol, 7, 2024
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4QYY
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![BU of 4qyy by Molmil](/molmil-images/mine/4qyy) | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase State | Descriptor: | (3R)-1-{2-[4-(4-acetylphenyl)piperazin-1-yl]-2-oxoethyl}-N-(3-chloro-4-hydroxyphenyl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Deng, Y, Shipps, G.W, Cooper, A, English, J.M, Annis, D.A, Carr, D, Nan, Y, Wang, T, Zhu, Y.H, Chuang, C, Dayananth, P, Hruza, A.W, Xiao, L, Jin, W, Kirschmeier, P, Windsor, W.T, Samatar, A.A. | Deposit date: | 2014-07-26 | Release date: | 2014-11-12 | Last modified: | 2023-09-20 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Discovery of Novel, Dual Mechanism ERK Inhibitors by Affinity Selection Screening of an Inactive Kinase. J.Med.Chem., 57, 2014
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6DCG
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![BU of 6dcg by Molmil](/molmil-images/mine/6dcg) | Discovery of MK-8353: An Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology | Descriptor: | (3S)-3-(methylsulfanyl)-1-(2-{4-[4-(1-methyl-1H-1,2,4-triazol-3-yl)phenyl]-3,6-dihydropyridin-1(2H)-yl}-2-oxoethyl)-N-(3-{6-[(propan-2-yl)oxy]pyridin-3-yl}-1H-indazol-5-yl)pyrrolidine-3-carboxamide, Mitogen-activated protein kinase 1, SULFATE ION | Authors: | Boga, S.B, Deng, Y, Zhu, L, Nan, Y, Cooper, A, Shipps Jr, G.W, Doll, R, Shih, N, Zhu, H, Sun, R, Wang, T, Paliwal, S, Tsui, H, Gao, X, Yao, X, Desai, J, Wang, J, Alhassan, A.B, Kelly, J, Patel, M, Muppalla, K, Gudipati, S, Zhang, L, Buevich, A, Hesk, D, Carr, D, Dayananth, P, Mei, H, Cox, K, Sherborne, B, Hruza, A.W, Xiao, L, Jin, W, Long, B, Liu, G, Taylor, S.A, Kirschmeier, P, Windsor, W.T, Bishop, R, Samatar, A.A. | Deposit date: | 2018-05-06 | Release date: | 2018-08-08 | Last modified: | 2023-10-11 | Method: | X-RAY DIFFRACTION (1.45 Å) | Cite: | MK-8353: Discovery of an Orally Bioavailable Dual Mechanism ERK Inhibitor for Oncology. ACS Med Chem Lett, 9, 2018
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8HQT
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8HQV
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8HQW
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![BU of 8hqw by Molmil](/molmil-images/mine/8hqw) | |
8HR0
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![BU of 8hr0 by Molmil](/molmil-images/mine/8hr0) | The complex structure of COPII coat with HCoV-OC43 DD sorting motif | Descriptor: | HCoV-OC43, Protein transport protein Sec23A, Protein transport protein Sec24A, ... | Authors: | Ma, W.F, Nan, Y.N, Yang, M.R, Li, Y.Q. | Deposit date: | 2022-12-14 | Release date: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.34 Å) | Cite: | Tighter ER retention of SARS-CoV-2 Omicron spike caused by a constellation of folding disruptive mutations To Be Published
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8HQX
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6Y6D
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![BU of 6y6d by Molmil](/molmil-images/mine/6y6d) | Tubulin-7-Aminonoscapine complex | Descriptor: | (3~{S})-7-azanyl-6-methoxy-3-[(5~{R})-4-methoxy-6-methyl-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinolin-5-yl]-3~{H}-2-benzofuran-1-one, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, CALCIUM ION, ... | Authors: | Oliva, M.A, Prota, A.E, Rodriguez-Salarichs, J, Gu, W, Bennani, Y.L, Jimenez-Barbero, J, Canales, A, Steinmetz, M.O, Diaz, J.F. | Deposit date: | 2020-02-26 | Release date: | 2020-07-22 | Last modified: | 2024-01-24 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Structural Basis of Noscapine Activation for Tubulin Binding. J.Med.Chem., 63, 2020
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5NKX
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![BU of 5nkx by Molmil](/molmil-images/mine/5nkx) | HRSV M2-1 core domain, P3221 crystal form | Descriptor: | M2-1 | Authors: | Almeida Hernandez, Y, Josts, I, Molina, I.G, de Pray-Gay, G, Tidow, H. | Deposit date: | 2017-04-03 | Release date: | 2018-01-03 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (2.00008678 Å) | Cite: | Structure and stability of the Human respiratory syncytial virus M2-1RNA-binding core domain reveals a compact and cooperative folding unit. Acta Crystallogr F Struct Biol Commun, 74, 2018
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5NOH
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![BU of 5noh by Molmil](/molmil-images/mine/5noh) | HRSV M2-1 core domain | Descriptor: | Transcription elongation factor M2-1 | Authors: | Josts, I, Almeida Hernandez, Y, Molina, I.G, de Prat-Gay, G, Tidow, H. | Deposit date: | 2017-04-12 | Release date: | 2018-01-03 | Last modified: | 2024-05-08 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structure and stability of the Human respiratory syncytial virus M2-1RNA-binding core domain reveals a compact and cooperative folding unit. Acta Crystallogr F Struct Biol Commun, 74, 2018
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3VUP
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![BU of 3vup by Molmil](/molmil-images/mine/3vup) | Beta-1,4-mannanase from the common sea hare Aplysia kurodai | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Beta-1,4-mannanase, SULFATE ION | Authors: | Mizutani, K, Tsuchiya, S, Toyoda, M, Nanbu, Y, Tominaga, K, Yuasa, K, Takahashi, N, Tsuji, A, Mikami, B. | Deposit date: | 2012-07-04 | Release date: | 2012-10-17 | Method: | X-RAY DIFFRACTION (1.05 Å) | Cite: | Structure of beta-1,4-mannanase from the common sea hare Aplysia kurodai at 1.05 A resolution. Acta Crystallogr.,Sect.F, 68, 2012
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