8THY
 
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6YSJ
 | | Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-amino-1-(4-bromophenyl)ethanone, DIMETHYL SULFOXIDE, ... | | Authors: | Scanlan, W, Heine, A, Klebe, G, Abazi, N, Paulus, A. | | Deposit date: | 2020-04-22 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.45 Å) | | Cite: | Thrombin in complex with 2-amino-1-(4-bromophenyl)ethan-1-one (j10)
To be published
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6YSX
 | | Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80) | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Hirudin variant-2, ... | | Authors: | Scanlan, W, Heine, A, Klebe, G, Abazi, N. | | Deposit date: | 2020-04-23 | | Release date: | 2021-05-12 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Thrombin in complex with 4-amino-N-(5-methylisoxazol-3-yl)benzenesulfonamide (j80)
To be published
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4UXV
 | | Cytoplasmic domain of bacterial cell division protein EzrA | | Descriptor: | SEPTATION RING FORMATION REGULATOR EZRA | | Authors: | Cleverley, R.M, Barrett, J.R, Basle, A, Khai-Bui, N, Hewitt, L, Solovyova, A, Xu, Z, Daniela, R.A, Dixon, N.E, Harry, E.J, Oakley, A.J, Vollmer, W, Lewis, R.J. | | Deposit date: | 2014-08-27 | | Release date: | 2014-10-22 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.961 Å) | | Cite: | Structure and Function of a Spectrin-Like Regulator of Bacterial Cytokinesis.
Nat.Commun., 5, 2014
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8TMW
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8TMV
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1WYC
 | | Structure of 6-aminohexanoate-dimer hydrolase, DN mutant | | Descriptor: | 6-aminohexanoate-dimer hydrolase | | Authors: | Negoro, S, Ohki, T, Shibata, N, Mizuno, N, Wakitani, Y, Tsurukame, J, Matsumoto, K, Kawamoto, I, Takeo, M, Higuchi, Y. | | Deposit date: | 2005-02-09 | | Release date: | 2006-02-21 | | Last modified: | 2024-05-29 | | Method: | X-RAY DIFFRACTION (1.58 Å) | | Cite: | Nylon-oligomer degrading enzyme/substrate complex: catalytic mechanism of 6-aminohexanoate-dimer hydrolase
J.Mol.Biol., 370, 2007
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8TCI
 | | Crystal structure of DNMT3C-DNMT3L in complex with CGG DNA | | Descriptor: | (5'-D(P*CP*AP*TP*G)-R(P*(PYO))-D(P*GP*GP*TP*CP*TP*AP*AP*TP*TP*AP*GP*AP*CP*CP*GP*CP*AP*TP*G)-3'), DNA (cytosine-5)-methyltransferase 3-like, DNA (cytosine-5)-methyltransferase 3C, ... | | Authors: | Khudaverdyan, N, Song, J. | | Deposit date: | 2023-07-01 | | Release date: | 2024-08-14 | | Last modified: | 2024-09-11 | | Method: | X-RAY DIFFRACTION (3.19 Å) | | Cite: | The structure of DNA methyltransferase DNMT3C reveals an activity-tuning mechanism for DNA methylation.
J.Biol.Chem., 300, 2024
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3L4G
 | | Crystal structure of Homo Sapiens cytoplasmic Phenylalanyl-tRNA synthetase | | Descriptor: | PHENYLALANINE, Phenylalanyl-tRNA synthetase alpha chain, Phenylalanyl-tRNA synthetase beta chain | | Authors: | Finarov, I, Moor, N, Kessler, N, Klipcan, L, Safro, M.G. | | Deposit date: | 2009-12-20 | | Release date: | 2010-03-09 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (3.3 Å) | | Cite: | Structure of human cytosolic phenylalanyl-tRNA synthetase: evidence for kingdom-specific design of the active sites and tRNA binding patterns.
Structure, 18, 2010
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8TWN
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8TFT
 | | Fab of O13-1 human IgG1 antibody bound to IgV domain of human TIM-3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, O-13-1 IgG1 Fab heavy chain, O-13-1 IgG1 Fab light chain, ... | | Authors: | Oganesyan, V.Y, van Dyk, N, Mazor, Y, Yang, C. | | Deposit date: | 2023-07-11 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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8TV3
 | | Fab 221-5 in complex with OspA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy chain of human monoclonal Fab 221-5, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-17 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (2.312 Å) | | Cite: | Fab 221-5 in complex with OspA
To Be Published
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8TBB
 | | F9S, novel TIM-3 targeting antibody, bound to IgV domain of TIM-3 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, F9S Fab heavy chain, F9S Fab light chain, ... | | Authors: | Oganesyan, V, van Dyk, N, Mazor, Y, Yang, C. | | Deposit date: | 2023-06-28 | | Release date: | 2024-08-28 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Generation of AZD7789, a novel PD-1 and TIM-3 targeting bispecific antibody, which binds to a differentiated epitope of TIM-3
To be published
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8TWT
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8TVD
 | | Fab 221-11 in complex with OspA | | Descriptor: | CHLORIDE ION, Heavy chain of Fab 221-11, Light chain of Fab 221-11, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (3.077 Å) | | Cite: | Fab 221-11 in complex with OspA
To Be Published
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8TVJ
 | | Fab 227-1 in complex with OspA | | Descriptor: | Heavy chain of Fab 227-1, Light chain of Fab 227-1, Outer surface protein A | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-18 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (3.168 Å) | | Cite: | Fab 227-1 in complex with OspA
To Be Published
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4URA
 | | Crystal structure of human JMJD2A in complex with compound 14a | | Descriptor: | 1,2-ETHANEDIOL, 2-(2H-1,2,3-triazol-4-yl)pyridine-4-carboxylic acid, LYSINE-SPECIFIC DEMETHYLASE 4A, ... | | Authors: | Krojer, T, England, K.S, Vollmar, M, Crawley, L, Williams, E, Riesebos, E, Szykowska, A, Burgess-Brown, N, Oppermann, U, Brennan, P.E, Bountra, C, Arrowsmith, C.H, Edwards, A, von Delft, F. | | Deposit date: | 2014-06-27 | | Release date: | 2015-06-17 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.23 Å) | | Cite: | Optimisation of a triazolopyridine based histone demethylase inhibitor yields a potent and selective KDM2A (FBXL11) inhibitor.
Medchemcomm, 5, 2014
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6BA0
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8TWW
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8TUZ
 | | Fab 857-2 in complex with OspA | | Descriptor: | 1,2-ETHANEDIOL, CHLORIDE ION, Heavy chain of human monoclonal antibody 857-2, ... | | Authors: | Rudolph, M.J, Mantis, N. | | Deposit date: | 2023-08-17 | | Release date: | 2024-08-28 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.186 Å) | | Cite: | Fab 857-2 in complex with OspA
To Be Published
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2L61
 | | Protein and metal cluster structure of the wheat metallothionein domain g-Ec-1. The second part of the puzzle. | | Descriptor: | CADMIUM ION, EC protein I/II | | Authors: | Loebus, J, Peroza, E.A, Bluethgen, N, Fox, T, Meyer-Klaucke, W, Zerbe, O, Freisinger, E. | | Deposit date: | 2010-11-12 | | Release date: | 2011-05-25 | | Last modified: | 2024-05-01 | | Method: | SOLUTION NMR | | Cite: | Protein and metal cluster structure of the wheat metallothionein domain gamma-E(c)-1: the second part of the puzzle.
J.Biol.Inorg.Chem., 16, 2011
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8U4Y
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6RRQ
 | | Crystal structure of tyrosinase PvdP from Pseudomonas aeruginosa bound to copper | | Descriptor: | COPPER (II) ION, GLYCEROL, PvdP | | Authors: | Wibowo, J.P, Batista, F.A, van Oosterwijk, N, Groves, M.R, Dekker, F.J, Quax, W.J. | | Deposit date: | 2019-05-20 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | A novel mechanism of inhibition by phenylthiourea on PvdP, a tyrosinase synthesizing pyoverdine of Pseudomonas aeruginosa.
Int.J.Biol.Macromol., 146, 2020
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4UZV
 | | Structure of a triple mutant of ASV-TfTrHb | | Descriptor: | ACETATE ION, HEMOGLOBIN, PROTOPORPHYRIN IX CONTAINING FE | | Authors: | Baiocco, P, Bonamore, A, Sciamanna, N, Ilari, A, Boechi, L, Boffi, A, Smulevich, G, Feis, A. | | Deposit date: | 2014-09-09 | | Release date: | 2014-09-17 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Role of Local Structure and Dynamics of Small Ligand Migration in Proteins: A Study of a Mutated Truncated Hemoprotein from Thermobifida Fusca by Time Resolved Mir Spectroscopy.
J.Phys.Chem.B, 118, 2014
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6BBD
 | | Structure of N-glycosylated porcine surfactant protein-D complexed with glycerol | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-2)-alpha-D-mannopyranose-(1-6)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, GLYCEROL, ... | | Authors: | van Eijk, M, Rynkiewicz, M.J, Khatri, K, Leymarie, N, Zaia, J, White, M.R, Hartshorn, K.L, Cafarella, T.R, van Die, I, Hessing, M, Seaton, B.A, Haagsman, H.P. | | Deposit date: | 2017-10-18 | | Release date: | 2018-05-23 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.898 Å) | | Cite: | Lectin-mediated binding and sialoglycans of porcine surfactant protein D synergistically neutralize influenza A virus.
J. Biol. Chem., 293, 2018
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