8TWT

Crystal structure of nitrile synthase AetD with substrate bound and cofactor partially assembled

Summary for 8TWT

Entry DOI	10.2210/pdb8twt/pdb
Related	8TWN
Descriptor	AetD, (2S)-2-azanyl-3-[5,7-bis(bromanyl)-1H-indol-3-yl]propanoic acid, D-MALATE, ... (7 entities in total)
Functional Keywords	nitrile synthase, non-heme iron enzyme, diiron enzyme, oxidoreductase
Biological source	Aetokthonos hydrillicola
Total number of polymer chains	2
Total formula weight	61994.85
Authors	Ye, N.,Drennan, C.L. (deposition date: 2023-08-21, release date: 2024-08-28, Last modification date: 2024-10-02)
Primary citation	Adak, S.,Ye, N.,Calderone, L.A.,Duan, M.,Lubeck, W.,Schafer, R.J.B.,Lukowski, A.L.,Houk, K.N.,Pandelia, M.E.,Drennan, C.L.,Moore, B.S. A single diiron enzyme catalyses the oxidative rearrangement of tryptophan to indole nitrile. Nat.Chem., 2024 Cited by PubMed: 39285206 DOI: 10.1038/s41557-024-01603-z PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.3 Å)

Structure validation