4WXH
 
 | | Carminomycin-4-O-methyltransferase (DnrK) variant (298Ser insert) in complex with S-adenosyl-L-homocysteine (SAH) and aclacinomycin T | | 分子名称: | (2R,3S)-1,4-DIMERCAPTOBUTANE-2,3-DIOL, Carminomycin 4-O-methyltransferase DnrK, S-ADENOSYL-L-HOMOCYSTEINE, ... | | 著者 | Metsa-Ketela, M, Niiranen, L. | | 登録日 | 2014-11-13 | | 公開日 | 2015-07-29 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Divergent evolution of an atypical S-adenosyl-l-methionine-dependent monooxygenase involved in anthracycline biosynthesis.
Proc.Natl.Acad.Sci.USA, 112, 2015
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4ICY
 | | Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE | | 分子名称: | 1,2-ETHANEDIOL, CHLORIDE ION, FLAVIN-ADENINE DINUCLEOTIDE, ... | | 著者 | Kallio, P, Patrikainen, P, Belogurov, G, Mantsala, P, Yang, K, Niemi, J, Metsa-Ketela, M. | | 登録日 | 2012-12-11 | | 公開日 | 2013-06-12 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Tracing the Evolution of Angucyclinone Monooxygenases: Structural Determinants for C-12b Hydroxylation and Substrate Inhibition in PgaE.
Biochemistry, 52, 2013
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4X4J
 | | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Putative oxygenase, SULFATE ION | | 著者 | Tsai, S.-C, Jackson, D.R, Patel, A, Barajas, J.F, Rohr, J, Yu, X, Liu, H.-W, Sasaki, E, Calveras, J, Metsa-Ketela, M. | | 登録日 | 2014-12-02 | | 公開日 | 2015-12-02 | | 最終更新日 | 2023-09-27 | | 実験手法 | X-RAY DIFFRACTION (2.65 Å) | | 主引用文献 | Structural and Functional Studies of BexE: Insights into Oxidation During BE-7585A Biosynthesis
To Be Published
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4KWI
 | | The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP and 11-deoxy-6-oxylandomycinone | | 分子名称: | 1,8-dihydroxy-3-methyltetraphene-6,7,12(5H)-trione, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Paananen, P, Patrikainen, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | | 登録日 | 2013-05-24 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
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4KWH
 | | The crystal structure of angucycline C-6 ketoreductase LanV with bound NADP | | 分子名称: | ACETIC ACID, DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Paananen, P, Patrikainen, P, Kallio, P, Mantsala, P, Niemi, J, Niiranen, L, Metsa-Ketela, M. | | 登録日 | 2013-05-24 | | 公開日 | 2013-07-31 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Structural and functional analysis of angucycline C-6 ketoreductase LanV involved in landomycin biosynthesis.
Biochemistry, 52, 2013
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2QA1
 | | Crystal structure of PgaE, an aromatic hydroxylase involved in angucycline biosynthesis | | 分子名称: | 1,2-ETHANEDIOL, FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, ... | | 著者 | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | | 登録日 | 2007-06-14 | | 公開日 | 2007-08-14 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
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2QA2
 | | Crystal structure of CabE, an aromatic hydroxylase from angucycline biosynthesis, determined to 2.7 A resolution | | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, Polyketide oxygenase CabE | | 著者 | Koskiniemi, H, Dobritzsch, D, Metsa-Ketela, M, Kallio, P, Niemi, J, Schneider, G. | | 登録日 | 2007-06-14 | | 公開日 | 2007-08-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal structures of two aromatic hydroxylases involved in the early tailoring steps of angucycline biosynthesis
J.Mol.Biol., 372, 2007
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4AMB
 | | Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | | 分子名称: | DEOXYURIDINE-5'-DIPHOSPHATE, SNOGD | | 著者 | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2012-03-08 | | 公開日 | 2012-09-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.62 Å) | | 主引用文献 | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
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4OSP
 | | The crystal structure of urdamycin C-6 ketoreductase domain UrdMred with bound NADP and rabelomycin | | 分子名称: | NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Oxygenase-reductase, rabelomycin | | 著者 | Niiranen, L, Paananen, P, Patrikainen, P, Metsa-Ketela, M. | | 登録日 | 2014-02-13 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | | 主引用文献 | Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
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4AN4
 | | Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | | 分子名称: | DEOXYURIDINE-5'-DIPHOSPHATE, GLYCOSYL TRANSFERASE | | 著者 | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2012-03-15 | | 公開日 | 2012-09-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
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4AMG
 | | Crystal structure of the glycosyltransferase SnogD from Streptomyces nogalater | | 分子名称: | SNOGD | | 著者 | Claesson, M, Siitonen, V, Dobritzsch, D, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2012-03-09 | | 公開日 | 2012-09-05 | | 最終更新日 | 2023-12-20 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Crystal Structure of the Glycosyltransferase Snogd from the Biosynthetic Pathway of the Nogalamycin in Streptomyces Nogalater.
FEBS J., 279, 2012
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4OSO
 | | The crystal structure of landomycin C-6 ketoreductase LanV with bound NADP and rabelomycin | | 分子名称: | DI(HYDROXYETHYL)ETHER, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Reductase homolog, ... | | 著者 | Paananen, P, Niiranen, L, Patrikainen, P, Metsa-Ketela, M. | | 登録日 | 2014-02-13 | | 公開日 | 2014-10-01 | | 最終更新日 | 2023-09-20 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Structure-based engineering of angucyclinone 6-ketoreductases.
Chem.Biol., 21, 2014
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5EPA
 | | Crystal structure of non-heme alpha ketoglutarate dependent carbocyclase SnoK from nogalamycin biosynthesis | | 分子名称: | 2-OXOGLUTARIC ACID, FE (III) ION, MAGNESIUM ION, ... | | 著者 | Selvaraj, B, Lindqvist, Y, Siitonen, V, Niiranen, L, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2015-11-11 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.24 Å) | | 主引用文献 | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5ERL
 | | Crystal structure of the epimerase SnoN in complex with Ni2+, succinate and nogalamycin RO | | 分子名称: | NICKEL (II) ION, Nogalamycin RO, SUCCINIC ACID, ... | | 著者 | Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2015-11-14 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.85 Å) | | 主引用文献 | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5EP9
 | | Crystal structure of the non-heme alpha ketoglutarate dependent epimerase SnoN from nogalamycin biosynthesis | | 分子名称: | 2-OXOGLUTARIC ACID, ACETATE ION, FE (III) ION, ... | | 著者 | Selvaraj, B, Lindqvist, Y, Niiranen, L, Siitonen, V, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2015-11-11 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.13 Å) | | 主引用文献 | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
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5EQU
 | | Crystal structure of the epimerase SnoN in complex with Fe3+, alpha ketoglutarate and nogalamycin RO | | 分子名称: | 2-OXOGLUTARIC ACID, FE (III) ION, Nogalamycin RO, ... | | 著者 | Selvaraj, B, Lindqvist, Y, Siitonen, V, Metsa-Ketela, M, Schneider, G. | | 登録日 | 2015-11-13 | | 公開日 | 2016-05-11 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Divergent non-heme iron enzymes in the nogalamycin biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 113, 2016
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4EX6
 | | Crystal structure of the alnumycin P phosphatase AlnB | | 分子名称: | AlnB, BORIC ACID, MAGNESIUM ION | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.25 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX9
 | | Crystal structure of the prealnumycin C-glycosynthase AlnA in complex with ribulose 5-phosphate | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, AlnA, CALCIUM ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (3.15 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX7
 | | Crystal structure of the alnumycin P phosphatase in complex with free phosphate | | 分子名称: | AlnB, BORIC ACID, MAGNESIUM ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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4EX8
 | | Crystal structure of the prealnumycin C-glycosynthase AlnA | | 分子名称: | AlnA, CALCIUM ION, CHLORIDE ION, ... | | 著者 | Oja, T, Niiranen, L, Sandalova, T, Klika, K.D, Niemi, J, Mantsala, P, Schneider, G, Metsa-Ketela, M. | | 登録日 | 2012-04-30 | | 公開日 | 2013-01-16 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | Structural basis for C-ribosylation in the alnumycin A biosynthetic pathway.
Proc.Natl.Acad.Sci.USA, 110, 2013
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