3ESS
 
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3Q9O
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3NY6
 | | Catalytic fragment of cholix toxin from vibrio cholerae in complex with inhibitor V30 | | Descriptor: | 2-[(5,6-dimethyl-4-oxo-3,4-dihydrothieno[2,3-d]pyrimidin-2-yl)sulfanyl]-N-(2-hydroxyethyl)acetamide, Cholix toxin, GLYCEROL, ... | | Authors: | Merrill, A.R, Jorgensen, R. | | Deposit date: | 2010-07-14 | | Release date: | 2010-12-29 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.68 Å) | | Cite: | Newly discovered and characterized antivirulence compounds inhibit bacterial mono-ADP-ribosyltransferase toxins.
Antimicrob.Agents Chemother., 55, 2011
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2Q6M
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4FXQ
 | | Full-length Certhrax toxin from Bacillus cereus in complex with Inhibitor P6 | | Descriptor: | 8-fluoro-2-(3-piperidin-1-ylpropanoyl)-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-6(2H)-one, CHLORIDE ION, Putative ADP-ribosyltransferase Certhrax, ... | | Authors: | Visschedyk, D.D, Dimov, S, Kimber, M.S, Park, H.W, Merrill, A.R. | | Deposit date: | 2012-07-03 | | Release date: | 2012-09-26 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (1.9599 Å) | | Cite: | Certhrax Toxin, an Anthrax-related ADP-ribosyltransferase from Bacillus cereus.
J.Biol.Chem., 287, 2012
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1U2R
 | | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Elongation factor 2, GUANOSINE-5'-DIPHOSPHATE, ... | | Authors: | Jorgensen, R, Yates, S.P, Nilsson, J, Prentice, G.A, Teal, D.J, Merrill, A.R, Andersen, G.R. | | Deposit date: | 2004-07-20 | | Release date: | 2004-09-14 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of ADP-ribosylated Ribosomal Translocase from Saccharomyces cerevisiae
J.Biol.Chem., 279, 2004
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3NTS
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4TR5
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3B82
 | | Structure of the eEF2-ExoA(E546H)-NAD+ complex | | Descriptor: | Elongation factor 2, Exotoxin A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Jorgensen, R, Merrill, A.R. | | Deposit date: | 2007-10-31 | | Release date: | 2008-06-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.35 Å) | | Cite: | The nature and character of the transition state for the ADP-ribosyltransferase reaction.
Embo Rep., 9, 2008
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2ZIT
 | | Structure of the eEF2-ExoA-NAD+ complex | | Descriptor: | Elongation factor 2, Exotoxin A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Jorgensen, R, Merrill, A.R. | | Deposit date: | 2008-02-24 | | Release date: | 2008-06-24 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (3 Å) | | Cite: | The nature and character of the transition state for the ADP-ribosyltransferase reaction.
Embo Rep., 9, 2008
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3B8H
 | | Structure of the eEF2-ExoA(E546A)-NAD+ complex | | Descriptor: | Elongation factor 2, Exotoxin A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Jorgensen, R, Merrill, A.R. | | Deposit date: | 2007-11-01 | | Release date: | 2008-06-17 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The nature and character of the transition state for the ADP-ribosyltransferase reaction.
Embo Rep., 9, 2008
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3B78
 | | Structure of the eEF2-ExoA(R551H)-NAD+ complex | | Descriptor: | Elongation factor 2, Exotoxin A, NICOTINAMIDE-ADENINE-DINUCLEOTIDE | | Authors: | Jorgensen, R, Merrill, A.R. | | Deposit date: | 2007-10-30 | | Release date: | 2008-06-17 | | Last modified: | 2021-10-20 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | The nature and character of the transition state for the ADP-ribosyltransferase reaction.
Embo Rep., 9, 2008
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6APY
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1XK9
 | | Pseudomanas exotoxin A in complex with the PJ34 inhibitor | | Descriptor: | Exotoxin A, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE | | Authors: | Yates, S.P, Taylor, P.J, Joergensen, R, Ferrraris, D, Zhang, J, Andersen, G.R, Merrill, A.R. | | Deposit date: | 2004-09-28 | | Release date: | 2005-05-17 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | Structure-function analysis of water-soluble inhibitors of the catalytic domain of exotoxin A from Pseudomonas aeruginosa
BIOCHEM.J., 385, 2005
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1ZM9
 | | Structure of eEF2-ETA in complex with PJ34 | | Descriptor: | Elongation factor 2, N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, exotoxin A | | Authors: | Joergensen, R, Merrill, A.R, Yates, S.P, Marquez, V.E, Schwan, A.L, Boesen, T, Andersen, G.R. | | Deposit date: | 2005-05-10 | | Release date: | 2005-05-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
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1ZM3
 | | Structure of the apo eEF2-ETA complex | | Descriptor: | Elongation factor 2, exotoxin A | | Authors: | Joergensen, R, Merrill, A.R, Yates, S.P, Marquez, V.E, Schwan, A.L, Boesen, T, Andersen, G.R. | | Deposit date: | 2005-05-10 | | Release date: | 2005-05-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.07 Å) | | Cite: | Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
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4FML
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1ZM4
 | | Structure of the eEF2-ETA-bTAD complex | | Descriptor: | BETA-METHYLENE-THIAZOLE-4-CARBOXYAMIDE-ADENINE DINUCLEOTIDE, Elongation factor 2, exotoxin A | | Authors: | Joergensen, R, Merrill, A.R, Yates, S.P, Marquez, V.E, Schwan, A.L, Boesen, T, Andersen, G.R. | | Deposit date: | 2005-05-10 | | Release date: | 2005-05-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
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1ZM2
 | | Structure of ADP-ribosylated eEF2 in complex with catalytic fragment of ETA | | Descriptor: | ADENOSINE-5-DIPHOSPHORIBOSE, Elongation factor 2, Exotoxin A | | Authors: | Joergensen, R, Merrill, A.R, Yates, S.P, Marquez, V.E, Schwan, A.L, Boesen, T, Andersen, G.R. | | Deposit date: | 2005-05-10 | | Release date: | 2005-05-24 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (3.07 Å) | | Cite: | Exotoxin A-eEF2 complex structure indicates ADP ribosylation by ribosome mimicry.
Nature, 436, 2005
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5EWK
 | | Scabin toxin from Streptomyces Scabies in complex with inhibitor PJ34 | | Descriptor: | N~2~,N~2~-DIMETHYL-N~1~-(6-OXO-5,6-DIHYDROPHENANTHRIDIN-2-YL)GLYCINAMIDE, Putative ADP-Ribosyltransferase Scabin | | Authors: | Ravulapalli, R, Lyons, B, Merrill, A.R. | | Deposit date: | 2015-11-20 | | Release date: | 2016-03-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Scabin, a Novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies.
J.Biol.Chem., 291, 2016
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5EWY
 | | Scabin toxin from Streptomyces Scabies in complex with inhibitor P6E | | Descriptor: | 4-(8-fluoranyl-6-oxidanylidene-1,3,4,5-tetrahydrobenzo[c][1,6]naphthyridin-2-yl)butanoic acid, Putative ADP-Ribosyltransferase Scabin | | Authors: | Ravulapalli, R, Lyons, B, Merrill, A.R. | | Deposit date: | 2015-11-22 | | Release date: | 2016-03-23 | | Last modified: | 2017-11-22 | | Method: | X-RAY DIFFRACTION (1.4 Å) | | Cite: | Scabin, a Novel DNA-acting ADP-ribosyltransferase from Streptomyces scabies.
J.Biol.Chem., 291, 2016
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5DAZ
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5DZQ
 | | C3larvin toxin, an ADP-ribosyltransferase from Paenibacillus larvae, Orthorhombic Form | | Descriptor: | GLYCEROL, MAGNESIUM ION, Toxin-like protein | | Authors: | Dutta, D, Ravulapalli, R, Merrill, A.R. | | Deposit date: | 2015-09-26 | | Release date: | 2015-10-14 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.892 Å) | | Cite: | Structural variability of C3larvin toxin. Intrinsic dynamics of the alpha / beta fold of the C3-like group of mono-ADP-ribosyltransferase toxins.
J. Biomol. Struct. Dyn., 34, 2016
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3KI0
 | | Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-D | | Descriptor: | 3-(morpholin-4-ylmethyl)-1,5-dihydro-6H-[1,2]diazepino[4,5,6-cd]indol-6-one, CHLORIDE ION, Cholix toxin | | Authors: | Jorgensen, R, Edwards, P.R, Merrill, A.R. | | Deposit date: | 2009-10-31 | | Release date: | 2010-10-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.29 Å) | | Cite: | Structure function analysis of soluble inhibitors of cholix toxin from Vibrio cholerae
To be Published
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3KI7
 | | Catalytic fragment of Cholix toxin from Vibrio Cholerae in complex with inhibitor GP-I | | Descriptor: | 2-{2-[4-(pyrrolidin-1-ylmethyl)phenyl]ethyl}-5,6-dihydroimidazo[4,5,1-jk][1,4]benzodiazepin-7(4H)-one, Cholix toxin | | Authors: | Jorgensen, R, Edwards, P.R, Merrill, A.R. | | Deposit date: | 2009-10-31 | | Release date: | 2010-10-27 | | Last modified: | 2023-09-06 | | Method: | X-RAY DIFFRACTION (1.32 Å) | | Cite: | Structure function analysis of soluble inhibitors of cholix toxin from Vibrio cholerae
To be Published
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