8DKG
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![BU of 8dkg by Molmil](/molmil-images/mine/8dkg) | Structure of PYCR1 Thr171Met variant complexed with NADH | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Isoform 3 of Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Meeks, K.R, Tanner, J.J. | Deposit date: | 2022-07-05 | Release date: | 2023-02-08 | Last modified: | 2023-10-25 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | Functional Impact of a Cancer-Related Variant in Human Delta 1 -Pyrroline-5-Carboxylate Reductase 1. Acs Omega, 8, 2023
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8TCV
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![BU of 8tcv by Molmil](/molmil-images/mine/8tcv) | Structure of PYCR1 complexed with 4-bromobenzene-1,3-dicarboxylic acid | Descriptor: | 4-bromobenzene-1,3-dicarboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.74 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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8TCZ
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![BU of 8tcz by Molmil](/molmil-images/mine/8tcz) | |
8TCW
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![BU of 8tcw by Molmil](/molmil-images/mine/8tcw) | |
8TCX
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![BU of 8tcx by Molmil](/molmil-images/mine/8tcx) | Structure of PYCR1 complexed with 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid | Descriptor: | 2,4-dioxo-1,2,3,4-tetrahydroquinazoline-6-carboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.72 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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8TD0
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![BU of 8td0 by Molmil](/molmil-images/mine/8td0) | Structure of PYCR1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid | Descriptor: | (3R,4S,7aR)-5-oxo-7a-phenylhexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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8TCU
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![BU of 8tcu by Molmil](/molmil-images/mine/8tcu) | |
8TD1
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![BU of 8td1 by Molmil](/molmil-images/mine/8td1) | |
8TCY
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![BU of 8tcy by Molmil](/molmil-images/mine/8tcy) | Structure of PYCR1 complexed with 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid | Descriptor: | 7-fluoro-2-oxo-1,2,3,4-tetrahydroquinoline-6-carboxylic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-03-06 | Last modified: | 2024-03-20 | Method: | X-RAY DIFFRACTION (1.95 Å) | Cite: | Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64, 2024
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8TD9
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![BU of 8td9 by Molmil](/molmil-images/mine/8td9) | Structure of PYCR1 complexed with NADH and L-pipecolic acid | Descriptor: | (2S)-piperidine-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.75 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TDC
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![BU of 8tdc by Molmil](/molmil-images/mine/8tdc) | Structure of PYCR1 complexed with NADH and 1,3-dithiane-2-carboxylic acid | Descriptor: | 1,3-dithiane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD3
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![BU of 8td3 by Molmil](/molmil-images/mine/8td3) | |
8TD4
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![BU of 8td4 by Molmil](/molmil-images/mine/8td4) | Structure of PYCR1 complexed with NADH and 1,3-Dithiolane-2-carboxylic acid | Descriptor: | 1,3-dithiolane-2-carboxylic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.76 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD2
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![BU of 8td2 by Molmil](/molmil-images/mine/8td2) | Structure of PYCR1 complexed with NADH and cyclobutane-1,1-dicarboxylic acid | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TDB
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![BU of 8tdb by Molmil](/molmil-images/mine/8tdb) | Structure of PYCR1 complexed with NADH and 1-hydroxyethane-1-sulfonate | Descriptor: | (1R)-1-hydroxyethane-1-sulfonic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD7
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![BU of 8td7 by Molmil](/molmil-images/mine/8td7) | Structure of PYCR1 complexed with 2S-hydroxy-3-methylbutyric acid | Descriptor: | (2S)-2-hydroxy-3-methylbutanoic acid, DI(HYDROXYETHYL)ETHER, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.61 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TDD
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![BU of 8tdd by Molmil](/molmil-images/mine/8tdd) | Structure of PYCR1 complexed with NADH and 2-(furan-2-yl)acetic acid | Descriptor: | (furan-2-yl)acetic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.91 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD8
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![BU of 8td8 by Molmil](/molmil-images/mine/8td8) | Structure of PYCR1 complexed with NADH and 2S-Hydroxy-3,3-dimethylbutyric acid | Descriptor: | (2S)-2-hydroxy-3,3-dimethylbutanoic acid, 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.71 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD6
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![BU of 8td6 by Molmil](/molmil-images/mine/8td6) | Structure of PYCR1 complexed with NADH and 2-(Methylthio)acetic acid | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, Pyrroline-5-carboxylate reductase 1, mitochondrial, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2023-07-02 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (2.08 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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8TD5
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![BU of 8td5 by Molmil](/molmil-images/mine/8td5) | |
8W0K
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![BU of 8w0k by Molmil](/molmil-images/mine/8w0k) | |
8VRE
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![BU of 8vre by Molmil](/molmil-images/mine/8vre) | Structure of PYCR1 complexed with NADH and N-formyl-L-proline | Descriptor: | 1,4-DIHYDRONICOTINAMIDE ADENINE DINUCLEOTIDE, 1-formyl-L-proline, Pyrroline-5-carboxylate reductase 1, ... | Authors: | Tanner, J.J, Meeks, K.R. | Deposit date: | 2024-01-21 | Release date: | 2024-07-03 | Method: | X-RAY DIFFRACTION (1.83 Å) | Cite: | Screening a knowledge-based library of low molecular weight compounds against the proline biosynthetic enzyme 1-pyrroline-5-carboxylate 1 (PYCR1) Protein Sci., 33, 2024
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