8TD0

Structure of PYCR1 complexed with 5-oxo-7a-phenyl-hexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid

Summary for 8TD0

Entry DOI	10.2210/pdb8td0/pdb
Descriptor	Pyrroline-5-carboxylate reductase 1, mitochondrial, SULFATE ION, (3R,4S,7aR)-5-oxo-7a-phenylhexahydropyrrolo[2,1-b][1,3]thiazole-3-carboxylic acid, ... (4 entities in total)
Functional Keywords	amino-acid biosynthesis, oxidoreductase, proline biosynthesis
Biological source	Homo sapiens (human)
Total number of polymer chains	5
Total formula weight	168573.75
Authors	Tanner, J.J.,Meeks, K.R. (deposition date: 2023-07-02, release date: 2024-03-06, Last modification date: 2024-03-20)
Primary citation	Meeks, K.R.,Ji, J.,Protopopov, M.V.,Tarkhanova, O.O.,Moroz, Y.S.,Tanner, J.J. Novel Fragment Inhibitors of PYCR1 from Docking-Guided X-ray Crystallography. J.Chem.Inf.Model., 64:1704-1718, 2024 Cited by PubMed: 38411104 DOI: 10.1021/acs.jcim.3c01879 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.2 Å)

Structure validation