1QFH
 
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5JP2
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1E05
 | | PLASMA ALPHA ANTITHROMBIN-III | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | | Authors: | McCoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W. | | Deposit date: | 2000-03-09 | | Release date: | 2000-06-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.62 Å) | | Cite: | Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
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1E04
 | | PLASMA BETA ANTITHROMBIN-III | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, GLYCEROL, ... | | Authors: | Mccoy, A.J, Skinner, R, Abrahams, J.-P, Pei, X.Y, Carrell, R.W. | | Deposit date: | 2000-03-09 | | Release date: | 2000-06-02 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
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1DZH
 | | P14-FLUORESCEIN-N135Q-S380C-ANTITHROMBIN-III | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | | Authors: | Mccoy, A.J, Huntington, J.A, Carrell, R.W. | | Deposit date: | 2000-02-28 | | Release date: | 2000-05-26 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.85 Å) | | Cite: | The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
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1E03
 | | PLASMA ALPHA ANTITHROMBIN-III AND PENTASACCHARIDE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose-(1-4)-2,3-di-O-methyl-beta-D-glucopyranuronic acid-(1-4)-2,3,6-tri-O-sulfo-alpha-D-glucopyranose-(1-4)-3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid-(1-4)-methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside, ... | | Authors: | McCoy, A.J, Jin, L, Abrahams, J.-P, Skinner, R, Carrell, R.W. | | Deposit date: | 2000-03-09 | | Release date: | 2000-06-02 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structure of Beta-Antithrombin and the Effect of Glycosylation on Antithrombin'S Heparin Affinity and Activity.
J.Mol.Biol., 326, 2003
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1DZG
 | | N135Q-S380C-ANTITHROMBIN-III | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ANTITHROMBIN-III, ... | | Authors: | McCoy, A.J, Huntington, J.A, Carrell, R.W. | | Deposit date: | 2000-02-28 | | Release date: | 2000-05-26 | | Last modified: | 2023-12-06 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The Conformational Activation of Antithrombin. A 2. 85-A Structure of a Fluorescein Derivative Reveals an Electrostatic Link between the Hinge and Heparin Binding Regions.
J.Biol.Chem., 275, 2000
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1ASK
 | | NUCLEAR TRANSPORT FACTOR 2 (NTF2) H66A MUTANT | | Descriptor: | NUCLEAR TRANSPORT FACTOR 2 | | Authors: | Mccoy, A.J, Stewart, M.J. | | Deposit date: | 1997-08-11 | | Release date: | 1998-01-28 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.
J.Mol.Biol., 272, 1997
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1AR0
 | | NUCLEAR TRANSPORT FACTOR 2 (NTF2) E42K MUTANT | | Descriptor: | NUCLEAR TRANSPORT FACTOR 2 | | Authors: | Mccoy, A.J, Stewart, M.J. | | Deposit date: | 1997-08-08 | | Release date: | 1997-12-24 | | Last modified: | 2024-05-22 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Nuclear protein import is decreased by engineered mutants of nuclear transport factor 2 (NTF2) that do not bind GDP-Ran.
J.Mol.Biol., 272, 1997
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1WBA
 | | WINGED BEAN ALBUMIN 1 | | Descriptor: | WINGED BEAN ALBUMIN 1 | | Authors: | Mccoy, A.J. | | Deposit date: | 1996-06-19 | | Release date: | 1997-01-11 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Crystallization and preliminary crystallographic data of the major albumin from Psophocarpus tetragonolobus (L.) DC.
J.Biol.Chem., 262, 1987
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2QYW
 | | Crystal structure of mouse vti1b Habc domain | | Descriptor: | Vesicle transport through interaction with t-SNAREs 1B homolog | | Authors: | Miller, S.E, Collins, B.M, McCoy, A.J, Robinson, M.S, Owen, D.J. | | Deposit date: | 2007-08-15 | | Release date: | 2007-11-27 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
Nature, 450, 2007
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2XA7
 | | AP2 clathrin adaptor core in active complex with cargo peptides | | Descriptor: | ADAPTOR-RELATED PROTEIN COMPLEX 2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA, ... | | Authors: | Jackson, L.P, Kelly, B.T, McCoy, A.J, Evans, P.R, Owen, D.J. | | Deposit date: | 2010-03-29 | | Release date: | 2010-07-21 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.1 Å) | | Cite: | A Large Scale Conformational Change Couples Membrane Recruitment to Cargo Binding in the Ap2 Clathrin Adaptor Complex
Cell(Cambridge,Mass.), 141, 2010
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2VGL
 | | AP2 CLATHRIN ADAPTOR CORE | | Descriptor: | ADAPTOR PROTEIN COMPLEX AP-2, ALPHA 2 SUBUNIT, AP-2 COMPLEX SUBUNIT BETA-1, ... | | Authors: | Owen, D.J, Collins, B.M, McCoy, A.J, Evans, P.R. | | Deposit date: | 2007-11-14 | | Release date: | 2007-12-25 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Molecular Architecture and Functional Model of the Endocytic Ap2 Complex
Cell(Cambridge,Mass.), 109, 2002
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6Z32
 | | Human cation-independent mannose 6-phosphate/IGF2 receptor domains 7-11 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Cation-independent mannose-6-phosphate receptor, SULFATE ION, ... | | Authors: | Bochel, A.J, Williams, C, McCoy, A.J, Hoppe, H, Winter, A.J, Nicholls, R.D, Harlos, K, Jones, Y.E, Berger, I, Hassan, B, Crump, M.P. | | Deposit date: | 2020-05-19 | | Release date: | 2020-08-19 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (3.47 Å) | | Cite: | Structure of the Human Cation-Independent Mannose 6-Phosphate/IGF2 Receptor Domains 7-11 Uncovers the Mannose 6-Phosphate Binding Site of Domain 9.
Structure, 28, 2020
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2QY7
 | | Crystal structure of human epsinR ENTH domain | | Descriptor: | Clathrin interactor 1 | | Authors: | Miller, S.E, Collins, B.M, McCoy, A.J, Robinson, M.S, Owen, D.J. | | Deposit date: | 2007-08-13 | | Release date: | 2007-11-27 | | Last modified: | 2024-02-21 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A SNARE-adaptor interaction is a new mode of cargo recognition in clathrin-coated vesicles.
Nature, 450, 2007
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4N3E
 | | Crystal structure of Hyp-1, a St John's wort PR-10 protein, in complex with 8-anilino-1-naphthalene sulfonate (ANS) | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, 8-ANILINO-1-NAPHTHALENE SULFONATE, Phenolic oxidative coupling protein, ... | | Authors: | Sliwiak, J, Dauter, Z, Mccoy, A.J, Read, R.J, Jaskolski, M. | | Deposit date: | 2013-10-07 | | Release date: | 2014-02-26 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.43 Å) | | Cite: | Likelihood-based molecular-replacement solution for a highly pathological crystal with tetartohedral twinning and sevenfold translational noncrystallographic symmetry.
Acta Crystallogr.,Sect.D, 70, 2014
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2V8S
 | | VTI1B HABC DOMAIN - EPSINR ENTH DOMAIN COMPLEX | | Descriptor: | CLATHRIN INTERACTOR 1, GLYCEROL, VESICLE TRANSPORT THROUGH INTERACTION WITH T-SNARES HOMOLOG 1B | | Authors: | Owen, D.J, McCoy, A.J, Collins, B.M, Miller, S.E. | | Deposit date: | 2007-08-14 | | Release date: | 2007-11-27 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | A Snare-Adaptor Interaction is a New Mode of Cargo Recognition in Clathrin Coated Vesicles
Nature, 450, 2007
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1QG2
 | | CANINE GDP-RAN R76E MUTANT | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN) | | Authors: | Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M. | | Deposit date: | 1999-04-20 | | Release date: | 1999-06-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
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1QG4
 | | CANINE GDP-RAN F72Y MUTANT | | Descriptor: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, PROTEIN (RAN) | | Authors: | Kent, H.M, Moore, M.S, Quimby, B.B, Baker, A.M.E, McCoy, A.J, Murphy, G.A, Corbett, A.H, Stewart, M. | | Deposit date: | 1999-04-20 | | Release date: | 1999-06-11 | | Last modified: | 2024-04-03 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Engineered mutants in the switch II loop of Ran define the contribution made by key residues to the interaction with nuclear transport factor 2 (NTF2) and the role of this interaction in nuclear protein import.
J.Mol.Biol., 289, 1999
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6QH5
 | | AP2 clathrin adaptor mu2T156-phosphorylated core in closed conformation | | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R. | | Deposit date: | 2019-01-15 | | Release date: | 2019-09-04 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.56 Å) | | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
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6QH6
 | | AP2 clathrin adaptor core with two cargo peptides in open+ conformation | | Descriptor: | AP-2 complex subunit alpha, AP-2 complex subunit beta, AP-2 complex subunit mu, ... | | Authors: | Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R. | | Deposit date: | 2019-01-15 | | Release date: | 2019-09-04 | | Last modified: | 2022-12-07 | | Method: | X-RAY DIFFRACTION (5 Å) | | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
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6QH7
 | | AP2 clathrin adaptor mu2T156-phosphorylated core with two cargo peptides in open+ conformation | | Descriptor: | ADAPTOR-RELATED PROTEIN COMPLEX 2, MU 2 SUBUNIT, C-TERMINAL DOMAIN, ... | | Authors: | Wrobel, A.G, Owen, D.J, McCoy, A.J, Evans, P.R. | | Deposit date: | 2019-01-15 | | Release date: | 2019-09-04 | | Method: | X-RAY DIFFRACTION (3.4 Å) | | Cite: | Temporal Ordering in Endocytic Clathrin-Coated Vesicle Formation via AP2 Phosphorylation.
Dev.Cell, 50, 2019
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1NMC
 | | COMPLEX BETWEEN NC10 ANTI-INFLUENZA VIRUS NEURAMINIDASE SINGLE CHAIN ANTIBODY WITH A 15 RESIDUE LINKER AND INFLUENZA VIRUS NEURAMINIDASE | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, CALCIUM ION, NEURAMINIDASE, ... | | Authors: | Malby, R.L, Mccoy, A.J, Kortt, A.A, Hudson, P.J, Colman, P.M. | | Deposit date: | 1997-12-21 | | Release date: | 1998-09-23 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Three-dimensional structures of single-chain Fv-neuraminidase complexes.
J.Mol.Biol., 279, 1998
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4CZ2
 | | Complex of human VARP-ANKRD1 with Rab32-GppCp. Selenomet derivative. | | Descriptor: | ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Perez-Dorado, I, Schaefer, I.B, McCoy, A.J, Owen, D.J, Evans, P.R. | | Deposit date: | 2014-04-16 | | Release date: | 2014-06-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.97 Å) | | Cite: | Varp is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface.
Dev.Cell, 29, 2014
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4CYM
 | | Complex of human VARP-ANKRD1 with Rab32-GppCp | | Descriptor: | ANKYRIN REPEAT DOMAIN-CONTAINING PROTEIN 27, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID GUANYLATE ESTER, ... | | Authors: | Perez-Dorado, I, Schaefer, I.B, McCoy, A.J, Owen, D.J, Evans, P.R. | | Deposit date: | 2014-04-13 | | Release date: | 2014-06-04 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Varp is Recruited on to Endosomes by Direct Interaction with Retromer, Where Together They Function in Export to the Cell Surface.
Dev.Cell, 29, 2014
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