3CT0
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4V0B
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![BU of 4v0b by Molmil](/molmil-images/mine/4v0b) | Escherichia coli FtsH hexameric N-domain | Descriptor: | ATP-DEPENDENT ZINC METALLOPROTEASE FTSH, SULFATE ION | Authors: | Serek-Heuberger, J, Martin, J, Lupas, A.N, Hartmann, M.D. | Deposit date: | 2014-09-13 | Release date: | 2015-01-21 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.55 Å) | Cite: | Structure and Evolution of N-Domains in Aaa Metalloproteases. J.Mol.Biol., 427, 2015
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5OCR
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![BU of 5ocr by Molmil](/molmil-images/mine/5ocr) | Crystal structure of the kappa-carrageenase zobellia_236 from Zobellia galactanivorans | Descriptor: | GLYCEROL, Kappa-carrageenase, MAGNESIUM ION | Authors: | Czjzek, M, Matard-Mann, M, Michel, G, Jeudy, A, Larocque, R. | Deposit date: | 2017-07-03 | Release date: | 2017-10-18 | Last modified: | 2024-01-17 | Method: | X-RAY DIFFRACTION (1.66 Å) | Cite: | Structural insights into marine carbohydrate degradation by family GH16 kappa-carrageenases. J. Biol. Chem., 292, 2017
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7NIP
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![BU of 7nip by Molmil](/molmil-images/mine/7nip) | |
5A1Q
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5ADP
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![BU of 5adp by Molmil](/molmil-images/mine/5adp) | Crystal structure of the A.17 antibody FAB fragment - Light chain S35R mutant | Descriptor: | FAB A.17 | Authors: | Chatziefthimiou, S.D, Smirnov, I.V, Golovin, A.V, Stepanova, A.V, Peng, Y, Zolotareva, O.I, Belogurov, A.A, Ponomarenko, N.A, Blackburn, G.M, Gabibov, A.A, Lerner, R, Wilmanns, M. | Deposit date: | 2015-08-21 | Release date: | 2016-11-09 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (2.13 Å) | Cite: | Robotic Qm/Mm-Driven Maturation of Antibody Combining Sites. Sci.Adv., 2, 2016
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8C6P
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![BU of 8c6p by Molmil](/molmil-images/mine/8c6p) | Fragment screening hit I bound to endothiapepsin | Descriptor: | 4-[(2-azanyl-4-methyl-1,3-thiazol-5-yl)methyl]benzenecarbonitrile, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C6Q
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![BU of 8c6q by Molmil](/molmil-images/mine/8c6q) | Fragment screening hit II bound to endothiapepsin | Descriptor: | 3-(4-methylimidazol-1-yl)-5-(trifluoromethyl)aniline, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.25 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C70
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![BU of 8c70 by Molmil](/molmil-images/mine/8c70) | Pyrrolidine fragment 1 bound to endothiapepsin | Descriptor: | (3~{R},4~{R})-4-[4-[(5-bromanylpyridin-3-yl)oxymethyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C71
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![BU of 8c71 by Molmil](/molmil-images/mine/8c71) | Pyrrolidine fragment 5b bound to endothiapepsin | Descriptor: | (3~{R},4~{R})-4-(3,4-dihydro-1~{H}-isoquinolin-2-yl)pyrrolidin-3-ol, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C72
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![BU of 8c72 by Molmil](/molmil-images/mine/8c72) | Pyrrolidine fragment 10b bound to endothiapepsin | Descriptor: | (3~{S},4~{S})-4-(4-pyridin-2-yl-1,2,3-triazol-1-yl)piperidin-3-ol, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C74
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![BU of 8c74 by Molmil](/molmil-images/mine/8c74) | Pyrrolidine fragment 10d bound to endothiapepsin | Descriptor: | (3~{R},4~{R})-4-[4-[(4-azanylphenoxy)methyl]-1,2,3-triazol-1-yl]pyrrolidin-3-ol, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C6S
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![BU of 8c6s by Molmil](/molmil-images/mine/8c6s) | Fragment screening hit III bound to endothiapepsin | Descriptor: | 4-(1,4-diazepan-1-ylsulfonyl)isoquinoline, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.1 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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8C6T
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![BU of 8c6t by Molmil](/molmil-images/mine/8c6t) | Fragment screening hit IV bound to endothiapepsin | Descriptor: | 1-[3,5-bis(chloranyl)phenoxy]propan-2-amine, Endothiapepsin, GLYCEROL | Authors: | Wiese, J.N, Buehrmann, M, Mueller, M.P, Rauh, D. | Deposit date: | 2023-01-12 | Release date: | 2023-05-24 | Method: | X-RAY DIFFRACTION (1.15 Å) | Cite: | Fragtory: Pharmacophore-Focused Design, Synthesis, and Evaluation of an sp 3 -Enriched Fragment Library. J.Med.Chem., 66, 2023
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1W66
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4V15
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![BU of 4v15 by Molmil](/molmil-images/mine/4v15) | Crystal structure of D-threonine aldolase from Alcaligenes xylosoxidans | Descriptor: | D-THREONINE ALDOLASE, MANGANESE (II) ION, PYRIDOXAL-5'-PHOSPHATE, ... | Authors: | Uhl, M.K, Oberdorfer, G, Steinkellner, G, Riegler, L, Schuermann, M, Gruber, K. | Deposit date: | 2014-09-24 | Release date: | 2015-03-25 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.5 Å) | Cite: | The Crystal Structure of D-Threonine Aldolase from Alcaligenes Xylosoxidans Provides Insight Into a Metal Ion Assisted Plp-Dependent Mechanism. Plos One, 10, 2015
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1MXD
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![BU of 1mxd by Molmil](/molmil-images/mine/1mxd) | Structure of a (Ca,Zn)-dependent alpha-amylase from the hyperthermophilic archaeon Pyrococcus woesei | Descriptor: | 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ACETATE ION, CALCIUM ION, ... | Authors: | Linden, A, Mayans, O, Meyer-Klaucke, W, Antranikian, G, Wilmanns, M. | Deposit date: | 2002-10-02 | Release date: | 2003-06-10 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Differential Regulation of a Hyperthermophilic alpha-Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc J.Biol.Chem., 278, 2003
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5AFG
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![BU of 5afg by Molmil](/molmil-images/mine/5afg) | Structure of the Stapled Peptide Bound to Mdm2 | Descriptor: | 1,8-DIETHYL-1,8-DIHYDRODIBENZO[3,4:7,8][1,2,3]TRIAZOLO[4',5':5,6]CYCLOOCTA[1,2-D][1,2,3]TRIAZOLE, E3 UBIQUITIN-PROTEIN LIGASE MDM2, STAPLED PEPTIDE | Authors: | Lau, Y.H, Wu, Y, Rossmann, M, de Andrade, P, Tan, Y.S, McKenzie, G.J, Venkitaraman, A.R, Hyvonen, M, Spring, D.R. | Deposit date: | 2015-01-22 | Release date: | 2016-01-27 | Last modified: | 2024-01-10 | Method: | X-RAY DIFFRACTION (1.9 Å) | Cite: | Double Strain-Promoted Macrocyclization for the Rapid Selection of Cell-Active Stapled Peptides. Angew.Chem.Int.Ed.Engl., 54, 2015
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1VCP
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1MXG
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![BU of 1mxg by Molmil](/molmil-images/mine/1mxg) | Crystal Structure of a (Ca,Zn)-dependent alpha-amylase from the hyperthermophilic archaeon Pyrococcus woesei in complex with acarbose | Descriptor: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, 2-{2-[2-2-(METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHANOL, 4,6-dideoxy-4-{[(1S,4R,5S,6S)-4,5,6-trihydroxy-3-(hydroxymethyl)cyclohex-2-en-1-yl]amino}-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose-(1-4)-alpha-D-glucopyranose, ... | Authors: | Linden, A, Mayans, O, Meyer-Klaucke, W, Antranikian, G, Wilmanns, M. | Deposit date: | 2002-10-02 | Release date: | 2003-06-10 | Last modified: | 2020-09-09 | Method: | X-RAY DIFFRACTION (1.6 Å) | Cite: | Differential Regulation of a Hyperthermophilic alpha-Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc J.Biol.Chem., 278, 2003
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5I6A
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![BU of 5i6a by Molmil](/molmil-images/mine/5i6a) | bicyclo[3.3.2]decapeptide | Descriptor: | ALA-PHE-GLY-LYD-VAL-PHE-PRO-GLN-ALA-GLY, DIMETHYL SULFOXIDE | Authors: | Bartoloni, M, Waltersperger, S, Bumann, M, Stocker, A, Darbre, T, Reymond, J.-L. | Deposit date: | 2016-02-16 | Release date: | 2016-03-09 | Last modified: | 2019-05-08 | Method: | X-RAY DIFFRACTION (0.813 Å) | Cite: | Stereoselective synthesis and structure determination of a bicyclo[3.3.2]decapeptide Arkivoc, 2014, 2014
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1VZW
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![BU of 1vzw by Molmil](/molmil-images/mine/1vzw) | Crystal structure of the bifunctional protein Pria | Descriptor: | GLYCEROL, PHOSPHORIBOSYL ISOMERASE A, SULFATE ION | Authors: | Kuper, J, Wilmanns, M. | Deposit date: | 2004-05-27 | Release date: | 2005-01-19 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Two-Fold Repeated (Beta-Alpha)(4) Half-Barrels May Provide a Molecular Tool for Dual Substrate Specificity Embo Rep., 6, 2005
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1MWO
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![BU of 1mwo by Molmil](/molmil-images/mine/1mwo) | Crystal Structure Analysis of the Hyperthermostable Pyrocoocus woesei alpha-amylase | Descriptor: | CALCIUM ION, ZINC ION, alpha amylase | Authors: | Linden, A, Mayans, O, Meyer-Klaucke, W, Antranikian, G, Wilmanns, M. | Deposit date: | 2002-09-30 | Release date: | 2003-06-10 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.2 Å) | Cite: | Differential Regulation of a Hyperthermophilic alpha-Amylase with a Novel (Ca,Zn) Two-metal Center by Zinc J.Biol.Chem., 278, 2003
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4USH
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![BU of 4ush by Molmil](/molmil-images/mine/4ush) | |
5W3O
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![BU of 5w3o by Molmil](/molmil-images/mine/5w3o) | CryoEM structure of rhinovirus B14 in complex with C5 Fab (33 degrees Celsius, molar ratio 1:3, empty particle) | Descriptor: | C5 antibody variable heavy domain, C5 antibody variable light domain, viral protein 1, ... | Authors: | Liu, Y, Dong, Y, Rossmann, M.G. | Deposit date: | 2017-06-08 | Release date: | 2017-07-12 | Last modified: | 2019-12-11 | Method: | ELECTRON MICROSCOPY (3.01 Å) | Cite: | Antibody-induced uncoating of human rhinovirus B14. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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