7PAY
 
 | | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium and GGsPP | | Descriptor: | Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, MAGNESIUM ION, ... | | Authors: | Giladi, M, Lisnyansky Bar-El, M, Haitin, Y. | | Deposit date: | 2021-07-30 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structural basis for long-chain isoprenoid synthesis by cis -prenyltransferases.
Sci Adv, 8, 2022
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7UR5
 | | allo-tRNAUTu1 in the A, P, and E sites of the E. coli ribosome | | Descriptor: | allo-tRNAUTu1 | | Authors: | Zhang, J, Krahn, N, Prabhakar, A, Vargas-Rodriguez, O, Krupkin, M, Fu, Z, Acosta-Reyes, F.J, Ge, X, Choi, J, Crnkovic, A, Ehrenberg, M, Viani Puglisi, E, Soll, D, Puglisi, J. | | Deposit date: | 2022-04-21 | | Release date: | 2022-08-10 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (2.6 Å) | | Cite: | Uncovering translation roadblocks during the development of a synthetic tRNA.
Nucleic Acids Res., 50, 2022
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7PAX
 | | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, FsPP and IPP | | Descriptor: | 3-METHYLBUT-3-ENYL TRIHYDROGEN DIPHOSPHATE, Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, ... | | Authors: | Giladi, M, Lisnyansky Bar-El, M, Haitin, Y. | | Deposit date: | 2021-07-30 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis for long-chain isoprenoid synthesis by cis -prenyltransferases.
Sci Adv, 8, 2022
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7PB1
 | | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGPP and IsPP | | Descriptor: | 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid, Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, ... | | Authors: | Giladi, M, Lisnyansky Bar-El, M, Haitin, Y. | | Deposit date: | 2021-07-30 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.59 Å) | | Cite: | Structural basis for long-chain isoprenoid synthesis by cis -prenyltransferases.
Sci Adv, 8, 2022
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7URM
 | | allo-tRNAUTu1A in the P site of the E. coli ribosome | | Descriptor: | allo-tRNAUTU1A | | Authors: | Zhang, J, Prabhakar, A, Krahn, N, Vargas-Rodriguez, O, Krupkin, M, Fu, Z, Acosta-Reyes, F.J, Ge, X, Choi, J, Crnkovic, A, Ehrenberg, M, Viani Puglisi, E, Soll, D, Puglisi, J. | | Deposit date: | 2022-04-22 | | Release date: | 2022-08-10 | | Last modified: | 2024-06-12 | | Method: | ELECTRON MICROSCOPY (3 Å) | | Cite: | Uncovering translation roadblocks during the development of a synthetic tRNA.
Nucleic Acids Res., 50, 2022
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1ZTB
 | | Crystal Structure of Chorismate Synthase from Mycobacterium tuberculosis | | Descriptor: | Chorismate synthase | | Authors: | Dias, M.V.B, Borges, J.C, Ely, F, Pereira, J.H, Canduri, F, Ramos, C.H.I, Frazzon, J, Palma, M.S, Basso, L.A, Santos, D.S, Azevedo Jr, W.F. | | Deposit date: | 2005-05-26 | | Release date: | 2006-05-16 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.65 Å) | | Cite: | Structure of chorismate synthase from Mycobacterium tuberculosis
J.Struct.Biol., 154, 2006
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7PB0
 | | Structure of the human heterotetrameric cis-prenyltransferase complex in complex with magnesium, GGsPP and IsPP | | Descriptor: | 3-methylbut-3-enylsulfanyl(phosphonooxy)phosphinic acid, Dehydrodolichyl diphosphate synthase complex subunit DHDDS, Dehydrodolichyl diphosphate synthase complex subunit NUS1, ... | | Authors: | Giladi, M, Lisnyansky Bar-El, M, Haitin, Y. | | Deposit date: | 2021-07-30 | | Release date: | 2022-06-01 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (2.301 Å) | | Cite: | Structural basis for long-chain isoprenoid synthesis by cis -prenyltransferases.
Sci Adv, 8, 2022
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1EYM
 | | FK506 BINDING PROTEIN MUTANT, HOMODIMERIC COMPLEX | | Descriptor: | FK506 BINDING PROTEIN | | Authors: | Rollins, C.T, Rivera, V.M, Woolfson, D.N, Keenan, T, Hatada, M, Adams, S.E, Andrade, L.J, Yaeger, D, van Schravendijk, M.R, Holt, D.A, Gilman, M, Clackson, T. | | Deposit date: | 2000-05-07 | | Release date: | 2000-08-09 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | A ligand-reversible dimerization system for controlling protein-protein interactions.
Proc.Natl.Acad.Sci.USA, 97, 2000
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5ZQR
 | | Tankyrase-2 in complex with compound 40c | | Descriptor: | 2-[4,6-difluoro-1-(2-hydroxyethyl)-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl]-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | Deposit date: | 2018-04-19 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.75 Å) | | Cite: | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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1EF3
 | | FIDARESTAT BOUND TO HUMAN ALDOSE REDUCTASE | | Descriptor: | (2S,4S)-2-AMINOFORMYL-6-FLUORO-SPIRO[CHROMAN-4,4'-IMIDAZOLIDINE]-2',5'-DIONE, ALDOSE REDUCTASE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE | | Authors: | Oka, M, Matsumoto, Y, Sugiyama, S, Tsuruta, N, Matsushima, M. | | Deposit date: | 2000-02-06 | | Release date: | 2001-02-07 | | Last modified: | 2023-08-09 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | A potent aldose reductase inhibitor, (2S,4S)-6-fluoro-2', 5'-dioxospiro[chroman-4,4'-imidazolidine]-2-carboxamide (Fidarestat): its absolute configuration and interactions with the aldose reductase by X-ray crystallography.
J.Med.Chem., 43, 2000
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6A84
 | | Tankyrase-2 in complex with compound 15d | | Descriptor: | 2-(4-chloro-1,2-dihydro-1'H-spiro[indole-3,4'-piperidin]-1'-yl)-5,6,7,8-tetrahydroquinazolin-4(3H)-one, GLYCEROL, PHOSPHATE ION, ... | | Authors: | Niwa, H, Shirai, F, Sato, S, Yoshimoto, N, Tsumura, T, Okue, M, Shirouzu, M, Seimiya, H, Umehara, T. | | Deposit date: | 2018-07-06 | | Release date: | 2019-04-03 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.98 Å) | | Cite: | Discovery of Novel Spiroindoline Derivatives as Selective Tankyrase Inhibitors.
J. Med. Chem., 62, 2019
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1EQN
 | | E.COLI PRIMASE CATALYTIC CORE | | Descriptor: | DNA PRIMASE | | Authors: | Podobnik, M, McInerney, P, O'Donnell, M, Kuriyan, J. | | Deposit date: | 2000-04-05 | | Release date: | 2000-06-30 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | A TOPRIM domain in the crystal structure of the catalytic core of Escherichia coli primase confirms a structural link to DNA topoisomerases.
J.Mol.Biol., 300, 2000
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1EDH
 | | E-CADHERIN DOMAINS 1 AND 2 IN COMPLEX WITH CALCIUM | | Descriptor: | CALCIUM ION, E-CADHERIN, MERCURY (II) ION | | Authors: | Nagar, B, Overduin, M, Ikura, M, Rini, J.M. | | Deposit date: | 1996-05-15 | | Release date: | 1997-01-11 | | Last modified: | 2024-02-07 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Structural basis of calcium-induced E-cadherin rigidification and dimerization.
Nature, 380, 1996
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1YOV
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6IBX
 | | Human PFKFB3 in complex with a N-Aryl 6-Aminoquinoxaline inhibitor 5 | | Descriptor: | 3-[[8-(1-methylindol-6-yl)quinoxalin-6-yl]amino]-~{N}-[(3~{S})-1-methylpiperidin-3-yl]pyridine-4-carboxamide, 6-O-phosphono-beta-D-fructofuranose, 6-phosphofructo-2-kinase/fructose-2,6-bisphosphatase 3, ... | | Authors: | Banaszak, K, Pawlik, H, Bialas, A, Fabritius, C.H, Nowak, M. | | Deposit date: | 2018-12-01 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.11 Å) | | Cite: | Synthesis of amide and sulfonamide substituted N-aryl 6-aminoquinoxalines as PFKFB3 inhibitors with improved physicochemical properties.
Bioorg. Med. Chem. Lett., 29, 2019
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5DEI
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1YUT
 | | Solution structure of Calcium-S100A13 (minimized mean structure) | | Descriptor: | CALCIUM ION, S100 calcium-binding protein A13 | | Authors: | Arnesano, F, Banci, L, Bertini, I, Fantoni, A, Tenori, L, Viezzoli, M.S, Structural Proteomics in Europe (SPINE) | | Deposit date: | 2005-02-14 | | Release date: | 2005-10-18 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Structural Interplay between Calcium(II) and Copper(II) Binding to S100A13 Protein
Angew.Chem.Int.Ed.Engl., 44, 2005
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7X93
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7X95
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6AGT
 | | Crystal structure of PfKRS complexed with chromone inhibitor | | Descriptor: | COBALT (II) ION, FORMIC ACID, LYSINE, ... | | Authors: | Yogavel, M, Sharma, A, Sharma, A, Baragana, B, Walpole, C. | | Deposit date: | 2018-08-14 | | Release date: | 2019-03-13 | | Last modified: | 2023-11-22 | | Method: | X-RAY DIFFRACTION (1.953 Å) | | Cite: | Lysyl-tRNA synthetase as a drug target in malaria and cryptosporidiosis.
Proc. Natl. Acad. Sci. U.S.A., 116, 2019
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7X94
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7X96
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1EX2
 | | CRYSTAL STRUCTURE OF BACILLUS SUBTILIS MAF PROTEIN | | Descriptor: | PHOSPHATE ION, PROTEIN MAF, beta-D-fructofuranose-(2-1)-alpha-D-glucopyranose | | Authors: | Minasov, G, Teplova, M, Stewart, G.C, Koonin, E.V, Anderson, W.F, Egli, M, Midwest Center for Structural Genomics (MCSG) | | Deposit date: | 2000-04-28 | | Release date: | 2000-06-14 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Functional implications from crystal structures of the conserved Bacillus subtilis protein Maf with and without dUTP.
Proc.Natl.Acad.Sci.USA, 97, 2000
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8WGE
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5DGT
 | | BENZOYLFORMATE DECARBOXYLASE H70A MUTANT at pH 8.5 FROM PSEUDOMONAS PUTIDA | | Descriptor: | 2-{3-[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]-4-METHYL-2-OXO-2,3-DIHYDRO-1,3-THIAZOL-5-YL}ETHYL TRIHYDROGEN DIPHOSPHATE, Benzoylformate decarboxylase, CALCIUM ION, ... | | Authors: | Bera, A.K, Hasson, M.S. | | Deposit date: | 2015-08-28 | | Release date: | 2015-09-23 | | Last modified: | 2023-09-27 | | Method: | X-RAY DIFFRACTION (1.081 Å) | | Cite: | BENZOYLFORMATE DECARBOXYLASE H70A MUTANT at pH 8.5 FROM PSEUDOMONAS PUTIDA
to be published
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