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PDB: 51787 件

8B1X
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Solution NMR structure of the single alpha helix peptide (P3-7)2
分子名称: P3-7_2
著者Escobedo, A, Coles, M, Diercks, T, Garcia, J, Millet, O, Salvatella, X.
登録日2022-09-12
公開日2023-01-25
最終更新日2024-06-19
実験手法SOLUTION NMR
主引用文献A glutamine-based single alpha-helix scaffold to target globular proteins.
Nat Commun, 13, 2022
4B4C
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Crystal structure of the DNA-binding domain of human CHD1.
分子名称: 1,2-ETHANEDIOL, CHROMODOMAIN-HELICASE-DNA-BINDING PROTEIN 1, GLYCEROL, ...
著者Allerston, C.K, Cooper, C.D.O, Shrestha, L, Vollmar, M, Burgess-Brown, N, Yue, W.W, Carpenter, E.P, Arrowsmith, C.H, Edwards, A, Bountra, C, von Delft, F, Gileadi, O.
登録日2012-07-30
公開日2012-08-15
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Crystal Structure of the DNA-Binding Domain of Human Chd1.
To be Published
2PE2
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CRYSTAL STRUCTURE OF HUMAN PHOSPHOINOSITIDE-DEPENDENT PROTEIN KINASE 1 (PDK1) 3-{5-[2-Oxo-5-ureido-1,2-dihydro-indol-(3Z)-ylidenemethyl]-1H-pyrrol-3-yl}-N-(2-piperidin-1-yl-ethyl)-benzamide COMPLEX
分子名称: 3-[5-({5-[(AMINOCARBONYL)AMINO]-2-OXO-2H-INDOL-3-YL}METHYL)-1H-PYRROL-3-YL]-N-(2-PIPERIDIN-1-YLETHYL)BENZAMIDE, 3-phosphoinositide-dependent protein kinase 1, GLYCEROL, ...
著者Whitlow, M, Adler, M.
登録日2007-04-01
公開日2007-06-19
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Indolinone based phosphoinositide-dependent kinase-1 (PDK1) inhibitors. Part 2: Optimization of BX-517.
Bioorg.Med.Chem.Lett., 17, 2007
4G5Z
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Crystal structure of the therapeutical antibody fragment of canakinumab in its unbound state
分子名称: canakinumab antibody fragment heavy chain, canakinumab antibody fragment light chain
著者Blech, M, Hoerer, S.
登録日2012-07-18
公開日2012-12-19
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.83 Å)
主引用文献One target-two different binding modes: Structural insights into gevokizumab and canakinumab interactions to interleukin-1beta
J.Mol.Biol., 425, 2013
4B0R
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Structure of the Deamidase-Depupylase Dop of the Prokaryotic Ubiquitin-like Modification Pathway
分子名称: DEAMIDASE-DEPUPYLASE DOP
著者Ozcelik, D, Barandun, J, Schmitz, N, Sutter, M, Guth, E, Damberger, F.F, Allain, F.H.-T, Ban, N, Weber-Ban, E.
登録日2012-07-04
公開日2012-09-12
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Structures of Pup ligase PafA and depupylase Dop from the prokaryotic ubiquitin-like modification pathway.
Nat Commun, 3, 2012
2J9Q
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A novel conformation for the TPR domain of pex5p
分子名称: PEROXISOMAL TARGETING SIGNAL 1 RECEPTOR, STRONTIUM ION
著者Stanley, W.A, Wilmanns, M, Kursula, P.
登録日2006-11-15
公開日2007-04-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献A Previously Unobserved Conformation for the Human Pex5P Receptor Suggests Roles for Intrinsic Flexibility and Rigid Domain Motions in Ligand Binding
Bmc Struct.Biol., 7, 2007
2J0D
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Crystal structure of human P450 3A4 in complex with erythromycin
分子名称: CYTOCHROME P450 3A4, ERYTHROMYCIN A, PROTOPORPHYRIN IX CONTAINING FE
著者Sjogren, T, Ekroos, M.
登録日2006-08-02
公開日2006-09-04
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献Structural Basis for Ligand Promiscuity in Cytochrome P450 3A4
Proc.Natl.Acad.Sci.USA, 103, 2006
1LU3
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Separate Fitting of the Anticodon Loop Region of tRNA (nucleotide 26-42) in the Low Resolution Cryo-EM Map of an EF-Tu Ternary Complex (GDP and Kirromycin) Bound to E. coli 70S Ribosome
分子名称: PHENYLALANINE TRANSFER RNA
著者Valle, M, Sengupta, J, Swami, N.K, Grassucci, R.A, Burkhardt, N, Nierhaus, K.H, Agrawal, R.K, Frank, J.
登録日2002-05-21
公開日2002-06-26
最終更新日2024-02-14
実験手法ELECTRON MICROSCOPY (16.799999 Å)
主引用文献Cryo-EM reveals an active role for aminoacyl-tRNA in the accommodation process.
EMBO J., 21, 2002
2J6Z
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Structural and functional characterisation of partner-switching regulating the environmental stress response in B. subtilis
分子名称: PHOSPHOSERINE PHOSPHATASE RSBU
著者Hardwick, S.W, Pane-Farre, J, Delumeau, O, Marles-Wright, J, Murray, J.W, Hecker, M, Lewis, R.J.
登録日2006-10-05
公開日2007-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Structural and functional characterization of partner switching regulating the environmental stress response in Bacillus subtilis.
J. Biol. Chem., 282, 2007
4BIJ
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Threading model of T7 large terminase
分子名称: DNA MATURASE B
著者Dauden, M.I, Martin-Benito, J, Sanchez-Ferrero, J.C, Pulido-Cid, M, Valpuesta, J.M, Carrascosa, J.L.
登録日2013-04-10
公開日2013-05-08
最終更新日2024-05-08
実験手法ELECTRON MICROSCOPY (16 Å)
主引用文献Large Terminase Conformational Change Induced by Connector Binding in Bacteriophage T7
J.Biol.Chem., 288, 2013
2ITT
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BU of 2itt by Molmil
Crystal structure of EGFR kinase domain L858R mutation in complex with AEE788
分子名称: 6-{4-[(4-ETHYLPIPERAZIN-1-YL)METHYL]PHENYL}-N-[(1R)-1-PHENYLETHYL]-7H-PYRROLO[2,3-D]PYRIMIDIN-4-AMINE, EPIDERMAL GROWTH FACTOR RECEPTOR
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.73 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
8AMO
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Crystal structure of M. tuberculosis CYP143
分子名称: CHLORIDE ION, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ...
著者Bukhdruker, S, Varaksa, T, Grudo, A, Marin, E, Kapranov, I, Shevtsov, M, Gilep, A, Strushkevich, N, Borshchevskiy, V.
登録日2022-08-03
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structural insights into 3Fe-4S ferredoxins diversity in M. tuberculosis highlighted by a first redox complex with P450.
Front Mol Biosci, 9, 2022
2IV0
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Thermal stability of isocitrate dehydrogenase from Archaeoglobus fulgidus studied by crystal structure analysis and engineering of chimers
分子名称: CHLORIDE ION, ISOCITRATE DEHYDROGENASE, ZINC ION
著者Stokke, R, Karlstrom, M, Yang, N, Leiros, I, Ladenstein, R, Birkeland, N.K, Steen, I.H.
登録日2006-06-08
公開日2007-04-17
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Thermal Stability of Isocitrate Dehydrogenase from Archaeoglobus Fulgidus Studied by Crystal Structure Analysis and Engineering of Chimers
Extremophiles, 11, 2007
4BG2
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X-ray Crystal Structure of PatF from Prochloron didemni
分子名称: PATF
著者Bent, A.F, Koehnke, J, Houssen, W.E, Smith, M.C.M, Jaspars, M, Naismith, J.H.
登録日2013-03-22
公開日2013-04-03
最終更新日2013-11-06
実験手法X-RAY DIFFRACTION (2.13 Å)
主引用文献Structure of Patf from Prochloron Didemni.
Acta Crystallogr.,Sect.F, 69, 2013
8B0Q
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Deinococcus radiodurans UvrC C-terminal half
分子名称: UvrABC system protein C
著者Timmins, J, Stelter, M.
登録日2022-09-08
公開日2023-02-15
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structural and functional insights into the activation of the dual incision activity of UvrC, a key player in bacterial NER.
Nucleic Acids Res., 51, 2023
4Y0P
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Bovine beta-lactoglobulin complex with tetracaine (BLG-TET)
分子名称: Beta-lactoglobulin, Tetracaine
著者Loch, J.I, Bonarek, P, Polit, A, Jablonski, M, Czub, M, Ye, X, Lewinski, K.
登録日2015-02-06
公開日2015-07-01
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献beta-Lactoglobulin interactions with local anaesthetic drugs - Crystallographic and calorimetric studies.
Int.J.Biol.Macromol., 80, 2015
2J2I
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Crystal Structure of the humab PIM1 in complex with LY333531
分子名称: (9R)-9-[(DIMETHYLAMINO)METHYL]-6,7,10,11-TETRAHYDRO-9H,18H-5,21:12,17-DIMETHENODIBENZO[E,K]PYRROLO[3,4-H][1,4,13]OXADIA ZACYCLOHEXADECINE-18,20-DIONE, PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE PIM-1, SULFATE ION
著者Debreczeni, J.E, Bullock, A.N, von Delft, F, Sundstrom, M, Arrowsmith, C, Edwards, A, Weigelt, J, Knapp, S.
登録日2006-08-16
公開日2007-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A systematic interaction map of validated kinase inhibitors with Ser/Thr kinases.
Proc. Natl. Acad. Sci. U.S.A., 104, 2007
4B9J
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Structure of self-complemented CssA subunit of enterotoxigenic Escherichia coli colonization factor CS6
分子名称: CS6 FIMBRIAL SUBUNIT A
著者Roy, S.P, Rahman, M.M, Yu, X.D, Tuittila, M, Knight, S.D, Zavialov, A.V.
登録日2012-09-04
公開日2012-11-07
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.542 Å)
主引用文献Crystal Structure of Enterotoxigenic Escherichia Coli Colonization Factor Cs6 Reveals a Novel Type of Functional Assembly.
Mol.Microbiol., 86, 2012
3GCZ
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Yokose virus Methyltransferase in complex with AdoMet
分子名称: GLYCEROL, Polyprotein, S-ADENOSYLMETHIONINE, ...
著者Bollati, M, Milani, M, Mastrangelo, E, Bolognesi, M, Structural Proteomics in Europe (SPINE)
登録日2009-02-23
公開日2009-03-24
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of a methyltransferase from a no-known-vector Flavivirus
Biochem.Biophys.Res.Commun., 382, 2009
2J7Y
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STRUCTURE OF 17-EPIESTRIOL-BOUND ESTROGEN RECEPTOR BETA LBD IN COMPLEX WITH LXXLL MOTIF FROM NCOA5
分子名称: (16ALPHA,17ALPHA)-ESTRA-1,3,5(10)-TRIENE-3,16,17-TRIOL, 1,2-ETHANEDIOL, BICARBONATE ION, ...
著者Pike, A.C.W, Brzozowski, A.M, Hubbard, R.E, Walton, J, Bonn, T, Thorsell, A.-G, Engstrom, O, Ljunggren, J, Gustaffson, J.-A, Carlquist, M.
登録日2006-10-17
公開日2006-11-07
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Structure of Agonist-Bound Estrogen Receptor Beta Lbd in Complex with Lxxll Motif from Ncoa5
To be Published
1LQG
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ESCHERICHIA COLI URACIL-DNA GLYCOSYLASE COMPLEX WITH URACIL-DNA GLYCOSYLASE INHIBITOR PROTEIN
分子名称: URACIL-DNA GLYCOSYLASE, URACIL-DNA GLYCOSYLASE INHIBITOR
著者Saikrishnan, K, Sagar, M.B, Ravishankar, R, Roy, S, Purnapatre, K, Handa, P, Varshney, U, Vijayan, M.
登録日2002-05-10
公開日2002-11-10
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Domain closure and action of uracil DNA glycosylase (UDG): structures of new crystal forms containing the Escherichia coli enzyme and a comparative study of the known structures involving UDG.
Acta Crystallogr.,Sect.D, 58, 2002
4GJB
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Crystal structure of renin in complex with NVP-BBV031 (compound 6)
分子名称: (3S)-N-(9H-xanthen-9-ylmethyl)piperidine-3-carboxamide, 2-acetamido-2-deoxy-beta-D-glucopyranose, Renin, ...
著者Ostermann, N, Zink, F, Kroemer, M.
登録日2012-08-09
公開日2013-02-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.75 Å)
主引用文献A novel class of oral direct Renin inhibitors: highly potent 3,5-disubstituted piperidines bearing a tricyclic p3-p1 pharmacophore.
J.Med.Chem., 56, 2013
2ITN
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Crystal structure of EGFR kinase domain G719S mutation in complex with AMP-PNP
分子名称: EPIDERMAL GROWTH FACTOR RECEPTOR, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER
著者Yun, C.-H, Boggon, T.J, Li, Y, Woo, S, Greulich, H, Meyerson, M, Eck, M.J.
登録日2006-05-25
公開日2007-04-03
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.47 Å)
主引用文献Structures of Lung Cancer-Derived Egfr Mutants and Inhibitor Complexes: Mechanism of Activation and Insights Into Differential Inhibitor Sensitivity
Cancer Cell, 11, 2007
2J24
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The functional role of the conserved active site proline of triosephosphate isomerase
分子名称: TRIOSEPHOSPHATE ISOMERASE, GLYCOSOMAL
著者Casteleijn, M.G, Alahuhta, M, Groebel, K, El-Sayed, I, Augustyns, K, Lambeir, A.M, Neubauer, P, Wierenga, R.K.
登録日2006-08-16
公開日2007-01-02
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Functional Role of the Conserved Active Site Proline of Triosephosphate Isomerase.
Biochemistry, 45, 2006
2J3P
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crystal structure of rat FGF1 at 1.4 A
分子名称: HEPARIN-BINDING GROWTH FACTOR 1, SULFATE ION
著者Kulahin, N, Kristensen, O, Berezin, V, Gajhede, M, Bock, E.
登録日2006-08-22
公開日2007-02-13
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Structure of Rat Acidic Fibroblast Growth Factor at 1.4 A Resolution.
Acta Crystallogr.,Sect.F, 63, 2007

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