1WVN
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7GQT
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![BU of 7gqt by Molmil](/molmil-images/mine/7gqt) | Crystal Structure of Werner helicase fragment 517-945 in complex with ATP | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, MAGNESIUM ION, ... | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (2.21 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7GQS
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![BU of 7gqs by Molmil](/molmil-images/mine/7gqs) | Crystal Structure of Werner helicase fragment 517-945 in complex with ADP | 分子名称: | 1,2-ETHANEDIOL, ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, ... | 著者 | Classen, M, Benz, J, Brugger, D, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.57 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7DKD
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![BU of 7dkd by Molmil](/molmil-images/mine/7dkd) | Stenotrophomonas maltophilia DPP7 in complex with Asn-Tyr | 分子名称: | ASPARAGINE, Dipeptidyl-peptidase, GLYCEROL, ... | 著者 | Sakamoto, Y, Nakamura, A, Suzuki, Y, Honma, N, Roppongi, S, Kushibiki, C, Yonezawa, N, Takahashi, M, Shida, Y, Gouda, H, Nonaka, T, Ogasawara, W, Tanaka, N. | 登録日 | 2020-11-23 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.92 Å) | 主引用文献 | Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. Sci Rep, 11, 2021
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7GQU
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![BU of 7gqu by Molmil](/molmil-images/mine/7gqu) | Crystal Structure of Werner helicase fragment 517-945 in covalent complex with N-[(E,1S)-1-cyclopropyl-3-methylsulfonylprop-2-enyl]-2-(1,1-difluoroethyl)-4-phenoxypyrimidine-5-carboxamide | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Bifunctional 3'-5' exonuclease/ATP-dependent helicase WRN, GLYCEROL, ... | 著者 | Classen, M, Benz, J, Brugger, D, Tagliente, O, Rudolph, M.G. | 登録日 | 2023-10-19 | 公開日 | 2024-05-01 | 最終更新日 | 2024-05-29 | 実験手法 | X-RAY DIFFRACTION (1.54 Å) | 主引用文献 | Chemoproteomic discovery of a covalent allosteric inhibitor of WRN helicase. Nature, 629, 2024
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7DKC
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![BU of 7dkc by Molmil](/molmil-images/mine/7dkc) | Stenotrophomonas maltophilia DPP7 in complex with Tyr-Tyr | 分子名称: | Dipeptidyl-peptidase, GLYCEROL, TYROSINE | 著者 | Sakamoto, Y, Nakamura, A, Suzuki, Y, Honma, N, Roppongi, S, Kushibiki, C, Yonezawa, N, Takahashi, M, Shida, Y, Gouda, H, Nonaka, T, Ogasawara, W, Tanaka, N. | 登録日 | 2020-11-23 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. Sci Rep, 11, 2021
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6RJL
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![BU of 6rjl by Molmil](/molmil-images/mine/6rjl) | Fragment AZ-018 binding at the TAZpS89/14-3-3 sigma interface | 分子名称: | 14-3-3 protein sigma, 5-(3-azanylpropyl)-4-phenyl-thiophene-2-carboximidamide, TAZpS89 | 著者 | Genet, S, Wolter, M, Guillory, X, Somsen, B, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | 登録日 | 2019-04-27 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.28 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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7DKE
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![BU of 7dke by Molmil](/molmil-images/mine/7dke) | Stenotrophomonas maltophilia DPP7 in complex with Phe-Tyr | 分子名称: | Dipeptidyl-peptidase, GLYCEROL, PHENYLALANINE, ... | 著者 | Sakamoto, Y, Nakamura, A, Suzuki, Y, Honma, N, Roppongi, S, Kushibiki, C, Yonezawa, N, Takahashi, M, Shida, Y, Gouda, H, Nonaka, T, Ogasawara, W, Tanaka, N. | 登録日 | 2020-11-23 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.91 Å) | 主引用文献 | Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. Sci Rep, 11, 2021
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7DDM
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![BU of 7ddm by Molmil](/molmil-images/mine/7ddm) | Crystal Structure of PenA39 beta-Lactamase | 分子名称: | (4S)-2-METHYL-2,4-PENTANEDIOL, ACETATE ION, ALA-ALA-ARG-ASP-ALA-ALA-VAL-SER-ASP-ALA-ALA-ALA, ... | 著者 | Nukaga, M, Hoshino, T, Papp-Wallace, K.M. | 登録日 | 2020-10-29 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Frameshift mutations in genes encoding PBP3 and PBP4 trigger an unusual, extreme beta-lactam resistance phenotype in Burkholderia multivorans To Be Published
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7DKB
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![BU of 7dkb by Molmil](/molmil-images/mine/7dkb) | Stenotrophomonas maltophilia DPP7 in complex with Val-Tyr | 分子名称: | Dipeptidyl-peptidase, TYROSINE, VALINE | 著者 | Sakamoto, Y, Nakamura, A, Suzuki, Y, Honma, N, Roppongi, S, Kushibiki, C, Yonezawa, N, Takahashi, M, Shida, Y, Gouda, H, Nonaka, T, Ogasawara, W, Tanaka, N. | 登録日 | 2020-11-23 | 公開日 | 2021-11-03 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | 主引用文献 | Structural basis for an exceptionally strong preference for asparagine residue at the S2 subsite of Stenotrophomonas maltophilia dipeptidyl peptidase 7. Sci Rep, 11, 2021
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1WDK
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![BU of 1wdk by Molmil](/molmil-images/mine/1wdk) | fatty acid beta-oxidation multienzyme complex from Pseudomonas fragi, form I (native2) | 分子名称: | 3,6,9,12,15-PENTAOXATRICOSAN-1-OL, 3-ketoacyl-CoA thiolase, ACETYL COENZYME *A, ... | 著者 | Ishikawa, M, Tsuchiya, D, Oyama, T, Tsunaka, Y, Morikawa, K. | 登録日 | 2004-05-17 | 公開日 | 2004-07-27 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Structural basis for channelling mechanism of a fatty acid beta-oxidation multienzyme complex Embo J., 23, 2004
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6S7U
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![BU of 6s7u by Molmil](/molmil-images/mine/6s7u) | Fumarate hydratase of Mycobacterium tuberculosis in complex with formate and allosteric modulator N-(5-(Azepan-1-ylsulfonyl)-2-methoxyphenyl)-2-(1H-indol-3-yl)acetamide | 分子名称: | FORMIC ACID, Fumarate hydratase class II, MAGNESIUM ION, ... | 著者 | Whitehouse, A.J, Libardo, M.D, Kasbekar, M, Brear, P, Fischer, G, Thomas, C.J, Barry, C.E, Boshoff, H.I, Coyne, A.G, Abell, C. | 登録日 | 2019-07-06 | 公開日 | 2019-09-25 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.48 Å) | 主引用文献 | Targeting of Fumarate Hydratase fromMycobacterium tuberculosisUsing Allosteric Inhibitors with a Dimeric-Binding Mode. J.Med.Chem., 62, 2019
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6S87
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6RM7
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![BU of 6rm7 by Molmil](/molmil-images/mine/6rm7) | Fragment AZ-026 binding at the p53pT387/14-3-3 sigma interface | 分子名称: | 14-3-3 protein sigma, 5-[3-(2-azanylethyl)imidazol-4-yl]-4-phenyl-thiophene-2-carboximidamide, CHLORIDE ION, ... | 著者 | Somsen, B, Wolter, M, Guillory, X, Genet, S, Leysen, S, Patel, J, Castaldi, P, Ottmann, C. | 登録日 | 2019-05-05 | 公開日 | 2020-06-17 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | Fragment-based Differential Targeting of PPI Stabilizer Interfaces. J.Med.Chem., 63, 2020
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6RFP
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![BU of 6rfp by Molmil](/molmil-images/mine/6rfp) | ERK2 MAP kinase with mutations at Helix-G | 分子名称: | Mitogen-activated protein kinase 1 | 著者 | Livnah, O, Eitan-Wexler, M. | 登録日 | 2019-04-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | 主引用文献 | The bacterial metalloprotease NleD selectively cleaves mitogen-activated protein kinases that have high flexibility in their activation loop. J.Biol.Chem., 295, 2020
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6RGE
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![BU of 6rge by Molmil](/molmil-images/mine/6rge) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with an inhibitor | 分子名称: | CITRIC ACID, NAD kinase 1, [(2~{R},3~{R},4~{R},5~{R})-2-[8-[3-[[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy]prop-1-ynyl]-6-azanyl-purin-9-yl]-5-(hydroxymethyl)-4-oxidanyl-oxolan-3-yl] dihydrogen phosphate | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (1.801 Å) | 主引用文献 | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complex with an inhibitor To Be Published
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6RG3
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![BU of 6rg3 by Molmil](/molmil-images/mine/6rg3) | Crystal structure of human Carbonic anhydrase II in complex with (R)-4-(2-benzylpiperazin-1-yl)benzenesulfonamide | 分子名称: | 4-[(2~{R})-2-(phenylmethyl)piperazin-1-yl]carbonylbenzenesulfonamide, Carbonic anhydrase 2, GLYCEROL, ... | 著者 | Ferraroni, M, Angeli, A, Supuran, C. | 登録日 | 2019-04-16 | 公開日 | 2020-05-13 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | 主引用文献 | Sulfonamides incorporating piperazine bioisosteres as potent human carbonic anhydrase I, II, IV and IX inhibitors. Bioorg.Chem., 91, 2019
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6RG8
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![BU of 6rg8 by Molmil](/molmil-images/mine/6rg8) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[4-(6-azanyl-9~{H}-purin-8-yl)but-3-ynylamino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.47 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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6RGC
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![BU of 6rgc by Molmil](/molmil-images/mine/6rgc) | Crystal structure of NAD kinase 1 from Listeria monocytogenes in complexe with an inhibitor | 分子名称: | (2~{R},3~{R},4~{S},5~{R})-2-(6-aminopurin-9-yl)-5-[[3-[6-azanyl-9-[(2~{R},3~{R},4~{S},5~{R})-5-(hydroxymethyl)-3,4-bis(oxidanyl)oxolan-2-yl]purin-8-yl]prop-2-ynyl-methyl-amino]methyl]oxolane-3,4-diol, CITRIC ACID, NAD kinase 1 | 著者 | Gelin, M, Labesse, G. | 登録日 | 2019-04-16 | 公開日 | 2020-02-19 | 最終更新日 | 2024-05-15 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | From Substrate to Fragments to Inhibitor ActiveIn VivoagainstStaphylococcus aureus. Acs Infect Dis., 6, 2020
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6RGW
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![BU of 6rgw by Molmil](/molmil-images/mine/6rgw) | Photorhabdus asymbiotica lectin PHL in complex with O-methylated PGL-1-derived disaccharide | 分子名称: | 1,2-ETHANEDIOL, 3,6-O-dimethyl-D-glucose, 4-(2-azanylethoxy)phenol, ... | 著者 | Houser, J, Fujdiarova, E, Jancarikova, G, Wimmerova, M. | 登録日 | 2019-04-17 | 公開日 | 2020-07-01 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Heptabladed beta-propeller lectins PLL2 and PHL from Photorhabdus spp. recognize O-methylated sugars and influence the host immune system. Febs J., 288, 2021
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7D9J
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![BU of 7d9j by Molmil](/molmil-images/mine/7d9j) | SpdH Spermidine dehydrogenase Y443A mutant | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Che, S, Zhang, Q, Bartlam, M. | 登録日 | 2020-10-13 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.19 Å) | 主引用文献 | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold. Febs J., 289, 2022
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7D9F
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![BU of 7d9f by Molmil](/molmil-images/mine/7d9f) | SpdH Spermidine dehydrogenase SeMet Structure | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, GLYCEROL, PROTOPORPHYRIN IX CONTAINING FE, ... | 著者 | Che, S, Zhang, Q, Bartlam, M. | 登録日 | 2020-10-13 | 公開日 | 2021-11-17 | 最終更新日 | 2022-04-20 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold. Febs J., 289, 2022
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6RYR
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![BU of 6ryr by Molmil](/molmil-images/mine/6ryr) | Nucleosome-CHD4 complex structure (single CHD4 copy) | 分子名称: | Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4,Chromodomain-helicase-DNA-binding protein 4, DNA (149-MER), Histone H2A type 1, ... | 著者 | Farnung, L, Ochmann, M, Cramer, P. | 登録日 | 2019-06-11 | 公開日 | 2020-07-15 | 最終更新日 | 2024-05-22 | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | 主引用文献 | Nucleosome-CHD4 chromatin remodeller structure maps human disease mutations. Elife, 9, 2020
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7D9I
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![BU of 7d9i by Molmil](/molmil-images/mine/7d9i) | SpdH Spermidine dehydrogenase D282A mutant | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, PROTOPORPHYRIN IX CONTAINING FE, Spermidine dehydrogenase, ... | 著者 | Che, S, Zhang, Q, Bartlam, M. | 登録日 | 2020-10-13 | 公開日 | 2021-11-17 | 最終更新日 | 2023-11-29 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure of Pseudomonas aeruginosa spermidine dehydrogenase: a polyamine oxidase with a novel heme-binding fold. Febs J., 289, 2022
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7DFX
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![BU of 7dfx by Molmil](/molmil-images/mine/7dfx) | |