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PDB: 51964 件
2ZNW
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BU of 2znw by Molmil
Crystal Structure of ScFv10 in Complex with Hen Egg Lysozyme
分子名称: 2-(2-{2-[2-(2-METHOXY-ETHOXY)-ETHOXY]-ETHOXY}-ETHOXY)-ETHANOL, Lysozyme C, ScFv10
著者DeSantis, M.E, Acchione, M, Li, M, Walter, R.L, Wlodawer, A, Smith-Gill, S.
登録日2008-05-02
公開日2009-01-27
最終更新日2017-10-11
実験手法X-RAY DIFFRACTION (2.71 Å)
主引用文献Specific fluorine labeling of the HyHEL10 antibody affects antigen binding and dynamics
Biochemistry, 51, 2012
5HQF
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BU of 5hqf by Molmil
DNA duplex containing a ribonolactone lesion
分子名称: DNA (5'-D(*CP*GP*CP*TP*CP*(RIB)P*CP*AP*CP*GP*C)-3'), DNA (5'-D(*GP*CP*GP*TP*GP*GP*GP*AP*(8OG)P*CP*G)-3')
著者Zalesak, J, Constant, J.F, Jourdan, M.
登録日2016-01-21
公開日2016-09-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Nuclear Magnetic Resonance Solution Structure of DNA Featuring Clustered 2'-Deoxyribonolactone and 8-Oxoguanine Lesions.
Biochemistry, 55, 2016
8OUS
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BU of 8ous by Molmil
CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 19
分子名称: (1S)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2-methyl-propan-1-ol, Mitogen-activated protein kinase kinase kinase 12
著者Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B.
登録日2023-04-24
公開日2023-07-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
4YI7
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BU of 4yi7 by Molmil
Anthranilate bound at active site of anthranilate phosphoribosyl transferase from Acinetobacter (AnPRT; TrpD)
分子名称: 2-AMINOBENZOIC ACID, Anthranilate phosphoribosyltransferase
著者Evans, G.L, Newton, M.S, Norris, G.E, Patrick, W.M.
登録日2015-02-28
公開日2015-09-02
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (1.853 Å)
主引用文献Substrate inhibition of protein in tryptophan biosynthesis pathway redirects flux to aromatic catabolism in Acinetobacter baylyi ADP1.
To Be Published
2ZQA
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BU of 2zqa by Molmil
Cefotaxime acyl-intermediate structure of class a beta-lacta Toho-1 E166A/R274N/R276N triple mutant
分子名称: Beta-lactamase Toho-1, CEFOTAXIME, C3' cleaved, ...
著者Nitanai, Y, Shimamura, T, Uchiyama, T, Ishii, Y, Takehira, M, Yutani, K, Matsuzawa, H, Miyano, M.
登録日2008-08-07
公開日2009-07-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (0.95 Å)
主引用文献Structural Basis of Extend Spectrum Beta-Lactamase in Correlation of Enzymatic Kinetics and Thermal Stability of Acyl-Intermediates
To be Published
8P3O
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BU of 8p3o by Molmil
Full-length bacterial polysaccharide co-polymerase WzzE mutant R267A from E. coli. C4 symmetry
分子名称: ECA polysaccharide chain length modulation protein
著者Wiseman, B, Hogbom, M.
登録日2023-05-18
公開日2023-07-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.9 Å)
主引用文献Alternating L4 loop architecture of the bacterial polysaccharide co-polymerase WzzE.
Commun Biol, 6, 2023
3V0R
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BU of 3v0r by Molmil
Crystal structure of Alternaria alternata allergen Alt a 1
分子名称: 2,5,6-triaminopyrimidin-4-ol, 8-aminooctanoic acid, Major allergen Alt a 1, ...
著者Chruszcz, M, Solberg, R, Osinski, T, Chapman, M.D, Minor, W.
登録日2011-12-08
公開日2012-06-13
最終更新日2022-04-13
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Alternaria alternata allergen Alt a 1: a unique beta-barrel protein dimer found exclusively in fungi.
J.Allergy Clin.Immunol., 130, 2012
6FZB
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BU of 6fzb by Molmil
AadA in complex with ATP, magnesium and streptomycin
分子名称: ADENOSINE-5'-TRIPHOSPHATE, CHLORIDE ION, DI(HYDROXYETHYL)ETHER, ...
著者Kanchugal P, S, Selmer, M.
登録日2018-03-14
公開日2018-06-13
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Structural mechanism of AadA, a dual-specificity aminoglycoside adenylyltransferase fromSalmonella enterica.
J. Biol. Chem., 293, 2018
7R2V
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BU of 7r2v by Molmil
Structure of nsp14 from SARS-CoV-2 in complex with SAH
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, Proofreading exoribonuclease nsp14, ...
著者Czarna, A, Plewka, J, Kresik, L, Matsuda, A, Abdulkarim, K, Robinson, C, OByrne, S, Cunningham, F, Georgiou, I, Pachota, M, Popowicz, G.M, Wyatt, P.G, Dubin, G, Pyrc, K.
登録日2022-02-06
公開日2022-03-09
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.53 Å)
主引用文献Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity.
Structure, 30, 2022
8OUR
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BU of 8our by Molmil
CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 16
分子名称: 5-[1-(3-morpholin-4-yl-1-bicyclo[1.1.1]pentanyl)-2-propan-2-yl-imidazol-4-yl]-3-(trifluoromethyloxy)pyridin-2-amine, Mitogen-activated protein kinase kinase kinase 12
著者Zebisch, M, McEwan, P.A, Barker, J.J, Cross, J.B.
登録日2023-04-24
公開日2023-07-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
8OUT
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BU of 8out by Molmil
CRYSTAL STRUCTURE OF DLK IN COMPLEX WITH COMPOUND 22
分子名称: (1R)-1-[4-[6-azanyl-5-(trifluoromethyloxy)pyridin-3-yl]-1-(3-fluoranyl-1-bicyclo[1.1.1]pentanyl)imidazol-2-yl]-2,2,2-tris(fluoranyl)ethanol, Mitogen-activated protein kinase kinase kinase 12
著者Zebisch, M, Akkermans, O, Barker, J.J, Cross, J.B.
登録日2023-04-24
公開日2023-07-26
最終更新日2024-06-19
実験手法X-RAY DIFFRACTION (1.935 Å)
主引用文献Discovery of IACS-52825, a Potent and Selective DLK Inhibitor for Treatment of Chemotherapy-Induced Peripheral Neuropathy.
J.Med.Chem., 66, 2023
5HUL
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BU of 5hul by Molmil
Crystal Structure of NadC Deletion Mutant in Cubic Space Group
分子名称: PHOSPHATE ION, Quinolinate phosphoribosyltransferase
著者Booth, W.T, Chruszcz, M.
登録日2016-01-27
公開日2017-01-25
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.855 Å)
主引用文献Streptococcus pyogenes quinolinate-salvage pathway-structural and functional studies of quinolinate phosphoribosyl transferase and NH3 -dependent NAD(+) synthetase.
FEBS J., 284, 2017
1KFA
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BU of 1kfa by Molmil
Crystal structure of Fab fragment complexed with gibberellin A4
分子名称: GIBBERELLIN A4, monoclonal antibody heavy chain, monoclonal antibody light chain
著者Murata, T, Fushinobu, S, Nakajima, M, Asami, O, Sassa, T, Wakagi, T, Yamaguchi, I.
登録日2001-11-20
公開日2002-09-11
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Crystal structure of the liganded anti-gibberellin A(4) antibody 4-B8(8)/E9 Fab fragment.
Biochem.Biophys.Res.Commun., 293, 2002
6YXO
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BU of 6yxo by Molmil
Structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1
分子名称: SWI/SNF complex subunit SMARCC1
著者Allen, M.D, Bycroft, M, Zinzalla, G.
登録日2020-05-03
公開日2021-04-21
最終更新日2021-11-03
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.
Commun Biol, 4, 2021
8P3P
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BU of 8p3p by Molmil
Full-length bacterial polysaccharide co-polymerase WzzE mutant R267E from E. coli. C4 symmetry
分子名称: ECA polysaccharide chain length modulation protein
著者Wiseman, B, Hogbom, M.
登録日2023-05-18
公開日2023-07-26
最終更新日2024-07-24
実験手法ELECTRON MICROSCOPY (2.5 Å)
主引用文献Alternating L4 loop architecture of the bacterial polysaccharide co-polymerase WzzE.
Commun Biol, 6, 2023
3D74
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BU of 3d74 by Molmil
Crystal structure of a pheromone binding protein mutant D35A, from Apis mellifera, soaked at pH 5.5
分子名称: N-BUTYL-BENZENESULFONAMIDE, Pheromone-binding protein ASP1
著者Pesenti, M.E, Spinelli, S, Bezirard, V, Briand, L, Pernollet, J.C, Tegoni, M, Cambillau, C.
登録日2008-05-20
公開日2009-05-26
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Queen bee pheromone binding protein pH-induced domain swapping favors pheromone release
J.Mol.Biol., 390, 2009
6YXP
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BU of 6yxp by Molmil
Higher resolution structure of the N-terminal module of the human SWI/SNF-subunit BAF155/SMARCC1
分子名称: SWI/SNF complex subunit SMARCC1
著者Allen, M.D, Bycroft, M, Zinzalla, G.
登録日2020-05-03
公開日2021-04-21
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.6 Å)
主引用文献SWI/SNF subunit BAF155 N-terminus structure informs the impact of cancer-associated mutations and reveals a potential drug binding site.
Commun Biol, 4, 2021
3UU5
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BU of 3uu5 by Molmil
The GLIC pentameric Ligand-Gated Ion Channel Loop2-20' mutant reduced in solution
分子名称: CHLORIDE ION, DIUNDECYL PHOSPHATIDYL CHOLINE, DODECYL-BETA-D-MALTOSIDE, ...
著者Sauguet, L, Nury, H, Corringer, P.J, Delarue, M.
登録日2011-11-28
公開日2012-05-16
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献A locally closed conformation of a bacterial pentameric proton-gated ion channel.
Nat.Struct.Mol.Biol., 19, 2012
5J3L
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BU of 5j3l by Molmil
Structure of Transcriptional Regulatory Repressor Protein - EthR from Mycobacterium Tuberculosis in complex with 1-((2-cyclopentylethyl)sulfonyl)pyrrolidine at 1.66A resolution
分子名称: 1-[(2-cyclopentylethyl)sulfonyl]pyrrolidine, HTH-type transcriptional regulator EthR
著者Blaszczyk, M, Surade, S, Nikiforov, P.O, Abell, C, Blundell, T.L.
登録日2016-03-31
公開日2017-03-29
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.66 Å)
主引用文献Fragment-Sized EthR Inhibitors Exhibit Exceptionally Strong Ethionamide Boosting Effect in Whole-Cell Mycobacterium tuberculosis Assays.
ACS Chem. Biol., 12, 2017
2ZVN
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BU of 2zvn by Molmil
NEMO CoZi domain incomplex with diubiquitin in P212121 space group
分子名称: NF-kappa-B essential modulator, UBC protein
著者Rahighi, S, Ikeda, F, Kawasaki, M, Akutsu, M, Suzuki, N, Kato, R, Kensche, T, Uejima, T, Bloor, S, Komander, D, Randow, F, Wakatsuki, S, Dikic, I.
登録日2008-11-12
公開日2009-03-24
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Specific recognition of linear ubiquitin chains by NEMO is important for NF-kappaB activation
Cell(Cambridge,Mass.), 136, 2009
5JML
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BU of 5jml by Molmil
X-ray structure of the complex between bovine pancreatic ribonuclease and penthachlorocarbonyliridate(III) (2 months of soaking)
分子名称: CARBON MONOXIDE, CHLORIDE ION, IRIDIUM ION, ...
著者Caterino, M, Petruk, A.A, Vergara, A, Ferraro, G, Merlino, A.
登録日2016-04-29
公開日2016-07-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.29 Å)
主引用文献Mapping the protein-binding sites for iridium(iii)-based CO-releasing molecules.
Dalton Trans, 45, 2016
2Z81
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BU of 2z81 by Molmil
Crystal structure of the TLR1-TLR2 heterodimer induced by binding of a tri-acylated lipopeptide
分子名称: (2R)-3-{[(2S)-3-HYDROXY-2-(PALMITOYLAMINO)PROPYL]THIO}PROPANE-1,2-DIYL DIHEXADECANOATE, 2-acetamido-2-deoxy-beta-D-glucopyranose, Toll-like receptor 2, ...
著者Lee, J.O, Jin, M.S, Kim, S.E, Heo, J.Y.
登録日2007-08-30
公開日2007-10-02
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Crystal Structure of the TLR1-TLR2 Heterodimer Induced by Binding of a Tri-Acylated Lipopeptide
Cell(Cambridge,Mass.), 130, 2007
2ZWF
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BU of 2zwf by Molmil
Crystal structure of the copper-bound tyrosinase in complex with a caddie protein from streptomyces castaneoglobisporus obtained by soaking the deoxy-form crystal in dioxygen-saturated solution for 80 minutes
分子名称: COPPER (II) ION, MelC, NITRATE ION, ...
著者Matoba, Y, Sugiyama, M.
登録日2008-12-03
公開日2009-12-15
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Crystallographic evidence of drastic movement of a copper ion toward the substrate tyrosine for starting hydroxylation reaction of tyrosinase
To be Published
5HFR
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BU of 5hfr by Molmil
Crystal structure of the second bromodomain H395R mutant of human BRD3
分子名称: 1,2-ETHANEDIOL, Bromodomain-containing protein 3, NITRATE ION
著者Tallant, C, Lori, C, Pasquo, A, Chiaraluce, R, Consalvi, V, Fonseca, M, von Delft, F, Arrowsmith, C.H, Edwards, A.M, Bountra, C, Knapp, S.
登録日2016-01-07
公開日2016-01-20
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Crystal structure of the second bromodomain H395R mutant of human BRD3
To Be Published
2Z7S
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BU of 2z7s by Molmil
Crystal Structure of the N-terminal Kinase Domain of Human RSK1 bound to Purvalnol A
分子名称: 2-({6-[(3-CHLOROPHENYL)AMINO]-9-ISOPROPYL-9H-PURIN-2-YL}AMINO)-3-METHYLBUTAN-1-OL, Ribosomal protein S6 kinase alpha-1
著者Ikuta, M, Munshi, S.K.
登録日2007-08-28
公開日2008-05-13
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structures of the N-terminal kinase domain of human RSK1 bound to three different ligands: Implications for the design of RSK1 specific inhibitors.
Protein Sci., 16, 2007

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件を2024-10-09に公開中

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