1UPR
 
 | | Crystal structure of the PEPP1 pleckstrin homology domain in complex with Inositol 1,3,4,5-tetrakisphosphate | | Descriptor: | INOSITOL-(1,3,4,5)-TETRAKISPHOSPHATE, PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY A MEMBER 4 | | Authors: | Milburn, C.C, Komander, D, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2003-10-10 | | Release date: | 2004-10-20 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.27 Å) | | Cite: | Crystal Structure of the Pleckstrin Homology Domain of Pepp1
To be Published
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1UPL
 | | Crystal structure of MO25 alpha | | Descriptor: | MO25 PROTEIN | | Authors: | Milburn, C.C, Boudeau, J, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2003-10-07 | | Release date: | 2004-01-22 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
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1UVR
 | | Structure of human PDK1 kinase domain in complex with BIM-8 | | Descriptor: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-[1-(3-AMINOPROPYL)-1H-INDOL-3-YL]-4-(1-METHYL-1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ... | | Authors: | Komander, D, Garrido-Franco, M, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2004-01-22 | | Release date: | 2004-03-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.81 Å) | | Cite: | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
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1L6N
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1LBZ
 | | Crystal Structure of a complex (P32 crystal form) of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with 3 Calcium ions and Fructose-1,6 bisphosphate | | Descriptor: | 1,6-di-O-phosphono-beta-D-fructofuranose, CALCIUM ION, fructose 1,6-bisphosphatase/inositol monophosphatase | | Authors: | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | | Deposit date: | 2002-04-04 | | Release date: | 2002-05-22 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop.
J.Biol.Chem., 277, 2002
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1UU8
 | | Structure of human PDK1 kinase domain in complex with BIM-1 | | Descriptor: | 3-PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE-1, 3-{1-[3-(DIMETHYLAMINO)PROPYL]-1H-INDOL-3-YL}-4-(1H-INDOL-3-YL)-1H-PYRROLE-2,5-DIONE, GLYCEROL, ... | | Authors: | Komander, D, Kular, G.S, Schuttelkopf, A.W, Deak, M, Prakash, K.R, Bain, J, Elliot, M, Garrido-Franco, M, Kozikowski, A.P, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2003-12-16 | | Release date: | 2004-03-04 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (2.5 Å) | | Cite: | Interactions of Ly333531 and Other Bisindolyl Maleimide Inhibitors with Pdk1
Structure, 12, 2004
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1UR8
 | | Interactions of a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-(acetylamido)-2-deoxy-D-glucono-1,5-lactone, CHITINASE B, GLYCEROL, ... | | Authors: | Vaaje-Kolstad, G, Vasella, A, Peter, M.G, Netter, C, Houston, D.R, Westereng, B, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F. | | Deposit date: | 2003-10-27 | | Release date: | 2004-04-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Interactions of a Family 18 Chitinase with the Designed Inhibitor Hm508 and its Degradation Product, Chitobiono-Delta-Lactone.
J.Biol.Chem., 279, 2004
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1LBX
 | | Crystal Structure of a ternary complex of dual activity FBPase/IMPase (AF2372) from Archaeoglobus fulgidus with Calcium ions and D-myo-Inositol-1-Phosphate | | Descriptor: | CALCIUM ION, D-MYO-INOSITOL-1-PHOSPHATE, fructose 1,6-bisphosphatase/inositol monophosphatase | | Authors: | Stieglitz, K.A, Johnson, K.A, Yang, H, Roberts, M.F, Seaton, B.A, Head, J.F, Stec, B. | | Deposit date: | 2002-04-04 | | Release date: | 2002-05-22 | | Last modified: | 2023-08-16 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Crystal structure of a dual activity IMPase/FBPase (AF2372) from Archaeoglobus fulgidus. The story of a mobile loop.
J.Biol.Chem., 277, 2002
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1MZ5
 | | Trypanosoma rangeli sialidase | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, sialidase | | Authors: | Buschiazzo, A, Tavares, G.A, Campetella, O, Spinelli, S, Cremona, M.L, Paris, G, Amaya, M.F, Frasch, A.C.C, Alzari, P.M. | | Deposit date: | 2002-10-05 | | Release date: | 2002-10-16 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Structural basis of sialyltransferase activity in trypanosomal sialidases
Embo J., 19, 2000
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1UR9
 | | Interactions of a family 18 chitinase with the designed inhibitor HM508, and its degradation product, chitobiono-delta-lactone | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-(acetylamido)-2-deoxy-D-glucono-1,5-lactone, CHITINASE B, GLYCEROL, ... | | Authors: | Vaaje-Kolstad, G, Vasella, A, Peter, M.G, Netter, C, Houston, D.R, Westereng, B, Synstad, B, Eijsink, V.G.H, Van Aalten, D.M.F. | | Deposit date: | 2003-10-27 | | Release date: | 2004-04-27 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | Interactions of a Family 18 Chitinase with the Designed Inhibitor Hm508 and its Degradation Product, Chitobiono-Delta-Lactone.
J.Biol.Chem., 279, 2004
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1MS1
 | | Monoclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, GLYCEROL, trans-sialidase | | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | | Deposit date: | 2002-09-19 | | Release date: | 2003-03-25 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
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1MR5
 | | Orthorhombic form of Trypanosoma cruzi trans-sialidase | | Descriptor: | trans-sialidase | | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | | Deposit date: | 2002-09-18 | | Release date: | 2003-03-18 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2.25 Å) | | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
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1MS8
 | | Triclinic form of Trypanosoma cruzi trans-sialidase, in complex with 3-deoxy-2,3-dehydro-N-acetylneuraminic acid (DANA) | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, trans-sialidase | | Authors: | Buschiazzo, A, Amaya, M.F, Cremona, M.L, Frasch, A.C, Alzari, P.M. | | Deposit date: | 2002-09-19 | | Release date: | 2003-03-25 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | The crystal structure and mode of action of trans-sialidase, a key enzyme in Trypanosoma cruzi pathogenesis
Mol.Cell, 10, 2002
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1WWE
 | | NMR Structure Determined for MLV NC complex with RNA Sequence UUUUGCU | | Descriptor: | 5'-R(P*UP*UP*UP*UP*GP*CP*U)-3', Nucleoprotein p10, ZINC ION | | Authors: | Dey, A, York, D, Smalls-Mantey, A, Summers, M.F. | | Deposit date: | 2005-01-05 | | Release date: | 2005-03-22 | | Last modified: | 2024-05-29 | | Method: | SOLUTION NMR | | Cite: | Composition and sequence-dependent binding of RNA to the nucleocapsid protein of Moloney murine leukemia virus(,)
Biochemistry, 44, 2005
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1N19
 | | Structure of the HSOD A4V mutant | | Descriptor: | COPPER (I) ION, SULFATE ION, Superoxide Dismutase [Cu-Zn], ... | | Authors: | Cardoso, R.M.F, Thayer, M.M, DiDonato, M, Lo, T.P, Bruns, C.K, Getzoff, E.D, Tainer, J.A. | | Deposit date: | 2002-10-16 | | Release date: | 2002-11-27 | | Last modified: | 2021-10-27 | | Method: | X-RAY DIFFRACTION (1.86 Å) | | Cite: | Insights into Lou Gehrig's disease from the structure and instability of the A4V mutant of human Cu,Zn superoxide dismutase.
J.Mol.Biol., 324, 2002
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1N1T
 | | Trypanosoma rangeli sialidase in complex with DANA at 1.6 A | | Descriptor: | 2-DEOXY-2,3-DEHYDRO-N-ACETYL-NEURAMINIC ACID, SULFATE ION, Sialidase | | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | | Deposit date: | 2002-10-20 | | Release date: | 2003-01-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The high resolution structures of free and
inhibitor-bound Trypanosoma rangeli
sialidase and its comparison with T. cruzi
trans-sialidase
J.Mol.Biol., 325, 2003
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1N1Y
 | | Trypanosoma rangeli sialidase in complex with sialic acid | | Descriptor: | N-acetyl-alpha-neuraminic acid, Sialidase | | Authors: | Amaya, M.F, Buschiazzo, A, Nguyen, T, Alzari, P.M. | | Deposit date: | 2002-10-21 | | Release date: | 2003-01-07 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | The high resolution structures of free and inhibitor-bound
Trypanosoma rangeli sialidase and its comparison with T.
cruzi trans-sialidase
J.Mol.Biol., 325, 2003
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1NH4
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1UNP
 | | Crystal structure of the pleckstrin homology domain of PKB alpha | | Descriptor: | RAC-ALPHA SERINE/THREONINE KINASE | | Authors: | Milburn, C.C, Deak, M, Kelly, S.M, Price, N.C, Alessi, D.R, van Aalten, D.M.F. | | Deposit date: | 2003-09-12 | | Release date: | 2004-09-16 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Binding of phosphatidylinositol 3,4,5-trisphosphate to the pleckstrin homology domain of protein kinase B induces a conformational change.
Biochem. J., 375, 2003
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1NAU
 | | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles | | Descriptor: | Glucagon | | Authors: | Ying, J, Ahn, J.-M, Jacobsen, N.E, Brown, M.F, Hruby, V.J. | | Deposit date: | 2002-11-28 | | Release date: | 2003-03-18 | | Last modified: | 2021-10-27 | | Method: | SOLUTION NMR | | Cite: | NMR Solution Structure of the Glucagon Antagonist [desHis1, desPhe6, Glu9]Glucagon Amide in the Presence of Perdeuterated Dodecylphosphocholine Micelles
Biochemistry, 42, 2003
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1TUK
 | | Crystal structure of liganded type 2 non specific lipid transfer protein from wheat | | Descriptor: | 1-MYRISTOYL-2-HYDROXY-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)], IODIDE ION, Nonspecific lipid-transfer protein 2G | | Authors: | Hoh, F, Pons, J.L, Gautier, M.F, De Lamotte, F, Dumas, C. | | Deposit date: | 2004-06-25 | | Release date: | 2005-04-05 | | Last modified: | 2017-10-11 | | Method: | X-RAY DIFFRACTION (1.12 Å) | | Cite: | Structure of a liganded type 2 non-specific lipid-transfer protein from wheat and the molecular basis of lipid binding.
Acta Crystallogr.,Sect.D, 61, 2005
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1N89
 | | Solution structure of a liganded type 2 wheat non-specific Lipid Transfer Protein | | Descriptor: | 1-MYRISTOYL-2-HYDROXY-SN-GLYCERO-3-[PHOSPHO-RAC-(1-GLYCEROL)], lipid transfer protein | | Authors: | Pons, J.L, de Lamotte, F, Gautier, M.F, Delsuc, M.A. | | Deposit date: | 2002-11-20 | | Release date: | 2003-03-18 | | Last modified: | 2023-06-14 | | Method: | SOLUTION NMR | | Cite: | Refined solution structure of a liganded type 2 wheat nonspecific lipid transfer protein.
J.Biol.Chem., 278, 2003
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1UPQ
 | | Crystal structure of the pleckstrin homology (PH) domain of PEPP1 | | Descriptor: | PEPP1, SULFATE ION | | Authors: | Milburn, C.C, Komander, D, Deak, M, Alessi, D.R, van Aalten, D.M.F. | | Deposit date: | 2003-10-09 | | Release date: | 2004-10-07 | | Last modified: | 2023-12-13 | | Method: | X-RAY DIFFRACTION (1.48 Å) | | Cite: | Crystal Structure of the Pleckstrin Homology Domain of Pepp1
To be Published
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1NZM
 | | NMR structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 complexed with the telomerase inhibitor RHPS4 | | Descriptor: | 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM, 5'-D(*TP*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION | | Authors: | Gavathiotis, E, Heald, R.A, Stevens, M.F.G, Searle, M.S. | | Deposit date: | 2003-02-18 | | Release date: | 2003-11-04 | | Last modified: | 2024-05-22 | | Method: | SOLUTION NMR | | Cite: | Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat
J.Mol.Biol., 334, 2003
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1UPK
 | | Crystal structure of MO25 in complex with a C-terminal peptide of STRAD | | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MO25 PROTEIN, STE-20 RELATED ADAPTOR | | Authors: | Milburn, C.C, Boudeau, J, Deak, M, Alessi, D.R, Van Aalten, D.M.F. | | Deposit date: | 2003-10-07 | | Release date: | 2004-01-22 | | Last modified: | 2019-04-10 | | Method: | X-RAY DIFFRACTION (1.85 Å) | | Cite: | Crystal Structure of Mo25 Alpha in Complex with the C-Terminus of the Pseudo Kinase Ste-20 Related Adaptor (Strad)
Nat.Struct.Mol.Biol., 11, 2004
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