1NZM

NMR structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 complexed with the telomerase inhibitor RHPS4

Summary for 1NZM

• Entry DOI: 10.2210/pdb1nzm/pdb
• Related: 1NP9
• Descriptor: 5'-D(*TP*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM (3 entities in total)
• Functional Keywords: quadruplex dna, telomeres, telomerase inhibition, nmr spectroscopy, molecular dynamics, drug-dna interaction, ttagggt repeat, dna
• Total number of polymer chains: 4
• Total formula weight: 9446.74

Authors

Gavathiotis, E.,Heald, R.A.,Stevens, M.F.G.,Searle, M.S. (deposition date: 2003-02-18, release date: 2003-11-04, Last modification date: 2022-02-23)

• Primary citation: Gavathiotis, E.,Heald, R.A.,Stevens, M.F.G.,Searle, M.S.; Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat; J.Mol.Biol., 334:25-36, 2003; PubMed: 14596797; DOI: 10.1016/j.jmb.2003.09.018

Experimental method

SOLUTION NMR