1NZM
NMR structure of the parallel-stranded DNA quadruplex d(TTAGGGT)4 complexed with the telomerase inhibitor RHPS4
Summary for 1NZM
Entry DOI | 10.2210/pdb1nzm/pdb |
Related | 1NP9 |
Descriptor | 5'-D(*TP*TP*AP*GP*GP*GP*T)-3', POTASSIUM ION, 3,11-DIFLUORO-6,8,13-TRIMETHYL-8H-QUINO[4,3,2-KL]ACRIDIN-13-IUM (3 entities in total) |
Functional Keywords | quadruplex dna, telomeres, telomerase inhibition, nmr spectroscopy, molecular dynamics, drug-dna interaction, ttagggt repeat, dna |
Total number of polymer chains | 4 |
Total formula weight | 9446.74 |
Authors | Gavathiotis, E.,Heald, R.A.,Stevens, M.F.G.,Searle, M.S. (deposition date: 2003-02-18, release date: 2003-11-04, Last modification date: 2024-05-22) |
Primary citation | Gavathiotis, E.,Heald, R.A.,Stevens, M.F.G.,Searle, M.S. Drug Recognition and Stabilisation of the Parallel-stranded DNA Quadruplex d(TTAGGGT)4 Containing the Human Telomeric Repeat J.Mol.Biol., 334:25-36, 2003 Cited by PubMed: 14596797DOI: 10.1016/j.jmb.2003.09.018 PDB entries with the same primary citation |
Experimental method | SOLUTION NMR |
Structure validation
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