PDB Search results for query - 일본 단백질구조 데이터 뱅크

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PDB: 61 results

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BU of 6o8u by Molmil

Crystal structure of IRAK4 in complex with compound 23
Descriptor:	GLYCEROL, Interleukin-1 receptor-associated kinase 4, N-[2,2-dimethyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, ...
Authors:	Kiefer, J.R, Yu, C, Drobnick, J, Bryan, M.C, Lupardus, P.J.
Deposit date:	2019-03-12
Release date:	2019-05-22
Last modified:	2019-07-24
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019

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BU of 6nw2 by Molmil

Structure of human RIPK1 kinase domain in complex with compound 11
Descriptor:	(5R)-5-methyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide, Receptor-interacting serine/threonine-protein kinase 1
Authors:	Fong, R, Lupardus, P.J.
Deposit date:	2019-02-05
Release date:	2019-05-01
Last modified:	2024-03-13
Method:	X-RAY DIFFRACTION (2 Å)
Cite:	Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group. Bioorg.Med.Chem.Lett., 29, 2019

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BU of 6o9d by Molmil

Structure of the IRAK4 kinase domain with compound 5
Descriptor:	Interleukin-1 receptor-associated kinase 4, N-{7-[4-(aminomethyl)piperidin-1-yl]quinolin-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide
Authors:	Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J.
Deposit date:	2019-03-13
Release date:	2019-05-22
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (2.51 Å)
Cite:	Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019

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BU of 6o95 by Molmil

Structure of the IRAK4 kinase domain with compound 41
Descriptor:	Interleukin-1 receptor-associated kinase 4, N-[(2R)-2-(hydroxymethyl)-2-methyl-6-(morpholin-4-yl)-2,3-dihydro-1-benzofuran-5-yl]pyrazolo[1,5-a]pyrimidine-3-carboxamide, SULFATE ION
Authors:	Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J.
Deposit date:	2019-03-13
Release date:	2019-05-22
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.77 Å)
Cite:	Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019

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BU of 6o94 by Molmil

Structure of the IRAK4 kinase domain with compound 17
Descriptor:	CALCIUM ION, Interleukin-1 receptor-associated kinase 4, N-{5-[4-(hydroxymethyl)piperidin-1-yl]-1-methyl-2-(morpholin-4-yl)-1H-benzimidazol-6-yl}pyrazolo[1,5-a]pyrimidine-3-carboxamide
Authors:	Yu, C, Drobnick, J, Bryan, M.C, Kiefer, J, Lupardus, P.J.
Deposit date:	2019-03-13
Release date:	2019-05-22
Last modified:	2024-04-03
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Development of Potent and Selective Pyrazolopyrimidine IRAK4 Inhibitors. J.Med.Chem., 62, 2019

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BU of 5ixd by Molmil

Structure of human JAK1 FERM/SH2 in complex with IFN lambda receptor
Descriptor:	CITRIC ACID, Interferon lambda receptor 1, Tyrosine-protein kinase JAK1
Authors:	Ferrao, R, Wallweber, H.J.A, Lupardus, P.J.
Deposit date:	2016-03-23
Release date:	2016-05-18
Last modified:	2023-09-27
Method:	X-RAY DIFFRACTION (2.85 Å)
Cite:	The Structural Basis for Class II Cytokine Receptor Recognition by JAK1. Structure, 24, 2016

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BU of 6rse by Molmil

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Descriptor:	Tyrosine-protein kinase JAK1, methyl ~{N}-[4-aminocarbonyl-1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[(4-ethenyl-2-fluoranyl-5-oxidanyl-phenyl)methyl]-3-fluoranyl-piperidin-4-yl]pyrazol-3-yl]carbamate
Authors:	Brown, D.G, Lupardus, P.J.
Deposit date:	2019-05-21
Release date:	2020-07-08
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published

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BU of 6rsh by Molmil

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Descriptor:	1-[(3~{R},4~{R})-4-(cyanomethyl)-3-fluoranyl-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1
Authors:	Brown, D.G, Lupardus, P.J.
Deposit date:	2019-05-21
Release date:	2020-07-08
Method:	X-RAY DIFFRACTION (1.71 Å)
Cite:	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published

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BU of 6rsb by Molmil

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Descriptor:	1-[(3~{R},4~{R})-4-(cyanomethyl)-1-[[4-(cyclohexen-1-yl)phenyl]methyl]-3-fluoranyl-piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1
Authors:	Brown, D.G, Lupardus, P.J.
Deposit date:	2019-05-21
Release date:	2020-07-08
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published

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BU of 6rsd by Molmil

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Descriptor:	1-[4-(cyanomethyl)-1-[(3-oxidanyl-4-phenyl-phenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1
Authors:	Brown, D.G, Lupardus, P.J.
Deposit date:	2019-05-21
Release date:	2020-07-08
Method:	X-RAY DIFFRACTION (1.76 Å)
Cite:	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published

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BU of 6rsc by Molmil

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
Descriptor:	1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide, Tyrosine-protein kinase JAK1
Authors:	Brown, D.G, Lupardus, P.J.
Deposit date:	2019-05-21
Release date:	2020-07-08
Method:	X-RAY DIFFRACTION (1.85 Å)
Cite:	Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class To Be Published

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