6NW2
Structure of human RIPK1 kinase domain in complex with compound 11
Summary for 6NW2
Entry DOI | 10.2210/pdb6nw2/pdb |
Descriptor | Receptor-interacting serine/threonine-protein kinase 1, (5R)-5-methyl-N-[(3S)-5-methyl-4-oxo-2,3,4,5-tetrahydro-1,5-benzoxazepin-3-yl]-4,5,6,7-tetrahydro-2H-indazole-3-carboxamide (3 entities in total) |
Functional Keywords | rip1, kinase, rip, rip1k ripk1, immune system, transferase-transferase inhibitor complex, transferase/transferase inhibitor |
Biological source | Homo sapiens (Human) |
Total number of polymer chains | 2 |
Total formula weight | 71558.47 |
Authors | Fong, R.,Lupardus, P.J. (deposition date: 2019-02-05, release date: 2019-05-01, Last modification date: 2024-03-13) |
Primary citation | Hamilton, G.L.,Chen, H.,Deshmukh, G.,Eigenbrot, C.,Fong, R.,Johnson, A.,Kohli, P.B.,Lupardus, P.J.,Liederer, B.M.,Ramaswamy, S.,Wang, H.,Wang, J.,Xu, Z.,Zhu, Y.,Vucic, D.,Patel, S. Potent and selective inhibitors of receptor-interacting protein kinase 1 that lack an aromatic back pocket group. Bioorg.Med.Chem.Lett., 29:1497-1501, 2019 Cited by PubMed: 31000154DOI: 10.1016/j.bmcl.2019.04.014 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2 Å) |
Structure validation
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