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6RSC

Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class

Summary for 6RSC
Entry DOI10.2210/pdb6rsc/pdb
Related6rsb
DescriptorTyrosine-protein kinase JAK1, 1-[4-(cyanomethyl)-1-[(4-phenylphenyl)methyl]piperidin-4-yl]-3-(cyclopropylcarbonylamino)pyrazole-4-carboxamide (3 entities in total)
Functional Keywordsinhibitor, complex, transferase
Biological sourceHomo sapiens (Human)
Total number of polymer chains2
Total formula weight70458.34
Authors
Brown, D.G.,Lupardus, P.J. (deposition date: 2019-05-21, release date: 2020-07-08)
Primary citationZak, M.,Gibbons, P.,Brown, D.G.
Structure based optimization of JAK1-ATP binding pocket Inhibitors in the aminopyrazole class
To Be Published,
Experimental method
X-RAY DIFFRACTION (1.85 Å)
Structure validation

217705

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