5JAA
 
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5MI8
 | | Structure of the phosphomimetic mutant of EF-Tu T383E | | Descriptor: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ACETATE ION, BETA-MERCAPTOETHANOL, ... | | Authors: | Talavera, A, Hendrix, J, Versees, W, De Gieter, S, Castro-Roa, D, Jurenas, D, Van Nerom, K, Vandenberk, N, Barth, A, De Greve, H, Hofkens, J, Zenkin, N, Loris, R, Garcia-Pino, A. | | Deposit date: | 2016-11-27 | | Release date: | 2017-12-20 | | Last modified: | 2019-10-16 | | Method: | X-RAY DIFFRACTION (2.18 Å) | | Cite: | Phosphorylation decelerates conformational dynamics in bacterial translation elongation factors.
Sci Adv, 4, 2018
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4ELY
 | | CCDBVFI:GYRA14EC | | Descriptor: | CHLORIDE ION, CcdB, DNA gyrase subunit A, ... | | Authors: | De Jonge, N, Simic, R, Buts, L, Haesaerts, S, Roelants, K, Garcia-Pino, A, Sterckx, Y, De Greve, H, Lah, J, Loris, R. | | Deposit date: | 2012-04-11 | | Release date: | 2012-05-30 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (1.932 Å) | | Cite: | Alternative interactions define gyrase specificity in the CcdB family.
Mol.Microbiol., 84, 2012
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5HOH
 | | RIBONUCLEASE T1 (ASN9ALA/THR93ALA DOUBLEMUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-14 | | Release date: | 1998-09-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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6Y2P
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6Y2Q
 | | Escherichia coli RnlA endoribonuclease | | Descriptor: | CHLORIDE ION, mRNA endoribonuclease toxin LS | | Authors: | Garcia-Rodriguez, G, Loris, R. | | Deposit date: | 2020-02-17 | | Release date: | 2021-05-12 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (2.99 Å) | | Cite: | Alternative dimerization is required for activity and inhibition of the HEPN ribonuclease RnlA.
Nucleic Acids Res., 49, 2021
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6XX8
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6XX6
 | | Arabidopsis thaliana Casein Kinase 2 (CK2) alpha-1 crystal form I | | Descriptor: | CHLORIDE ION, Casein kinase II subunit alpha-1, PIVALIC ACID, ... | | Authors: | Demulder, M, De Veylder, L, Loris, R. | | Deposit date: | 2020-01-27 | | Release date: | 2020-04-15 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.84919691 Å) | | Cite: | Crystal structure of Arabidopsis thaliana casein kinase 2 alpha 1.
Acta Crystallogr.,Sect.F, 76, 2020
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5J9I
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5JA9
 | | Crystal structure of the HigB2 toxin in complex with Nb6 | | Descriptor: | 1,2-ETHANEDIOL, Nanobody 6, SULFATE ION, ... | | Authors: | Hadzi, S, Loris, R. | | Deposit date: | 2016-04-12 | | Release date: | 2017-04-05 | | Last modified: | 2017-05-17 | | Method: | X-RAY DIFFRACTION (1.849 Å) | | Cite: | Ribosome-dependent Vibrio cholerae mRNAse HigB2 is regulated by a beta-strand sliding mechanism.
Nucleic Acids Res., 45, 2017
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4QO1
 | | p53 DNA binding domain in complex with Nb139 | | Descriptor: | Cellular tumor antigen p53, Nb139 Nanobody against the DNA-binding domain of p53, ZINC ION | | Authors: | De Gieter, S, Bethuyne, J, Gettemans, J, Garcia-Pino, A, Loris, R. | | Deposit date: | 2014-06-19 | | Release date: | 2014-10-29 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (1.924 Å) | | Cite: | A nanobody modulates the p53 transcriptional program without perturbing its functional architecture.
Nucleic Acids Res., 42, 2014
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1LES
 | | LENTIL LECTIN COMPLEXED WITH SUCROSE | | Descriptor: | CALCIUM ION, LENTIL LECTIN, MANGANESE (II) ION, ... | | Authors: | Hamelryck, T, Loris, R. | | Deposit date: | 1995-08-23 | | Release date: | 1995-12-07 | | Last modified: | 2024-02-14 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | NMR, molecular modeling, and crystallographic studies of lentil lectin-sucrose interaction.
J.Biol.Chem., 270, 1995
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7B22
 | | Vibrio cholerae ParD2 Antitoxin | | Descriptor: | Antitoxin ParD | | Authors: | Garcia-Rodriguez, G, Loris, R. | | Deposit date: | 2020-11-25 | | Release date: | 2021-10-06 | | Last modified: | 2024-01-31 | | Method: | X-RAY DIFFRACTION (3.08 Å) | | Cite: | Entropic pressure controls the oligomerization of the Vibrio cholerae ParD2 antitoxin.
Acta Crystallogr D Struct Biol, 77, 2021
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4Z33
 | | Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2 | | Descriptor: | ACETATE ION, D-MYO-INOSITOL-4,5-BISPHOSPHATE, GLYCEROL, ... | | Authors: | Egea-Jimenez, A.L, Gallardo, R, Garcia-Pino, A, Ivarsson, Y, Wawrzyniak, A.M, Kashyap, R, Loris, R, Schymkowitz, J, Rousseau, F, Zimmermann, P. | | Deposit date: | 2015-03-30 | | Release date: | 2016-06-29 | | Last modified: | 2024-01-10 | | Method: | X-RAY DIFFRACTION (2.45 Å) | | Cite: | Crystal structure of the syntenin PDZ1 and PDZ2 tandem in complex with the Frizzled 7 C-terminal fragment and PIP2
To Be Published
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4ELZ
 | | CCDBVFI:GYRA14VFI | | Descriptor: | CcdB, DNA gyrase subunit A, GLYCEROL | | Authors: | De Jonge, N, Simic, M, Buts, L, Haesaerts, S, Roelants, K, Garcia-Pino, A, Sterckx, Y, De Greve, H, Lah, J, Loris, R. | | Deposit date: | 2012-04-11 | | Release date: | 2012-05-30 | | Last modified: | 2023-09-13 | | Method: | X-RAY DIFFRACTION (2.2 Å) | | Cite: | Alternative interactions define gyrase specificity in the CcdB family.
Mol.Microbiol., 84, 2012
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4HOH
 | | RIBONUCLEASE T1 (THR93ALA MUTANT) COMPLEXED WITH 2'GMP | | Descriptor: | CALCIUM ION, GUANOSINE-2'-MONOPHOSPHATE, PROTEIN (RIBONUCLEASE T1) | | Authors: | Langhorst, U, Loris, R, Denisov, V.P, Doumen, J, Roose, P, Maes, D, Halle, B, Steyaert, J. | | Deposit date: | 1998-09-14 | | Release date: | 1998-09-23 | | Last modified: | 2023-09-20 | | Method: | X-RAY DIFFRACTION (2.05 Å) | | Cite: | Dissection of the structural and functional role of a conserved hydration site in RNase T1.
Protein Sci., 8, 1999
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2PHR
 | | Pterocarpus angolensis lectin (PAL) in complex with Man-7D1 | | Descriptor: | CALCIUM ION, Lectin, MANGANESE (II) ION, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Imberty, A, Loris, R. | | Deposit date: | 2007-04-12 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | How a plant lectin recognizes high mannose oligosaccharides
Plant Physiol., 144, 2007
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2PHF
 | | Pterocarpus angolensis lectin complexed with Man-6 | | Descriptor: | CALCIUM ION, Lectin, MANGANESE (II) ION, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Imberty, A, Loris, R. | | Deposit date: | 2007-04-11 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (2.1 Å) | | Cite: | How a plant lectin recognizes high mannose oligosaccharides
Plant Physiol., 144, 2007
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2PHX
 | | Pterocarpus angolensis lectin (PAL) in complex with Man-5 | | Descriptor: | CALCIUM ION, Lectin, MANGANESE (II) ION, ... | | Authors: | Garcia-Pino, A, Buts, L, Wyns, L, Imberty, A, Loris, R. | | Deposit date: | 2007-04-12 | | Release date: | 2007-07-10 | | Last modified: | 2023-08-30 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | How a plant lectin recognizes high mannose oligosaccharides
Plant Physiol., 144, 2007
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1X75
 | | CcdB:GyrA14 complex | | Descriptor: | Cytotoxic protein ccdB, DNA gyrase subunit A | | Authors: | Dao-Thi, M.H, Van Melderen, L, De Genst, E, Wyns, L, Loris, R. | | Deposit date: | 2004-08-13 | | Release date: | 2005-05-17 | | Last modified: | 2024-03-13 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Molecular Basis of Gyrase Poisoning by the Addiction Toxin CcdB
J.Mol.Biol., 348, 2005
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1YC8
 | | cAbAn33- Y37V/E44G/R45L triple mutant | | Descriptor: | anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | Authors: | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | Deposit date: | 2004-12-22 | | Release date: | 2005-06-14 | | Last modified: | 2023-08-23 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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1YC7
 | | cAbAn33 VHH fragment against VSG | | Descriptor: | SULFATE ION, anti-VSG immunoglobulin heavy chain variable domain cAbAn33 | | Authors: | Conrath, K, Vincke, C, Stijlemans, B, Schymkowitz, J, Wyns, L, Muyldermans, S, Loris, R. | | Deposit date: | 2004-12-22 | | Release date: | 2005-06-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Antigen Binding and Solubility Effects upon the Veneering of a Camel VHH in Framework-2 to Mimic a VH.
J.Mol.Biol., 350, 2005
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1XFP
 | | Crystal structure of the CDR2 germline reversion mutant of cAb-Lys3 in complex with hen egg white lysozyme | | Descriptor: | FORMIC ACID, Lysozyme C, heavy chain antibody | | Authors: | De Genst, E, Handelberg, F, Van Meirhaeghe, A, Vynck, S, Loris, R, Wyns, L, Muyldermans, S. | | Deposit date: | 2004-09-15 | | Release date: | 2004-09-28 | | Last modified: | 2013-02-06 | | Method: | X-RAY DIFFRACTION (1.5 Å) | | Cite: | Chemical Basis for the Affinity Maturation of a Camel Single Domain Antibody
J.Biol.Chem., 279, 2004
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1IOA
 | | ARCELIN-5, A LECTIN-LIKE DEFENSE PROTEIN FROM PHASEOLUS VULGARIS | | Descriptor: | ARCELIN-5A, alpha-L-fucopyranose-(1-3)-[2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)]2-acetamido-2-deoxy-beta-D-glucopyranose | | Authors: | Hamelryck, T, Loris, R. | | Deposit date: | 1996-10-02 | | Release date: | 1996-12-23 | | Last modified: | 2020-07-29 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of arcelin-5, a lectin-like defense protein from Phaseolus vulgaris
J.Biol.Chem., 271, 1996
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2MF2
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