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PDB: 491 件
5T27
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mPI3Kd IN COMPLEX WITH 5d
分子名称: 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.6 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T23
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PI3Kg IN COMPLEX WITH 5d
分子名称: 3-(benzotriazol-1-yl)-5-[1-methyl-5-[(1~{S})-1-morpholin-4-ylethyl]-1,2,4-triazol-3-yl]pyrazin-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.78 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2I
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mPI3Kd IN COMPLEX WITH 7k
分子名称: 1-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-4-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2D
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BU of 5t2d by Molmil
mPI3Kd IN COMPLEX WITH 7j
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]-~{N},~{N}-dimethyl-pyrazole-1-sulfonamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
5T2M
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BU of 5t2m by Molmil
mPI3Kd IN COMPLEX WITH 7m
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]benzamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
2I74
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BU of 2i74 by Molmil
Crystal structure of mouse Peptide N-Glycanase C-terminal domain in complex with mannopentaose
分子名称: ACETATE ION, GLYCEROL, PNGase, ...
著者Zhou, X, Zhao, G, Wang, L, Li, G, Lennarz, W.J, Schindelin, H.
登録日2006-08-30
公開日2006-10-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and biochemical studies of the C-terminal domain of mouse peptide-N-glycanase identify it as a mannose-binding module.
Proc.Natl.Acad.Sci.Usa, 103, 2006
5T2G
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BU of 5t2g by Molmil
mPI3Kd IN COMPLEX WITH 7i
分子名称: 4-[3-azanyl-6-[1-methyl-5-(1-phenylcyclopropyl)-1,2,4-triazol-3-yl]pyrazin-2-yl]pyrazole-1-carboxamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit delta isoform
著者Petersen, J, Terstige, I, Perry, M, Svensson, T, Tyrchan, C, Lindmark, H, Oster, L.
登録日2016-08-23
公開日2017-04-19
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.55 Å)
主引用文献Discovery of triazole aminopyrazines as a highly potent and selective series of PI3K delta inhibitors.
Bioorg. Med. Chem. Lett., 27, 2017
1MVG
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NMR solution structure of chicken Liver basic Fatty Acid Binding Protein (Lb-FABP)
分子名称: Liver basic Fatty Acid Binding Protein
著者Vasile, F, Ragona, L, Catalano, M, Zetta, L, Perduca, M, Monaco, H, Molinari, H.
登録日2002-09-25
公開日2003-03-04
最終更新日2024-05-22
実験手法SOLUTION NMR
主引用文献Solution Structure of chicken Liver basic type Fatty Acid Binding Protein
J.BIOMOL.NMR, 25, 2003
2JN3
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BU of 2jn3 by Molmil
NMR structure of cl-BABP complexed to chenodeoxycholic acid
分子名称: CHENODEOXYCHOLIC ACID, Fatty acid-binding protein, liver
著者Eliseo, T, Ragona, L, Catalano, M, Assfalf, M, Paci, M, Zetta, L, Molinari, H, Cicero, D.O.
登録日2006-12-22
公開日2007-07-03
最終更新日2023-12-20
実験手法SOLUTION NMR
主引用文献Structural and dynamic determinants of ligand binding in the ternary complex of chicken liver bile acid binding protein with two bile salts revealed by NMR
Biochemistry, 46, 2007
2K62
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BU of 2k62 by Molmil
NMR solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based Gd(III)-chelate
分子名称: (3alpha,5alpha,8alpha)-3-[(N,N-bis{2-[bis(carboxymethyl)amino]ethyl}-L-gamma-glutamyl)amino]cholan-24-oic acid, Liver fatty acid-binding protein, YTTERBIUM (III) ION
著者Tomaselli, S, Zanzoni, S, Ragona, L, Gianolio, E, Aime, S, Assfalg, M, Molinari, H.
登録日2008-07-03
公開日2008-11-04
最終更新日2024-05-29
実験手法SOLUTION NMR
主引用文献Solution structure of the supramolecular adduct between a liver cytosolic bile acid binding protein and a bile acid-based gadolinium(III)-chelate, a potential hepatospecific magnetic resonance imaging contrast agent.
J.Med.Chem., 51, 2008
2KCN
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BU of 2kcn by Molmil
Solution structure of the antifungal protein PAF from Penicillium chrysogenum
分子名称: Antifungal protein
著者Batta, G, Barna, T, Gaspari, Z, Sandor, S, Kover, K.E, Binder, U, Sarg, B, Kaiserer, L, Chhillar, A.K, Eigentler, A, Leiter, E, Hegedus, N, Pocsi, I, Lindner, H, Marx, F.
登録日2008-12-23
公開日2009-07-21
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Functional aspects of the solution structure and dynamics of PAF--a highly-stable antifungal protein from Penicillium chrysogenum
Febs J., 276, 2009
2LBA
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BU of 2lba by Molmil
Solution structure of chicken ileal BABP in complex with glycochenodeoxycholic acid
分子名称: BABP protein, GLYCOCHENODEOXYCHOLIC ACID
著者Zanzoni, S, Assfalg, M, Giorgetti, A, D'Onofrio, M, Molinari, H.
登録日2011-03-28
公開日2011-09-14
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural Requirements for Cooperativity in Ileal Bile Acid-binding Proteins.
J.Biol.Chem., 286, 2011
2RDI
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BU of 2rdi by Molmil
Snapshots of a Y-family DNA polymerase in replication: Dpo4 in apo and binary/ternary complex forms
分子名称: DI(HYDROXYETHYL)ETHER, DNA polymerase IV, GLYCEROL
著者Wong, J.H.Y, Ling, H.
登録日2007-09-24
公開日2008-06-24
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Snapshots of a Y-family DNA polymerase in replication: substrate-induced conformational transitions and implications for fidelity of Dpo4.
J.Mol.Biol., 379, 2008
4BX0
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BU of 4bx0 by Molmil
Crystal Structure of a Monomeric Variant of murine Chronophin (Pyridoxal Phosphate phosphatase)
分子名称: GLYCEROL, MAGNESIUM ION, PYRIDOXAL PHOSPHATE PHOSPHATASE
著者Kestler, C, Knobloch, G, Gohla, A, Schindelin, H.
登録日2013-07-08
公開日2013-12-25
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Chronophin Dimerization is Required for Proper Positioning of its Substrate Specificity Loop
J.Biol.Chem., 289, 2014
1FM0
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BU of 1fm0 by Molmil
MOLYBDOPTERIN SYNTHASE (MOAD/MOAE)
分子名称: CHLORIDE ION, MOLYBDOPTERIN CONVERTING FACTOR, SUBUNIT 1, ...
著者Rudolph, M.J, Wuebbens, M.M, Rajagolpalan, K.V, Schindelin, H.
登録日2000-08-15
公開日2001-01-17
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Crystal structure of molybdopterin synthase and its evolutionary relationship to ubiquitin activation.
Nat.Struct.Biol., 8, 2001
1FR9
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BU of 1fr9 by Molmil
STRUCTURE OF E. COLI MOBA
分子名称: ACETATE ION, MOLYBDOPTERIN-GUANINE DINUCLEOTIDE BIOSYNTHESIS PROTEIN, ZINC ION
著者Lake, M.W, Temple, C.A, Rajagopalan, K.V, Schindelin, H.
登録日2000-09-07
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis.
J.Biol.Chem., 275, 2000
1FRW
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STRUCTURE OF E. COLI MOBA WITH BOUND GTP AND MANGANESE
分子名称: ACETATE ION, GUANOSINE-5'-TRIPHOSPHATE, MANGANESE (II) ION, ...
著者Lake, M.W, Temple, C.A, Rajagopalan, K.V, Schindelin, H.
登録日2000-09-07
公開日2001-01-10
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献The crystal structure of the Escherichia coli MobA protein provides insight into molybdopterin guanine dinucleotide biosynthesis.
J.Biol.Chem., 275, 2000
4D80
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Metallosphera sedula Vps4 crystal structure
分子名称: AAA ATPASE, CENTRAL DOMAIN PROTEIN
著者Caillat, C, Macheboeuf, P, Wu, Y, McCarthy, A.A, Boeri-Erba, E, Effantin, G, Gottlinger, H.G, Weissenhorn, W, Renesto, P.
登録日2014-12-02
公開日2015-10-28
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (3.6 Å)
主引用文献Asymmetric Ring Structure of Vps4 Required for Escrt-III Disassembly.
Nat.Commun., 6, 2015
2NRO
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BU of 2nro by Molmil
MoeA K279Q
分子名称: Molybdopterin biosynthesis protein moeA
著者Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
登録日2006-11-02
公開日2007-01-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.5 Å)
主引用文献Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
2NRP
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MoeA R350A
分子名称: GLYCEROL, Molybdopterin biosynthesis protein moeA
著者Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
登録日2006-11-02
公開日2007-01-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
1NVJ
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Deletion Mutant (Delta 141) of Molybdopterin Synthase
分子名称: FORMIC ACID, GLYCEROL, Molybdopterin converting factor subunit 2, ...
著者Rudolph, M.J, Wuebbens, M.M, Turque, O, Rajagopalan, K.V, Schindelin, H.
登録日2003-02-03
公開日2003-05-06
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Structural Studies of Molybdopterin Synthase Provide Insights into its Catalytic Mechanism
J.Biol.Chem., 278, 2003
2O7I
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BU of 2o7i by Molmil
The X-ray crystal structure of a thermophilic cellobiose binding protein bound with cellobiose
分子名称: Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein, beta-D-glucopyranose-(1-4)-beta-D-glucopyranose
著者Cuneo, M.J, Hellinga, H.W.
登録日2006-12-11
公開日2007-03-20
最終更新日2023-08-30
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural Analysis of Semi-specific Oligosaccharide Recognition by a Cellulose-binding Protein of Thermotoga maritima Reveals Adaptations for Functional Diversification of the Oligopeptide Periplasmic Binding Protein Fold.
J.Biol.Chem., 284, 2009
2NRS
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MoeA S371W
分子名称: Molybdopterin biosynthesis protein moeA
著者Nicolas, J, Xiang, S, Schindelin, H, Rajagopalan, K.V.
登録日2006-11-02
公開日2007-01-16
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Mutational Analysis of Escherichia coli MoeA: Two Functional Activities Map to the Active Site Cleft.
Biochemistry, 46, 2007
1G8L
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BU of 1g8l by Molmil
CRYSTAL STRUCTURE OF ESCHERICHIA COLI MOEA
分子名称: GLYCEROL, MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN
著者Xiang, S, Nichols, J, Rajagopalan, K.V, Schindelin, H.
登録日2000-11-17
公開日2001-05-02
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9, 2001
1G8R
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MOEA
分子名称: GLYCEROL, MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN
著者Xiang, S, Nichols, J, Rajagopalan, K.V, Schindelin, H.
登録日2000-11-20
公開日2001-05-02
最終更新日2023-08-09
実験手法X-RAY DIFFRACTION (2.65 Å)
主引用文献The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9, 2001

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