1G8R

MOEA

Summary for 1G8R

• Entry DOI: 10.2210/pdb1g8r/pdb
• Related: 1G8L
• Descriptor: MOLYBDOPTERIN BIOSYNTHESIS MOEA PROTEIN, GLYCEROL (3 entities in total)
• Functional Keywords: molybdenum cofactor biosynthesis, metal binding protein
• Biological source: Escherichia coli
• Total number of polymer chains: 2
• Total formula weight: 89317.25

Authors

Xiang, S.,Nichols, J.,Rajagopalan, K.V.,Schindelin, H. (deposition date: 2000-11-20, release date: 2001-05-02, Last modification date: 2023-08-09)

Primary citation

Xiang, S.,Nichols, J.,Rajagopalan, K.V.,Schindelin, H.
The crystal structure of Escherichia coli MoeA and its relationship to the multifunctional protein gephyrin.
Structure, 9:299-310, 2001

PubMed Abstract: Molybdenum cofactor (Moco) biosynthesis is an evolutionarily conserved pathway present in archaea, eubacteria, and eukaryotes. In humans, genetic abnormalities in the biosynthetic pathway result in Moco deficiency, which is accompanied by severe neurological symptoms and death shortly after birth. The Escherichia coli MoeA and MogA proteins are involved in the final step of Moco biosynthesis: the incorporation of molybdenum into molybdopterin (MPT), the organic pyranopterin moiety of Moco.

PubMed: 11525167
DOI: 10.1016/S0969-2126(01)00588-3

Experimental method

X-RAY DIFFRACTION (2.65 Å)