8D30
 
 | | Crystal structure of the human COPB2 WD-domains | | 分子名称: | 1,2-ETHANEDIOL, Coatomer subunit beta' | | 著者 | Zeng, H, Dong, A, Hutchinson, A, Seitova, A, Loppnau, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-05-31 | | 公開日 | 2022-11-16 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystal structure of the human COPB2 WD-domains
To Be Published
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6A32
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6GPD
 | | Crystal structure of the ligand-free form of domain 1 from TmArgBP | | 分子名称: | Amino acid ABC transporter, periplasmic amino acid-binding protein,Amino acid ABC transporter, periplasmic amino acid-binding protein | | 著者 | Smaldone, G, Balasco, N, Ruggiero, A, Berisio, R, Vitagliano, L. | | 登録日 | 2018-06-05 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection.
Int. J. Biol. Macromol., 119, 2018
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6GGP
 | | Structure of the ligand-free form of truncated ArgBP (residues 20-233) from T. maritima | | 分子名称: | Amino acid ABC transporter, periplasmic amino acid-binding protein | | 著者 | Smaldone, G, Berisio, R, Balasco, N, D'Auria, S, Vitagliano, L, Ruggiero, A. | | 登録日 | 2018-05-03 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.03 Å) | | 主引用文献 | Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization.
Biochim. Biophys. Acta, 1866, 2018
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6GGV
 | | Structure of the arginine-bound form of truncated (residues 20-233) ArgBP from T. maritima | | 分子名称: | ARGININE, Amino acid ABC transporter, periplasmic amino acid-binding protein, ... | | 著者 | Smaldone, G, Berisio, R, Balasco, N, D'Auria, S, Vitagliano, L, Ruggiero, A. | | 登録日 | 2018-05-04 | | 公開日 | 2018-06-13 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.69 Å) | | 主引用文献 | Domain swapping dissection in Thermotoga maritima arginine binding protein: How structural flexibility may compensate destabilization.
Biochim. Biophys. Acta, 1866, 2018
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6GPC
 | | Crystal structure of the arginine-bound form of domain 1 from TmArgBP | | 分子名称: | ARGININE, Amino acid ABC transporter, periplasmic amino acid-binding protein,Amino acid ABC transporter, ... | | 著者 | Smaldone, G, Balasco, N, Ruggiero, A, Berisio, R, Vitagliano, L. | | 登録日 | 2018-06-05 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | | 主引用文献 | Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection.
Int. J. Biol. Macromol., 119, 2018
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6GPM
 | | Crystal structure of domain 2 from TmArgBP | | 分子名称: | Amino acid ABC transporter, periplasmic amino acid-binding protein | | 著者 | Smaldone, G, Balasco, N, Ruggiero, A, Berisio, R, Vitagliano, L. | | 登録日 | 2018-06-06 | | 公開日 | 2018-08-15 | | 最終更新日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.73 Å) | | 主引用文献 | Domain communication in Thermotoga maritima Arginine Binding Protein unraveled through protein dissection.
Int. J. Biol. Macromol., 119, 2018
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1K6F
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1LSQ
 | | RIBONUCLEASE A WITH ASN 67 REPLACED BY A BETA-ASPARTYL RESIDUE | | 分子名称: | RIBONUCLEASE A, SULFATE ION | | 著者 | Esposito, L, Sica, F, Vitagliano, L, Zagari, A, Mazzarella, L. | | 登録日 | 1996-06-25 | | 公開日 | 1997-01-11 | | 最終更新日 | 2023-08-09 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Deamidation in proteins: the crystal structure of bovine pancreatic ribonuclease with an isoaspartyl residue at position 67.
J.Mol.Biol., 257, 1996
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5EOC
 | | Crystal structure of Fab C2 in complex with a Cyclic variant of Hepatitis C Virus E2 epitope I | | 分子名称: | ALA-CYS-GLN-LEU-ILE-ASN-THR-ASN-GLY-SER-TRP-HIS-ILE-CYS, Fab fragment (Heavy chain), Fab fragment (Light chain) | | 著者 | Berisio, R, Ruggiero, A, Sandomenico, A, Patel, A.H, Ruvo, M, Vitagliano, L. | | 登録日 | 2015-11-10 | | 公開日 | 2016-02-10 | | 最終更新日 | 2024-01-10 | | 実験手法 | X-RAY DIFFRACTION (1.98 Å) | | 主引用文献 | Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422.
J.Virol., 90, 2016
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1DY5
 | | Deamidated derivative of bovine pancreatic ribonuclease | | 分子名称: | ACETATE ION, ISOPROPYL ALCOHOL, RIBONUCLEASE A, ... | | 著者 | Esposito, L, Vitagliano, L, Sica, F, Zagari, A, Mazzarella, L. | | 登録日 | 2000-01-27 | | 公開日 | 2000-03-28 | | 最終更新日 | 2023-12-06 | | 実験手法 | X-RAY DIFFRACTION (0.87 Å) | | 主引用文献 | The Ultrahigh Resolution Crystal Structure of Ribonuclease A Containing an Isoaspartyl Residue: Hydration and Sterochemical Analysis.
J.Mol.Biol., 297, 2000
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8IJ1
 | | Protomer 1 and 2 of the asymmetry trimer of the Cul2-Rbx1-EloBC-FEM1B ubiquitin ligase complex | | 分子名称: | Cullin-2, E3 ubiquitin-protein ligase RBX1, Elongin-B, ... | | 著者 | Dai, Z, Liang, L, Yin, Y.X. | | 登録日 | 2023-02-24 | | 公開日 | 2024-02-28 | | 最終更新日 | 2024-04-03 | | 実験手法 | ELECTRON MICROSCOPY (4.2 Å) | | 主引用文献 | Structural insights into the ubiquitylation strategy of the oligomeric CRL2 FEM1B E3 ubiquitin ligase.
Embo J., 43, 2024
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6QMN
 | | Crystal structure of a Ribonuclease A-Onconase chimera | | 分子名称: | PHOSPHATE ION, Ribonuclease pancreatic | | 著者 | Esposito, L, Vitagliano, L, Ruggiero, A, Picone, D, Leone, S, Donnarumma, F. | | 登録日 | 2019-02-07 | | 公開日 | 2019-05-08 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Structure, stability and aggregation propensity of a Ribonuclease A-Onconase chimera.
Int.J.Biol.Macromol., 133, 2019
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1LA6
 | | The crystal structure of Trematomus newnesi hemoglobin in a partial hemichrome state | | 分子名称: | CARBON MONOXIDE, Hemoglobin alpha-1 chain, Hemoglobin beta-1/2 chain, ... | | 著者 | Riccio, A, Vitagliano, L, di Prisco, G, Zagari, A, Mazzarella, L. | | 登録日 | 2002-03-28 | | 公開日 | 2002-07-31 | | 最終更新日 | 2023-08-16 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The crystal structure of a tetrameric hemoglobin in a partial hemichrome state
Proc.Natl.Acad.Sci.USA, 99, 2002
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3TCO
 | | Crystallographic and spectroscopic characterization of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability | | 分子名称: | 1,2-ETHANEDIOL, Thioredoxin (TrxA-1) | | 著者 | Esposito, L, Ruggiero, A, Masullo, M, Ruocco, M.R, Lamberti, A, Arcari, P, Zagari, A, Vitagliano, L. | | 登録日 | 2011-08-09 | | 公開日 | 2011-11-30 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystallographic and spectroscopic characterizations of Sulfolobus solfataricus TrxA1 provide insights into the determinants of thioredoxin fold stability.
J.Struct.Biol., 177, 2012
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9CUX
 | | Crystal Structure of SETDB1 Tudor domain in complex with UNC100016 | | 分子名称: | (2E)-N-(4-{[6-(dimethylamino)hexyl]amino}-2-{[5-(dimethylamino)pentyl]amino}quinazolin-6-yl)but-2-enamide, 1,2-ETHANEDIOL, Histone-lysine N-methyltransferase SETDB1, ... | | 著者 | Silva, M, Dong, A, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2024-07-26 | | 公開日 | 2024-10-02 | | 実験手法 | X-RAY DIFFRACTION (1.27 Å) | | 主引用文献 | Crystal Structure of SETDB1 Tudor domain in complex with UNC100016
To be published
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7A99
 | | Crystal structure of the Phe57Trp mutant of the arginine-bound form of domain 1 from TmArgBP | | 分子名称: | ACETATE ION, ARGININE, Amino acid ABC transporter, ... | | 著者 | Balasco, N, Vitagliano, L, Smaldone, G, Ruggiero, A. | | 登録日 | 2020-09-01 | | 公開日 | 2020-11-04 | | 最終更新日 | 2024-01-31 | | 実験手法 | X-RAY DIFFRACTION (1.79 Å) | | 主引用文献 | Development of a Protein Scaffold for Arginine Sensing Generated through the Dissection of the Arginine-Binding Protein from Thermotoga maritima .
Int J Mol Sci, 21, 2020
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2H8F
 | | Crystal structure of deoxy hemoglobin from Trematomus bernacchii at pH 6.2 | | 分子名称: | Hemoglobin alpha subunit, Hemoglobin beta subunit, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Mazzarella, L, Vergara, A, Vitagliano, L, Merlino, A, Bonomi, G, Scala, S, Verde, C, di Prisco, G. | | 登録日 | 2006-06-07 | | 公開日 | 2006-08-29 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.3 Å) | | 主引用文献 | High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect.
Proteins, 65, 2006
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6NM4
 | | Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor | | 分子名称: | 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ... | | 著者 | Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC) | | 登録日 | 2019-01-10 | | 公開日 | 2019-02-13 | | 最終更新日 | 2023-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Discovery of a chemical probe for PRDM9.
Nat Commun, 10, 2019
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2H8D
 | | Crystal structure of deoxy hemoglobin from Trematomus bernacchii at pH 8.4 | | 分子名称: | Hemoglobin alpha subunit, Hemoglobin beta subunit, POTASSIUM ION, ... | | 著者 | Mazzarella, L, Vergara, A, Vitagliano, L, Merlino, A, Bonomi, G, Scala, S, Verde, C, di Prisco, G. | | 登録日 | 2006-06-07 | | 公開日 | 2006-08-29 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | High resolution crystal structure of deoxy hemoglobin from Trematomus bernacchii at different pH values: The role of histidine residues in modulating the strength of the root effect.
Proteins, 65, 2006
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8EM8
 | | Co-crystal structure of the cGMP-dependent protein kinase PKG from Plasmodium falciparum in complex with RY-1-165 | | 分子名称: | UNKNOWN ATOM OR ION, [(3R)-3-{[(4M)-4-(4-cyclopropyl-2-phenyl-1H-imidazol-1-yl)pyrimidin-2-yl]amino}pyrrolidin-1-yl](1,3-thiazol-2-yl)methanone, cGMP-dependent protein kinase, ... | | 著者 | Hutchinson, A, Dong, A, Seitova, A, Bhanot, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-09-27 | | 公開日 | 2022-11-02 | | 最終更新日 | 2024-08-07 | | 実験手法 | X-RAY DIFFRACTION (2.54 Å) | | 主引用文献 | Structure-Activity Relationship of a Pyrrole Based Series of PfPKG Inhibitors as Anti-Malarials.
J.Med.Chem., 67, 2024
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8F8E
 | | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound | | 分子名称: | (3P)-N-[(1S)-3-amino-1-(3-chloro-4-fluorophenyl)-3-oxopropyl]-3-(4-chloro-2-fluorophenyl)-1H-pyrazole-4-carboxamide, CITRIC ACID, DDB1- and CUL4-associated factor 1 | | 著者 | Kimani, S, Li, A, Dong, A, Li, Y, Hutchinson, A, Seitova, A, Wilson, B, Al-Awar, R, Vedadi, M, Brown, P, Arrowsmith, C.H, Edwards, A.M, Halabelian, L, Structural Genomics Consortium (SGC) | | 登録日 | 2022-11-21 | | 公開日 | 2023-03-01 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal structure of the WDR domain of human DCAF1 in complex with OICR-8268 compound
To be published
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3NG6
 | | The crystal structure of hemoglobin I from Trematomus newnesi in deoxygenated state obtained through an oxidation/reduction cycle in which potassium hexacyanoferrate and sodium dithionite were alternatively added | | 分子名称: | Hemoglobin subunit alpha-1, Hemoglobin subunit beta-1/2, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Vergara, A, Vitagliano, L, Merlino, A, Sica, F, Marino, K, Mazzarella, L. | | 登録日 | 2010-06-11 | | 公開日 | 2010-07-28 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | An order-disorder transition plays a role in switching off the root effect in fish hemoglobins.
J.Biol.Chem., 285, 2010
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3NFE
 | | The crystal structure of hemoglobin I from trematomus newnesi in deoxygenated state | | 分子名称: | Hemoglobin subunit alpha-1, Hemoglobin subunit beta-1/2, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | Vergara, A, Vitagliano, L, Merlino, A, Sica, F, Marino, K, Mazzarella, L. | | 登録日 | 2010-06-10 | | 公開日 | 2010-07-07 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | | 主引用文献 | An order-disorder transition plays a role in switching off the root effect in fish hemoglobins.
J.Biol.Chem., 285, 2010
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3GKV
 | | X-ray structure of an intermediate along the oxidation pathway of Trematomus bernacchii hemoglobin | | 分子名称: | CARBON MONOXIDE, Hemoglobin subunit alpha, Hemoglobin subunit beta, ... | | 著者 | Merlino, A, Vitagliano, L, Sica, F, Vergara, A, Mazzarella, L. | | 登録日 | 2009-03-11 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Combined crystallographic and spectroscopic analysis of Trematomus bernacchii hemoglobin highlights analogies and differences in the peculiar oxidation pathway of Antarctic fish hemoglobins
Biopolymers, 91, 2009
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