7O3D
 
 | | Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly | | Descriptor: | Transcription elongation factor SPT6 | | Authors: | Kasiliauskaite, A, Kubicek, K, Klumpler, T, Zanova, M, Zapletal, D, Novacek, J, Stefl, R. | | Deposit date: | 2021-04-01 | | Release date: | 2022-04-13 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (3.71 Å) | | Cite: | Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
Nucleic Acids Res., 50, 2022
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7O6B
 | | Cooperation between the intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly | | Descriptor: | Transcription elongation factor SPT6 | | Authors: | Kasiliauskaite, A, Kubicek, K, Klumpler, T, Zanova, M, Zapletal, D, Novacek, J, Stefl, R. | | Deposit date: | 2021-04-09 | | Release date: | 2022-04-20 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Cooperation between intrinsically disordered and ordered regions of Spt6 regulates nucleosome and Pol II CTD binding, and nucleosome assembly.
Nucleic Acids Res., 50, 2022
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5O2O
 | | Lytic transglycosylase in action | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Transglycosylase | | Authors: | Williams, A.H, Hoauz, A, Boneca, I.G. | | Deposit date: | 2017-05-22 | | Release date: | 2018-06-13 | | Last modified: | 2024-10-09 | | Method: | X-RAY DIFFRACTION (1.43 Å) | | Cite: | Lytic transglycosylase in action
To Be Published
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5O29
 | | Lytic transglycosylase in action | | Descriptor: | Transglycosylase | | Authors: | Williams, A.H, Hoauz, A, Boneca, I.G. | | Deposit date: | 2017-05-19 | | Release date: | 2018-03-14 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.3785 Å) | | Cite: | A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
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5O1J
 | | Lytic transglycosylase in action | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-1,6-anhydro-N-acetyl-beta-D-glucopyranosamine, Putative soluble lytic murein transglycosylase, ZINC ION | | Authors: | Williams, A.H, Rateau, L, Hoauz, A, Boneca, I.G. | | Deposit date: | 2017-05-18 | | Release date: | 2018-03-14 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
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5O2N
 | | Lytic transglycosylase in action | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-alpha-D-glucopyranose, CITRATE ANION, ... | | Authors: | Williams, A.H, Hoauz, A, Boneca, I.G. | | Deposit date: | 2017-05-22 | | Release date: | 2018-03-14 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.513 Å) | | Cite: | A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
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5O24
 | | Lytic transglycosylase in action | | Descriptor: | 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, Transglycosylase | | Authors: | Williams, A.H, Hoauz, A, Boneca, I.G. | | Deposit date: | 2017-05-19 | | Release date: | 2018-03-14 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.429 Å) | | Cite: | A step-by-stepin crystalloguide to bond cleavage and 1,6-anhydro-sugar product synthesis by a peptidoglycan-degrading lytic transglycosylase.
J. Biol. Chem., 293, 2018
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4V4K
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6QCM
 | | Cryo em structure of the Listeria stressosome | | Descriptor: | RsbR protein, RsbR protein,RsbR protein, RsbS protein | | Authors: | Williams, A.H, Redzej, A, Waksman, G, Cossart, P. | | Deposit date: | 2018-12-28 | | Release date: | 2019-08-21 | | Last modified: | 2024-11-13 | | Method: | ELECTRON MICROSCOPY (4.21 Å) | | Cite: | The cryo-electron microscopy supramolecular structure of the bacterial stressosome unveils its mechanism of activation.
Nat Commun, 10, 2019
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3LJ5
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4D05
 | | Structure and activity of a minimal-type ATP-dependent DNA ligase from a psychrotolerant bacterium | | Descriptor: | ADENOSINE MONOPHOSPHATE, ATP-DEPENDENT DNA LIGASE, MAGNESIUM ION, ... | | Authors: | Williamson, A, Rothweiler, U, Leiros, H.-K.S. | | Deposit date: | 2014-04-24 | | Release date: | 2014-11-12 | | Last modified: | 2019-06-26 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Enzyme-Adenylate Structure of a Bacterial ATP-Dependent DNA Ligase with a Minimized DNA-Binding Surface
Acta Crystallogr.,Sect.D, 70, 2014
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7LP3
 | | Structure of Nedd4L WW3 domain | | Descriptor: | Angiomotin, E3 ubiquitin-protein ligase NEDD4-like, SULFATE ION | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.61 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7LP2
 | | Structure of Nedd4L WW3 domain | | Descriptor: | Angiomotin, E3 ubiquitin-protein ligase, GLYCEROL, ... | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.88 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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7LP1
 | | Structure of Nedd4L WW3 domain | | Descriptor: | E3 ubiquitin-protein ligase NEDD4-like, GLYCEROL, NITRATE ION | | Authors: | Alian, A, Alam, S.L, Thompson, T, Rheinemann, L, Sundquist, W.I. | | Deposit date: | 2021-02-11 | | Release date: | 2021-07-28 | | Last modified: | 2023-10-18 | | Method: | X-RAY DIFFRACTION (1.35 Å) | | Cite: | Interactions between AMOT PPxY motifs and NEDD4L WW domains function in HIV-1 release.
J.Biol.Chem., 297, 2021
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2POH
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8F7Z
 | | VRC34.01_mm28 bound to fusion peptide | | Descriptor: | HIV-1 Env Fusion Peptide, VRC34_m228 Light Chain, VRC34_mm28 Heavy Chain | | Authors: | Olia, A.S, Kwong, P.D. | | Deposit date: | 2022-11-21 | | Release date: | 2023-11-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Antibody-directed evolution reveals a mechanism for enhanced neutralization at the HIV-1 fusion peptide site.
Nat Commun, 14, 2023
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8F7T
 | | Glycan-Base ConC Env Trimer | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, HIV-1 Env gp120, ... | | Authors: | Olia, A.S, Kwong, P.D. | | Deposit date: | 2022-11-20 | | Release date: | 2023-09-27 | | Method: | ELECTRON MICROSCOPY (4.1 Å) | | Cite: | Soluble prefusion-closed HIV-envelope trimers with glycan-covered bases.
Iscience, 26, 2023
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7OXL
 | | Crystal structure of human Spermine Oxidase | | Descriptor: | (4S)-2-METHYL-2,4-PENTANEDIOL, CHLORIDE ION, FAD-MDL72527 adduct, ... | | Authors: | Impagliazzo, A, Johannsson, S, Thomsen, M, Krapp, S. | | Deposit date: | 2021-06-22 | | Release date: | 2022-07-13 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structure of human spermine oxidase in complex with a highly selective allosteric inhibitor.
Commun Biol, 5, 2022
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6HY2
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8U6X
 | | ATP-dependent DNA ligase Lig E from Neisseria gonorrhoeae | | Descriptor: | ADENOSINE MONOPHOSPHATE, DNA (5'-D(*AP*TP*TP*GP*CP*GP*AP*CP*CP*CP*CP*AP*CP*TP*AP*TP*CP*GP*GP*AP*A)-3'), DNA (5'-D(*TP*TP*CP*CP*GP*AP*TP*AP*GP*TP*GP*GP*GP*GP*TP*CP*GP*CP*AP*AP*T)-3'), ... | | Authors: | Williamson, A, Pan, J. | | Deposit date: | 2023-09-14 | | Release date: | 2024-01-31 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.44 Å) | | Cite: | A role for the ATP-dependent DNA ligase lig E of Neisseria gonorrhoeae in biofilm formation.
Bmc Microbiol., 24, 2024
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6H5F
 | | LtgA disordered Helix | | Descriptor: | Putative soluble lytic murein transglycosylase | | Authors: | Williams, A.H. | | Deposit date: | 2018-07-24 | | Release date: | 2019-08-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Defective lytic transglycosylase disrupts cell morphogenesis by hindering cell wall de-O-acetylation inNeisseria meningitidis.
Elife, 9, 2020
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2QIV
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4K9S
 | | Peptidoglycan O-acetylesterase in action, setmet | | Descriptor: | GDSL-like Lipase/Acylhydrolase family protein | | Authors: | Williams, A.H, Gompert Boneca, I. | | Deposit date: | 2013-04-21 | | Release date: | 2014-09-03 | | Last modified: | 2024-10-16 | | Method: | X-RAY DIFFRACTION (2.334 Å) | | Cite: | Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
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4K40
 | | Peptidoglycan O-acetylesterase in action, 0 min | | Descriptor: | GDSL-like Lipase/Acylhydrolase family protein | | Authors: | Williams, A.H, Gompert Boneca, I. | | Deposit date: | 2013-04-11 | | Release date: | 2014-09-03 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.634 Å) | | Cite: | Visualization of a substrate-induced productive conformation of the catalytic triad of the Neisseria meningitidis peptidoglycan O-acetylesterase reveals mechanistic conservation in SGNH esterase family members.
Acta Crystallogr.,Sect.D, 70, 2014
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2QIA
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