2PQ6
 
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3C6D
 | | The pseudo-atomic structure of dengue immature virus | | Descriptor: | Polyprotein, prM | | Authors: | Li, L. | | Deposit date: | 2008-02-04 | | Release date: | 2008-04-08 | | Last modified: | 2024-02-21 | | Method: | ELECTRON MICROSCOPY (12.5 Å) | | Cite: | The flavivirus precursor membrane-envelope protein complex: structure and maturation
Science, 319, 2008
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4E5X
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8FNZ
 | | Acetylated tau repeat 1 and 2 fragment (AcR1R2) | | Descriptor: | Microtubule-associated protein tau, acetylated repeat 1 and 2 fragment | | Authors: | Li, L, Nguyen, A.B, Mullapudi, V, Joachimiak, L. | | Deposit date: | 2022-12-29 | | Release date: | 2023-06-28 | | Last modified: | 2024-10-23 | | Method: | ELECTRON MICROSCOPY (3.88 Å) | | Cite: | Disease-associated patterns of acetylation stabilize tau fibril formation.
Structure, 31, 2023
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3B9O
 | | long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN | | Descriptor: | Alkane monooxygenase, FLAVIN MONONUCLEOTIDE | | Authors: | Li, L, Yang, W, Xu, F, Bartlam, M, Rao, Z. | | Deposit date: | 2007-11-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase
J.Mol.Biol., 376, 2008
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3B9N
 | | Crystal structure of long-chain alkane monooxygenase (LadA) | | Descriptor: | Alkane monooxygenase | | Authors: | Li, L, Yang, W, Xu, F, Bartlam, M, Rao, Z. | | Deposit date: | 2007-11-06 | | Release date: | 2008-01-15 | | Last modified: | 2023-11-01 | | Method: | X-RAY DIFFRACTION (2.7 Å) | | Cite: | Crystal structure of long-chain alkane monooxygenase (LadA) in complex with coenzyme FMN: unveiling the long-chain alkane hydroxylase
J.Mol.Biol., 376, 2008
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3ZIU
 | | Crystal structure of Mycoplasma mobile Leucyl-tRNA Synthetase with Leu-AMS in the active site | | Descriptor: | 5'-O-(L-leucylsulfamoyl)adenosine, GLYCEROL, LEUCYL-TRNA SYNTHETASE | | Authors: | Li, L, Palencia, A, Lukk, T, Li, Z, Luthey-Schulten, Z.A, Cusack, S, Martinis, S.A, Boniecki, M.T. | | Deposit date: | 2013-01-10 | | Release date: | 2013-02-27 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Leucyl-tRNA Synthetase Editing Domain Functions as a Molecular Rheostat to Control Codon Ambiguity in Mycoplasma Pathogens.
Proc.Natl.Acad.Sci.USA, 110, 2013
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7SH0
 | | CRYSTAL STRUCTURE OF ENDOPLASMIC RETICULUM AMINOPEPTIDASE 2 (ERAP2) COMPLEX WITH A HIGHLY SELECTIVE AND POTENT SMALL MOLECULE | | Descriptor: | (2S)-N-hydroxy-3-(4-methoxyphenyl)-2-[4-({[5-(pyridin-2-yl)thiophene-2-sulfonyl]amino}methyl)-1H-1,2,3-triazol-1-yl]propanamide, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, ... | | Authors: | Li, L, Bouvier, M. | | Deposit date: | 2021-10-07 | | Release date: | 2022-07-20 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (3.2 Å) | | Cite: | Discovery of the First Selective Nanomolar Inhibitors of ERAP2 by Kinetic Target-Guided Synthesis.
Angew.Chem.Int.Ed.Engl., 61, 2022
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5NKM
 | | SMG8-SMG9 complex | | Descriptor: | 1,2-ETHANEDIOL, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, DI(HYDROXYETHYL)ETHER, ... | | Authors: | Li, L, Basquin, J, Conti, E. | | Deposit date: | 2017-03-31 | | Release date: | 2017-04-19 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (2.493 Å) | | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.
RNA, 23, 2017
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5NKK
 | | SMG8-SMG9 complex GDP bound | | Descriptor: | 1,2-ETHANEDIOL, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ... | | Authors: | Li, L, Basquin, J, Conti, E. | | Deposit date: | 2017-03-31 | | Release date: | 2017-04-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.64 Å) | | Cite: | Structure of a SMG8-SMG9 complex identifies a G-domain heterodimer in the NMD effector proteins.
RNA, 23, 2017
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1QVO
 | | STRUCTURES OF HLA-A*1101 IN COMPLEX WITH IMMUNODOMINANT NONAMER AND DECAMER HIV-1 EPITOPES CLEARLY REVEAL THE PRESENCE OF A MIDDLE ANCHOR RESIDUE | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ... | | Authors: | Li, L, McNicholl, J.M, Bouvier, M. | | Deposit date: | 2003-08-28 | | Release date: | 2004-06-01 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.22 Å) | | Cite: | Structures of HLA-A*1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue.
J.Immunol., 172, 2004
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7N8T
 | | Crystal Structure of AMP-bound Human JNK2 | | Descriptor: | ADENOSINE MONOPHOSPHATE, HEXAETHYLENE GLYCOL, Mitogen-activated protein kinase 9 | | Authors: | Li, L, Gurbani, D, Westover, K.D. | | Deposit date: | 2021-06-15 | | Release date: | 2022-06-22 | | Last modified: | 2023-10-25 | | Method: | X-RAY DIFFRACTION (1.69 Å) | | Cite: | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
J.Med.Chem., 66, 2023
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6P2F
 | | Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | | Authors: | Li, L, Batliwala, M, Bouvier, M. | | Deposit date: | 2019-05-21 | | Release date: | 2019-10-16 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (1.482 Å) | | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
J.Biol.Chem., 294, 2019
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6P23
 | | Structure of a nested set of N-terminally extended MHC I-peptides provide novel insights into antigen processing presentation | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | | Authors: | Li, L, Batliwala, M, Bouvier, M. | | Deposit date: | 2019-05-20 | | Release date: | 2019-10-16 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (1.595 Å) | | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
J.Biol.Chem., 294, 2019
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7XB0
 | | Crystal structure of Omicron BA.2 RBD complexed with hACE2 | | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiotensin-converting enzyme 2, ... | | Authors: | Li, L, Liao, H, Meng, Y, Li, W. | | Deposit date: | 2022-03-19 | | Release date: | 2022-07-06 | | Last modified: | 2024-10-30 | | Method: | X-RAY DIFFRACTION (2.9 Å) | | Cite: | Structural basis of human ACE2 higher binding affinity to currently circulating Omicron SARS-CoV-2 sub-variants BA.2 and BA.1.1.
Cell, 185, 2022
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6P27
 | | Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | | Authors: | Li, L, Batliwala, M, Bouvier, M. | | Deposit date: | 2019-05-21 | | Release date: | 2019-10-16 | | Last modified: | 2024-11-06 | | Method: | X-RAY DIFFRACTION (1.593 Å) | | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
J.Biol.Chem., 294, 2019
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6P2C
 | | Structure of a nested set of N-terminally extended MHC I-peptides provides novel insights into antigen processing and presentation | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, B-8 alpha chain, ... | | Authors: | Li, L, Batliwala, M, Bouvier, M. | | Deposit date: | 2019-05-21 | | Release date: | 2019-10-16 | | Last modified: | 2024-10-23 | | Method: | X-RAY DIFFRACTION (1.396 Å) | | Cite: | ERAP1 enzyme-mediated trimming and structural analyses of MHC I-bound precursor peptides yield novel insights into antigen processing and presentation.
J.Biol.Chem., 294, 2019
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6P2S
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1Q94
 | | Structures of HLA-A*1101 in complex with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle anchor residue | | Descriptor: | Beta-2-microglobulin, HLA class I histocompatibility antigen, A-11 alpha chain, ... | | Authors: | Li, L, McNicholl, J.M, Bouvier, M. | | Deposit date: | 2003-08-22 | | Release date: | 2004-06-01 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.4 Å) | | Cite: | Structures of HLA-A*1101 complexed with immunodominant nonamer and decamer HIV-1 epitopes clearly reveal the presence of a middle, secondary anchor residue.
J.Immunol., 172, 2004
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8E13
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8E8I
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8E2Z
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8ELC
 | | Human JNK2 bound to covalent inhibitor YL2056 | | Descriptor: | 4-(dimethylamino)-N-{4-[(3S)-3-({4-[(8R)-2-phenylpyrazolo[1,5-a]pyridin-3-yl]pyrimidin-2-yl}amino)pyrrolidine-1-carbonyl]phenyl}butanamide, Mitogen-activated protein kinase 9 | | Authors: | Li, L, Gurbani, D, Westover, K.D. | | Deposit date: | 2022-09-23 | | Release date: | 2023-06-28 | | Last modified: | 2024-11-13 | | Method: | X-RAY DIFFRACTION (2.072 Å) | | Cite: | Development of a Covalent Inhibitor of c-Jun N-Terminal Protein Kinase (JNK) 2/3 with Selectivity over JNK1.
J.Med.Chem., 66, 2023
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8EC5
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5DY3
 | | Crystal structure of Dbr2 | | Descriptor: | Artemisinic aldehyde Delta(11(13)) reductase, DI(HYDROXYETHYL)ETHER, FLAVIN MONONUCLEOTIDE, ... | | Authors: | Li, L, Chen, T.T, Xu, Y.C. | | Deposit date: | 2015-09-24 | | Release date: | 2016-10-05 | | Last modified: | 2024-03-20 | | Method: | X-RAY DIFFRACTION (1.82 Å) | | Cite: | The Crystal structure of Dbr2
to be published
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