4OUS
 
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6JV0
 | | Crystal Structure of N-terminal domain of ArgZ, bound to Product, an arginine dihydrolase from the Ornithine-Ammonia Cycle in Cyanobacteria | | 分子名称: | 1,2-ETHANEDIOL, L-ornithine, Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2024-03-27 | | 実験手法 | X-RAY DIFFRACTION (1.14 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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4MS9
 | | Native RNA-10mer Structure: ccggcgccgg | | 分子名称: | Native RNA duplex 10mer, STRONTIUM ION | | 著者 | Sheng, J, Li, L, Engelhart, A.E, Gan, J, Wang, J, Szostak, J.W. | | 登録日 | 2013-09-18 | | 公開日 | 2014-02-12 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (1.32 Å) | | 主引用文献 | Structural insights into the effects of 2'-5' linkages on the RNA duplex.
Proc.Natl.Acad.Sci.USA, 111, 2014
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4OUM
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7WHW
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with AMPPCP (E1-ATP state) | | 分子名称: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-16 | | 実験手法 | ELECTRON MICROSCOPY (3.1 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7WHV
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in detergent with beryllium fluoride (E2P state) | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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6LCP
 | | Cryo-EM structure of Dnf1 from Chaetomium thermophilum in the E2P state | | 分子名称: | (2S)-3-(hexadecanoyloxy)-2-[(9Z)-octadec-9-enoyloxy]propyl 2-(trimethylammonio)ethyl phosphate, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... | | 著者 | He, Y, Xu, J, Wu, X, Li, L. | | 登録日 | 2019-11-19 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.48 Å) | | 主引用文献 | Structures of a P4-ATPase lipid flippase in lipid bilayers.
Protein Cell, 11, 2020
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4EGS
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4K7E
 | | Crystal structure of Junin virus nucleoprotein | | 分子名称: | Nucleoprotein | | 著者 | Zhang, Y.J, Li, L, Liu, X, Dong, S.S, Wang, W.M, Huo, T, Rao, Z.H, Yang, C. | | 登録日 | 2013-04-17 | | 公開日 | 2013-08-07 | | 最終更新日 | 2013-10-16 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Crystal structure of Junin virus nucleoprotein
J.Gen.Virol., 94, 2013
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5Z58
 | | Cryo-EM structure of a human activated spliceosome (early Bact) at 4.9 angstrom. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | 登録日 | 2018-01-17 | | 公開日 | 2018-09-19 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (4.9 Å) | | 主引用文献 | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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5Z56
 | | cryo-EM structure of a human activated spliceosome (mature Bact) at 5.1 angstrom. | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, BUD13 homolog, Cell division cycle 5-like protein, ... | | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | 登録日 | 2018-01-17 | | 公開日 | 2018-09-19 | | 最終更新日 | 2020-10-14 | | 実験手法 | ELECTRON MICROSCOPY (5.1 Å) | | 主引用文献 | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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4FCO
 | | Crystal structure of bace1 with its inhibitor | | 分子名称: | Beta-secretase 1, N-[(2S,3R)-4-{[2-(1-benzylpiperidin-4-yl)ethyl]amino}-3-hydroxy-1-phenylbutan-2-yl]-5-[methyl(methylsulfonyl)amino]-N'-[(1R)-1-phenylethyl]benzene-1,3-dicarboxamide, SULFATE ION, ... | | 著者 | Chen, T.T, Chen, W.Y, Li, L, Xu, Y.C. | | 登録日 | 2012-05-25 | | 公開日 | 2013-05-29 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | Flexibility of the Flap in the Active Site of BACE1 as Revealed by Crystal Structures and MD simulations
To be Published, 2012
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5Z57
 | | Cryo-EM structure of the human activated spliceosome (late Bact) at 6.5 angstrom | | 分子名称: | 116 kDa U5 small nuclear ribonucleoprotein component, ALANINE, BUD13 homolog, ... | | 著者 | Zhang, X, Yan, C, Zhan, X, Li, L, Lei, J, Shi, Y. | | 登録日 | 2018-01-17 | | 公開日 | 2018-09-19 | | 最終更新日 | 2024-10-30 | | 実験手法 | ELECTRON MICROSCOPY (6.5 Å) | | 主引用文献 | Structure of the human activated spliceosome in three conformational states.
Cell Res., 28, 2018
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4L9A
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6KQD
 | | Thermus thermophilus initial transcription complex comprising sigma A and 5'-OH RNA of 3 nt | | 分子名称: | 2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE, DNA (5'-D(*CP*CP*T*GP*CP*AP*TP*CP*CP*GP*TP*GP*AP*GP*TP*CP*CP*AP*GP*GP*G)-3'), DNA (5'-D(*TP*AP*TP*AP*AP*TP*GP*GP*GP*AP*GP*CP*TP*GP*TP*CP*AP*CP*GP*GP*AP*TP*GP*CP*AP*GP*G*)-3'), ... | | 著者 | Zhang, Y, Li, L, Ebright, R.H. | | 登録日 | 2019-08-17 | | 公開日 | 2020-03-11 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | RNA extension drives a stepwise displacement of an initiation-factor structural module in initial transcription.
Proc.Natl.Acad.Sci.USA, 117, 2020
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7D8M
 | | Crystal structure of DyP | | 分子名称: | Dye-decolorizing peroxidase, OXYGEN MOLECULE, PROTOPORPHYRIN IX CONTAINING FE | | 著者 | He, C, Jia, R, Wang, T, Li, L.Q. | | 登録日 | 2020-10-08 | | 公開日 | 2021-08-18 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Revealing two important tryptophan residues with completely different roles in a dye-decolorizing peroxidase from Irpex lacteus F17.
Biotechnol Biofuels, 14, 2021
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5XYX
 | | The structure of p38 alpha in complex with a triazol inhibitor | | 分子名称: | Mitogen-activated protein kinase 14, N-(2-chloro-6-fluorobenzyl)-5-(furan-2-yl)-2H-1,2,4-triazol-3-amine | | 著者 | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. | | 登録日 | 2017-07-11 | | 公開日 | 2018-01-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2.61 Å) | | 主引用文献 | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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5XYY
 | | The structure of p38 alpha in complex with a triazol inhibitor | | 分子名称: | 3-(5-{[(2-chloro-6-fluorophenyl)methyl]amino}-4H-1,2,4-triazol-3-yl)phenol, Mitogen-activated protein kinase 14 | | 著者 | Wang, Y.L, Sun, Y.Z, Cao, R, Liu, D, Li, L, Qi, X.B, Huang, N. | | 登録日 | 2017-07-11 | | 公開日 | 2018-01-17 | | 最終更新日 | 2024-04-10 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | In Silico Identification of a Novel Hinge-Binding Scaffold for Kinase Inhibitor Discovery.
J. Med. Chem., 60, 2017
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8WDD
 | | Crystal structure of BSA in complex with B1 | | 分子名称: | Albumin, ~{N},~{N}-dimethyl-6-[(~{E})-2-(1-methylpyridin-1-ium-4-yl)ethenyl]naphthalen-2-amine | | 著者 | Chen, X, Ge, Y.H, Yang, H, Fang, B, Li, L. | | 登録日 | 2023-09-14 | | 公開日 | 2024-09-18 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (3.9 Å) | | 主引用文献 | Crystal structure of BSA in complex with B1
To Be Published
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7F7F
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with beryllium fluoride (resting state) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2021-06-29 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-09 | | 実験手法 | ELECTRON MICROSCOPY (3.81 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DRX
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with beryllium fluoride (E2P state) | | 分子名称: | (4S,7R)-4-HYDROXY-N,N,N-TRIMETHYL-9-OXO-7-[(PALMITOYLOXY)METHYL]-3,5,8-TRIOXA-4-PHOSPHAHEXACOSAN-1-AMINIUM 4-OXIDE, Alkylphosphocholine resistance protein LEM3, BERYLLIUM TRIFLUORIDE ION, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-30 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (2.9 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DSH
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in 90PS with AMPPCP (E1-ATP state) | | 分子名称: | Alkylphosphocholine resistance protein LEM3, MAGNESIUM ION, PHOSPHOMETHYLPHOSPHONIC ACID ADENYLATE ESTER, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2022-03-30 | | 実験手法 | ELECTRON MICROSCOPY (3.67 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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7DSI
 | | Cryo-EM structure of Dnf1 from Saccharomyces cerevisiae in yeast lipids with AMPPCP ( resting state ) | | 分子名称: | 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-6)-2-acetamido-2-deoxy-beta-D-glucopyranose, Alkylphosphocholine resistance protein LEM3, ... | | 著者 | Xu, J, He, Y, Wu, X, Li, L. | | 登録日 | 2020-12-31 | | 公開日 | 2022-03-23 | | 最終更新日 | 2024-10-23 | | 実験手法 | ELECTRON MICROSCOPY (3.21 Å) | | 主引用文献 | Conformational changes of a phosphatidylcholine flippase in lipid membranes.
Cell Rep, 38, 2022
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5ZIT
 | | Crystal structure of human Enterovirus D68 RdRp in complex with NADPH | | 分子名称: | DI(HYDROXYETHYL)ETHER, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, RdRp | | 著者 | Wang, M.L, Li, L, Chen, Y.P, Jiang, H, Zhang, Y, Su, D. | | 登録日 | 2018-03-17 | | 公開日 | 2019-04-17 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (3.196 Å) | | 主引用文献 | Structure of the enterovirus D68 RNA-dependent RNA polymerase in complex with NADPH implicates an inhibitor binding site in the RNA template tunnel.
J.Struct.Biol., 2020
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6JUZ
 | | Crystal Structure of N-terminal domain of ArgZ(N71S) covalently bond to a reaction intermediate | | 分子名称: | 1,2-ETHANEDIOL, ARGININE, Sll1336 protein | | 著者 | Zhuang, N, Li, L, Wu, X, Zhuang, Y. | | 登録日 | 2019-04-15 | | 公開日 | 2020-01-15 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.21 Å) | | 主引用文献 | Crystal structures and biochemical analyses of the bacterial arginine dihydrolase ArgZ suggests a "bond rotation" catalytic mechanism.
J.Biol.Chem., 295, 2020
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