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PDB: 120 results

7M0Y
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BU of 7m0y by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Trametinib
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.45 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0Z
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BU of 7m0z by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and CH5126766
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-(3-fluoro-4-{[4-methyl-2-oxo-7-(pyrimidin-2-yloxy)-2H-chromen-3-yl]methyl}pyridin-2-yl)-N'-methylsulfuric diamide, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0X
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BU of 7m0x by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and PD0325901
Descriptor: CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, GLYCEROL, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (2.47 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0V
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BU of 7m0v by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Cobimetinib
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.16 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0W
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BU of 7m0w by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Pimasertib
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, N-[(2S)-2,3-dihydroxypropyl]-3-[(2-fluoro-4-iodophenyl)amino]pyridine-4-carboxamide, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0U
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BU of 7m0u by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Binimetinib
Descriptor: 5-[(4-bromo-2-fluorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.09 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
7M0T
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BU of 7m0t by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP and Selumetinib
Descriptor: 5-[(4-bromo-2-chlorophenyl)amino]-4-fluoro-N-(2-hydroxyethoxy)-1-methyl-1H-benzimidazole-6-carboxamide, Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, ...
Authors:Li, K, Gonzalez Del-Pino, G, Ha, B.H, Park, E, Eck, M.J.
Deposit date:2021-03-11
Release date:2021-04-21
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.19 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
2QIY
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BU of 2qiy by Molmil
yeast Deubiquitinase Ubp3 and Bre5 cofactor complex
Descriptor: UBP3-associated protein BRE5, Ubiquitin carboxyl-terminal hydrolase 3
Authors:Li, K, Liu, X, Marmorstein, R.
Deposit date:2007-07-05
Release date:2007-10-30
Last modified:2023-08-30
Method:X-RAY DIFFRACTION (1.69 Å)
Cite:Molecular basis for bre5 cofactor recognition by the ubp3 deubiquitylating enzyme.
J.Mol.Biol., 372, 2007
5V6J
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BU of 5v6j by Molmil
Glycan binding protein Y3 from mushroom Coprinus comatus possesses anti-leukemic activity
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, TMV resistance protein Y3
Authors:Li, K, Zhang, P, Gang, Y, Xia, C, Polston, J.E, Li, G, Li, S, Lin, Z, Yang, L.-J, Bruner, S.D, Ding, Y.
Deposit date:2017-03-16
Release date:2017-08-16
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (1.18 Å)
Cite:Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5V6I
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BU of 5v6i by Molmil
Glycan binding protein Y3 from mushroom Coprinus comatus possesses anti-leukemic activity - Pt derivative
Descriptor: 2-[N-CYCLOHEXYLAMINO]ETHANE SULFONIC ACID, CHLORIDE ION, PLATINUM (II) ION, ...
Authors:Li, K, Zhang, P, Gang, Y, Xia, C, Polston, J.E, Li, G, Li, S, Lin, Z, Yang, L.-J, Bruner, S.D, Ding, Y.
Deposit date:2017-03-16
Release date:2017-08-16
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (1.7 Å)
Cite:Cytotoxic protein from the mushroom Coprinus comatus possesses a unique mode for glycan binding and specificity.
Proc. Natl. Acad. Sci. U.S.A., 114, 2017
5DMM
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BU of 5dmm by Molmil
Crystal Structure of the Homocysteine Methyltransferase MmuM from Escherichia coli, Metallated form
Descriptor: 2-AMINO-4-MERCAPTO-BUTYRIC ACID, BETA-MERCAPTOETHANOL, Homocysteine S-methyltransferase, ...
Authors:Li, K, Li, G, Bradbury, L.M.T, Andrew, H.D, Bruner, S.D.
Deposit date:2015-09-09
Release date:2015-11-25
Last modified:2024-05-01
Method:X-RAY DIFFRACTION (1.779 Å)
Cite:Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
Biochem.J., 473, 2016
5DMN
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BU of 5dmn by Molmil
Crystal Structure of the Homocysteine Methyltransferase MmuM from Escherichia coli, Apo form
Descriptor: Homocysteine S-methyltransferase, SULFATE ION
Authors:Li, K, Li, G, Bradbury, L.M.T, Andrew, H.D, Bruner, S.D.
Deposit date:2015-09-09
Release date:2015-11-25
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.892 Å)
Cite:Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
Biochem.J., 473, 2016
5DML
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BU of 5dml by Molmil
Crystal Structure of the Homocysteine Methyltransferase MmuM from Escherichia coli, Oxidized form
Descriptor: CHLORIDE ION, Homocysteine S-methyltransferase
Authors:Li, K, Li, G, Bradbury, L.M.T, Andrew, H.D, Bruner, S.D.
Deposit date:2015-09-09
Release date:2015-11-25
Last modified:2024-10-30
Method:X-RAY DIFFRACTION (2.452 Å)
Cite:Crystal structure of the homocysteine methyltransferase MmuM from Escherichia coli.
Biochem.J., 473, 2016
1ZX2
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BU of 1zx2 by Molmil
Crystal Structure of Yeast UBP3-associated Protein BRE5
Descriptor: UBP3-associated protein BRE5
Authors:Li, K, Zhao, K, Ossareh-Nazari, B, Da, G, Dargemont, C, Marmorstein, R.
Deposit date:2005-06-06
Release date:2005-06-21
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Structural basis for interaction between the Ubp3 deubiquitinating enzyme and its Bre5 cofactor
J.Biol.Chem., 280, 2005
5KAJ
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BU of 5kaj by Molmil
Crystal structure of a dioxygenase in the Crotonase superfamily in P21, A319C mutant
Descriptor: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase, [[(2~{R},3~{S},4~{R},5~{R})-5-(6-aminopurin-9-yl)-4-oxidanyl-3-phosphonooxy-oxolan-2-yl]methoxy-oxidanyl-phosphoryl] [(3~{R})-4-[[3-[2-[(~{E})-2-[3,5-bis(oxidanyl)phenyl]-1-oxidanyl-ethenyl]sulfanylethylamino]-3-oxidanylidene-propyl]amino]-2,2-dimethyl-3-oxidanyl-4-oxidanylidene-butyl] hydrogen phosphate
Authors:Li, K, Fielding, E.N, Condurso, H.L, Bruner, S.D.
Deposit date:2016-06-01
Release date:2017-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.681 Å)
Cite:Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase.
Acta Crystallogr D Struct Biol, 73, 2017
6V2W
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BU of 6v2w by Molmil
Crystal structure of the BRAF:MEK1 kinases in complex with AMPPNP
Descriptor: Dual specificity mitogen-activated protein kinase kinase 1, MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ...
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-11-25
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.12 Å)
Cite:Allosteric MEK inhibitors act on BRAF/MEK complexes to block MEK activation.
Proc.Natl.Acad.Sci.USA, 118, 2021
6V2U
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BU of 6v2u by Molmil
Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
Descriptor: CHLORIDE ION, Dabrafenib, Serine/threonine-protein kinase B-raf
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-11-25
Release date:2020-12-02
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (3.78 Å)
Cite:Crystal structure of the insect cell-expressed WT-BRAF kinase in complex with Dabrafenib
To Be Published
5KAH
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BU of 5kah by Molmil
Crystal structure of a dioxygenase in the Crotonase superfamily in P21, V425T mutant
Descriptor: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL DIHYDROGEN DIPHOSPHATE
Authors:Li, K, Fielding, E.N, Condurso, H.L, Bruner, S.D.
Deposit date:2016-06-01
Release date:2017-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.779 Å)
Cite:Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase.
Acta Crystallogr D Struct Biol, 73, 2017
5KAG
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BU of 5kag by Molmil
Crystal structure of a dioxygenase in the Crotonase superfamily in P21
Descriptor: (3,5-dihydroxyphenyl)acetyl-CoA 1,2-dioxygenase, OXYGEN MOLECULE, [(2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-4-HYDROXY-3-(PHOSPHONOOXY)TETRAHYDROFURAN-2-YL]METHYL (3R)-4-({3-[(2-{[(3,5-DIHYDROXYPHENYL)ACETYL]AMINO}ETHYL)AMINO]-3-OXOPROPYL}AMINO)-3-HYDROXY-2,2-DIMETHYL-4-OXOBUTYL DIHYDROGEN DIPHOSPHATE
Authors:Li, K, Fielding, E.N, Condurso, H.L, Bruner, S.D.
Deposit date:2016-06-01
Release date:2017-06-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.456 Å)
Cite:Probing the structural basis of oxygen binding in a cofactor-independent dioxygenase.
Acta Crystallogr D Struct Biol, 73, 2017
5IG8
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BU of 5ig8 by Molmil
Crystal structure of macrocyclase MdnB from Microcystis aeruginosa MRC
Descriptor: ATP grasp ligase
Authors:Li, K, Condurso, H.L, Bruner, S.D.
Deposit date:2016-02-27
Release date:2016-09-21
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.278 Å)
Cite:Structural basis for precursor protein-directed ribosomal peptide macrocyclization.
Nat.Chem.Biol., 12, 2016
5IG9
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BU of 5ig9 by Molmil
Crystal structure of macrocyclase MdnC bound with precursor peptide MdnA from Microcystis aeruginosa MRC
Descriptor: ATP grasp ligase, Microviridin
Authors:Li, K, Condurso, H.L, Bruner, S.D.
Deposit date:2016-02-27
Release date:2016-09-21
Last modified:2024-03-06
Method:X-RAY DIFFRACTION (2.665 Å)
Cite:Structural basis for precursor protein-directed ribosomal peptide macrocyclization.
Nat.Chem.Biol., 12, 2016
6PP9
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BU of 6pp9 by Molmil
Crystal structure of BRAF:MEK1 complex
Descriptor: 5-[(2-fluoro-4-iodophenyl)amino]-N-(2-hydroxyethoxy)imidazo[1,5-a]pyridine-6-carboxamide, CHLORIDE ION, Dual specificity mitogen-activated protein kinase kinase 1, ...
Authors:Li, K, Gonzalez Del-Pino, G, Park, E, Eck, M.J.
Deposit date:2019-07-05
Release date:2019-10-09
Last modified:2023-10-11
Method:X-RAY DIFFRACTION (2.59 Å)
Cite:Architecture of autoinhibited and active BRAF-MEK1-14-3-3 complexes.
Nature, 575, 2019
6M6R
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BU of 6m6r by Molmil
Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) C-terminal domain with 5'-ppp 8-mer ssRNA
Descriptor: Dicer Related Helicase, RNA (5'-R(*(GTP)P*GP*CP*CP*GP*CP*CP*C)-3'), ZINC ION
Authors:Li, K, Zheng, J, Wirawan, M, Xiong, Z, Fedorova, O, Griffin, P, Plyle, A, Luo, D.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (1.89 Å)
Cite:Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
Nucleic Acids Res., 49, 2021
6M6Q
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BU of 6m6q by Molmil
Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) N-terminal domain
Descriptor: Dicer Related Helicase
Authors:Li, K, Zheng, J, Wirawan, M, Xiong, Z, Fedorova, O, Griffin, P, Plyle, A, Luo, D.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2024-05-29
Method:X-RAY DIFFRACTION (2.8 Å)
Cite:Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
Nucleic Acids Res., 49, 2021
6M6S
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BU of 6m6s by Molmil
Crystal structure of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3) C-terminal domain with 5'-ppp 12-mer dsRNA
Descriptor: Dicer Related Helicase, RNA (5'-R(*(GTP)P*GP*CP*GP*CP*GP*CP*GP*CP*GP*CP*C)-3'), ZINC ION
Authors:Li, K, Zheng, J, Wirawan, M, Xiong, Z, Fedorova, O, Griffin, P, Plyle, A, Luo, D.
Deposit date:2020-03-16
Release date:2021-03-17
Last modified:2023-11-29
Method:X-RAY DIFFRACTION (1.6 Å)
Cite:Insights into the structure and RNA-binding specificity of Caenorhabditis elegans Dicer-related helicase 3 (DRH-3).
Nucleic Acids Res., 49, 2021

226707

數據於2024-10-30公開中

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