3HK2
| Crystal structure of T. thermophilus Argonaute N478 mutant protein complexed with DNA guide strand and 19-nt RNA target strand | 分子名称: | 5'-D(P*TP*GP*AP*GP*GP*TP*AP*GP*TP*AP*GP*GP*TP*TP*GP*TP*AP*TP*AP*GP*T)-3', 5'-R(*UP*AP*UP*AP*CP*AP*AP*CP*CP*UP*AP*CP*UP*AP*CP*CP*UP*CP*G)-3', Argonaute, ... | 著者 | Wang, Y, Li, H, Sheng, G, Patel, D.J. | 登録日 | 2009-05-22 | 公開日 | 2009-10-06 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | Nucleation, propagation and cleavage of target RNAs in Ago silencing complexes. Nature, 461, 2009
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2PP6
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3ON4
| Crystal structure of TetR transcriptional regulator from Legionella pneumophila | 分子名称: | DI(HYDROXYETHYL)ETHER, SODIUM ION, Transcriptional regulator, ... | 著者 | Michalska, K, Li, H, Gu, M, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2010-08-27 | 公開日 | 2010-09-22 | 最終更新日 | 2011-07-13 | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | 主引用文献 | Crystal structure of TetR transcriptional regulator from Legionella pneumophila To be Published
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4PAG
| ABC transporter solute binding protein from Sulfurospirillum deleyianum DSM 6946 | 分子名称: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, DI(HYDROXYETHYL)ETHER, HISTIDINE, ... | 著者 | Chang, C, Endres, M, Li, H, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-04-08 | 公開日 | 2014-04-30 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.901 Å) | 主引用文献 | Crystal structure of ABC transporter solute binding protein from Sulfurospirillum deleyianum DSM 6946 To Be Published
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2P1Z
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3NVK
| Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle | 分子名称: | 50S ribosomal protein L7Ae, Fibrillarin-like rRNA/tRNA 2'-O-methyltransferase, NOP5/NOP56 related protein, ... | 著者 | Xue, S, Wang, R, Li, H. | 登録日 | 2010-07-08 | 公開日 | 2011-07-20 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (3.209 Å) | 主引用文献 | Structural basis for substrate placement by an archaeal box C/D ribonucleoprotein particle. Mol.Cell, 39, 2010
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4JX1
| Crystal structure of reduced Cytochrome P450cam-putidaredoxin complex bound to camphor and 5-exo-hydroxycamphor | 分子名称: | 1,1'-hexane-1,6-diyldipyrrolidine-2,5-dione, 5-EXO-HYDROXYCAMPHOR, CALCIUM ION, ... | 著者 | Tripathi, S.M, Li, H, Poulos, T.L. | 登録日 | 2013-03-27 | 公開日 | 2013-06-19 | 最終更新日 | 2023-09-20 | 実験手法 | X-RAY DIFFRACTION (2.087 Å) | 主引用文献 | Structural basis for effector control and redox partner recognition in cytochrome P450. Science, 340, 2013
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1S4K
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2QHK
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4OAT
| The crystal structure of a solute-binding protein (N280D mutant) from Anabaena variabilis ATCC 29413 in complex with isoleucine. | 分子名称: | Amino acid/amide ABC transporter substrate-binding protein, HAAT family, CHLORIDE ION, ... | 著者 | Tan, K, Li, H, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-01-06 | 公開日 | 2014-01-15 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.199 Å) | 主引用文献 | The crystal structure of a solute-binding protein (N280D mutant) from Anabaena variabilis ATCC 29413 in complex with isoleucine. To be Published
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4OBB
| The crystal structure of a solute-binding protein from Anabaena variabilis ATCC 29413 in complex with (3S)-3-methyl-2-oxopentanoic acid. | 分子名称: | (3S)-3-methyl-2-oxopentanoic acid, Amino acid/amide ABC transporter substrate-binding protein, HAAT family, ... | 著者 | Tan, K, Li, H, Jedrzejczak, R, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-01-07 | 公開日 | 2014-03-19 | 最終更新日 | 2023-12-06 | 実験手法 | X-RAY DIFFRACTION (1.526 Å) | 主引用文献 | The crystal structure of a solute-binding protein from Anabaena variabilis ATCC 29413 in complex with (3S)-3-methyl-2-oxopentanoic acid. To be Published
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4CUM
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with (9aS)-2-amino-9a-methyl-6,7,8,9,9a,10-hexahydrobenzo[g]pteridin-4(3H)-one | 分子名称: | (9aS)-2-amino-9a-methyl-6,7,8,9,9a,10-hexahydrobenzo[g]pteridin-4(3H)-one, ACETATE ION, ARGININE, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-20 | 公開日 | 2014-05-28 | 最終更新日 | 2014-07-16 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry, 53, 2014
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4D34
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with 2-(2-(1H-imidazol-1-yl)pyrimidin-4-yl)-N-(3- fluorophenethyl)ethan-1-amine | 分子名称: | 2-(3-fluorophenyl)-N-{2-[2-(1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}ethanamine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-10-20 | 公開日 | 2014-12-24 | 最終更新日 | 2015-03-04 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
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4CTZ
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine | 分子名称: | (S)-6-(2-amino-2-(3-(2-(4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-15 | 公開日 | 2014-05-07 | 最終更新日 | 2014-12-03 | 実験手法 | X-RAY DIFFRACTION (2.01 Å) | 主引用文献 | Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57, 2014
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4CUL
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with 6-acetyl-2-amino-7,7-dimethyl-7,8-dihydropteridin-4(3H)-one | 分子名称: | 6-acetyl-2-amino-7,7-dimethyl-7,8-dihydropteridin-4(3H)-one, ACETATE ION, ARGININE, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-20 | 公開日 | 2014-05-28 | 最終更新日 | 2014-07-16 | 実験手法 | X-RAY DIFFRACTION (2.23 Å) | 主引用文献 | Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry, 53, 2014
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3PNH
| Structure of Bovine Endothelial Nitric Oxide Synthase Heme Domain in complex with 6-(((3R,4R)-4-(2-((2-FLUORO-2-(3-FLUOROPHENYL) ETHYL)AMINO)ETHOXY)PYRROLIDIN-3-YL)METHYL)-4-METHYLPYRIDIN-2-AMINE | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 6-{[(3R,4R)-4-(2-{[(2R)-2-fluoro-2-(3-fluorophenyl)ethyl]amino}ethoxy)pyrrolidin-3-yl]methyl}-4-methylpyridin-2-amine, ACETATE ION, ... | 著者 | Delker, S.L, Li, H, Poulos, T.L. | 登録日 | 2010-11-18 | 公開日 | 2011-10-05 | 最終更新日 | 2024-02-21 | 実験手法 | X-RAY DIFFRACTION (1.93 Å) | 主引用文献 | Improved Synthesis of Chiral Pyrrolidine Inhibitors and Their Binding Properties to Neuronal Nitric Oxide Synthase. J.Med.Chem., 54, 2011
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2IKB
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7VQX
| Cryo-EM structure of human vasoactive intestinal polypeptide receptor 2 (VIP2R) in complex with PACAP27 and Gs | 分子名称: | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2, Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short, ... | 著者 | Xu, Y.N, Feng, W.B, Zhou, Q.T, Liang, A.Y, Li, J, Dai, A.T, Zhao, F.H, Yan, J.H, Chen, C.W, Li, H, Zhao, L.H, Xia, T, Jiang, Y, Xu, H.E, Yang, D.H, Wang, M.W. | 登録日 | 2021-10-21 | 公開日 | 2022-05-18 | 実験手法 | ELECTRON MICROSCOPY (2.74 Å) | 主引用文献 | A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2. Nat Commun, 13, 2022
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4CUN
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with (9aS)-2-amino-9a-methyl-8,9,9a,10-tetrahydrobenzo[g]pteridine-4,6(3H,7H)-dione | 分子名称: | (9aS)-2-amino-9a-methyl-8,9,9a,10-tetrahydrobenzo[g]pteridine-4,6(3H,7H)-dione, ACETATE ION, ARGININE, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-20 | 公開日 | 2014-05-28 | 最終更新日 | 2014-07-16 | 実験手法 | X-RAY DIFFRACTION (2.48 Å) | 主引用文献 | Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry, 53, 2014
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4CVG
| Structure of bovine endothelial nitric oxide synthase heme domain (H4B-free) supplemented with 50uM Zn acetate and with poor binding of 6-acetyl-2-amino-7,7-dimethyl-7,8-dihydropteridin-4(3H)-one. | 分子名称: | ACETATE ION, ARGININE, GLYCEROL, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-25 | 公開日 | 2014-05-28 | 最終更新日 | 2014-07-16 | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | 主引用文献 | Communication between the Zinc and Tetrahydrobiopterin Binding Sites in Nitric Oxide Synthase. Biochemistry, 53, 2014
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2IS5
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4PDY
| Crystal structure of aminoglycoside phosphotransferase from Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 | 分子名称: | Aminoglycoside phosphotransferase, HISTIDINE, THIOCYANATE ION | 著者 | Chang, C, Li, H, Bearden, J, Joachimiak, A, Midwest Center for Structural Genomics (MCSG) | 登録日 | 2014-04-22 | 公開日 | 2014-05-07 | 最終更新日 | 2023-12-27 | 実験手法 | X-RAY DIFFRACTION (1.35 Å) | 主引用文献 | Crystal structure of aminoglycoside phosphotransferase from Alicyclobacillus acidocaldarius subsp. acidocaldarius DSM 446 To be published
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4CU0
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl) ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine | 分子名称: | (R)-6-(3-amino-2-(5-(2-(6-amino-4-methylpyridin-2-yl)ethyl)pyridin-3-yl)propyl)-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-15 | 公開日 | 2014-05-07 | 最終更新日 | 2014-06-04 | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | 主引用文献 | Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57, 2014
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4CTY
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl) ethyl)phenyl)ethyl)-4-methylpyridin-2-amine | 分子名称: | (R)-6-(2-Amino-2-(3-(2-(6-amino-4-methylpyridin-2-yl)ethyl)phenyl)ethyl)-4-methylpyridin-2-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-03-15 | 公開日 | 2014-05-07 | 最終更新日 | 2014-06-04 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Nitric Oxide Synthase Inhibitors that Interact with Both a Heme Propionate and Tetrahydrobiopterin Show High Isoform Selectivity. J.Med.Chem., 57, 2014
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4D3A
| Structure of bovine endothelial nitric oxide synthase heme domain in complex with 3-(3-fluorophenyl)-N-2-(2-(5-methyl-1H-imidazol-1-yl) pyrimidin-4-yl)ethylpropan-1-amine | 分子名称: | 3-(3-fluorophenyl)-N-{2-[2-(5-methyl-1H-imidazol-1-yl)pyrimidin-4-yl]ethyl}propan-1-amine, 5,6,7,8-TETRAHYDROBIOPTERIN, ACETATE ION, ... | 著者 | Chreifi, G, Li, H, Poulos, T.L. | 登録日 | 2014-10-20 | 公開日 | 2014-12-24 | 最終更新日 | 2015-03-04 | 実験手法 | X-RAY DIFFRACTION (2.252 Å) | 主引用文献 | Novel 2,4-Disubstituted Pyrimidines as Potent, Selective, and Cell-Permeable Inhibitors of Neuronal Nitric Oxide Synthase. J.Med.Chem., 58, 2015
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