6GQA
 
 | | Cell division regulator S. pneumoniae GpsB | | Descriptor: | Cell cycle protein GpsB | | Authors: | Lewis, R.J, Rutter, Z.J. | | Deposit date: | 2018-06-07 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Nat Commun, 10, 2019
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6GQN
 | | Cell division regulator, S. pneumoniae GpsB, in complex with peptide fragment of Penicillin Binding Protein PBP2a | | Descriptor: | Cell cycle protein GpsB, NICKEL (II) ION, SULFATE ION, ... | | Authors: | Lewis, R.J, Rutter, Z.J. | | Deposit date: | 2018-06-07 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.8 Å) | | Cite: | The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Nat Commun, 10, 2019
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6CUN
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6CUK
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1FC3
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1B0N
 | | SINR PROTEIN/SINI PROTEIN COMPLEX | | Descriptor: | PROTEIN (SINI PROTEIN), PROTEIN (SINR PROTEIN), ZINC ION | | Authors: | Lewis, R.J, Brannigan, J.A, Offen, W.A, Smith, I, Wilkinson, A.J. | | Deposit date: | 1998-11-11 | | Release date: | 1999-01-13 | | Last modified: | 2023-12-27 | | Method: | X-RAY DIFFRACTION (1.9 Å) | | Cite: | An evolutionary link between sporulation and prophage induction in the structure of a repressor:anti-repressor complex.
J.Mol.Biol., 283, 1998
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1QMP
 | | Phosphorylated aspartate in the crystal structure of the sporulation response regulator, Spo0A | | Descriptor: | CALCIUM ION, Stage 0 sporulation protein A | | Authors: | Lewis, R.J, Brannigan, J.A, Muchova, K, Barak, I, Wilkinson, A.J. | | Deposit date: | 1999-10-04 | | Release date: | 1999-11-14 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2 Å) | | Cite: | Phosphorylated aspartate in the structure of a response regulator protein.
J. Mol. Biol., 294, 1999
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1DZ3
 | | DOMAIN-SWAPPING IN THE SPORULATION RESPONSE REGULATOR SPO0A | | Descriptor: | SULFATE ION, Stage 0 sporulation protein A | | Authors: | Lewis, R.J, Brannigan, J.A, Muchova, K, Leonard, G, Barak, I, Wilkinson, A.J. | | Deposit date: | 2000-02-15 | | Release date: | 2000-04-10 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.65 Å) | | Cite: | Domain swapping in the sporulation response regulator Spo0A.
J. Mol. Biol., 297, 2000
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1W53
 | | Kinase recruitment domain of the stress phosphatase RsbU | | Descriptor: | GLYCEROL, PHOSPHOSERINE PHOSPHATASE RSBU, XENON | | Authors: | Delumeau, O, Dutta, S, Brigulla, M, Kuhnke, G, Hardwick, S.W, Voelker, U, Yudkin, M.D, Lewis, R.J. | | Deposit date: | 2004-08-05 | | Release date: | 2004-08-05 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Functional and Structural Characterization of Rsbu, a Stress Signaling Protein Phosphatase 2C
J.Biol.Chem., 279, 2004
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4UY3
 | | Cytoplasmic domain of bacterial cell division protein ezra | | Descriptor: | SEPTATION RING FORMATION REGULATOR EZRA | | Authors: | Cleverley, R.M, Barrett, J.R, Basle, A, Khai-Bui, N, Hewitt, L, Solovyova, A, Xu, Z, Daniela, R.A, Dixon, N.E, Harry, E.J, Oakley, A.J, Vollmer, W, Lewis, R.J. | | Deposit date: | 2014-08-28 | | Release date: | 2014-10-22 | | Last modified: | 2024-05-01 | | Method: | X-RAY DIFFRACTION (2.6 Å) | | Cite: | Structure and Function of a Spectrin-Like Regulator of Bacterial Cytokinesis.
Nat.Commun., 5, 2014
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4UXV
 | | Cytoplasmic domain of bacterial cell division protein EzrA | | Descriptor: | SEPTATION RING FORMATION REGULATOR EZRA | | Authors: | Cleverley, R.M, Barrett, J.R, Basle, A, Khai-Bui, N, Hewitt, L, Solovyova, A, Xu, Z, Daniela, R.A, Dixon, N.E, Harry, E.J, Oakley, A.J, Vollmer, W, Lewis, R.J. | | Deposit date: | 2014-08-27 | | Release date: | 2014-10-22 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (3.961 Å) | | Cite: | Structure and Function of a Spectrin-Like Regulator of Bacterial Cytokinesis.
Nat.Commun., 5, 2014
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1MVI
 | | N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA, NMR, 15 STRUCTURES | | Descriptor: | MVIIA | | Authors: | Nielsen, K.J, Thomas, L, Lewis, R.J, Alewood, P.F, Craik, D.J. | | Deposit date: | 1996-08-02 | | Release date: | 1997-08-12 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.
J.Mol.Biol., 263, 1996
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1MVJ
 | | N-TYPE CALCIUM CHANNEL BLOCKER, OMEGA-CONOTOXIN MVIIA NMR, 15 STRUCTURES | | Descriptor: | SVIB | | Authors: | Nielsen, K.J, Thomas, L, Lewis, R.J, Alewood, P.F, Craik, D.J. | | Deposit date: | 1996-08-02 | | Release date: | 1997-08-12 | | Last modified: | 2017-11-29 | | Method: | SOLUTION NMR | | Cite: | A consensus structure for omega-conotoxins with different selectivities for voltage-sensitive calcium channel subtypes: comparison of MVIIA, SVIB and SNX-202.
J.Mol.Biol., 263, 1996
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1MTQ
 | | THREE-DIMENSIONAL SOLUTION STRUCTURE OF ALPHA-CONOTOXIN GID BY NMR SPECTROSCOPY | | Descriptor: | alpha-conotoxin GID | | Authors: | Nicke, A, Loughnan, M.L, Millard, E.L, Alewood, P.F, Adams, D.J, Daly, N.L, Craik, D.J, Lewis, R.J. | | Deposit date: | 2002-09-22 | | Release date: | 2003-02-11 | | Last modified: | 2020-06-24 | | Method: | SOLUTION NMR | | Cite: | Isolation, Structure, and Activity of GID, a Novel alpha 4/7-Conotoxin with an Extended N-terminal Sequence
J.BIOL.CHEM., 278, 2003
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4UG3
 | | B. subtilis GpsB N-terminal Domain | | Descriptor: | CELL CYCLE PROTEIN GPSB | | Authors: | Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Moller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. | | Deposit date: | 2015-03-21 | | Release date: | 2015-11-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins.
Mol.Microbiol., 99, 2016
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4UG1
 | | GpsB N-terminal domain | | Descriptor: | CELL CYCLE PROTEIN GPSB, IMIDAZOLE, NICKEL (II) ION | | Authors: | Rismondo, J, Cleverley, R.M, Lane, H.V, Grohennig, S, Steglich, A, Muller, L, Krishna Mannala, G, Hain, T, Lewis, R.J, Halbedel, S. | | Deposit date: | 2015-03-20 | | Release date: | 2015-11-25 | | Last modified: | 2023-12-20 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | Structure of the Bacterial Cell Division Determinant Gpsb and its Interaction with Penicillin Binding Proteins.
Mol.Microbiol., 99, 2016
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7TXF
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7B1O
 | | Crystal structure of the indoleamine 2,3-dioxygenase 1 (IDO1) in complex with compound 22 | | Descriptor: | 4-chloranyl-N-[(1R)-1-[(1S,5R)-3-quinolin-4-yloxy-6-bicyclo[3.1.0]hexanyl]propyl]benzamide, Indoleamine 2,3-dioxygenase 1 | | Authors: | Lammens, A, Krapp, S, Lewis, R.T, Hamilton, M.M. | | Deposit date: | 2020-11-25 | | Release date: | 2021-09-29 | | Method: | X-RAY DIFFRACTION (2.58 Å) | | Cite: | Discovery of IACS-9779 and IACS-70465 as Potent Inhibitors Targeting Indoleamine 2,3-Dioxygenase 1 (IDO1) Apoenzyme.
J.Med.Chem., 64, 2021
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5T90
 | | Structural mechanisms for alpha-conotoxin selectivity at the human alpha3beta4 nicotinic acetylcholine receptor | | Descriptor: | Acetylcholine-binding protein, LsIA | | Authors: | Abraham, N, Healy, M, Ragnarsson, L, Brust, A, Alewood, P, Lewis, R. | | Deposit date: | 2016-09-08 | | Release date: | 2017-04-12 | | Last modified: | 2023-10-04 | | Method: | X-RAY DIFFRACTION (2.8 Å) | | Cite: | Structural mechanisms for alpha-conotoxin activity at the human alpha 3 beta 4 nicotinic acetylcholine receptor.
Sci Rep, 7, 2017
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6TIF
 | | ReoM- Listeria monocytogenes | | Descriptor: | SULFATE ION, UPF0297 protein lmo1503 | | Authors: | Rutter, Z.J, Lewis, R.J. | | Deposit date: | 2019-11-22 | | Release date: | 2020-06-10 | | Last modified: | 2024-01-24 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | PrkA controls peptidoglycan biosynthesis through the essential phosphorylation of ReoM.
Elife, 9, 2020
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2VY9
 | | Molecular architecture of the stressosome, a signal integration and transduction hub | | Descriptor: | ANTI-SIGMA-FACTOR ANTAGONIST | | Authors: | Marles-Wright, J, Grant, T, Delumeau, O, van Duinen, G, Firbank, S.J, Lewis, P.J, Murray, J.W, Newman, J.A, Quin, M.B, Race, P.R, Rohou, A, Tichelaar, W, van Heel, M, Lewis, R.J. | | Deposit date: | 2008-07-21 | | Release date: | 2008-10-14 | | Last modified: | 2011-07-13 | | Method: | X-RAY DIFFRACTION (2.3 Å) | | Cite: | Molecular Architecture of the "Stressosome," a Signal Integration and Transduction Hub
Science, 322, 2008
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7BN9
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7N43
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5NHL
 | | Human Erk2 with an Erk1/2 inhibitor | | Descriptor: | (6~{R})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION | | Authors: | Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M. | | Deposit date: | 2017-03-21 | | Release date: | 2017-04-19 | | Last modified: | 2024-05-08 | | Method: | X-RAY DIFFRACTION (2.07 Å) | | Cite: | Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
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6GPZ
 | | Cell division regulator GpsB in complex with peptide fragment of L. monocytogenes Penicillin Binding Protein PBPA1 | | Descriptor: | Cell cycle protein GpsB, IMIDAZOLE, LmPBPA1, ... | | Authors: | Cleverley, R.M, Lewis, R.J, Rutter, Z.J. | | Deposit date: | 2018-06-07 | | Release date: | 2019-01-23 | | Last modified: | 2024-01-17 | | Method: | X-RAY DIFFRACTION (1.6 Å) | | Cite: | The cell cycle regulator GpsB functions as cytosolic adaptor for multiple cell wall enzymes.
Nat Commun, 10, 2019
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