5N06
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![BU of 5n06 by Molmil](/molmil-images/mine/5n06) | |
2XV7
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![BU of 2xv7 by Molmil](/molmil-images/mine/2xv7) | Crystal structure of vascular endothelial growth factor D | Descriptor: | VASCULAR ENDOTHELIAL GROWTH FACTOR D, alpha-D-mannopyranose, beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose | Authors: | Leppanen, V.-M, Jeltsch, M, Anisimov, A, Tvorogov, D, Aho, K, Kalkkinen, N, Toivanen, P, Yla-Herttuala, S, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2010-10-23 | Release date: | 2011-01-12 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural Determinants of Vascular Endothelial Growth Factor-D - Receptor Binding and Specificity. Blood, 117, 2011
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5MYB
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![BU of 5myb by Molmil](/molmil-images/mine/5myb) | Homodimerization of Tie2 Fibronectin-like domains 2 and 3 in space group P21 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | Authors: | Leppanen, V.-M, Saharinen, P, Alitalo, K. | Deposit date: | 2017-01-26 | Release date: | 2017-04-26 | Last modified: | 2024-05-01 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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5MYA
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![BU of 5mya by Molmil](/molmil-images/mine/5mya) | Homodimerization of Tie2 Fibronectin-like domains 1-3 in space group C2 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, Angiopoietin-1 receptor, ... | Authors: | Leppanen, V.-M, Saharinen, P, Alitalo, K. | Deposit date: | 2017-01-26 | Release date: | 2017-04-26 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.9 Å) | Cite: | Structural basis of Tie2 activation and Tie2/Tie1 heterodimerization. Proc. Natl. Acad. Sci. U.S.A., 114, 2017
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4BSJ
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![BU of 4bsj by Molmil](/molmil-images/mine/4bsj) | Crystal structure of VEGFR-3 extracellular domains D4-5 | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR 3 | Authors: | Leppanen, V.-M, Tvorogov, D, Kisko, K, Prota, A.E, Jeltsch, M, Anisimov, A, Markovic-Mueller, S, Stuttfeld, E, Goldie, K.N, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2013-06-10 | Release date: | 2013-07-31 | Last modified: | 2020-07-29 | Method: | X-RAY DIFFRACTION (2.5 Å) | Cite: | Structural and Mechanistic Insights Into Vegfr-3 Ligand Binding and Activation Proc.Natl.Acad.Sci.USA, 110, 2013
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1QHM
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![BU of 1qhm by Molmil](/molmil-images/mine/1qhm) | ESCHERICHIA COLI PYRUVATE FORMATE LYASE LARGE DOMAIN | Descriptor: | PYRUVATE FORMATE-LYASE | Authors: | Leppanen, V.-M, Merckel, M.C, Ollis, D.L, Wong, K.K, Kozarich, J.W, Goldman, A. | Deposit date: | 1999-05-19 | Release date: | 2000-05-24 | Last modified: | 2023-12-27 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Pyruvate formate lyase is structurally homologous to type I ribonucleotide reductase. Structure Fold.Des., 7, 1999
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1QEZ
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![BU of 1qez by Molmil](/molmil-images/mine/1qez) | SULFOLOBUS ACIDOCALDARIUS INORGANIC PYROPHOSPHATASE: AN ARCHAEL PYROPHOSPHATASE. | Descriptor: | MAGNESIUM ION, PROTEIN (INORGANIC PYROPHOSPHATASE) | Authors: | Leppanen, V.-M, Nummelin, H, Hansen, T, Lahti, R, Schafer, G, Goldman, A. | Deposit date: | 1999-04-06 | Release date: | 1999-04-14 | Last modified: | 2023-08-16 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Sulfolobus acidocaldarius inorganic pyrophosphatase: structure, thermostability, and effect of metal ion in an archael pyrophosphatase. Protein Sci., 8, 1999
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2UUR
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![BU of 2uur by Molmil](/molmil-images/mine/2uur) | N-terminal NC4 domain of collagen IX | Descriptor: | 1,2-ETHANEDIOL, COLLAGEN ALPHA-1(IX) CHAIN, SULFATE ION, ... | Authors: | Leppanen, V.-M, Tossavainen, H, Permi, P, Lehtio, L, Ronnholm, G, Goldman, A, Kilpelainen, I, Pihlajamaa, T. | Deposit date: | 2007-03-07 | Release date: | 2007-06-05 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Crystal Structure of the N-Terminal Nc4 Domain of Collagen Ix, a Zinc Binding Member of the Laminin-Neurexin-Sex Hormone Binding Globulin (Lns) Domain Family. J.Biol.Chem., 282, 2007
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2X1X
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![BU of 2x1x by Molmil](/molmil-images/mine/2x1x) | CRYSTAL STRUCTURE OF VEGF-C IN COMPLEX WITH DOMAINS 2 AND 3 OF VEGFR2 IN A TETRAGONAL CRYSTAL FORM | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, MERCURY (II) ION, ... | Authors: | Leppanen, V.-M, Prota, A.E, Jeltsch, M, Anisimov, A, Kalkkinen, N, Strandin, T, Lankinen, H, Goldman, A, Ballmer-Hofer, K, Alitalo, K. | Deposit date: | 2010-01-08 | Release date: | 2010-02-09 | Last modified: | 2023-12-20 | Method: | X-RAY DIFFRACTION (3.1 Å) | Cite: | Structural Determinants of Growth Factor Binding and Specificity by Vegf Receptor 2. Proc.Natl.Acad.Sci.USA, 107, 2010
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3V2A
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![BU of 3v2a by Molmil](/molmil-images/mine/3v2a) | VEGFR-2/VEGF-A COMPLEX STRUCTURE | Descriptor: | Vascular endothelial growth factor A, Vascular endothelial growth factor receptor 2 | Authors: | Brozzo, M.S, Leppanen, V.-M, Winkler, F.K, Ballmer-Hofer, K. | Deposit date: | 2011-12-12 | Release date: | 2012-01-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.204 Å) | Cite: | Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood, 119, 2012
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3V6B
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![BU of 3v6b by Molmil](/molmil-images/mine/3v6b) | VEGFR-2/VEGF-E complex structure | Descriptor: | VEGF-E, Vascular endothelial growth factor receptor 2 | Authors: | Brozzo, M.S, Leppanen, V.-M, Winkler, F.K, Kisko, K, Ballmer-Hofer, K. | Deposit date: | 2011-12-19 | Release date: | 2012-01-18 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (3.205 Å) | Cite: | Thermodynamic and structural description of allosterically regulated VEGFR-2 dimerization. Blood, 119, 2012
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1MZO
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![BU of 1mzo by Molmil](/molmil-images/mine/1mzo) | Crystal structure of pyruvate formate-lyase with pyruvate | Descriptor: | PYRUVIC ACID, Pyruvate formate-lyase, TRIETHYLENE GLYCOL | Authors: | Lehtio, L, Leppanen, V.-M, Kozarich, J.W, Goldman, A. | Deposit date: | 2002-10-09 | Release date: | 2002-12-11 | Last modified: | 2023-11-15 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Structure of Escherichia coli pyruvate formate-lyase with pyruvate. Acta Crystallogr.,Sect.D, 58, 2002
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2V5E
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![BU of 2v5e by Molmil](/molmil-images/mine/2v5e) | The structure of the GDNF:Coreceptor complex: Insights into RET signalling and heparin binding. | Descriptor: | 1,2-ETHANEDIOL, 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, ... | Authors: | Parkash, V, Leppanen, V.-M, Virtanen, H, Jurvansuu, J.-M, Bespalov, M.M, Sidorova, Y.A, Runeberg-Roos, P, Saarma, M, Goldman, A. | Deposit date: | 2008-10-03 | Release date: | 2008-10-21 | Last modified: | 2023-12-13 | Method: | X-RAY DIFFRACTION (2.35 Å) | Cite: | The Structure of the Glial Cell Line-Derived Neurotrophic Factor-Coreceptor Complex: Insights Into Ret Signaling and Heparin Binding. J.Biol.Chem., 283, 2008
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