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PDB: 15 results

8U18
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BU of 8u18 by Molmil
Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo
Descriptor: 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor,GCN4 isoform 1, ...
Authors:Sarson-Lawrence, K.S, Hardy, J.M, Leis, A, Babon, J.J, Kershaw, N.J.
Deposit date:2023-08-30
Release date:2024-02-07
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin.
Nat Commun, 15, 2024
6MUW
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BU of 6muw by Molmil
The structure of the Plasmodium falciparum 20S proteasome.
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.6 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
6MUV
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The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.8 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
6MUX
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BU of 6mux by Molmil
The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2018-10-23
Release date:2019-08-07
Last modified:2024-03-13
Method:ELECTRON MICROSCOPY (3.9 Å)
Cite:The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis.
Nat Microbiol, 4, 2019
7T3X
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BU of 7t3x by Molmil
Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant
Descriptor: Serine/threonine-protein kinase PINK1
Authors:Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D.
Deposit date:2021-12-09
Release date:2021-12-22
Last modified:2023-10-18
Method:X-RAY DIFFRACTION (3.53 Å)
Cite:Activation mechanism of PINK1.
Nature, 602, 2022
7T4K
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Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B
Descriptor: Serine/threonine-protein kinase PINK1, putative
Authors:Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D.
Deposit date:2021-12-10
Release date:2022-01-12
Last modified:2024-10-16
Method:ELECTRON MICROSCOPY (3.25 Å)
Cite:Activation mechanism of PINK1.
Nature, 602, 2022
7T4N
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BU of 7t4n by Molmil
Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant
Descriptor: Serine/threonine-protein kinase PINK1, putative
Authors:Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D.
Deposit date:2021-12-10
Release date:2022-01-12
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.35 Å)
Cite:Activation mechanism of PINK1.
Nature, 602, 2022
7T4L
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BU of 7t4l by Molmil
Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B
Descriptor: Serine/threonine-protein kinase PINK1, putative
Authors:Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D.
Deposit date:2021-12-10
Release date:2022-01-12
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (3.28 Å)
Cite:Activation mechanism of PINK1.
Nature, 602, 2022
7T4M
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BU of 7t4m by Molmil
Structure of dodecameric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant
Descriptor: Serine/threonine-protein kinase PINK1, putative
Authors:Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D.
Deposit date:2021-12-10
Release date:2022-01-12
Last modified:2024-02-28
Method:ELECTRON MICROSCOPY (2.48 Å)
Cite:Activation mechanism of PINK1.
Nature, 602, 2022
8UYF
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BU of 8uyf by Molmil
Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer
Descriptor: Serine/threonine-protein kinase Pink1, mitochondrial
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Last modified:2024-10-09
Method:ELECTRON MICROSCOPY (2.75 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYI
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BU of 8uyi by Molmil
Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer
Descriptor: ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Method:ELECTRON MICROSCOPY (3.13 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
8UYH
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BU of 8uyh by Molmil
Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer
Descriptor: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ...
Authors:Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D.
Deposit date:2023-11-13
Release date:2024-01-31
Last modified:2024-10-30
Method:ELECTRON MICROSCOPY (2.84 Å)
Cite:Interaction of PINK1 with nucleotides and kinetin.
Sci Adv, 10, 2024
7LXV
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BU of 7lxv by Molmil
Structure of human 20S proteasome with bound MPI-5
Descriptor: N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ...
Authors:Metcalfe, R.D, Morton, C.J, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LXT
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BU of 7lxt by Molmil
Structure of Plasmodium falciparum 20S proteasome with bound bortezomib
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Morton, C.J, Metcalfe, R.D, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.4 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021
7LXU
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BU of 7lxu by Molmil
Structure of Plasmodium falciparum 20S proteasome with bound MPI-5
Descriptor: 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ...
Authors:Metcalfe, R.D, Morton, C.J, Xie, S.C, Liu, B, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W.
Deposit date:2021-03-05
Release date:2021-09-22
Last modified:2022-04-13
Method:ELECTRON MICROSCOPY (3.1 Å)
Cite:Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome.
Proc.Natl.Acad.Sci.USA, 118, 2021

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