8U18
| Cryo-EM structure of murine Thrombopoietin receptor ectodomain in complex with Tpo | Descriptor: | 2-acetamido-2-deoxy-beta-D-glucopyranose, Thrombopoietin, Thrombopoietin receptor,GCN4 isoform 1, ... | Authors: | Sarson-Lawrence, K.S, Hardy, J.M, Leis, A, Babon, J.J, Kershaw, N.J. | Deposit date: | 2023-08-30 | Release date: | 2024-02-07 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | Cryo-EM structure of the extracellular domain of murine Thrombopoietin Receptor in complex with Thrombopoietin. Nat Commun, 15, 2024
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6MUW
| The structure of the Plasmodium falciparum 20S proteasome. | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.6 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6MUV
| The structure of the Plasmodium falciparum 20S proteasome in complex with two PA28 activators | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.8 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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6MUX
| The structure of the Plasmodium falciparum 20S proteasome in complex with one PA28 activator | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Xie, S.C, Hanssen, E, Gillett, D.L, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2018-10-23 | Release date: | 2019-08-07 | Last modified: | 2024-03-13 | Method: | ELECTRON MICROSCOPY (3.9 Å) | Cite: | The structure of the PA28-20S proteasome complex from Plasmodium falciparum and implications for proteostasis. Nat Microbiol, 4, 2019
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7T3X
| Structure of unphosphorylated Pediculus humanus (Ph) PINK1 D334A mutant | Descriptor: | Serine/threonine-protein kinase PINK1 | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-09 | Release date: | 2021-12-22 | Last modified: | 2023-10-18 | Method: | X-RAY DIFFRACTION (3.53 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4K
| Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with kinked alpha-C helix in chain B | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-10-16 | Method: | ELECTRON MICROSCOPY (3.25 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4N
| Structure of dimeric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.35 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4L
| Structure of dimeric phosphorylated Pediculus humanus (Ph) PINK1 with extended alpha-C helix in chain B | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (3.28 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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7T4M
| Structure of dodecameric unphosphorylated Pediculus humanus (Ph) PINK1 D357A mutant | Descriptor: | Serine/threonine-protein kinase PINK1, putative | Authors: | Gan, Z.Y, Leis, A, Dewson, G, Glukhova, A, Komander, D. | Deposit date: | 2021-12-10 | Release date: | 2022-01-12 | Last modified: | 2024-02-28 | Method: | ELECTRON MICROSCOPY (2.48 Å) | Cite: | Activation mechanism of PINK1. Nature, 602, 2022
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8UYF
| Structure of nucleotide-free Pediculus humanus (Ph) PINK1 dimer | Descriptor: | Serine/threonine-protein kinase Pink1, mitochondrial | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Last modified: | 2024-10-09 | Method: | ELECTRON MICROSCOPY (2.75 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8UYI
| Structure of ADP-bound and phosphorylated Pediculus humanus (Ph) PINK1 dimer | Descriptor: | ADENOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Serine/threonine-protein kinase Pink1, ... | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Method: | ELECTRON MICROSCOPY (3.13 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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8UYH
| Structure of AMP-PNP-bound Pediculus humanus (Ph) PINK1 dimer | Descriptor: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Serine/threonine-protein kinase Pink1, ... | Authors: | Gan, Z.Y, Kirk, N.S, Leis, A, Komander, D. | Deposit date: | 2023-11-13 | Release date: | 2024-01-31 | Last modified: | 2024-10-30 | Method: | ELECTRON MICROSCOPY (2.84 Å) | Cite: | Interaction of PINK1 with nucleotides and kinetin. Sci Adv, 10, 2024
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7LXV
| Structure of human 20S proteasome with bound MPI-5 | Descriptor: | N-[(1R)-2-([1,1'-biphenyl]-4-yl)-1-boronoethyl]-1-methyl-L-prolinamide, Proteasome subunit alpha type-1, Proteasome subunit alpha type-2, ... | Authors: | Metcalfe, R.D, Morton, C.J, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-03-05 | Release date: | 2021-09-22 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LXT
| Structure of Plasmodium falciparum 20S proteasome with bound bortezomib | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Morton, C.J, Metcalfe, R.D, Liu, B, Xie, S.C, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-03-05 | Release date: | 2021-09-22 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.4 Å) | Cite: | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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7LXU
| Structure of Plasmodium falciparum 20S proteasome with bound MPI-5 | Descriptor: | 20S proteasome alpha-1 subunit, 20S proteasome alpha-2 subunit, 20S proteasome alpha-3 subunit, ... | Authors: | Metcalfe, R.D, Morton, C.J, Xie, S.C, Liu, B, Hanssen, E, Leis, A.P, Tilley, L, Griffin, M.D.W. | Deposit date: | 2021-03-05 | Release date: | 2021-09-22 | Last modified: | 2022-04-13 | Method: | ELECTRON MICROSCOPY (3.1 Å) | Cite: | Design of proteasome inhibitors with oral efficacy in vivo against Plasmodium falciparum and selectivity over the human proteasome. Proc.Natl.Acad.Sci.USA, 118, 2021
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