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PDB: 93 件
6NC7
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Lipid II flippase MurJ, inward open conformation
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, Lipid II flippase MurJ, SULFATE ION
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2018-12-11
公開日2019-04-17
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Visualizing conformation transitions of the Lipid II flippase MurJ.
Nat Commun, 10, 2019
6OT5
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BU of 6ot5 by Molmil
Structure of the TRPV3 K169A sensitized mutant in the presence of 2-APB at 3.6 A resolution
分子名称: 2-aminoethyl diphenylborinate, Transient receptor potential cation channel subfamily V member 3,Transient receptor potential cation channel subfamily V member 3
著者Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
登録日2019-05-02
公開日2019-05-22
最終更新日2019-12-18
実験手法ELECTRON MICROSCOPY (3.6 Å)
主引用文献Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
6OT2
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Structure of the TRPV3 K169A sensitized mutant in apo form at 4.1 A resolution
分子名称: Transient receptor potential cation channel subfamily V member 3
著者Zubcevic, L, Borschel, W.F, Hsu, A.L, Borgnia, M.J, Lee, S.-Y.
登録日2019-05-02
公開日2019-05-22
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Regulatory switch at the cytoplasmic interface controls TRPV channel gating.
Elife, 8, 2019
8E4O
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The closed C1-state mouse TRPM8 structure in complex with putative PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.43 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4L
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The open state mouse TRPM8 structure in complex with the cooling agonist C3, AITC, and PI(4,5)P2
分子名称: 3-isothiocyanatoprop-1-ene, CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, ...
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.32 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4N
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The closed C1-state mouse TRPM8 structure in complex with PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
実験手法ELECTRON MICROSCOPY (3.07 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4Q
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The closed C0-state flycatcher TRPM8 structure in complex with PI(4,5)P2
分子名称: Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.51 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4P
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Mouse TRPM8 structure determined in the ligand- and PI(4,5)P2-free condition, Class I , C0 state
分子名称: CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily M member 8
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.59 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8E4M
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The intermediate C2-state mouse TRPM8 structure in complex with the cooling agonist C3 and PI(4,5)P2
分子名称: CALCIUM ION, Transient receptor potential cation channel subfamily M member 8, [(2R)-2-octanoyloxy-3-[oxidanyl-[(1R,2R,3S,4R,5R,6S)-2,3,6-tris(oxidanyl)-4,5-diphosphonooxy-cyclohexyl]oxy-phosphoryl]oxy-propyl] octanoate, ...
著者Yin, Y, Zhang, F, Feng, S, Butay, K.J, Borgnia, M.J, Im, W, Lee, S.-Y.
登録日2022-08-18
公開日2022-10-26
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (3.44 Å)
主引用文献Activation mechanism of the mouse cold-sensing TRPM8 channel by cooling agonist and PIP 2.
Science, 378, 2022
8FC7
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Cryo-EM structure of the human TRPV4 - RhoA in complex with GSK2798745
分子名称: 1-({(5S,7S)-3-[5-(2-hydroxypropan-2-yl)pyrazin-2-yl]-7-methyl-2-oxo-1-oxa-3-azaspiro[4.5]decan-7-yl}methyl)-1H-benzimidazole-6-carbonitrile, GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, ...
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.3 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FCA
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Cryo-EM structure of the human TRPV4 - RhoA in complex with 4alpha-Phorbol 12,13-didecanoate
分子名称: (1aR,1bS,4aS,7aS,7bS,8R,9R,9aS)-9a-(decanoyloxy)-4a,7b-dihydroxy-3-(hydroxymethyl)-1,1,6,8-tetramethyl-5-oxo-1a,1b,4,4a,5,7a,7b,8,9,9a-decahydro-1H-cyclopropa[3,4]benzo[1,2-e]azulen-9-yl decanoate, CHOLESTEROL HEMISUCCINATE, Transient receptor potential cation channel subfamily V member 4
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.41 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FC9
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Cryo-EM structure of the human TRPV4 - RhoA, apo condition
分子名称: GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Transforming protein RhoA, ...
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.75 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
8FC8
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Cryo-EM structure of the human TRPV4 in complex with GSK1016790A
分子名称: CHOLESTEROL HEMISUCCINATE, N-[(2S)-1-{4-[N-(2,4-dichlorobenzene-1-sulfonyl)-L-seryl]piperazin-1-yl}-4-methyl-1-oxopentan-2-yl]-1-benzothiophene-2-carboxamide, Transient receptor potential cation channel subfamily V member 4
著者Kwon, D.H, Lee, S.-Y, Zhang, F.
登録日2022-12-01
公開日2023-07-12
最終更新日2024-06-19
実験手法ELECTRON MICROSCOPY (3.47 Å)
主引用文献TRPV4-Rho GTPase complex structures reveal mechanisms of gating and disease.
Nat Commun, 14, 2023
5T77
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Crystal structure of the MOP flippase MurJ
分子名称: (2R)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, (2S)-2,3-dihydroxypropyl (9Z)-octadec-9-enoate, CALCIUM ION, ...
著者Kuk, A.C.Y, Lee, S.-Y.
登録日2016-09-02
公開日2016-12-28
最終更新日2024-03-06
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Crystal structure of the MOP flippase MurJ in an inward-facing conformation.
Nat. Struct. Mol. Biol., 24, 2017
6BPQ
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BU of 6bpq by Molmil
Structure of the cold- and menthol-sensing ion channel TRPM8
分子名称: Transient receptor potential cation channel subfamily M member 8
著者Yin, Y, Wu, M, Zubcevic, L, Borschel, W.F, Lander, G.C, Lee, S.-Y.
登録日2017-11-25
公開日2017-12-13
最終更新日2024-03-13
実験手法ELECTRON MICROSCOPY (4.1 Å)
主引用文献Structure of the cold- and menthol-sensing ion channel TRPM8.
Science, 359, 2018
6BW5
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Human GPT (DPAGT1) in complex with tunicamycin
分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
著者Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y.
登録日2017-12-14
公開日2018-02-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
6BW6
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BU of 6bw6 by Molmil
Human GPT (DPAGT1) H129 variant in complex with tunicamycin
分子名称: (1R)-2-{[(S)-{[(2S)-2,3-dihydroxypropyl]oxy}(hydroxy)phosphoryl]oxy}-1-[(hexadecanoyloxy)methyl]ethyl (9Z)-octadec-9-enoate, Tunicamycin, UDP-N-acetylglucosamine--dolichyl-phosphate N-acetylglucosaminephosphotransferase
著者Yoo, J, Kuk, A.C.Y, Mashalidis, E.H, Lee, S.-Y.
登録日2017-12-14
公開日2018-02-21
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献GlcNAc-1-P-transferase-tunicamycin complex structure reveals basis for inhibition of N-glycosylation.
Nat. Struct. Mol. Biol., 25, 2018
3TIJ
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Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae
分子名称: DECYL-BETA-D-MALTOPYRANOSIDE, NupC family protein, SODIUM ION, ...
著者Johnson, Z.L, Cheong, C.-G, Lee, S.-Y.
登録日2011-08-20
公開日2012-03-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (2.436 Å)
主引用文献Crystal structure of a concentrative nucleoside transporter from Vibrio cholerae at 2.4A
Nature, 483, 2012
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