3HXB
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![BU of 3hxb by Molmil](/molmil-images/mine/3hxb) | Engineered RabGGTase in complex with a peptidomimetic inhibitor (compound 6) | 分子名称: | Geranylgeranyl transferase type-2 subunit alpha, Geranylgeranyl transferase type-2 subunit beta, N-[(benzyloxy)carbonyl]-D-tyrosyl-L-phenylalanyl-L-tyrosine, ... | 著者 | Guo, Z, Alexandrov, K, Waldmann, H, Goody, R.S, Blankenfeldt, W. | 登録日 | 2009-06-20 | 公開日 | 2009-09-08 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2.25 Å) | 主引用文献 | Design, synthesis, and characterization of Peptide-based rab geranylgeranyl transferase inhibitors J.Med.Chem., 52, 2009
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5O15
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![BU of 5o15 by Molmil](/molmil-images/mine/5o15) | Crystal structure of bifunctional dehydratase-cyclase domain in ambruticin biosynthesis | 分子名称: | AmbC, GLYCEROL | 著者 | Sung, K.H, Berkhan, G, Hollmann, T, Wagner, L, Hahn, F, Blankenfeldt, W. | 登録日 | 2017-05-18 | 公開日 | 2017-11-08 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.174 Å) | 主引用文献 | Insights into the Dual Activity of a Bifunctional Dehydratase-Cyclase Domain. Angew. Chem. Int. Ed. Engl., 57, 2018
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3JVL
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![BU of 3jvl by Molmil](/molmil-images/mine/3jvl) | Crystal structure of bromodomain 2 of mouse Brd4 | 分子名称: | 1,2-ETHANEDIOL, BETA-MERCAPTOETHANOL, Bromodomain-containing protein 4 | 著者 | Vollmuth, F, Blankenfeldt, W, Geyer, M. | 登録日 | 2009-09-17 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.2 Å) | 主引用文献 | Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
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5O30
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![BU of 5o30 by Molmil](/molmil-images/mine/5o30) | |
8VQX
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![BU of 8vqx by Molmil](/molmil-images/mine/8vqx) | |
3JZ9
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![BU of 3jz9 by Molmil](/molmil-images/mine/3jz9) | Crystal structure of the GEF domain of DrrA/SidM from Legionella pneumophila | 分子名称: | Uncharacterized protein DrrA | 著者 | Schoebel, S, Oesterlin, L.K, Blankenfeldt, W, Goody, R.S, Itzen, A. | 登録日 | 2009-09-23 | 公開日 | 2010-01-19 | 最終更新日 | 2017-11-01 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | RabGDI displacement by DrrA from Legionella is a consequence of its guanine nucleotide exchange activity. Mol.Cell, 36, 2009
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3JVK
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![BU of 3jvk by Molmil](/molmil-images/mine/3jvk) | Crystal structure of bromodomain 1 of mouse Brd4 in complex with histone H3-K(ac)14 | 分子名称: | 1,2-ETHANEDIOL, Bromodomain-containing protein 4, histone H3.3 peptide | 著者 | Vollmuth, F, Blankenfeldt, W, Geyer, M. | 登録日 | 2009-09-17 | 公開日 | 2009-10-13 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structures of the Dual Bromodomains of the P-TEFb-activating Protein Brd4 at Atomic Resolution J.Biol.Chem., 284, 2009
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8BCJ
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![BU of 8bcj by Molmil](/molmil-images/mine/8bcj) | |
8BCI
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![BU of 8bci by Molmil](/molmil-images/mine/8bci) | |
8B4A
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![BU of 8b4a by Molmil](/molmil-images/mine/8b4a) | |
3KH3
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5X9O
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![BU of 5x9o by Molmil](/molmil-images/mine/5x9o) | Crystal structure of the BCL6 BTB domain in complex with Compound 1a | 分子名称: | 1,2-ETHANEDIOL, 5-[(2-chloranyl-4-nitro-phenyl)amino]-1,3-dihydrobenzimidazol-2-one, B-cell lymphoma 6 protein, ... | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-03-08 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.58 Å) | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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3KH4
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5X4M
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![BU of 5x4m by Molmil](/molmil-images/mine/5x4m) | Crystal structure of the BCL6 BTB domain in complex with Compound 1 | 分子名称: | B-cell lymphoma 6 protein, N-phenyl-1,3,5-triazine-2,4-diamine | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-02-13 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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5X4Q
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![BU of 5x4q by Molmil](/molmil-images/mine/5x4q) | Crystal structure of the BCL6 BTB domain in complex with Compound 7 | 分子名称: | 1,2-ETHANEDIOL, 5-[[5-chloranyl-2-(pyridin-3-ylmethylamino)pyrimidin-4-yl]amino]-1,3-dihydroindol-2-one, B-cell lymphoma 6 protein, ... | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-02-13 | 公開日 | 2017-05-24 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Discovery of a B-Cell Lymphoma 6 Protein-Protein Interaction Inhibitor by a Biophysics-Driven Fragment-Based Approach J. Med. Chem., 60, 2017
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5X9P
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![BU of 5x9p by Molmil](/molmil-images/mine/5x9p) | Crystal structure of the BCL6 BTB domain in complex with Compound 5 | 分子名称: | 3-[[4-chloranyl-2-nitro-5-[(2-oxidanylidene-1,3-dihydrobenzimidazol-5-yl)amino]phenyl]amino]propanoic acid, B-cell lymphoma 6 protein | 著者 | Sogabe, S, Ida, K, Lane, W, Snell, G. | 登録日 | 2017-03-08 | 公開日 | 2017-08-16 | 最終更新日 | 2023-11-22 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Discovery of a novel B-cell lymphoma 6 (BCL6)-corepressor interaction inhibitor by utilizing structure-based drug design Bioorg. Med. Chem., 25, 2017
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6I9U
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6I9W
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![BU of 6i9w by Molmil](/molmil-images/mine/6i9w) | Crystal structure of the halohydrin dehalogenase HheG T123G mutant | 分子名称: | (R,R)-2,3-BUTANEDIOL, CHLORIDE ION, Putative oxidoreductase | 著者 | Kluenemann, T, Blankenfeldt, W, Schallmey, A. | 登録日 | 2018-11-26 | 公開日 | 2019-08-21 | 最終更新日 | 2024-01-24 | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | 主引用文献 | Position 123 of halohydrin dehalogenase HheG plays an important role in stability, activity, and enantioselectivity. Sci Rep, 9, 2019
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3EUV
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![BU of 3euv by Molmil](/molmil-images/mine/3euv) | Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10, W102T, Y154T) in complex with BiotinGPP | 分子名称: | (2E,6E)-3,7-dimethyl-8-({5-[(3aS,4S,6aR)-2-oxohexahydro-1H-thieno[3,4-d]imidazol-4-yl]pentanoyl}amino)octa-2,6-dien-1-yl trihydrogen diphosphate, Protein farnesyltransferase subunit beta, Protein farnesyltransferase/geranylgeranyltransferase type-1 subunit alpha, ... | 著者 | Guo, Z, Nguyen, U.T.T, Delon, C, Bon, R.S, Blankenfeldt, W, Goody, R.S, Waldmann, H, Wolters, D, Alexandrov, K. | 登録日 | 2008-10-11 | 公開日 | 2009-07-07 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | 主引用文献 | Analysis of the eukaryotic prenylome by isoprenoid affinity tagging Nat.Chem.Biol., 5, 2009
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5MBR
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5MCR
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![BU of 5mcr by Molmil](/molmil-images/mine/5mcr) | Quadruplex with flipped tetrad formed by an artificial sequence | 分子名称: | Artificial quadruplex with propeller, diagonal and lateral loop | 著者 | Dickerhoff, J, Haase, L, Langel, W, Weisz, K. | 登録日 | 2016-11-10 | 公開日 | 2017-04-19 | 最終更新日 | 2024-05-15 | 実験手法 | SOLUTION NMR | 主引用文献 | Tracing Effects of Fluorine Substitutions on G-Quadruplex Conformational Changes. ACS Chem. Biol., 12, 2017
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3DST
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![BU of 3dst by Molmil](/molmil-images/mine/3dst) | Crystal structure of RabGGTase(DELTA LRR; DELTA IG)in complex with geranylgeranyl pyrophosphate | 分子名称: | CALCIUM ION, GERANYLGERANYL DIPHOSPHATE, Geranylgeranyl transferase type-2 subunit alpha, ... | 著者 | Guo, Z, Yu, S, Goody, R.S, Alexandrov, K, Blankenfeldt, W. | 登録日 | 2008-07-14 | 公開日 | 2008-09-09 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Structures of RabGGTase-substrate/product complexes provide insights into the evolution of protein prenylation Embo J., 27, 2008
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5MZW
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![BU of 5mzw by Molmil](/molmil-images/mine/5mzw) | Crystal structure of the decarboxylase AibA/AibB | 分子名称: | GLYCEROL, Glutaconate CoA-transferase family, subunit A, ... | 著者 | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | 登録日 | 2017-02-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.52 Å) | 主引用文献 | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
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5MZY
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![BU of 5mzy by Molmil](/molmil-images/mine/5mzy) | Crystal structure of the decarboxylase AibA/AibB in complex with a possible transition state analog | 分子名称: | (1~{R},2~{S})-2-methylcyclohexane-1-carboxylic acid, ACETATE ION, GLYCEROL, ... | 著者 | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | 登録日 | 2017-02-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.6 Å) | 主引用文献 | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
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5N00
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![BU of 5n00 by Molmil](/molmil-images/mine/5n00) | Crystal structure of the decarboxylase AibA/AibB C56A variant | 分子名称: | ACETATE ION, Glutaconate CoA-transferase family, subunit A, ... | 著者 | Bock, T, Luxenburger, E, Hoffmann, J, Schuetza, V, Feiler, C, Mueller, R, Blankenfeldt, W. | 登録日 | 2017-02-02 | 公開日 | 2017-05-31 | 最終更新日 | 2024-01-17 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | AibA/AibB Induces an Intramolecular Decarboxylation in Isovalerate Biosynthesis by Myxococcus xanthus. Angew. Chem. Int. Ed. Engl., 56, 2017
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