1TLH
 
 | | T4 AsiA bound to sigma70 region 4 | | 分子名称: | 10 kDa anti-sigma factor, RNA polymerase sigma factor rpoD | | 著者 | Lambert, L.J, Wei, Y, Schirf, V, Demeler, B, Werner, M.H. | | 登録日 | 2004-06-09 | | 公開日 | 2004-11-23 | | 最終更新日 | 2024-05-01 | | 実験手法 | SOLUTION NMR | | 主引用文献 | T4 AsiA blocks DNA recognition by remodeling sigma(70) region 4
Embo J., 23, 2004
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1TL6
 | | Solution structure of T4 bacteriphage AsiA monomer | | 分子名称: | 10 kDa anti-sigma factor | | 著者 | Lambert, L.J, Wei, Y, Schirf, V, Demeler, B, Werner, M.H. | | 登録日 | 2004-06-09 | | 公開日 | 2005-06-21 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | T4 AsiA blocks DNA recognition by remodeling sigma70 region 4
Embo J., 23, 2004
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1TKV
 | | Solution Structure of T4 AsiA Dimer | | 分子名称: | 10 kDa anti-sigma factor | | 著者 | Lambert, L.J, Schirf, V, Demeler, B, Cadene, M, Werner, M.H. | | 登録日 | 2004-06-09 | | 公開日 | 2004-06-22 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Flipping a genetic switch by subunit exchange
Embo J., 20, 2001
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1TTY
 | | Solution structure of sigma A region 4 from Thermotoga maritima | | 分子名称: | RNA polymerase sigma factor rpoD | | 著者 | Lambert, L.J, Wei, Y, Schirf, V, Demeler, B, Werner, M.H. | | 登録日 | 2004-06-23 | | 公開日 | 2004-11-23 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | T4 AsiA blocks DNA recognition by remodeling sigma(70) region 4
Embo J., 23, 2004
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6YID
 | | Crystal structure of ULK2 in complex with SBI-0206965 | | 分子名称: | 2-({5-bromo-2-[(3,4,5-trimethoxyphenyl)amino]pyrimidin-4-yl}oxy)-N-methylbenzene-1-carboximidic acid, Serine/threonine-protein kinase ULK2 | | 著者 | Chaikuad, A, Ren, H, Bakas, N.A, Lambert, L.J, Cosford, N.D.P, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-04-01 | | 公開日 | 2020-06-17 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.7 Å) | | 主引用文献 | Design, Synthesis, and Characterization of an Orally Active Dual-Specific ULK1/2 Autophagy Inhibitor that Synergizes with the PARP Inhibitor Olaparib for the Treatment of Triple-Negative Breast Cancer.
J.Med.Chem., 63, 2020
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6YAT
 | | Crystal structure of STK4 (MST1) in complex with compound 6 | | 分子名称: | (2R)-3-(cyclohexylamino)-2-hydroxypropane-1-sulfonic acid, 4-[5-(3-chlorophenyl)-7~{H}-pyrrolo[2,3-d]pyrimidin-4-yl]morpholine, GLYCEROL, ... | | 著者 | Chaikuad, A, Bata, N, Limpert, A.S, Lambert, L.J, Bakas, N.A, Cosford, N.D.P, Knapp, S, Structural Genomics Consortium (SGC) | | 登録日 | 2020-03-13 | | 公開日 | 2020-04-29 | | 最終更新日 | 2024-01-24 | | 実験手法 | X-RAY DIFFRACTION (2.58 Å) | | 主引用文献 | Inhibitors of the Hippo Pathway Kinases STK3/MST2 and STK4/MST1 Have Utility for the Treatment of Acute Myeloid Leukemia.
J.Med.Chem., 65, 2022
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7MHD
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635 | | 分子名称: | Fatty acid synthase, N,N-diethyl-4-{2-[(2-fluorophenyl)methyl]-1,3-thiazol-4-yl}benzene-1-sulfonamide | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.03 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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7MHE
 | | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7957 | | 分子名称: | 1,2-ETHANEDIOL, 4-{4-[2-(4-fluorophenyl)-1,3-thiazol-4-yl]benzene-1-sulfonyl}morpholine, Fatty acid synthase | | 著者 | Aleshin, A.E, Lambert, L, Liddington, R.C, Cosford, N. | | 登録日 | 2021-04-15 | | 公開日 | 2022-04-20 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | | 主引用文献 | Thioesterase Domain of Human Fatty Acid Synthase (FASN-TE) binding a competitive inhibitor SBP-7635
To Be Published
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