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PDB: 21374 件
7OCJ
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Crystal structure of E.coli LexA in complex with nanobody NbSOS2(Nb14509)
分子名称: 1,2-ETHANEDIOL, LexA repressor, NbSOS2 (14509)
著者Maso, L, Vascon, F, Chinellato, M, Pardon, E, Steyaert, J, Angelini, A, Tondi, D, Cendron, L.
登録日2021-04-27
公開日2022-10-26
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Nanobodies targeting LexA autocleavage disclose a novel suppression strategy of SOS-response pathway.
Structure, 30, 2022
7TTY
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BU of 7tty by Molmil
Crystal structure of potent neutralizing antibody 10-40 in complex with bat WIV1 receptor-binding domain
分子名称: 1040 heavy chain, 1040 light chain, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Reddem, E.R, Shapiro, L.
登録日2022-02-02
公開日2022-05-04
最終更新日2023-10-18
実験手法X-RAY DIFFRACTION (3.11 Å)
主引用文献An antibody class with a common CDRH3 motif broadly neutralizes sarbecoviruses.
Sci Transl Med, 14, 2022
6Q2W
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Crystal structure of human ROR gamma LBD in complex with a quinoline sulfonamide inverse agonist
分子名称: (2~{S})-1-[2,4-bis(chloranyl)-3-[[4-imidazol-1-yl-2-(trifluoromethyl)quinolin-8-yl]oxymethyl]phenyl]sulfonyl-~{N}-methyl-pyrrolidine-2-carboxamide, Nuclear receptor ROR-gamma
著者Ciesielski, F, Amaudrut, J, Argiriadi, M.A, Barth, M, Breinlinger, E.C, Calderwood, D.J, Cusack, K.P, Kort, M.E, Montalbetti, C, Potin, D, Poupardin, O, Spitzer, L.
登録日2018-12-03
公開日2019-05-29
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Discovery of novel quinoline sulphonamide derivatives as potent, selective and orally active ROR gamma inverse agonists.
Bioorg.Med.Chem.Lett., 29, 2019
7O7T
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BU of 7o7t by Molmil
Structure of the PL6 family alginate lyase Patl3640 from Pseudoalteromonas atlantica T6c in complex with 4-deoxy-L-erythro-5-hexoseulose uronic acid
分子名称: 1,2-ETHANEDIOL, 4-deoxy-L-erythro-hex-5-ulosuronic acid, GLYCEROL, ...
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-13
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.05 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
7O84
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Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans in complex with substrate
分子名称: 4-deoxy-alpha-L-erythro-hex-4-enopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid, 4-deoxy-alpha-L-erythro-hex-4-enopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid-(1-4)-alpha-L-gulopyranuronic acid, Alginate lyase
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-14
公開日2021-07-28
最終更新日2024-05-01
実験手法X-RAY DIFFRACTION (2.177 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
7O77
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Structure of the PL6 family alginate lyase Patl3640 from Pseudoalteromonas atlantica T6c
分子名称: GLYCEROL, Poly(Beta-D-mannuronate) lyase
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-13
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (2.321 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
7O78
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Structure of the PL6 family chondroitinase B from Pseudopedobacter saltans, Pedsa3807
分子名称: Polysaccharide lyase from Pseudopedobacter saltans, Pedsa3807
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-13
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.58 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
7O7A
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BU of 7o7a by Molmil
Structure of the PL6 family alginate lyase Pedsa0632 from Pseudopedobacter saltans
分子名称: Aliginate lyase
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-13
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.99 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
7O79
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BU of 7o79 by Molmil
Structure of the PL6 family polysaccharide lyase Pedsa3628 from Pseudopedobacter saltans
分子名称: PHOSPHATE ION, Poly(Beta-D-mannuronate) lyase
著者Ballut, L, Violot, S, Carrique, L, Aghajari, N.
登録日2021-04-13
公開日2021-07-28
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.93 Å)
主引用文献Exploring molecular determinants of polysaccharide lyase family 6-1 enzyme activity.
Glycobiology, 31, 2021
6NPY
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BU of 6npy by Molmil
Cryo-EM structure of NLRP3 bound to NEK7
分子名称: ADENOSINE-5'-DIPHOSPHATE, NACHT, LRR and PYD domains-containing protein 3, ...
著者Sharif, H, Wang, L, Wang, W.L, Wu, H.
登録日2019-01-18
公開日2019-06-19
最終更新日2024-03-20
実験手法ELECTRON MICROSCOPY (3.8 Å)
主引用文献Structural mechanism for NEK7-licensed activation of NLRP3 inflammasome.
Nature, 570, 2019
6Q7J
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BU of 6q7j by Molmil
GH3 exo-beta-xylosidase (XlnD) in complex with xylobiose aziridine activity based probe
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Davies, G.J, Rowland, R.J, Wu, L, Moroz, O, Blagova, E.
登録日2018-12-13
公開日2019-06-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.14 Å)
主引用文献Dynamic and Functional Profiling of Xylan-Degrading Enzymes inAspergillusSecretomes Using Activity-Based Probes.
Acs Cent.Sci., 5, 2019
6NFW
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BU of 6nfw by Molmil
Potyvirus viral protein genome linked (VPg) emulates the m7G cap to recruit the eukaryotic translation initiation factor eIF4E
分子名称: VPg
著者Borden, K, Volpon, L, Osborne, M.
登録日2018-12-21
公開日2019-11-06
最終更新日2024-05-15
実験手法SOLUTION NMR
主引用文献Structural studies of the eIF4E-VPg complex reveal a direct competition for capped RNA: Implications for translation.
Proc.Natl.Acad.Sci.USA, 116, 2019
6NM4
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BU of 6nm4 by Molmil
Crystal structure of SAM-bound PRDM9 in complex with MRK-740 inhibitor
分子名称: 4-[3-(3,5-dimethoxyphenyl)-1,2,4-oxadiazol-5-yl]-1-methyl-9-(2-methylpyridin-4-yl)-1,4,9-triazaspiro[5.5]undecane, Histone-lysine N-methyltransferase PRDM9, S-ADENOSYLMETHIONINE, ...
著者Ivanochko, D, Halabelian, L, Fischer, C, Sanders, J.M, Kattar, S.D, Brown, P.J, Edwards, A.M, Bountra, C, Arrowsmith, C.H, Structural Genomics Consortium (SGC)
登録日2019-01-10
公開日2019-02-13
最終更新日2023-10-11
実験手法X-RAY DIFFRACTION (2.58 Å)
主引用文献Discovery of a chemical probe for PRDM9.
Nat Commun, 10, 2019
6GVH
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BU of 6gvh by Molmil
Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-4-chloro-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine
分子名称: 5-(6-azanyl-4-chloranyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F.
登録日2018-06-21
公開日2019-10-02
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.74 Å)
主引用文献Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.
Acs Med.Chem.Lett., 10, 2019
6QE8
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BU of 6qe8 by Molmil
Crystal structure of Aspergillus niger GH11 endoxylanase XynA in complex with xylobiose epoxide activity based probe
分子名称: (1~{R},3~{S},4~{R},5~{R})-5-[(2~{S},3~{R},4~{S},5~{R})-3,4,5-tris(oxidanyl)oxan-2-yl]oxycyclohexane-1,2,3,4-tetrol, 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, Endo-1,4-beta-xylanase A, ...
著者Wu, L, Rowland, R.J, Davies, G.J.
登録日2019-01-07
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献Dynamic and Functional Profiling of Xylan-Degrading Enzymes inAspergillusSecretomes Using Activity-Based Probes.
Acs Cent.Sci., 5, 2019
6Q7I
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BU of 6q7i by Molmil
GH3 exo-beta-xylosidase (XlnD)
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Davies, G.J, Rowland, R.J, Wu, L, Moroz, O, Blagova, E.
登録日2018-12-13
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.48 Å)
主引用文献Dynamic and Functional Profiling of Xylan-Degrading Enzymes inAspergillusSecretomes Using Activity-Based Probes.
Acs Cent.Sci., 5, 2019
6Q8N
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BU of 6q8n by Molmil
GH10 endo-xylanase in complex with xylobiose epoxide inhibitor
分子名称: (1~{R},2~{S},4~{S},5~{R})-cyclohexane-1,2,3,4,5-pentol, 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Davies, G.J, Rowland, R.J, Wu, L, Moroz, O, Blagova, E.
登録日2018-12-15
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.76 Å)
主引用文献Dynamic and Functional Profiling of Xylan-Degrading Enzymes inAspergillusSecretomes Using Activity-Based Probes.
Acs Cent.Sci., 5, 2019
6Q8M
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BU of 6q8m by Molmil
GH10 endo-xylanase
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-xylanase, ...
著者Davies, G.J, Rowland, R.J, Wu, L, Moroz, O, Blagova, E.
登録日2018-12-15
公開日2019-06-05
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.42 Å)
主引用文献Dynamic and Functional Profiling of Xylan-Degrading Enzymes inAspergillusSecretomes Using Activity-Based Probes.
Acs Cent.Sci., 5, 2019
6GVI
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BU of 6gvi by Molmil
Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-1H-pyrazolo[3,4-d]pyrimidine-4,6-diamine
分子名称: 3-(2-azanyl-1,3-benzoxazol-5-yl)-1-propan-2-yl-pyrazolo[3,4-d]pyrimidine-4,6-diamine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F.
登録日2018-06-21
公開日2019-10-02
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.
Acs Med.Chem.Lett., 10, 2019
5JKG
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BU of 5jkg by Molmil
The crystal structure of FGFR4 kinase domain in complex with LY2874455
分子名称: 2-[4-[E-2-[5-[(1R)-1-[3,5-bis(chloranyl)pyridin-4-yl]ethoxy]-1H-indazol-3-yl]ethenyl]pyrazol-1-yl]ethanol, Fibroblast growth factor receptor 4
著者Wu, D, Chen, L, Chen, Y.
登録日2016-04-26
公開日2016-10-05
最終更新日2024-03-20
実験手法X-RAY DIFFRACTION (2.352 Å)
主引用文献Crystal Structure of the FGFR4/LY2874455 Complex Reveals Insights into the Pan-FGFR Selectivity of LY2874455
Plos One, 11, 2016
6GVG
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Crystal structure of PI3K alpha in complex with 3-(2-Amino-benzooxazol-5-yl)-1-isopropyl-4-methyl-1H-pyrazolo[3,4-d]pyrimidin-6-ylamine
分子名称: 5-(6-azanyl-4-methyl-1-propan-2-yl-pyrazolo[3,4-d]pyrimidin-3-yl)-1,3-benzoxazol-2-amine, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform
著者Ouvry, G, Aurelly, M, Bonnary, L, Borde, E, Bouix-Peter, C, Chantalat, L, Clary, L, Defoin-Platel, C, Deret, S, Forissier, M, Harris, C.S, Isabet, T, Lamy, L, Luzy, A.P, Pascau, J, Soulet, C, Taddei, A, Taquet, N, Tomas, L, Thoreau, E, Varvier, E, Vial, E, Hennequin, L.F.
登録日2018-06-21
公開日2019-10-02
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Impact of Minor Structural Modifications on Properties of a Series of mTOR Inhibitors.
Acs Med.Chem.Lett., 10, 2019
1YMV
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BU of 1ymv by Molmil
SIGNAL TRANSDUCTION PROTEIN CHEY MUTANT WITH PHE 14 REPLACED BY GLY, SER 15 REPLACED BY GLY, AND MET 17 REPLACED BY GLY
分子名称: CHEY, MAGNESIUM ION
著者Bellsolell, L, Coll, M.
登録日1995-12-14
公開日1996-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献The three-dimensional structure of two mutants of the signal transduction protein CheY suggest its molecular activation mechanism.
J.Mol.Biol., 257, 1996
1YMU
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BU of 1ymu by Molmil
SIGNAL TRANSDUCTION PROTEIN CHEY MUTANT WITH MET 17 REPLACED BY GLY (M17G)
分子名称: CHEY
著者Bellsolell, L, Coll, M.
登録日1995-12-14
公開日1996-04-03
最終更新日2024-02-14
実験手法X-RAY DIFFRACTION (2.3 Å)
主引用文献The three-dimensional structure of two mutants of the signal transduction protein CheY suggest its molecular activation mechanism.
J.Mol.Biol., 257, 1996
5L7F
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BU of 5l7f by Molmil
Crystal structure of MMP12 mutant K421A in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21.
分子名称: 1,2-ETHANEDIOL, BROMIDE ION, CALCIUM ION, ...
著者Tepshi, L, Bordenave, T, Rouanet-Mehouas, C, Devel, L, Dive, V, Stura, E.A.
登録日2016-06-03
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (1.8 Å)
主引用文献Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.
Bioconjug.Chem., 27, 2016
5L79
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BU of 5l79 by Molmil
Crystal structure of MMP12 in complex with RXP470.1 conjugated with fluorophore Cy5,5 in space group P21212.
分子名称: 1,2-ETHANEDIOL, CALCIUM ION, CY5.5-PEG2, ...
著者Tepshi, L, Bordenave, T, Devel, L, Dive, V, Stura, E.A.
登録日2016-06-02
公開日2016-09-14
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.07 Å)
主引用文献Synthesis and in Vitro and in Vivo Evaluation of MMP-12 Selective Optical Probes.
Bioconjug.Chem., 27, 2016

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