3D1G
| Structure of a small molecule inhibitor bound to a DNA sliding clamp | Descriptor: | DNA polymerase III subunit beta, [(5R)-5-(2,3-dibromo-5-ethoxy-4-hydroxybenzyl)-4-oxo-2-thioxo-1,3-thiazolidin-3-yl]acetic acid | Authors: | Georgescu, R.E, Yurieva, O, Seung-Sup, K, Kuriyan, J, Kong, X.-P, O'Donnell, M. | Deposit date: | 2008-05-05 | Release date: | 2008-07-29 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (1.64 Å) | Cite: | Structure of a small-molecule inhibitor of a DNA polymerase sliding clamp. Proc.Natl.Acad.Sci.Usa, 105, 2008
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3DQX
| chicken c-Src kinase domain in complex with ATPgS | Descriptor: | ADENOSINE MONOPHOSPHATE, Proto-oncogene tyrosine-protein kinase Src | Authors: | Azam, M, Seeliger, M.A, Gray, N, Kuriyan, J, Daley, G.Q. | Deposit date: | 2008-07-09 | Release date: | 2008-09-23 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Activation of tyrosine kinases by mutation of the gatekeeper threonine. Nat.Struct.Mol.Biol., 15, 2008
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3TFD
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2024-02-28 | Method: | X-RAY DIFFRACTION (1.96 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF8
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120 | Descriptor: | Alr2278 protein, PROTOPORPHYRIN IX CONTAINING FE, SODIUM ION | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (2.1302 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TF0
| Crystal structure of an H-NOX protein from T. tengcongensis | Descriptor: | ACETATE ION, Methyl-accepting chemotaxis protein, OXYGEN MOLECULE, ... | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.743 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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3TFG
| Crystal structure of an H-NOX protein from Nostoc sp. PCC 7120, L66W/L67W double mutant | Descriptor: | Alr2278 protein, MALONIC ACID, PROTOPORPHYRIN IX CONTAINING FE | Authors: | Winter, M.B, Herzik Jr, M.A, Kuriyan, J, Marletta, M.A. | Deposit date: | 2011-08-15 | Release date: | 2011-11-09 | Last modified: | 2023-09-13 | Method: | X-RAY DIFFRACTION (1.9003 Å) | Cite: | Tunnels modulate ligand flux in a heme nitric oxide/oxygen binding (H-NOX) domain. Proc.Natl.Acad.Sci.USA, 108, 2011
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1XDV
| Experimentally Phased Structure of Human the Son of Sevenless protein at 4.1 Ang. | Descriptor: | Son of sevenless protein homolog 1 | Authors: | Sondermann, H, Soisson, S.M, Boykevisch, S, Yang, S.S, Bar-Sagi, D, Kuriyan, J. | Deposit date: | 2004-09-08 | Release date: | 2004-11-02 | Last modified: | 2023-08-23 | Method: | X-RAY DIFFRACTION (4.1 Å) | Cite: | Structural analysis of autoinhibition in the ras activator son of sevenless. Cell(Cambridge,Mass.), 119, 2004
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2HQA
| Crystal structure of the catalytic alpha subunit of E. Coli replicative DNA polymerase III | Descriptor: | DNA polymerase III alpha subunit, PHOSPHATE ION | Authors: | Lamers, M.H, Georgescu, R.E, Lee, S.G, O'Donnell, M, Kuriyan, J. | Deposit date: | 2006-07-18 | Release date: | 2006-09-19 | Last modified: | 2017-10-18 | Method: | X-RAY DIFFRACTION (2.6 Å) | Cite: | Crystal Structure of the Catalytic alpha Subunit of E. coli Replicative DNA Polymerase III. Cell(Cambridge,Mass.), 126, 2006
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2POL
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1DBH
| DBL AND PLECKSTRIN HOMOLOGY DOMAINS FROM HSOS1 | Descriptor: | PROTEIN (HUMAN SOS 1) | Authors: | Soisson, S.M, Kuriyan, J. | Deposit date: | 1998-12-17 | Release date: | 1998-12-23 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of the Dbl and pleckstrin homology domains from the human Son of sevenless protein. Cell(Cambridge,Mass.), 95, 1998
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2II0
| Crystal Structure of catalytic domain of Son of sevenless (Rem-Cdc25) in the absence of Ras | Descriptor: | Son of sevenless homolog 1 | Authors: | Freedman, T.S, Sondermann, H, Friedland, G.D, Kortemme, T, Bar-Sagi, D, Marqusee, S, Kuriyan, J. | Deposit date: | 2006-09-27 | Release date: | 2006-10-31 | Last modified: | 2023-08-30 | Method: | X-RAY DIFFRACTION (2.02 Å) | Cite: | A Ras-induced conformational switch in the Ras activator Son of sevenless. Proc.Natl.Acad.Sci.Usa, 103, 2006
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2IJE
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2HCK
| SRC FAMILY KINASE HCK-QUERCETIN COMPLEX | Descriptor: | 3,5,7,3',4'-PENTAHYDROXYFLAVONE, CALCIUM ION, HEMATOPOETIC CELL KINASE HCK | Authors: | Sicheri, F, Moarefi, I, Kuriyan, J. | Deposit date: | 1997-02-25 | Release date: | 1997-08-20 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (3 Å) | Cite: | Crystal structure of the Src family tyrosine kinase Hck. Nature, 385, 1997
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1IAJ
| CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (APO) | Descriptor: | TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ZINC ION | Authors: | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | Deposit date: | 2001-03-22 | Release date: | 2001-06-06 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol.Cell, 7, 2001
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1J90
| Crystal Structure of Drosophila Deoxyribonucleoside Kinase | Descriptor: | 2'-DEOXYCYTIDINE, Deoxyribonucleoside kinase, SULFATE ION | Authors: | Johansson, K, Ramaswamy, S, Ljungkrantz, C, Knecht, W, Piskur, J, Munch-Petersen, B, Eriksson, S, Eklund, H. | Deposit date: | 2001-05-23 | Release date: | 2001-11-28 | Last modified: | 2024-02-07 | Method: | X-RAY DIFFRACTION (2.56 Å) | Cite: | Structural basis for substrate specificities of cellular deoxyribonucleoside kinases. Nat.Struct.Biol., 8, 2001
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1IA9
| CRYSTAL STRUCTURE OF THE ATYPICAL PROTEIN KINASE DOMAIN OF A TRP CA-CHANNEL, CHAK (AMPPNP COMPLEX) | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, TRANSIENT RECEPTOR POTENTIAL-RELATED PROTEIN, ... | Authors: | Yamaguchi, H, Matsushita, M, Nairn, A.C, Kuriyan, J. | Deposit date: | 2001-03-22 | Release date: | 2001-06-06 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2 Å) | Cite: | Crystal structure of the atypical protein kinase domain of a TRP channel with phosphotransferase activity. Mol.Cell, 7, 2001
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2DYF
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1R43
| Crystal structure of beta-alanine synthase from Saccharomyces kluyveri (selenomethionine substituted protein) | Descriptor: | 2,3-DIHYDROXY-1,4-DITHIOBUTANE, 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BETA-AMINO ISOBUTYRATE, ... | Authors: | Lundgren, S, Gojkovic, Z, Piskur, J, Dobritzsch, D. | Deposit date: | 2003-10-03 | Release date: | 2003-11-11 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (2.8 Å) | Cite: | Yeast beta-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases J.Biol.Chem., 278
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1R3N
| Crystal structure of beta-alanine synthase from Saccharomyces kluyveri | Descriptor: | BETA-AMINO ISOBUTYRATE, ZINC ION, beta-alanine synthase | Authors: | Lundgren, S, Gojkovic, Z, Piskur, J, Dobritzsch, D. | Deposit date: | 2003-10-02 | Release date: | 2003-11-11 | Last modified: | 2024-04-03 | Method: | X-RAY DIFFRACTION (2.7 Å) | Cite: | Yeast beta-Alanine Synthase Shares a Structural Scaffold and Origin with Dizinc-dependent Exopeptidases J.Biol.Chem., 278, 2003
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1TDF
| CRYSTAL STRUCTURE OF ESCHERICHIA COLI THIOREDOXIN REDUCTASE REFINED AT 2 ANGSTROM RESOLUTION: IMPLICATIONS FOR A LARGE CONFORMATIONAL CHANGE DURING CATALYSIS | Descriptor: | FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, THIOREDOXIN REDUCTASE | Authors: | Waksman, G, Krishna, T.S.R, Williams Junior, C.H, Kuriyan, J. | Deposit date: | 1994-01-14 | Release date: | 1994-11-30 | Last modified: | 2024-02-14 | Method: | X-RAY DIFFRACTION (2.3 Å) | Cite: | Crystal structure of Escherichia coli thioredoxin reductase refined at 2 A resolution. Implications for a large conformational change during catalysis. J.Mol.Biol., 236, 1994
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3BOG
| Snow Flea Antifreeze Protein Quasi-racemate | Descriptor: | 6.5 kDa glycine-rich antifreeze protein, UNKNOWN LIGAND | Authors: | Pentelute, B.L, Kent, S.B.H, Gates, Z.P, Tereshko, V, Kossiakoff, A.A, Kurutz, J, Dashnau, J, Vaderkooi, J.M. | Deposit date: | 2007-12-17 | Release date: | 2008-09-23 | Last modified: | 2021-10-20 | Method: | X-RAY DIFFRACTION (1.2 Å) | Cite: | X-ray structure of snow flea antifreeze protein determined by racemic crystallization of synthetic protein enantiomers J.Am.Chem.Soc., 130, 2008
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2F86
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2DDT
| Crystal structure of sphingomyelinase from Bacillus cereus with magnesium ion | Descriptor: | 2-(N-MORPHOLINO)-ETHANESULFONIC ACID, MAGNESIUM ION, SULFATE ION, ... | Authors: | Ago, H, Oda, M, Tsuge, H, Katunuma, N, Miyano, M, Sakurai, J, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-02-02 | Release date: | 2006-05-02 | Last modified: | 2024-03-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural basis of the sphingomyelin phosphodiesterase activity in neutral sphingomyelinase from Bacillus cereus. J.Biol.Chem., 281, 2006
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2DDS
| Crystal structure of sphingomyelinase from Bacillus cereus with cobalt ion | Descriptor: | COBALT (II) ION, Sphingomyelin phosphodiesterase | Authors: | Ago, H, Oda, M, Takahashi, M, Tsuge, H, Ochi, S, Katunuma, N, Miyano, M, Sakurai, J, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-02-02 | Release date: | 2006-05-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus. J.Biol.Chem., 281, 2006
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2DDR
| Crystal structure of sphingomyelinase from Bacillus cereus with calcium ion | Descriptor: | CALCIUM ION, Sphingomyelin phosphodiesterase | Authors: | Ago, H, Oda, M, Takahashi, M, Tsuge, H, Ochi, S, Katunuma, N, Miyano, M, Sakurai, J, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | Deposit date: | 2006-02-02 | Release date: | 2006-05-02 | Last modified: | 2011-07-13 | Method: | X-RAY DIFFRACTION (1.4 Å) | Cite: | Structural Basis of the Sphingomyelin Phosphodiesterase Activity in Neutral Sphingomyelinase from Bacillus cereus. J.Biol.Chem., 281, 2006
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