7BOS
 
 | | Human SIRT2 in complex with myristoyl thiourea inhibitor, No.13 | | 分子名称: | Myristoyl thiourea inhibitor, No.13, N-dodecylmethanethioamide, ... | | 著者 | Kudo, N, Olsen, C.A, Minoru, Y. | | 登録日 | 2020-03-19 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration.
Rsc Chem Biol, 2, 2021
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7BOT
 | | Human SIRT2 in complex with myristoyl thiourea inhibitor, No.23 | | 分子名称: | N-dodecylmethanethioamide, NAD-dependent protein deacetylase sirtuin-2, ZINC ION, ... | | 著者 | Kudo, N, Olsen, C.A, Minoru, Y. | | 登録日 | 2020-03-19 | | 公開日 | 2021-03-24 | | 最終更新日 | 2023-11-29 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Mechanism-based inhibitors of SIRT2: structure-activity relationship, X-ray structures, target engagement, regulation of alpha-tubulin acetylation and inhibition of breast cancer cell migration.
Rsc Chem Biol, 2, 2021
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3H3T
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3H3Q
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3H3S
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3H3R
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5Y4H
 | | Human SIRT3 in complex with halistanol sulfate | | 分子名称: | NAD-dependent protein deacetylase sirtuin-3, mitochondrial, THr-Arg-Ser-GLY-ALY-VAL-MET-ARG-ARG-LEU-ARG-ARG, ... | | 著者 | Kudo, N, Ito, A, Yoshida, M. | | 登録日 | 2017-08-03 | | 公開日 | 2018-05-16 | | 最終更新日 | 2024-10-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Halistanol sulfates I and J, new SIRT1-3 inhibitory steroid sulfates from a marine sponge of the genus Halichondria
J. Antibiot., 71, 2018
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2Z9Z
 | | Crystal structure of CERT START domain(N504A mutant), in complex with C10-diacylglycerol | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, Lipid-transfer protein CERT | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2007-09-26 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.74 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2Z9Y
 | | Crystal structure of CERT START domain in complex with C10-diacylglycerol | | 分子名称: | (2S)-3-hydroxypropane-1,2-diyl didecanoate, Lipid-transfer protein CERT | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2007-09-26 | | 公開日 | 2008-02-12 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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5Y0Z
 | | Human SIRT2 in complex with a specific inhibitor, NPD11033 | | 分子名称: | (1~{R},9~{S})-11-[(2~{R})-3-[2,4-bis(2-methylbutan-2-yl)phenoxy]-2-oxidanyl-propyl]-7,11-diazatricyclo[7.3.1.0^{2,7}]trideca-2,4-dien-6-one, NAD-dependent protein deacetylase sirtuin-2, ZINC ION | | 著者 | Kudo, N, Ito, A, Yoshida, M. | | 登録日 | 2017-07-19 | | 公開日 | 2018-07-25 | | 最終更新日 | 2023-11-22 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Identification of a novel small molecule that inhibits deacetylase but not defatty-acylase reaction catalysed by SIRT2.
Philos. Trans. R. Soc. Lond., B, Biol. Sci., 373, 2018
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2E3M
 | | Crystal structure of CERT START domain | | 分子名称: | Lipid-transfer protein CERT | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2E3S
 | | Crystal structure of CERT START domain co-crystallized with C24-ceramide (P21) | | 分子名称: | Lipid-transfer protein CERT | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.94 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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3VTG
 | | High choriolytic enzyme 1 (HCE-1), a hatching enzyme zinc-protease from Oryzias latipes (Medaka fish) | | 分子名称: | High choriolytic enzyme 1, ZINC ION | | 著者 | Kudo, N, Yasumasu, S, Iuchi, I, Tanokura, M. | | 登録日 | 2012-05-30 | | 公開日 | 2013-06-05 | | 最終更新日 | 2017-11-22 | | 実験手法 | X-RAY DIFFRACTION (1.34 Å) | | 主引用文献 | Crystal Structure of High choriolytic enzyme 1 (HCE-1), a hatching enzyme from Oryzias latipes (Medaka fish)
To be Published
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3VVH
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2E3P
 | | Crystal structure of CERT START domain in complex with C16-cearmide (P1) | | 分子名称: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2E3N
 | | Crystal structure of CERT START domain in complex with C6-ceramide (P212121) | | 分子名称: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)HEXANAMIDE | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.4 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2E3R
 | | Crystal structure of CERT START domain in complex with C18-ceramide (P1) | | 分子名称: | Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2E3O
 | | Crystal structure of CERT START domain in complex with C16-ceramide (P212121) | | 分子名称: | DIMETHYL SULFOXIDE, Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)PALMITAMIDE | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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2E3Q
 | | Crystal structure of CERT START domain in complex with C18-ceramide (P212121) | | 分子名称: | DIMETHYL SULFOXIDE, Lipid-transfer protein CERT, N-((E,2S,3R)-1,3-DIHYDROXYOCTADEC-4-EN-2-YL)STEARAMIDE | | 著者 | Kudo, N, Kumagai, K, Wakatsuki, S, Nishijima, M, Hanada, K, Kato, R. | | 登録日 | 2006-11-28 | | 公開日 | 2007-12-18 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.08 Å) | | 主引用文献 | Structural basis for specific lipid recognition by CERT responsible for nonvesicular trafficking of ceramide.
Proc.Natl.Acad.Sci.Usa, 105, 2008
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4Y6Q
 | | Human SIRT2 in complex with 2-O-myristoyl-ADP-ribose | | 分子名称: | NAD-dependent protein deacetylase sirtuin-2, ZINC ION, [(2S,3R,4R,5R)-5-[[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-3,4-bis(oxidanyl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl]oxy-oxidanyl-phosphoryl]oxymethyl]-2,4-bis(oxidanyl)oxolan-3-yl] tetradecanoate | | 著者 | Kudo, N, Ito, A, Yoshida, M. | | 登録日 | 2015-02-13 | | 公開日 | 2016-01-06 | | 最終更新日 | 2023-11-08 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Kinetic and Structural Basis for Acyl-Group Selectivity and NAD(+) Dependence in Sirtuin-Catalyzed Deacylation.
Biochemistry, 54, 2015
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4Y6O
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4Y6L
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1V3Y
 | | The crystal structure of peptide deformylase from Thermus thermophilus HB8 | | 分子名称: | Peptide deformylase | | 著者 | Kamo, M, Kudo, N, Lee, W.C, Ito, K, Motoshim, H, Tanokura, M, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 2003-11-07 | | 公開日 | 2004-12-28 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (1.81 Å) | | 主引用文献 | The crystal structure of peptide deformylase from Thermus thermophilus HB8
to be published
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1EQK
 | | SOLUTION STRUCTURE OF ORYZACYSTATIN-I, A CYSTEINE PROTEINASE INHIBITOR OF THE RICE, ORYZA SATIVA L. JAPONICA | | 分子名称: | ORYZACYSTATIN-I | | 著者 | Nagata, K, Kudo, N, Abe, K, Arai, S, Tanokura, M. | | 登録日 | 2000-04-05 | | 公開日 | 2001-01-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Three-dimensional solution structure of oryzacystatin-I, a cysteine proteinase inhibitor of the rice, Oryza sativa L. japonica.
Biochemistry, 39, 2000
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3AAD
 | | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction | | 分子名称: | Histone chaperone ASF1A, SULFATE ION, Transcription initiation factor TFIID subunit 1 | | 著者 | Akai, Y, Adachi, N, Hayashi, Y, Eitoku, M, Sano, N, Natsume, R, Kudo, N, Tanokura, M, Senda, T, Horikoshi, M. | | 登録日 | 2009-11-16 | | 公開日 | 2010-04-28 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | | 主引用文献 | Structure of the histone chaperone CIA/ASF1-double bromodomain complex linking histone modifications and site-specific histone eviction
Proc.Natl.Acad.Sci.USA, 107, 2010
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