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PDB: 121 件
5JP3
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BU of 5jp3 by Molmil
Structure of Xanthomonas campestris effector protein XopD bound to ubiquitin
分子名称: Polyubiquitin-B, Xanthomonas outer protein D
著者Pruneda, J.N, Komander, D.
登録日2016-05-03
公開日2016-07-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5JP1
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BU of 5jp1 by Molmil
Structure of Xanthomonas campestris effector protein XopD bound to tomato SUMO
分子名称: (4S,5S)-1,2-DITHIANE-4,5-DIOL, MALONATE ION, Small ubiquitin-related modifier, ...
著者Pruneda, J.N, Komander, D.
登録日2016-05-03
公開日2016-07-27
最終更新日2024-01-10
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献The Molecular Basis for Ubiquitin and Ubiquitin-like Specificities in Bacterial Effector Proteases.
Mol.Cell, 63, 2016
5LRV
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BU of 5lrv by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to Lys11-linked diubiquitin
分子名称: GLYCEROL, OTU domain-containing protein 7B, PHOSPHATE ION, ...
著者Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
登録日2016-08-22
公開日2016-10-19
最終更新日2023-11-15
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
5LRW
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BU of 5lrw by Molmil
Structure of Cezanne/OTUD7B OTU domain bound to ubiquitin
分子名称: GLYCEROL, OTU domain-containing protein 7B, Polyubiquitin-B
著者Mevissen, T.E.T, Kulathu, Y, Mulder, M.P.C, Geurink, P.P, Maslen, S.L, Gersch, M, Elliott, P.R, Burke, J.E, van Tol, B.D.M, Akutsu, M, El Oualid, F, Kawasaki, M, Freund, S.M.V, Ovaa, H, Komander, D.
登録日2016-08-22
公開日2016-10-19
最終更新日2017-09-13
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Molecular basis of Lys11-polyubiquitin specificity in the deubiquitinase Cezanne.
Nature, 538, 2016
3ZJE
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BU of 3zje by Molmil
A20 OTU domain in reversibly oxidised (SOH) state
分子名称: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZNZ
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BU of 3znz by Molmil
Crystal structure of OTULIN OTU domain (C129A) in complex with Met1- di ubiquitin
分子名称: POLYUBIQUITIN-C, PROTEIN FAM105B, SULFATE ION
著者Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D.
登録日2013-02-18
公開日2013-06-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
3ZNX
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BU of 3znx by Molmil
Crystal structure of the OTU domain of OTULIN D336A mutant
分子名称: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
著者Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D.
登録日2013-02-18
公開日2013-06-26
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.35 Å)
主引用文献Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
3ZJF
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A20 OTU domain with irreversibly oxidised Cys103 from 270 min H2O2 soak.
分子名称: A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJD
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A20 OTU domain in reduced, active state at 1.87 A resolution
分子名称: 1,2-ETHANEDIOL, A20P50, CHLORIDE ION
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.87 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
3ZJG
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BU of 3zjg by Molmil
A20 OTU domain with irreversibly oxidised Cys103 from 60 min H2O2 soak.
分子名称: CHLORIDE ION, TUMOR NECROSIS FACTOR ALPHA-INDUCED PROTEIN 3
著者Kulathu, Y, Garcia, F.J, Mevissen, T.E.T, Busch, M, Arnaudo, N, Carroll, K.S, Barford, D, Komander, D.
登録日2013-01-17
公開日2013-03-06
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (1.92 Å)
主引用文献Regulation of A20 and Other Otu Deubiquitinases by Reversible Oxidation
Nat.Commun., 4, 2013
5OE7
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BU of 5oe7 by Molmil
Structure of OTULIN bound to the Met1-linked diubiquitin activity probe
分子名称: Polyubiquitin-C, Ubiquitin thioesterase otulin
著者Elliott, P.R, Komander, D.
登録日2017-07-07
公開日2017-09-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.95 Å)
主引用文献A Linear Diubiquitin-Based Probe for Efficient and Selective Detection of the Deubiquitinating Enzyme OTULIN.
Cell Chem Biol, 24, 2017
3ZNV
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BU of 3znv by Molmil
Crystal structure of the OTU domain of OTULIN at 1.3 Angstroms.
分子名称: CALCIUM ION, CHLORIDE ION, GLYCEROL, ...
著者Keusekotten, K, Elliott, P.R, Glockner, L, Kulathu, Y, Wauer, T, Krappmann, D, Hofmann, K, Komander, D.
登録日2013-02-18
公開日2013-06-26
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Otulin Antagonizes Lubac Signaling by Specifically Hydrolyzing met1-Linked Polyubiquitin.
Cell(Cambridge,Mass.), 153, 2013
6HEJ
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BU of 6hej by Molmil
Structure of human USP28
分子名称: SULFATE ION, Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.79 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6GZS
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BU of 6gzs by Molmil
Structure of Chlamydia trachomatis effector protein ChlaDUB1 bound to ubiquitin
分子名称: Deubiquitinase and deneddylase Dub1, GLYCEROL, Polyubiquitin-B, ...
著者Pruneda, J.N, Komander, D.
登録日2018-07-05
公開日2018-11-14
最終更新日2018-12-05
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献A Chlamydia effector combining deubiquitination and acetylation activities induces Golgi fragmentation.
Nat Microbiol, 3, 2018
6HEK
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BU of 6hek by Molmil
Structure of human USP28 bound to Ubiquitin-PA
分子名称: CHLORIDE ION, Polyubiquitin-B, TETRAETHYLENE GLYCOL, ...
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEM
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BU of 6hem by Molmil
Structure of the C-terminal domain of USP25 (748-1048)
分子名称: GLYCEROL, SODIUM ION, Ubiquitin carboxyl-terminal hydrolase 25
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEH
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BU of 6heh by Molmil
Structure of the catalytic domain of USP28 (insertion deleted)
分子名称: 1,2-ETHANEDIOL, CHLORIDE ION, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.26 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEI
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BU of 6hei by Molmil
Structure of the catalytic domain of USP28 (insertion deleted) bound to Ubiquitin-PA
分子名称: 1,2-ETHANEDIOL, Polyubiquitin-B, Ubiquitin carboxyl-terminal hydrolase 28,Ubiquitin carboxyl-terminal hydrolase 28
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (1.64 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6HEL
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BU of 6hel by Molmil
Structure of human USP25
分子名称: Ubiquitin carboxyl-terminal hydrolase 25
著者Gersch, M, Komander, D.
登録日2018-08-20
公開日2019-03-27
最終更新日2024-01-17
実験手法X-RAY DIFFRACTION (2.941 Å)
主引用文献Distinct USP25 and USP28 Oligomerization States Regulate Deubiquitinating Activity.
Mol.Cell, 74, 2019
6I9C
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BU of 6i9c by Molmil
Structure of the OTU domain of OTULIN G281R mutant
分子名称: CHLORIDE ION, GLYCEROL, Ubiquitin thioesterase otulin
著者Damgaard, R.B, Elliott, P.R, Swatek, K.N, Maher, E.R, Stepensky, P, Elpeleg, O, Komander, D, Berkun, Y.
登録日2018-11-22
公開日2019-03-06
最終更新日2024-05-15
実験手法X-RAY DIFFRACTION (1.77 Å)
主引用文献OTULIN deficiency in ORAS causes cell type-specific LUBAC degradation, dysregulated TNF signalling and cell death.
Embo Mol Med, 11, 2019
2WX1
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BU of 2wx1 by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked tri-ubiquitin, P212121
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (3 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WWZ
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BU of 2wwz by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P212121
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
2WX0
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BU of 2wx0 by Molmil
TAB2 NZF DOMAIN IN COMPLEX WITH Lys63-linked di-ubiquitin, P21
分子名称: MITOGEN-ACTIVATED PROTEIN KINASE KINASE KINASE 7-INTERACTING PROTEIN 2, UBIQUITIN, ZINC ION
著者Kulathu, Y, Akutsu, M, Bremm, A, Hofmann, K, Komander, D.
登録日2009-10-30
公開日2009-11-24
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Two-Sided Ubiquitin Binding Explains Specificity of the Tab2 Nzf Domain
Nat.Struct.Mol.Biol., 16, 2009
4BOP
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BU of 4bop by Molmil
Structure of OTUD1 OTU domain
分子名称: OTU DOMAIN-CONTAINING PROTEIN 1, PHOSPHATE ION
著者Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
登録日2013-05-22
公開日2013-07-17
最終更新日2024-05-08
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013
4BOZ
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Structure of OTUD2 OTU domain in complex with K11-linked di ubiquitin
分子名称: GLYCEROL, UBIQUITIN THIOESTERASE OTU1, UBIQUITIN-C
著者Mevissen, T.E.T, Hospenthal, M.K, Geurink, P.P, Elliott, P.R, Akutsu, M, Arnaudo, N, Ekkebus, R, Kulathu, Y, Wauer, T, El Oualid, F, Freund, S.M.V, Ovaa, H, Komander, D.
登録日2013-05-22
公開日2013-07-17
最終更新日2023-12-20
実験手法X-RAY DIFFRACTION (3.03 Å)
主引用文献Otu Deubiquitinases Reveal Mechanisms of Linkage Specificity and Enable Ubiquitin Chain Restriction Analysis.
Cell(Cambridge,Mass.), 154, 2013

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