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PDB: 84 件
8T94
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Influenza PAN endonuclease with 6-(4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl)-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxylic acid
分子名称: (6M)-3-hydroxy-4-oxo-6-[(4M)-4-(1H-tetrazol-5-yl)-2-(trifluoromethyl)phenyl]-1,4-dihydropyridine-2-carboxylic acid, MANGANESE (II) ION, Polymerase acidic protein
著者Kohlbrand, A.J, Cohen, S.M.
登録日2023-06-23
公開日2024-05-08
実験手法X-RAY DIFFRACTION (2.11 Å)
主引用文献Structural Studies of Inhibitors with Clinically Relevant Influenza Endonuclease Variants.
Biochemistry, 63, 2024
7V04
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The N-terminal domain of PA endonuclease from the influenza H1N1 viral polymerase in complex with 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide
分子名称: 6-bromo-3-hydroxy-4-oxo-1,4-dihydropyridine-2-carboxamide, MANGANESE (II) ION, Polymerase acidic protein
著者Kohlbrand, A.J, Stokes, R.W, Karges, J, Seo, H, Sankaran, B, Cohen, S.M.
登録日2022-05-09
公開日2022-12-21
最終更新日2023-10-25
実験手法X-RAY DIFFRACTION (1.91 Å)
主引用文献Carboxylic Acid Isostere Derivatives of Hydroxypyridinones as Core Scaffolds for Influenza Endonuclease Inhibitors.
Acs Med.Chem.Lett., 14, 2023
3F0M
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BU of 3f0m by Molmil
Crystal structure of radical D105N Synechocystis sp. PcyA
分子名称: 1,2-ETHANEDIOL, BILIVERDINE IX ALPHA, Phycocyanobilin:ferredoxin oxidoreductase
著者Kohler, A.C, Gae, D.D.
登録日2008-10-25
公開日2009-10-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.5 Å)
主引用文献Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants.
Biochemistry, 49, 2010
3F0L
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Crystal structure of oxidized D105N Synechocystis sp. PcyA
分子名称: 1,2-ETHANEDIOL, BILIVERDINE IX ALPHA, Phycocyanobilin:ferredoxin oxidoreductase
著者Kohler, A.C, Gae, D.D.
登録日2008-10-25
公開日2009-10-13
最終更新日2023-12-27
実験手法X-RAY DIFFRACTION (1.3 Å)
主引用文献Structural basis for hydration dynamics in radical stabilization of bilin reductase mutants.
Biochemistry, 49, 2010
1MJ0
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BU of 1mj0 by Molmil
SANK E3_5: an artificial Ankyrin repeat protein
分子名称: 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SANK E3_5 Protein, SULFATE ION
著者Kohl, A, Binz, H.K, Forrer, P, Stumpp, M.T, Plueckthun, A, Gruetter, M.G.
登録日2002-08-26
公開日2003-01-21
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.031 Å)
主引用文献Designed to be stable: Crystal structure of a consensus ankyrin repeat protein
Proc.Natl.Acad.Sci.USA, 100, 2003
3M99
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BU of 3m99 by Molmil
Structure of the Ubp8-Sgf11-Sgf73-Sus1 SAGA DUB module
分子名称: Protein SUS1, SAGA-associated factor 11, SAGA-associated factor 73, ...
著者Kohler, A, Zimmerman, E, Schneider, M, Hurt, E, Zheng, N.
登録日2010-03-21
公開日2010-05-05
最終更新日2023-09-06
実験手法X-RAY DIFFRACTION (2.7 Å)
主引用文献Structural basis for assembly and activation of the heterotetrameric SAGA histone H2B deubiquitinase module.
Cell(Cambridge,Mass.), 141, 2010
2BKK
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BU of 2bkk by Molmil
Crystal structure of Aminoglycoside Phosphotransferase APH(3')-IIIa in complex with the inhibitor AR_3a
分子名称: ADENOSINE-5'-DIPHOSPHATE, AMINOGLYCOSIDE 3'-PHOSPHOTRANSFERASE, DESIGNED ANKYRIN REPEAT INHIBITOR AR_3A, ...
著者Kohl, A, Amstutz, P, Parizek, P, Binz, H.K, Briand, C, Capitani, G, Forrer, P, Pluckthun, A, Grutter, M.G.
登録日2005-02-16
公開日2005-08-09
最終更新日2023-12-13
実験手法X-RAY DIFFRACTION (2.15 Å)
主引用文献Allosteric Inhibition of Aminoglycoside Phosphotransferase by a Designed Ankyrin Repeat Protein
Structure, 13, 2005
4MI7
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Crystal Structure of Salmonella Effector Protein GtgE
分子名称: Bacteriophage encoded virulence factor, SULFATE ION
著者Kohler, A.C, Stebbins, C.E.
登録日2013-08-30
公開日2014-02-12
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (1.65 Å)
主引用文献Structural and enzymatic characterization of a host-specificity determinant from Salmonella.
Acta Crystallogr.,Sect.D, 70, 2014
8QVW
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BU of 8qvw by Molmil
Cryo-EM structure of the peptide binding domain of human SRP68/72
分子名称: Signal recognition particle subunit SRP68, Signal recognition particle subunit SRP72
著者Zhong, Y, Feng, J, Koh, A.F, Kotecha, A, Greber, B.J, Ataide, S.F.
登録日2023-10-18
公開日2024-02-07
実験手法ELECTRON MICROSCOPY (3 Å)
主引用文献Structure of nPBD of human SRP68/72
To Be Published
8P73
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Cryo-EM structure of CAK in complex with inhibitor ICEC0829
分子名称: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidine-3,4-diol, CDK-activating kinase assembly factor MAT1, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8ORM
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BU of 8orm by Molmil
Cryo-EM structure of CAK-THZ1
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-04-14
公開日2023-08-30
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6Y
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BU of 8p6y by Molmil
Cryo-EM structure of CAK in complex with nucleotide analogue ATPgS
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2023-08-30
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6V
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BU of 8p6v by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0942
分子名称: (3R,4R)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2023-08-30
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8PLZ
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BU of 8plz by Molmil
Cryo-EM structure of CAK in complex with inhibitor CT7030
分子名称: (3~{R},4~{R})-4-[[[7-[(2-methoxyphenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-06-27
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P7L
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Cryo-EM structure of CDK7 subunit of CAK in complex with inhibitor LDC4297
分子名称: 2-[(3S)-piperidin-3-yl]oxy-8-propan-2-yl-N-[(2-pyrazol-1-ylphenyl)methyl]pyrazolo[1,5-a][1,3,5]triazin-4-amine, CDK-activating kinase assembly factor MAT1, Cyclin-dependent kinase 7
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P71
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BU of 8p71 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0574
分子名称: (3R,4S)-4-[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]pyrrolidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P79
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BU of 8p79 by Molmil
Cryo-EM structure of CAK with averaged inhibitor density
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.7 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6Z
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BU of 8p6z by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0510-R
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.1 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6W
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Cryo-EM structure of CAK in complex with inhibitor BS-181
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P70
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BU of 8p70 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0510-S
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P74
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Cryo-EM structure of CAK in complex with inhibitor ICEC0880 (ring-up conformation)
分子名称: (2S,3S)-3-[[7-[(2-bromophenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2.2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P75
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Cryo-EM structure of CAK in complex with inhibitor ICEC0880 (ring-down conformation)
分子名称: (2S,3S)-3-[[7-[(2-bromophenyl)methylamino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]butane-1,2,4-triol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P6X
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Cryo-EM structure of CAK in complex with inhibitor BS-194
分子名称: (2S,3S)-3-{[7-(benzylamino)-3-(1-methylethyl)pyrazolo[1,5-a]pyrimidin-5-yl]amino}butane-1,2,4-triol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.9 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P76
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Cryo-EM structure of CAK in complex with inhibitor ICEC0914
分子名称: CDK-activating kinase assembly factor MAT1, Cyclin-H, Cyclin-dependent kinase 7, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (2 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024
8P77
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BU of 8p77 by Molmil
Cryo-EM structure of CAK in complex with inhibitor ICEC0943
分子名称: (3S,4S)-4-[[[7-[(phenylmethyl)amino]-3-propan-2-yl-pyrazolo[1,5-a]pyrimidin-5-yl]amino]methyl]piperidin-3-ol, CDK-activating kinase assembly factor MAT1, Cyclin-H, ...
著者Cushing, V.I, Koh, A.F, Feng, J, Jurgaityte, K, Bahl, A.K, Ali, S, Kotecha, A, Greber, B.J.
登録日2023-05-30
公開日2024-03-20
最終更新日2024-03-27
実験手法ELECTRON MICROSCOPY (1.8 Å)
主引用文献High-resolution cryo-EM of the human CDK-activating kinase for structure-based drug design.
Nat Commun, 15, 2024

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