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PDB: 53 results
8G4U
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BU of 8g4u by Molmil
Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase
Descriptor: EryAIII
Authors:Keatinge-Clay, A.T.
Deposit date:2023-02-10
Release date:2023-03-01
Last modified:2024-05-22
Method:X-RAY DIFFRACTION (2.9 Å)
Cite:Crystal structures reveal the framework of cis -acyltransferase modular polyketide synthases.
Biorxiv, 2023
8CZC
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BU of 8czc by Molmil
AT from first module of the pikromycin synthase
Descriptor: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
Authors:Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
Deposit date:2022-05-24
Release date:2022-06-08
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.86 Å)
Cite:Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
3EL6
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BU of 3el6 by Molmil
Crystal Structure of the Erythromycin Dehydratase
Descriptor: CHLORIDE ION, Erythromycin dehydratase, SULFATE ION
Authors:Keatinge-Clay, A.T.
Deposit date:2008-09-20
Release date:2008-11-11
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.85 Å)
Cite:Crystal structure of the erythromycin polyketide synthase dehydratase.
J.Mol.Biol., 384, 2008
7UWR
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BU of 7uwr by Molmil
KSQ+AT from first module of the pikromycin synthase
Descriptor: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
Authors:Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
Deposit date:2022-05-03
Release date:2022-06-08
Last modified:2024-06-12
Method:ELECTRON MICROSCOPY (2.61 Å)
Cite:Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
2Z5L
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BU of 2z5l by Molmil
The first ketoreductase of the tylosin PKS
Descriptor: Tylactone synthase starter module and modules 1 & 2
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2007-07-14
Release date:2007-08-28
Last modified:2023-11-01
Method:X-RAY DIFFRACTION (1.95 Å)
Cite:A tylosin ketoreductase reveals how chirality is determined in polyketides
Chem.Biol., 14, 2007
1TQY
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BU of 1tqy by Molmil
The Actinorhodin Ketosynthase/Chain Length Factor
Descriptor: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
Authors:Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
Deposit date:2004-06-18
Release date:2004-07-27
Last modified:2023-08-23
Method:X-RAY DIFFRACTION (2 Å)
Cite:An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
5KKU
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BU of 5kku by Molmil
Crystal structure of an N-terminal dehydratase from difficidin assembly line
Descriptor: Polyketide synthase type I
Authors:Keatinge-Clay, A.T, Zeng, J.
Deposit date:2016-06-22
Release date:2016-12-21
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.22 Å)
Cite:A Dehydratase Provides Insights into Split Bimodules and Polypeptide Docking in trans-AT Polyketide Synthases
To Be Published
1NM2
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BU of 1nm2 by Molmil
Malonyl-CoA:ACP Transacylase
Descriptor: ACETIC ACID, NICKEL (II) ION, malonyl CoA:acyl carrier protein malonyltransferase
Authors:Keatinge-Clay, A.T, Shelat, A.A, Savage, D.F, Tsai, S, Miercke, L.J.W, O'Connell III, J.D, Khosla, C, Stroud, R.M.
Deposit date:2003-01-08
Release date:2003-01-21
Last modified:2023-08-16
Method:X-RAY DIFFRACTION (2 Å)
Cite:Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
Structure, 11, 2003
2FR0
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BU of 2fr0 by Molmil
The first ketoreductase of the erythromycin synthase (crystal form 1)
Descriptor: Erythromycin synthase, EryAI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2006-01-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.81 Å)
Cite:The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
2FR1
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BU of 2fr1 by Molmil
The first ketoreductase of the erythromycin synthase (crystal form 2)
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, erythromycin synthase, EryAI
Authors:Keatinge-Clay, A.T, Stroud, R.M.
Deposit date:2006-01-18
Release date:2006-04-04
Last modified:2024-04-03
Method:X-RAY DIFFRACTION (1.79 Å)
Cite:The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
5D2E
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BU of 5d2e by Molmil
crystal structure of an N-terminal ketoreductase from macrolactin assembly line
Descriptor: GLYCEROL, MlnE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
Authors:Keatinge-clay, A.T, Zeng, J.
Deposit date:2015-08-05
Release date:2015-08-26
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (1.72 Å)
Cite:The crystal structure of an N-terminal ketoreductase from macrolactin polyketide synthase
To Be Published
3NYR
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BU of 3nyr by Molmil
Malonyl-CoA Ligase Ternary Product Complex with Malonyl-CoA and AMP bound
Descriptor: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, MALONYL-COENZYME A, ...
Authors:Hughes, A.J, Keatinge-Clay, A.T.
Deposit date:2010-07-15
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.45 Å)
Cite:Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Functional Showcasing of Streptomyces coelicolor MatB.
Chem.Biol., 18, 2011
4W61
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BU of 4w61 by Molmil
Crystal structure of beta-ketoacyl thiolase B (BktB) from Ralstonia eutropha
Descriptor: Beta-ketothiolase BktB
Authors:Fage, C.D, Keatinge-Clay, A.T.
Deposit date:2014-08-19
Release date:2015-09-09
Last modified:2023-09-27
Method:X-RAY DIFFRACTION (2.01 Å)
Cite:Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous beta-ketoacyl thiolase fromRalstonia eutropha.
J. Mol. Catal., B Enzym., 121, 2015
5ELP
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BU of 5elp by Molmil
Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
Descriptor: NRPS/PKS protein
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Zogzas, C.E.
Deposit date:2015-11-04
Release date:2016-01-13
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (2.93 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERB
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BU of 5erb by Molmil
Ketosynthase from module 5 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
Descriptor: Polyketide synthase
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Meinke, J.
Deposit date:2015-11-13
Release date:2015-12-23
Last modified:2017-09-27
Method:X-RAY DIFFRACTION (4.2 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ENY
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BU of 5eny by Molmil
Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168
Descriptor: Polyketide synthase PksL
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-11-09
Release date:2015-12-23
Last modified:2016-11-02
Method:X-RAY DIFFRACTION (4 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERF
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BU of 5erf by Molmil
Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168
Descriptor: Polyketide synthase PksL
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2015-11-14
Release date:2015-12-23
Last modified:2019-12-25
Method:X-RAY DIFFRACTION (3.1 Å)
Cite:The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
3NYQ
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BU of 3nyq by Molmil
Malonyl-CoA Ligase Ternary Product Complex with Methylmalonyl-CoA and AMP bound
Descriptor: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
Authors:Hughes, A.J, Keatinge-Clay, A.T.
Deposit date:2010-07-15
Release date:2011-03-30
Last modified:2024-02-21
Method:X-RAY DIFFRACTION (1.43 Å)
Cite:Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Functional Showcasing of Streptomyces coelicolor MatB.
Chem.Biol., 18, 2011
1MZJ
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BU of 1mzj by Molmil
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
Descriptor: ACETYL GROUP, Beta-ketoacylsynthase III, COENZYME A
Authors:Pan, H, Tsai, S.C, Meadows, E.S, Miercke, L.J.W, Keatinge-Clay, A, O'Connell, J, Khosla, C, Stroud, R.M.
Deposit date:2002-10-08
Release date:2002-12-11
Last modified:2011-07-13
Method:X-RAY DIFFRACTION (2.1 Å)
Cite:Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
4DIF
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BU of 4dif by Molmil
Structure of A1-type ketoreductase
Descriptor: AmphB, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2012-01-30
Release date:2013-02-13
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.521 Å)
Cite:Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity
To be Published
6B2V
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BU of 6b2v by Molmil
Pyran synthase domain from module nine of the sorangicin pathway
Descriptor: SorB
Authors:Wagner, D.T, Keatinge-Clay, A.T.
Deposit date:2017-09-20
Release date:2018-04-18
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.55 Å)
Cite:Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
6CCA
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BU of 6cca by Molmil
Crystal structure of DszA carbon methyltransferase
Descriptor: DisA protein
Authors:Meinke, J.L, Keatinge-Clay, A.T.
Deposit date:2018-02-06
Release date:2018-12-05
Last modified:2024-03-13
Method:X-RAY DIFFRACTION (1.75 Å)
Cite:Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
5KTK
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BU of 5ktk by Molmil
Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
Descriptor: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase PksJ
Authors:Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
Deposit date:2016-07-11
Release date:2016-09-07
Last modified:2023-10-04
Method:X-RAY DIFFRACTION (1.98 Å)
Cite:Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
To Be Published
3QP9
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BU of 3qp9 by Molmil
The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase
Descriptor: Type I polyketide synthase PikAII
Authors:Zheng, J, Keatinge-Clay, A.T.
Deposit date:2011-02-11
Release date:2011-05-11
Last modified:2023-09-13
Method:X-RAY DIFFRACTION (1.88 Å)
Cite:Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases.
J.Mol.Biol., 410, 2011
4QXL
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BU of 4qxl by Molmil
Crystal Structure of FLHE
Descriptor: Flagellar protein flhE
Authors:Lee, J, Monzingo, A.F, Keatinge-Clay, A.T, Harshey, R.M.
Deposit date:2014-07-21
Release date:2015-01-14
Last modified:2017-11-22
Method:X-RAY DIFFRACTION (1.512 Å)
Cite:Structure of Salmonella FlhE, Conserved Member of a Flagellar Type III Secretion Operon.
J.Mol.Biol., 427, 2015

 

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數據於2024-09-11公開中

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