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PDB: 53 件
8G4U
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BU of 8g4u by Molmil
Final ketosynthase+acyltransferase of the erythromycin modular polyketide synthase
分子名称: EryAIII
著者Keatinge-Clay, A.T.
登録日2023-02-10
公開日2023-03-01
最終更新日2024-05-22
実験手法X-RAY DIFFRACTION (2.9 Å)
主引用文献Crystal structures reveal the framework of cis -acyltransferase modular polyketide synthases.
Biorxiv, 2023
8CZC
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AT from first module of the pikromycin synthase
分子名称: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
著者Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
登録日2022-05-24
公開日2022-06-08
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.86 Å)
主引用文献Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
3EL6
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Crystal Structure of the Erythromycin Dehydratase
分子名称: CHLORIDE ION, Erythromycin dehydratase, SULFATE ION
著者Keatinge-Clay, A.T.
登録日2008-09-20
公開日2008-11-11
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.85 Å)
主引用文献Crystal structure of the erythromycin polyketide synthase dehydratase.
J.Mol.Biol., 384, 2008
7UWR
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KSQ+AT from first module of the pikromycin synthase
分子名称: Narbonolide/10-deoxymethynolide synthase PikA1, modules 1 and 2
著者Keatinge-Clay, A.T, Dickinson, M.S, Miyazawa, T, McCool, R.S.
登録日2022-05-03
公開日2022-06-08
最終更新日2024-06-12
実験手法ELECTRON MICROSCOPY (2.61 Å)
主引用文献Priming enzymes from the pikromycin synthase reveal how assembly-line ketosynthases catalyze carbon-carbon chemistry.
Structure, 30, 2022
2Z5L
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BU of 2z5l by Molmil
The first ketoreductase of the tylosin PKS
分子名称: Tylactone synthase starter module and modules 1 & 2
著者Keatinge-Clay, A.T, Stroud, R.M.
登録日2007-07-14
公開日2007-08-28
最終更新日2023-11-01
実験手法X-RAY DIFFRACTION (1.95 Å)
主引用文献A tylosin ketoreductase reveals how chirality is determined in polyketides
Chem.Biol., 14, 2007
1TQY
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BU of 1tqy by Molmil
The Actinorhodin Ketosynthase/Chain Length Factor
分子名称: ACETYL GROUP, Actinorhodin polyketide putative beta-ketoacyl synthase 1, Actinorhodin polyketide putative beta-ketoacyl synthase 2, ...
著者Keatinge-Clay, A.T, Maltby, D.A, Medzihradszky, K.F, Khosla, C, Stroud, R.M.
登録日2004-06-18
公開日2004-07-27
最終更新日2023-08-23
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An antibiotic factory caught in action.
Nat.Struct.Mol.Biol., 11, 2004
5KKU
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BU of 5kku by Molmil
Crystal structure of an N-terminal dehydratase from difficidin assembly line
分子名称: Polyketide synthase type I
著者Keatinge-Clay, A.T, Zeng, J.
登録日2016-06-22
公開日2016-12-21
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.22 Å)
主引用文献A Dehydratase Provides Insights into Split Bimodules and Polypeptide Docking in trans-AT Polyketide Synthases
To Be Published
1NM2
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BU of 1nm2 by Molmil
Malonyl-CoA:ACP Transacylase
分子名称: ACETIC ACID, NICKEL (II) ION, malonyl CoA:acyl carrier protein malonyltransferase
著者Keatinge-Clay, A.T, Shelat, A.A, Savage, D.F, Tsai, S, Miercke, L.J.W, O'Connell III, J.D, Khosla, C, Stroud, R.M.
登録日2003-01-08
公開日2003-01-21
最終更新日2023-08-16
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Catalysis, Specificity, and ACP Docking Site of Streptomyces coelicolor Malonyl-CoA:ACP Transacylase
Structure, 11, 2003
2FR0
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BU of 2fr0 by Molmil
The first ketoreductase of the erythromycin synthase (crystal form 1)
分子名称: Erythromycin synthase, EryAI, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Keatinge-Clay, A.T, Stroud, R.M.
登録日2006-01-18
公開日2006-04-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.81 Å)
主引用文献The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
2FR1
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The first ketoreductase of the erythromycin synthase (crystal form 2)
分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, erythromycin synthase, EryAI
著者Keatinge-Clay, A.T, Stroud, R.M.
登録日2006-01-18
公開日2006-04-04
最終更新日2024-04-03
実験手法X-RAY DIFFRACTION (1.79 Å)
主引用文献The Structure of a Ketoreductase Determines the Organization of the beta-Carbon Processing Enzymes of Modular Polyketide Synthases
Structure, 14, 2006
5D2E
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crystal structure of an N-terminal ketoreductase from macrolactin assembly line
分子名称: GLYCEROL, MlnE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ...
著者Keatinge-clay, A.T, Zeng, J.
登録日2015-08-05
公開日2015-08-26
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (1.72 Å)
主引用文献The crystal structure of an N-terminal ketoreductase from macrolactin polyketide synthase
To Be Published
3NYR
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Malonyl-CoA Ligase Ternary Product Complex with Malonyl-CoA and AMP bound
分子名称: ADENOSINE MONOPHOSPHATE, MAGNESIUM ION, MALONYL-COENZYME A, ...
著者Hughes, A.J, Keatinge-Clay, A.T.
登録日2010-07-15
公開日2011-03-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.45 Å)
主引用文献Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Functional Showcasing of Streptomyces coelicolor MatB.
Chem.Biol., 18, 2011
4W61
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BU of 4w61 by Molmil
Crystal structure of beta-ketoacyl thiolase B (BktB) from Ralstonia eutropha
分子名称: Beta-ketothiolase BktB
著者Fage, C.D, Keatinge-Clay, A.T.
登録日2014-08-19
公開日2015-09-09
最終更新日2023-09-27
実験手法X-RAY DIFFRACTION (2.01 Å)
主引用文献Coenzyme A-free activity, crystal structure, and rational engineering of a promiscuous beta-ketoacyl thiolase fromRalstonia eutropha.
J. Mol. Catal., B Enzym., 121, 2015
5ELP
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BU of 5elp by Molmil
Ketosynthase from module 1 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
分子名称: NRPS/PKS protein
著者Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Zogzas, C.E.
登録日2015-11-04
公開日2016-01-13
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (2.93 Å)
主引用文献The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERB
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BU of 5erb by Molmil
Ketosynthase from module 5 of the bacillaene synthase from Bacillus amyloliquefaciens FZB42
分子名称: Polyketide synthase
著者Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T, Meinke, J.
登録日2015-11-13
公開日2015-12-23
最終更新日2017-09-27
実験手法X-RAY DIFFRACTION (4.2 Å)
主引用文献The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ENY
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BU of 5eny by Molmil
Ketosynthase from module 6 connected to acyl carrier protein from module 5 (unobservable) of the bacillaene synthase from Bacillus subtilis 168
分子名称: Polyketide synthase PksL
著者Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
登録日2015-11-09
公開日2015-12-23
最終更新日2016-11-02
実験手法X-RAY DIFFRACTION (4 Å)
主引用文献The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
5ERF
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BU of 5erf by Molmil
Ketosynthase from module 6 of the bacillaene synthase from Bacillus subtilis 168
分子名称: Polyketide synthase PksL
著者Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
登録日2015-11-14
公開日2015-12-23
最終更新日2019-12-25
実験手法X-RAY DIFFRACTION (3.1 Å)
主引用文献The LINKS motif zippers trans-acyltransferase polyketide synthase assembly lines into a biosynthetic megacomplex.
J.Struct.Biol., 193, 2016
3NYQ
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BU of 3nyq by Molmil
Malonyl-CoA Ligase Ternary Product Complex with Methylmalonyl-CoA and AMP bound
分子名称: ADENOSINE MONOPHOSPHATE, CHLORIDE ION, MAGNESIUM ION, ...
著者Hughes, A.J, Keatinge-Clay, A.T.
登録日2010-07-15
公開日2011-03-30
最終更新日2024-02-21
実験手法X-RAY DIFFRACTION (1.43 Å)
主引用文献Enzymatic Extender Unit Generation for In Vitro Polyketide Synthase Reactions: Structural and Functional Showcasing of Streptomyces coelicolor MatB.
Chem.Biol., 18, 2011
1MZJ
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BU of 1mzj by Molmil
Crystal Structure of the Priming beta-Ketosynthase from the R1128 Polyketide Biosynthetic Pathway
分子名称: ACETYL GROUP, Beta-ketoacylsynthase III, COENZYME A
著者Pan, H, Tsai, S.C, Meadows, E.S, Miercke, L.J.W, Keatinge-Clay, A, O'Connell, J, Khosla, C, Stroud, R.M.
登録日2002-10-08
公開日2002-12-11
最終更新日2011-07-13
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Crystal structure of the priming beta-ketosynthase from the R1128 polyketide biosynthetic pathway
Structure, 10
4DIF
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BU of 4dif by Molmil
Structure of A1-type ketoreductase
分子名称: AmphB, GLYCEROL, NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE
著者Zheng, J, Keatinge-Clay, A.T.
登録日2012-01-30
公開日2013-02-13
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.521 Å)
主引用文献Structure and mutagenesis of A2-type ketoreductase from modular polyketide synthase reveals insights into stereospecificity
To be Published
6B2V
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BU of 6b2v by Molmil
Pyran synthase domain from module nine of the sorangicin pathway
分子名称: SorB
著者Wagner, D.T, Keatinge-Clay, A.T.
登録日2017-09-20
公開日2018-04-18
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.55 Å)
主引用文献Structural and Functional Studies of a Pyran Synthase Domain from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
6CCA
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BU of 6cca by Molmil
Crystal structure of DszA carbon methyltransferase
分子名称: DisA protein
著者Meinke, J.L, Keatinge-Clay, A.T.
登録日2018-02-06
公開日2018-12-05
最終更新日2024-03-13
実験手法X-RAY DIFFRACTION (1.75 Å)
主引用文献Structural and Functional Studies of a gem-Dimethylating Methyltransferase from a trans-Acyltransferase Assembly Line.
ACS Chem. Biol., 13, 2018
5KTK
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BU of 5ktk by Molmil
Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
分子名称: NADPH DIHYDRO-NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, Polyketide synthase PksJ
著者Wagner, D.T, Gay, D.C, Keatinge-Clay, A.T.
登録日2016-07-11
公開日2016-09-07
最終更新日2023-10-04
実験手法X-RAY DIFFRACTION (1.98 Å)
主引用文献Ketoreductase from module 3 of the bacillaene synthase from Bacillus subtilis 168
To Be Published
3QP9
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The Structure of a C2-type Ketoreductase from a Modular Polyketide Synthase
分子名称: Type I polyketide synthase PikAII
著者Zheng, J, Keatinge-Clay, A.T.
登録日2011-02-11
公開日2011-05-11
最終更新日2023-09-13
実験手法X-RAY DIFFRACTION (1.88 Å)
主引用文献Structural and functional analysis of c2-type ketoreductases from modular polyketide synthases.
J.Mol.Biol., 410, 2011
4QXL
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Crystal Structure of FLHE
分子名称: Flagellar protein flhE
著者Lee, J, Monzingo, A.F, Keatinge-Clay, A.T, Harshey, R.M.
登録日2014-07-21
公開日2015-01-14
最終更新日2017-11-22
実験手法X-RAY DIFFRACTION (1.512 Å)
主引用文献Structure of Salmonella FlhE, Conserved Member of a Flagellar Type III Secretion Operon.
J.Mol.Biol., 427, 2015

 

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