8QOO
| Crystal structure of human Sirt2 in complex with the peptide-based pseudo-inhibitor TNFn-4.1 | Descriptor: | (2S,3R)-3-dodecylsulfanyl-2-methyl-butanoic acid, (2S,3S)-3-dodecylsulfanyl-2-methyl-butanoic acid, (R,R)-2,3-BUTANEDIOL, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-09-29 | Release date: | 2024-10-09 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | Development of potent TNFa-Myr-based pseudo-inhibitors for Sirtuin 2 To Be Published
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8QT0
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-3 | Descriptor: | 1,2-ETHANEDIOL, 3-dodecylsulfanyl-3-methyl-butanoic acid, DI(HYDROXYETHYL)ETHER, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.85 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QT4
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-6 and NAD+ | Descriptor: | (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QT2
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-6 | Descriptor: | (R,R)-2,3-BUTANEDIOL, 1,2-ETHANEDIOL, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QT8
| Crystal structure of human Sirt2 in complex with a TNFa-Myr analogue TNFn-34 | Descriptor: | 3-dodecylsulfanylpropanoic acid, NAD-dependent protein deacetylase sirtuin-2, Peptide-based TNFa-Myr analogue TNFn-34, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.65 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QT1
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-5 | Descriptor: | (2S)-2-dodecylsulfanylpropanoic acid, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-2, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QTU
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-3 and NAD+ | Descriptor: | 1,2-ETHANEDIOL, 3-dodecylsulfanyl-3-methyl-butanoic acid, NAD-dependent protein deacetylase sirtuin-2, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-13 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.8 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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8QT3
| Crystal structure of human Sirt2 in complex with the super-slow substrate TNFn-5 and NAD+ | Descriptor: | (2S)-2-dodecylsulfanylpropanoic acid, 1,2-ETHANEDIOL, NAD-dependent protein deacetylase sirtuin-2, ... | Authors: | Friedrich, F, Kalbas, D, Meleshin, M, Einsle, O, Schutkowski, M, Jung, M. | Deposit date: | 2023-10-12 | Release date: | 2024-10-23 | Method: | X-RAY DIFFRACTION (1.55 Å) | Cite: | New Super-Slow Substrates as novel Sirtuin-Inhibitors To Be Published
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