Loading
PDBj
English日本語简体中文繁體中文한국어
✖
ﾒﾆｭｰPDBj@FacebookPDBj@TwitterPDBj@YouTubewwPDB FoundationwwPDB
RCSB PDBPDBeBMRBAdv. SearchSearch help
PDB: 381 件
7B8A
DownloadVisualize
BU of 7b8a by Molmil
Notum-Fragment 110
分子名称: 1,2-ETHANEDIOL, 1-cyclohexyl-3-(2-pyridin-4-ylethyl)urea, 2-acetamido-2-deoxy-beta-D-glucopyranose, ...
著者Zhao, Y, Jonees, E.Y.
登録日2020-12-12
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.23 Å)
主引用文献Notum Fragment Screen
To Be Published
7B89
DownloadVisualize
BU of 7b89 by Molmil
Notum-Fragment077
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ...
著者Zhao, Y, Jonees, E.Y.
登録日2020-12-12
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.84 Å)
主引用文献Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
7B8F
DownloadVisualize
BU of 7b8f by Molmil
Notum-Fragment 154
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-(benzimidazol-1-ylmethyl)benzenecarbonitrile, ...
著者Zhao, Y, Jonees, E.Y.
登録日2020-12-12
公開日2022-01-12
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.62 Å)
主引用文献Structural Analysis and Development of Notum Fragment Screening Hits.
Acs Chem Neurosci, 13, 2022
4V2A
DownloadVisualize
BU of 4v2a by Molmil
human Unc5A ectodomain
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, NETRIN RECEPTOR UNC5A
著者Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
登録日2014-10-08
公開日2014-11-05
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Neuron, 84, 2014
6ZUV
DownloadVisualize
BU of 6zuv by Molmil
Notum fragment 286
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, Palmitoleoyl-protein carboxylesterase NOTUM, ...
著者Zhao, Y, Jones, E.Y.
登録日2020-07-23
公開日2020-11-11
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.54 Å)
主引用文献5-Phenyl-1,3,4-oxadiazol-2(3 H )-ones Are Potent Inhibitors of Notum Carboxylesterase Activity Identified by the Optimization of a Crystallographic Fragment Screening Hit.
J.Med.Chem., 63, 2020
1MHE
DownloadVisualize
BU of 1mhe by Molmil
THE HUMAN NON-CLASSICAL MAJOR HISTOCOMPATIBILITY COMPLEX MOLECULE HLA-E
分子名称: BETA-2-MICROGLOBULIN, HLA CLASS I HISTOCOMPATIBILITY ANTIGEN HLA-E, PEPTIDE (VMAPRTVLL), ...
著者O'Callaghan, C.A, Tormo, J, Willcox, B.E, Braud, V.B, Jakobsen, B.K, Stuart, D.I, Mcmichael, A.J, Bell, J.I, Jones, E.Y.
登録日1998-08-24
公開日1999-03-23
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (2.85 Å)
主引用文献Structural features impose tight peptide binding specificity in the nonclassical MHC molecule HLA-E.
Mol.Cell, 1, 1998
3SUA
DownloadVisualize
BU of 3sua by Molmil
Crystal structure of the intracellular domain of Plexin-B1 in complex with Rac1
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
著者Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
登録日2011-07-11
公開日2011-09-07
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (4.39 Å)
主引用文献A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3SU8
DownloadVisualize
BU of 3su8 by Molmil
Crystal structure of a truncated intracellular domain of Plexin-B1 in complex with Rac1
分子名称: MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-GUANYLATE ESTER, Plexin-B1, ...
著者Bell, C.H, Aricescu, A.R, Jones, E.Y, Siebold, C.
登録日2011-07-11
公開日2011-09-28
最終更新日2024-02-28
実験手法X-RAY DIFFRACTION (3.2 Å)
主引用文献A Dual Binding Mode for RhoGTPases in Plexin Signalling.
Plos Biol., 9, 2011
3MFF
DownloadVisualize
BU of 3mff by Molmil
1F1E8hu TCR
分子名称: ARGININE, GLYCEROL, T cell receptor alpha chain, ...
著者van Boxel, G.I, Holmes, S, Fugger, L, Jones, E.Y.
登録日2010-04-02
公開日2010-06-02
最終更新日2014-03-05
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献An alternative conformation of the T-cell receptor alpha constant region
J.Mol.Biol., 400, 2010
6TV4
DownloadVisualize
BU of 6tv4 by Molmil
CFF-Notum complex
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CAFFEINE, DIMETHYL SULFOXIDE, ...
著者Zhao, Y, Jones, E.Y.
登録日2020-01-08
公開日2020-10-28
最終更新日2024-01-24
実験手法X-RAY DIFFRACTION (1.53 Å)
主引用文献Caffeine inhibits Notum activity by binding at the catalytic pocket.
Commun Biol, 3, 2020
6TUZ
DownloadVisualize
BU of 6tuz by Molmil
Theophylline-Notum complex
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
著者Zhao, Y, Jones, E.Y.
登録日2020-01-08
公開日2020-10-28
最終更新日2024-10-09
実験手法X-RAY DIFFRACTION (1.24 Å)
主引用文献Caffeine inhibits Notum activity by binding at the catalytic pocket.
Commun Biol, 3, 2020
4UFR
DownloadVisualize
BU of 4ufr by Molmil
Structure of the ectodomain of LGR5 in complex with R-spondin-2 (Fu1Fu2)
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, LEUCINE-RICH REPEAT-CONTAINING G-PROTEIN COUPLED RECEPTOR 5, ...
著者Zebisch, M, Jones, E.Y.
登録日2015-03-18
公開日2015-07-08
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Crystal Structure of R-Spondin 2 in Complex with the Ectodomains of its Receptors Lgr5 and Znrf3.
J.Struct.Biol., 191, 2015
4V2B
DownloadVisualize
BU of 4v2b by Molmil
rat Unc5D Ig domain 1
分子名称: PROTEIN UNC5D
著者Seiradake, E, del Toro, D, Nagel, D, Cop, F, Haertl, R, Ruff, T, Seyit-Bremer, G, Harlos, K, Border, E.C, Acker-Palmer, A, Jones, E.Y, Klein, R.
登録日2014-10-08
公開日2014-11-05
最終更新日2015-07-22
実験手法X-RAY DIFFRACTION (2 Å)
主引用文献Flrt Structure: Balancing Repulsion and Cell Adhesion in Cortical and Vascular Development
Neuron, 84, 2014
4UZ1
DownloadVisualize
BU of 4uz1 by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM III - 1.4A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, NOTUM, SULFATE ION
著者Zebisch, M, Jones, E.Y.
登録日2014-09-04
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.4 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
7QVZ
DownloadVisualize
BU of 7qvz by Molmil
ARUK3001043_Notum
分子名称: 1,2-ETHANEDIOL, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
著者Zhao, Y, Hillier, J, Willis, N.J, Mahy, W, Fish, P, Jones, E.Y.
登録日2022-01-24
公開日2022-05-04
最終更新日2024-01-31
実験手法X-RAY DIFFRACTION (1.47 Å)
主引用文献Structure Activity Analysis of Notum Fragment Screen Hits with Development
To Be Published
4UYZ
DownloadVisualize
BU of 4uyz by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM II - 2.8A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, POLY ALA, ...
著者Zebisch, M, Jones, E.Y.
登録日2014-09-03
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.8 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UZJ
DownloadVisualize
BU of 4uzj by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM FROM DROSOPHILA - CRYSTAL FORM I - 2.4A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, NOTUM
著者Zebisch, M, Jones, E.Y.
登録日2014-09-05
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UZ9
DownloadVisualize
BU of 4uz9 by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VII - SOS COMPLEX - 2.2A
分子名称: 1,3,4,6-tetra-O-sulfo-beta-D-fructofuranose-(2-1)-2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, CHLORIDE ION, ...
著者Zebisch, M, Jones, E.Y.
登録日2014-09-04
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.2 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UZL
DownloadVisualize
BU of 4uzl by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I MYRISTOLEATE COMPLEX - 2.1A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, Myristoleic acid, PROTEIN NOTUM HOMOLOG
著者Zebisch, M, Jones, E.Y.
登録日2014-09-05
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.1 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UZA
DownloadVisualize
BU of 4uza by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM VIII - PHOSPHATE COMPLEX - 2.4A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, PHOSPHATE ION, PROTEIN NOTUM HOMOLOG
著者Zebisch, M, Jones, E.Y.
登録日2014-09-04
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (2.4 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UZK
DownloadVisualize
BU of 4uzk by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM FROM DROSOPHILA - CRYSTAL FORM II - 1.9A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, NOTUM
著者Zebisch, M, Jones, E.Y.
登録日2014-09-05
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.9 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
4UYW
DownloadVisualize
BU of 4uyw by Molmil
STRUCTURE OF THE WNT DEACYLASE NOTUM - CRYSTAL FORM I HEPARIN FRAGMENT COMPLEX - 1.7A
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, 4-deoxy-2-O-sulfo-alpha-L-threo-hex-4-enopyranuronic acid-(1-4)-2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose, PROTEIN NOTUM HOMOLOG
著者Zebisch, M, Jones, E.Y.
登録日2014-09-03
公開日2015-02-25
最終更新日2020-07-29
実験手法X-RAY DIFFRACTION (1.7 Å)
主引用文献Notum Deacylates Wnt Proteins to Suppress Signalling Activity.
Nature, 519, 2015
7PJR
DownloadVisualize
BU of 7pjr by Molmil
Notum_ARUK3000438
分子名称: 1-[4-chloranyl-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
著者Vecchia, L, Zhao, Y, Fish, P, Jones, E.Y.
登録日2021-08-24
公開日2022-09-07
最終更新日2023-03-22
実験手法X-RAY DIFFRACTION (1.51 Å)
主引用文献Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022
7PK3
DownloadVisualize
BU of 7pk3 by Molmil
Notum_ARUK3001185
分子名称: 1-[2,4-bis(chloranyl)-3-(trifluoromethyl)phenyl]-1,2,3-triazole, 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, ...
著者Vecchia, L, Hillier, J, Zhao, Y, Fish, P, Jones, E.Y.
登録日2021-08-25
公開日2022-09-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.41 Å)
主引用文献Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022
7PKV
DownloadVisualize
BU of 7pkv by Molmil
Notum_Inhibitor ARUK3000223
分子名称: 2-acetamido-2-deoxy-beta-D-glucopyranose, DIMETHYL SULFOXIDE, Palmitoleoyl-protein carboxylesterase NOTUM, ...
著者Ruza, R, Zhao, Y, Fish, P, Jones, E.Y.
登録日2021-08-26
公開日2022-09-07
最終更新日2024-02-07
実験手法X-RAY DIFFRACTION (1.68 Å)
主引用文献Design of a Potent, Selective, and Brain-Penetrant Inhibitor of Wnt-Deactivating Enzyme Notum by Optimization of a Crystallographic Fragment Hit.
J.Med.Chem., 65, 2022

225946

件を2024-10-09に公開中

PDB statisticsPDBj update infoContact PDBjnumon