6DRB
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6drb by Molmil](/molmil-images/mine/6drb) | Crystal Structure of the YopH PTP1B WPD loop Chimera 3 PTPase bound to tungstate | 分子名称: | TUNGSTATE(VI)ION, Targeted effector protein | 著者 | Morales, Y, Johnson, S.J, Hengge, A.C. | 登録日 | 2018-06-11 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.745 Å) | 主引用文献 | A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
|
|
6DR1
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dr1 by Molmil](/molmil-images/mine/6dr1) | YopH PTP1B Chimera 2 PTPase | 分子名称: | Targeted effector protein | 著者 | Morales, Y, Johnson, S.J, Hengge, A.C. | 登録日 | 2018-06-11 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
|
|
6DR7
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6dr7 by Molmil](/molmil-images/mine/6dr7) | YopH PTP1B WPD loop Chimera 2 PTPase bound to vanadate | 分子名称: | ACETATE ION, Targeted effector protein, VANADATE ION | 著者 | Moise, G, Morales, Y, Johnson, S.J, Hengge, A.C. | 登録日 | 2018-06-11 | 公開日 | 2018-08-29 | 最終更新日 | 2023-10-11 | 実験手法 | X-RAY DIFFRACTION (1.849 Å) | 主引用文献 | A YopH PTP1B Chimera Shows the Importance of the WPD-Loop Sequence to the Activity, Structure, and Dynamics of Protein Tyrosine Phosphatases. Biochemistry, 57, 2018
|
|
4ZI4
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zi4 by Molmil](/molmil-images/mine/4zi4) | |
6XEA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xea by Molmil](/molmil-images/mine/6xea) | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to vanadate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.549 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
6XEE
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xee by Molmil](/molmil-images/mine/6xee) | Crystal Structure of the PTP1B YopH WPD loop Chimera 4 apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, DI(HYDROXYETHYL)ETHER, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.501 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
6XE8
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xe8 by Molmil](/molmil-images/mine/6xe8) | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.952 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
6XED
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xed by Molmil](/molmil-images/mine/6xed) | Crystal Structure of the PTP1B YopH WPD loop Chimera 3 bound to tungstate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.795 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
6XEF
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xef by Molmil](/molmil-images/mine/6xef) | Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to vanadate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.048 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
6XEG
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 6xeg by Molmil](/molmil-images/mine/6xeg) | Crystal structure of the PTP1B YopH WPD loop Chimera 4 bound to tungstate | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, BENZAMIDINE, MAGNESIUM ION, ... | 著者 | Olsen, K.J, Shen, R, Johnson, S.J, Hengge, A.C. | 登録日 | 2020-06-12 | 公開日 | 2021-12-15 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2.549 Å) | 主引用文献 | Insights into the importance of WPD-loop sequence for activity and structure in protein tyrosine phosphatases. Chem Sci, 13, 2022
|
|
4YAA
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4yaa by Molmil](/molmil-images/mine/4yaa) | YopH W354Y Yersinia enterocolitica PTPase apo form | 分子名称: | ACETATE ION, SULFATE ION, Tyrosine-protein phosphatase YopH | 著者 | Moise, G.E, Johnson, S.J, Hengge, A.C. | 登録日 | 2015-02-17 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
|
|
7L0C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l0c by Molmil](/molmil-images/mine/7l0c) | Ligand-free PTP1B T177G | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1 | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | 登録日 | 2020-12-11 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
|
|
7L0M
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l0m by Molmil](/molmil-images/mine/7l0m) | Vanadate-bound YopH G352T | 分子名称: | Protein-tyrosine-phosphatase, VANADATE ION | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | 登録日 | 2020-12-11 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
|
|
7L0I
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l0i by Molmil](/molmil-images/mine/7l0i) | Ligand-free YopH G352T | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, Protein-tyrosine-phosphatase | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | 登録日 | 2020-12-11 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
|
|
7L0H
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7l0h by Molmil](/molmil-images/mine/7l0h) | Vanadate-bound PTP1B T177G | 分子名称: | Tyrosine-protein phosphatase non-receptor type 1, VANADATE ION | 著者 | Shen, R.D, Hengge, A.C, Johnson, S.J. | 登録日 | 2020-12-11 | 公開日 | 2021-05-12 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Single Residue on the WPD-Loop Affects the pH Dependency of Catalysis in Protein Tyrosine Phosphatases. Jacs Au, 1, 2021
|
|
7MPC
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mpc by Molmil](/molmil-images/mine/7mpc) | Structure of SsoPTP bound to vanadate | 分子名称: | SsoPTP, VANADATE ION | 著者 | Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. | 登録日 | 2021-05-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.75 Å) | 主引用文献 | Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality. Biochemistry, 60, 2021
|
|
7MPD
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 7mpd by Molmil](/molmil-images/mine/7mpd) | Structure of SsoPTP bound to 2-chloroethylsulfonate | 分子名称: | 2-chloroethane-1-sulfonic acid, 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, SsoPTP | 著者 | Pinkston, J.A, Olsen, K.J, Hengge, A.C, Johnson, S.J. | 登録日 | 2021-05-04 | 公開日 | 2021-09-22 | 最終更新日 | 2023-10-18 | 実験手法 | X-RAY DIFFRACTION (1.05 Å) | 主引用文献 | Significant Loop Motions in the SsoPTP Protein Tyrosine Phosphatase Allow for Dual General Acid Functionality. Biochemistry, 60, 2021
|
|
4Z6B
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4z6b by Molmil](/molmil-images/mine/4z6b) | |
4ZN5
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 4zn5 by Molmil](/molmil-images/mine/4zn5) | YopH W354Y Yersinia enterocolitica PTPase bond with Divanadate glycerol ester in the active site | 分子名称: | ACETATE ION, Divanadate Glycerol ester, GLYCEROL, ... | 著者 | Moise, G.E, Johnson, S.J, Hengge, A.C. | 登録日 | 2015-05-04 | 公開日 | 2015-10-28 | 最終更新日 | 2023-09-27 | 実験手法 | X-RAY DIFFRACTION (1.12 Å) | 主引用文献 | Conservative Tryptophan Mutants of the Protein Tyrosine Phosphatase YopH Exhibit Impaired WPD-Loop Function and Crystallize with Divanadate Esters in Their Active Sites. Biochemistry, 54, 2015
|
|
8V5C
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v5c by Molmil](/molmil-images/mine/8v5c) | IpaD (122-321) Bound to Deoxycholate | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCEROL, Invasin IpaD | 著者 | Barker, S.A, Dickenson, N.E, Johnson, S.J. | 登録日 | 2023-11-30 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (1.96 Å) | 主引用文献 | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence. J.Biol.Chem., 2024
|
|
8V5E
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v5e by Molmil](/molmil-images/mine/8v5e) | IpaD (122-321) Pi-helix Mutant (delta Q148) Bound to Deoxycholate | 分子名称: | (3ALPHA,5BETA,12ALPHA)-3,12-DIHYDROXYCHOLAN-24-OIC ACID, GLYCEROL, Invasin IpaD | 著者 | Barker, S.A, Dickenson, N.E, Johnson, S.J. | 登録日 | 2023-11-30 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence. J.Biol.Chem., 2024
|
|
8V7S
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v7s by Molmil](/molmil-images/mine/8v7s) | IpaD (122-321) Apo Structure | 分子名称: | Invasin IpaD | 著者 | Barker, S.A, Dickenson, N.E, Johnson, S.J, Morales, Y. | 登録日 | 2023-12-04 | 公開日 | 2024-08-21 | 実験手法 | X-RAY DIFFRACTION (2.708 Å) | 主引用文献 | Structural and functional characterization of the IpaD pi-helix reveals critical roles in DOC interaction, T3SS apparatus maturation, and Shigella virulence. J.Biol.Chem., 2024
|
|
8V7Q
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 8v7q by Molmil](/molmil-images/mine/8v7q) | |
3F99
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3f99 by Molmil](/molmil-images/mine/3f99) | W354F Yersinia enterocolitica PTPase apo form | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Tyrosine-protein phosphatase yopH | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | 登録日 | 2008-11-13 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
|
|
3F9A
![Download](/newweb/media/icons/dl.png) ![Visualize](/newweb/media/icons/hoh_3d.png)
![BU of 3f9a by Molmil](/molmil-images/mine/3f9a) | W354F Yersinia enterocolitica PTPase complexed with tungstate | 分子名称: | TUNGSTATE(VI)ION, Tyrosine-protein phosphatase yopH | 著者 | Brandao, T.A.S, Robinson, H, Johnson, S.J, Hengge, A.C. | 登録日 | 2008-11-13 | 公開日 | 2009-01-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.69 Å) | 主引用文献 | Impaired acid catalysis by mutation of a protein loop hinge residue in a YopH mutant revealed by crystal structures. J.Am.Chem.Soc., 131, 2009
|
|