PDB Search results for query - Protein Data Bank Japan

PDB: 139 results

Crystal structure of the DNA-binding domain of human p53 with extended N terminus
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Natan, E, Fersht, A.R.
Deposit date:	2010-11-04
Release date:	2011-03-30
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (1.68 Å)
Cite:	Interaction of the P53 DNA-Binding Domain with its N-Terminal Extension Modulates the Stability of the P53 Tetramer. J.Mol.Biol., 409, 2011

6Q8P

Structure of CLK1 with bound N-methyl-10-nitropyrido[3,4-g]quinazolin-2-amine
Descriptor:	Dual specificity protein kinase CLK1, POTASSIUM ION, ~{N}-methyl-10-nitro-pyrido[3,4-g]quinazolin-2-amine
Authors:	Joerger, A.C, Chatterjee, D, Schroeder, M, Tazarki, H, Zeinyeh, W, Esvan, Y.J, Khiari, J, Josselin, B, Baratte, B, Bach, S, Ruchaud, S, Anizon, F, Giraud, F, Moreau, P, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2018-12-15
Release date:	2019-02-20
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (3 Å)
Cite:	New pyrido[3,4-g]quinazoline derivatives as CLK1 and DYRK1A inhibitors: synthesis, biological evaluation and binding mode analysis. Eur J Med Chem, 166, 2019

5AB9

Structure of the p53 cancer mutant Y220C with bound small molecule 7- ethyl-3-(piperidin-4-yl)-1H-indole
Descriptor:	7-ethyl-3-(piperidin-4-yl)-1H-indole, CELLULAR TUMOR ANTIGEN P53, DI(HYDROXYETHYL)ETHER, ...
Authors:	Joerger, A.C.
Deposit date:	2015-08-04
Release date:	2015-12-16
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.36 Å)
Cite:	Exploiting Transient Protein States for the Design of Small-Molecule Stabilizers of Mutant P53. Structure, 23, 2015

5A7B

Structure of the p53 cancer Y220C bound to the stabilizing small molecule PhiKan5211
Descriptor:	2-[[4-(diethylamino)piperidin-1-yl]methyl]-6-ethynyl-4-(3-phenoxyprop-1-ynyl)phenol, CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C.
Deposit date:	2015-07-03
Release date:	2015-09-30
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.4 Å)
Cite:	Experimental and Theoretical Evaluation of the Ethynyl Moiety as a Halogen Bioisostere. Acs Chem.Biol., 10, 2015

3ZME

Structure of the p53 core domain mutant Y220C bound to the small molecule PhiKan7242
Descriptor:	2-(4-(4-fluorophenyl)-5-(1H-pyrrol-1-yl)-1H-pyrazol-1-yl)-N,N-dimethylethanamine, Cellular tumor antigen p53, ZINC ION
Authors:	Joerger, A.C, Wilcken, R.
Deposit date:	2013-02-07
Release date:	2013-05-08
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (1.35 Å)
Cite:	Small molecule induced reactivation of mutant p53 in cancer cells. Nucleic Acids Res., 41, 2013

2J1Z

Human p53 core domain mutant M133L-V203A-N239Y-N268D-F270L
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J21

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R282W
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.6 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1Y

Human p53 core domain mutant M133L-V203A-N239Y-G245S-N268D
Descriptor:	CALCIUM ION, CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.69 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J20

Human p53 core domain mutant M133L-V203A-N239Y-N268D-R273C
Descriptor:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
Authors:	Joerger, A.C, Ang, H.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1X

Human p53 core domain mutant M133L-V203A-Y220C-N239Y-N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.65 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2J1W

Human p53 core domain mutant M133L-V143A-V203A-N239Y-N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2006-08-15
Release date:	2006-09-20
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structural Basis for Understanding Oncogenic P53 Mutations and Designing Rescue Drugs. Proc.Natl.Acad.Sci.USA, 103, 2006

2BIO

human p53 core domain mutant M133L-V203A-N239Y-R249S-N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2005-01-25
Release date:	2005-01-26
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIQ

human p53 core domain mutant T123A-M133L-H168R-V203A-N239Y-R249S- N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2005-01-25
Release date:	2005-01-26
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

1HL2

Crystal structure of N-acetylneuraminate lyase from E. coli mutant L142R in complex with b-hydroxypyruvate
Descriptor:	3-HYDROXYPYRUVIC ACID, N-ACETYLNEURAMINATE LYASE SUBUNIT
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2003-03-12
Release date:	2003-05-09
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Mimicking Natural Evolution in Vitro: An N-Acetylneuraminate Lyase Mutant with an Increased Dihydrodipicolinate Synthase Activity Proc.Natl.Acad.Sci.USA, 100, 2003

2BIP

human p53 core domain mutant M133L-H168R-V203A-N239Y-R249S-N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2005-01-25
Release date:	2005-01-26
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIN

human p53 core domain mutant M133L-H168R-V203A-N239Y-N268D
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2005-01-25
Release date:	2005-01-26
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

2BIM

human p53 core domain mutant M133L-V203A-N239Y-N268D-R273H
Descriptor:	CELLULAR TUMOR ANTIGEN P53, SULFATE ION, ZINC ION
Authors:	Joerger, A.C, Fersht, A.R.
Deposit date:	2005-01-25
Release date:	2005-01-26
Last modified:	2023-12-13
Method:	X-RAY DIFFRACTION (1.98 Å)
Cite:	Structures of P53 Cancer Mutants and Mechanism of Rescue by Second-Site Suppressor Mutations J.Biol.Chem., 280, 2005

6SHZ

p53 cancer mutant Y220C
Descriptor:	1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ...
Authors:	Joerger, A.C, Structural Genomics Consortium (SGC)
Deposit date:	2019-08-08
Release date:	2020-02-19
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.24 Å)
Cite:	Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020

5G4N

Crystal structure of the p53 cancer mutant Y220C in complex with a difluorinated derivative of the small molecule stabilizer Phikan083
Descriptor:	1-[9-(2,2-difluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, GLYCEROL, ...
Authors:	Joerger, A.C, Bauer, M, Jones, R.N, Spencer, J.
Deposit date:	2016-05-13
Release date:	2016-06-22
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.35 Å)
Cite:	Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016

5G4M

Crystal structure of the p53 cancer mutant Y220C in complex with a monofluorinated derivative of the small molecule stabilizer Phikan083
Descriptor:	1,2-ETHANEDIOL, 1-[9-(2-fluoroethyl)-9H-carbazol-3-yl]-N-methylmethanamine, CELLULAR TUMOR ANTIGEN P53, ...
Authors:	Joerger, A.C, Bauer, M.
Deposit date:	2016-05-13
Release date:	2016-06-22
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.38 Å)
Cite:	Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016

5G4O

Crystal structure of the p53 cancer mutant Y220C in complex with a trifluorinated derivative of the small molecule stabilizer Phikan083
Descriptor:	CELLULAR TUMOR ANTIGEN P53, N,N-dimethyl-1-[9-(2,2,2-trifluoroethyl)-9H-carbazol-3-yl]methanamine, ZINC ION
Authors:	Joerger, A.C, Bauer, M, Baud, M.G.J, Spencer, J.
Deposit date:	2016-05-13
Release date:	2016-06-22
Last modified:	2024-01-10
Method:	X-RAY DIFFRACTION (1.48 Å)
Cite:	Harnessing Fluorine-Sulfur Contacts and Multipolar Interactions for the Design of P53 Mutant Y220C Rescue Drugs. Acs Chem.Biol., 11, 2016

3ZY0

Crystal structure of a truncated variant of the human p63 tetramerization domain lacking the C-terminal helix
Descriptor:	TUMOR PROTEIN P63
Authors:	Joerger, A.C.
Deposit date:	2011-08-16
Release date:	2011-11-30
Last modified:	2019-05-08
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Structure and Kinetic Stability of the P63 Tetramerization Domain. J.Mol.Biol., 415, 2012

1UOL

Crystal structure of the human p53 core domain mutant M133L/V203A/N239Y/N268D at 1.9 A resolution.
Descriptor:	CELLULAR TUMOR ANTIGEN P53, ZINC ION
Authors:	Joerger, A.C, Allen, M.D, Fersht, A.R.
Deposit date:	2003-09-19
Release date:	2003-10-16
Last modified:	2024-05-08
Method:	X-RAY DIFFRACTION (1.9 Å)
Cite:	Crystal Structure of a Superstable Mutant of Human P53 Core Domain. Insights Into the Mechanism of Rescuing Oncogenic Mutations J.Biol.Chem., 279, 2004

6SI2

p53 cancer mutant Y220S
Descriptor:	1,2-ETHANEDIOL, Cellular tumor antigen p53, GLYCEROL, ...
Authors:	Joerger, A.C, Bauer, M.R, Structural Genomics Consortium (SGC)
Deposit date:	2019-08-08
Release date:	2020-02-19
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.5 Å)
Cite:	Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020

6SI4

p53 cancer mutant Y220S in complex with small-molecule stabilizer PK9323
Descriptor:	1-[9-ethyl-7-(1,3-thiazol-4-yl)carbazol-3-yl]-~{N}-methyl-methanamine, Cellular tumor antigen p53, GLYCEROL, ...
Authors:	Joerger, A.C, Kraemer, A, Knapp, S, Structural Genomics Consortium (SGC)
Deposit date:	2019-08-08
Release date:	2020-02-19
Last modified:	2024-01-24
Method:	X-RAY DIFFRACTION (1.8 Å)
Cite:	Targeting Cavity-Creating p53 Cancer Mutations with Small-Molecule Stabilizers: the Y220X Paradigm. Acs Chem.Biol., 15, 2020

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Total results:	139
Displayed results:	25
Sorted by:	Hit score (from highest)
Deposition authors:	"Joerger, A.C."