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PDB: 47 results

5NHF
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Human Erk2 with an Erk1/2 inhibitor
Descriptor: 2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-5-(phenylmethyl)-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2024-10-16
Method:X-RAY DIFFRACTION (2.14 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHJ
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Human Erk2 with an Erk1/2 inhibitor
Descriptor: 5-(2-methoxyethyl)-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.12 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHP
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Human Erk2 with an Erk1/2 inhibitor
Descriptor: 5-(2-methoxyethyl)-1-methyl-2-[2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-22
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.99 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHL
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BU of 5nhl by Molmil
Human Erk2 with an Erk1/2 inhibitor
Descriptor: (6~{R})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.07 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHH
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BU of 5nhh by Molmil
Human Erk2 with an Erk1/2 inhibitor
Descriptor: 5-(2-methoxyethyl)-2-[2-(oxan-4-ylamino)pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-21
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (1.94 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHO
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BU of 5nho by Molmil
Human Erk2 with an Erk1/2 inhibitor
Descriptor: (6~{S})-5-(2-methoxyethyl)-6-methyl-2-[5-methyl-2-[(2-methylpyrazol-3-yl)amino]pyrimidin-4-yl]-6,7-dihydro-1~{H}-pyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-22
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.24 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NHV
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BU of 5nhv by Molmil
Human Erk2 with an Erk1/2 inhibitor
Descriptor: 7-[2-(oxan-4-ylamino)pyrimidin-4-yl]-3,4-dihydro-2~{H}-pyrrolo[1,2-a]pyrazin-1-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-22
Release date:2017-04-19
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
5NGU
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BU of 5ngu by Molmil
Human Erk2 with an Erk1/2 inhibitor
Descriptor: 2-[2-[[4-(4-methylpiperazin-1-yl)phenyl]amino]pyrimidin-4-yl]-1,5,6,7-tetrahydropyrrolo[3,2-c]pyridin-4-one, Mitogen-activated protein kinase 1, SULFATE ION
Authors:Debreczeni, J.E, Ward, R.A, Bethel, P, Cook, C, Davies, E, Eckersley, K, Fairley, G, Feron, L, Flemington, V, Graham, M.A, Greenwood, R, Hopcroft, P, Howard, T.D, Hudson, J, James, M, Jones, C.D, Jones, C.R, Lamont, S, Lewis, R, Lindsay, N, Roberts, K, Simpson, I, StGallay, S, Swallow, S, Tonge, M.
Deposit date:2017-03-20
Release date:2017-04-19
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (2.74 Å)
Cite:Structure-Guided Discovery of Potent and Selective Inhibitors of ERK1/2 from a Modestly Active and Promiscuous Chemical Start Point.
J. Med. Chem., 60, 2017
2WFH
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BU of 2wfh by Molmil
The Human Slit 2 Dimerization Domain D4
Descriptor: SLIT HOMOLOG 2 PROTEIN C-PRODUCT, SULFATE ION
Authors:Seiradake, E, von Philipsborn, A.C, Henry, M, Fritz, M, Lortat-Jacob, H, Jamin, M, Hemrika, W, Bastmeyer, M, Cusack, S, McCarthy, A.A.
Deposit date:2009-04-06
Release date:2009-04-21
Last modified:2023-12-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Structure and functional relevance of the Slit2 homodimerization domain.
EMBO Rep., 10, 2009
4HEO
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BU of 4heo by Molmil
Hendra virus Phosphoprotein C terminal domain
Descriptor: CHLORIDE ION, MAGNESIUM ION, Phosphoprotein
Authors:Yabukarski, F, Tarbouriech, N, Jamin, M.
Deposit date:2012-10-04
Release date:2013-10-09
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (1.65 Å)
Cite:Atomic Resolution Description of the Interaction between the Nucleoprotein and Phosphoprotein of Hendra Virus.
Plos Pathog., 9, 2013
8B8V
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BU of 8b8v by Molmil
Crystal structure of the Rabies virus RNA free nucleoprotein- phosphoprotein complex
Descriptor: DI(HYDROXYETHYL)ETHER, Nucleoprotein, Phosphoprotein
Authors:Gerard, F.C.A, Jamin, M, Bourhis, J.M.
Deposit date:2022-10-05
Release date:2023-03-15
Last modified:2024-02-07
Method:X-RAY DIFFRACTION (2.3 Å)
Cite:Structure and Dynamics of the Unassembled Nucleoprotein of Rabies Virus in Complex with Its Phosphoprotein Chaperone Module.
Viruses, 14, 2022
8BJW
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BU of 8bjw by Molmil
Structure of Tupaia Paramyxovirus C protein
Descriptor: DI(HYDROXYETHYL)ETHER, Protein C
Authors:Bourhis, J.M, Jamin, M.
Deposit date:2022-11-08
Release date:2023-08-30
Method:X-RAY DIFFRACTION (2.39 Å)
Cite:Orthoparamyxovirinae C Proteins Have a Common Origin and a Common Structural Organization.
Biomolecules, 13, 2023
4CO6
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BU of 4co6 by Molmil
Crystal structure of the Nipah virus RNA free nucleoprotein- phosphoprotein complex
Descriptor: BROMIDE ION, CHLORIDE ION, NUCLEOPROTEIN, ...
Authors:Yabukarksi, F, Lawrence, P, Tarbouriech, N, Bourhis, J.M, Jensen, M.R, Ruigrok, R.W.H, Blackledge, M, Volchkov, V, Jamin, M.
Deposit date:2014-01-27
Release date:2014-08-13
Last modified:2024-10-23
Method:X-RAY DIFFRACTION (2.498 Å)
Cite:Structure of Nipah Virus Unassembled Nucleoprotein in Complex with its Viral Chaperone.
Nat.Struct.Mol.Biol., 21, 2014
3PMK
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BU of 3pmk by Molmil
Crystal structure of the Vesicular Stomatitis Virus RNA free nucleoprotein/phosphoprotein complex
Descriptor: Nucleocapsid protein, Phosphoprotein
Authors:Leyrat, C, Yabukarski, F, Tarbouriech, N, Ruigrok, R.W.H, Jamin, M.
Deposit date:2010-11-17
Release date:2011-10-05
Last modified:2023-09-06
Method:X-RAY DIFFRACTION (3.03 Å)
Cite:Structure of the Vesicular Stomatitis Virus N0-P Complex
Plos Pathog., 7, 2011
3L32
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BU of 3l32 by Molmil
Structure of the dimerisation domain of the rabies virus phosphoprotein
Descriptor: Phosphoprotein
Authors:Ivanov, I, Crepin, T, Jamin, M, Ruigrok, R.W.H.
Deposit date:2009-12-16
Release date:2010-02-16
Last modified:2024-03-20
Method:X-RAY DIFFRACTION (1.5 Å)
Cite:Structure of the dimerisation domain of the rabies virus phosphoprotein
J.Virol., 2010
2K47
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BU of 2k47 by Molmil
Solution structure of the C-terminal N-RNA binding domain of the Vesicular Stomatitis Virus Phosphoprotein
Descriptor: Phosphoprotein
Authors:Ribeiro, E.A, Favier, A, Gerard, F.C, Leyrat, C, Brutscher, B, Blondel, D, Ruigrok, R.W, Blackledge, M, Jamin, M.
Deposit date:2008-05-28
Release date:2008-09-09
Last modified:2024-05-29
Method:SOLUTION NMR
Cite:Solution Structure of the C-Terminal Nucleoprotein-RNA Binding Domain of the Vesicular Stomatitis Virus Phosphoprotein.
J.Mol.Biol., 2008
4TYH
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BU of 4tyh by Molmil
Ternary complex of P38 and MK2 with a P38 inhibitor
Descriptor: MAP kinase-activated protein kinase 2, Mitogen-activated protein kinase 14, N-[5-(dimethylsulfamoyl)-2-methylphenyl]-1-phenyl-5-propyl-1H-pyrazole-4-carboxamide
Authors:Cumming, J.G, Debreczeni, J.E, Edfeldt, F, Evertsson, F, Harrison, M, Holdgate, G, James, M, Lamont, S, Oldham, K, Sullivan, J.E, Wells, S.
Deposit date:2014-07-08
Release date:2015-07-22
Last modified:2023-12-27
Method:X-RAY DIFFRACTION (3 Å)
Cite:Discovery of substrate selective, ATP-competitive P38 alpha MAP kinase inhibitors
To Be Published
4GJW
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BU of 4gjw by Molmil
Structure of the tetramerization domain of Nipah virus phosphoprotein
Descriptor: ARGININE, CHLORIDE ION, GLYCEROL, ...
Authors:Yabukarski, F, Tarbouriech, N, Jamin, M.
Deposit date:2012-08-10
Release date:2014-02-12
Last modified:2017-11-15
Method:X-RAY DIFFRACTION (3 Å)
Cite:Nipah Virus Phosphoprotein Oligomerisation domain
To be Published
2XD5
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BU of 2xd5 by Molmil
Structural insights into the catalytic mechanism and the role of Streptococcus pneumoniae PBP1b
Descriptor: CHLORIDE ION, N-BENZOYL-D-ALANINE, PENICILLIN-BINDING PROTEIN 1B, ...
Authors:Macheboeuf, P, Lemaire, D, Jamin, M, Dideberg, O, Dessen, A.
Deposit date:2010-04-29
Release date:2010-05-26
Last modified:2024-11-06
Method:X-RAY DIFFRACTION (2.5 Å)
Cite:Structural Insights Into the Catalytic Mechanism and the Role of Streptococcus Pneumoniae Pbp1B
To be Published
3T4R
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BU of 3t4r by Molmil
Lettuce Necrotic Yellow Virus Phosphoprotein C-Terminal Domain
Descriptor: MAGNESIUM ION, Phosphoprotein
Authors:Martinez, N, Tarbouriech, N, Jamin, M.
Deposit date:2011-07-26
Release date:2013-01-30
Last modified:2024-10-09
Method:X-RAY DIFFRACTION (2 Å)
Cite:Structure of the C-terminal domain of lettuce necrotic yellows virus phosphoprotein.
J.Virol., 87, 2013
2JLN
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BU of 2jln by Molmil
Structure of Mhp1, a nucleobase-cation-symport-1 family transporter
Descriptor: MERCURY (II) ION, MHP1, SODIUM ION
Authors:Weyand, S, Shimamura, T, Yajima, S, Suzuki, S, Mirza, O, Krusong, K, Carpenter, E.P, Rutherford, N.G, Hadden, J.M, O'Reilly, J, Ma, P, Saidijam, M, Patching, S.G, Hope, R.J, Norbertczak, H.T, Roach, P.C.J, Iwata, S, Henderson, P.J.F, Cameron, A.D.
Deposit date:2008-09-11
Release date:2008-10-28
Last modified:2024-05-08
Method:X-RAY DIFFRACTION (2.85 Å)
Cite:Structure and Molecular Mechanism of a Nucleobase-Cation-Symport-1 Family Transporter.
Science, 322, 2008
4PEP
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BU of 4pep by Molmil
THE MOLECULAR AND CRYSTAL STRUCTURES OF MONOCLINIC PORCINE PEPSIN REFINED AT 1.8 ANGSTROMS RESOLUTION
Descriptor: PEPSIN
Authors:Andreeva, N, Fedorov, A.A, Sielecki, A, James, M.
Deposit date:1989-12-18
Release date:1990-04-15
Last modified:2024-11-13
Method:X-RAY DIFFRACTION (1.8 Å)
Cite:Molecular and crystal structures of monoclinic porcine pepsin refined at 1.8 A resolution.
J.Mol.Biol., 214, 1990
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