8UWU
 
 | | EmrE structure in the proton-bound state (WT/L51I heterodimer) | | 分子名称: | SMR family multidrug efflux protein EmrE | | 著者 | Li, J, Sae Her, A, Besch, A, Ramirez, B, Crames, M, Banigan, J.R, Mueller, C, Marsiglia, W.M, Zhang, Y, Traaseth, N.J. | | 登録日 | 2023-11-08 | | 公開日 | 2024-05-29 | | 最終更新日 | 2024-07-03 | | 実験手法 | SOLID-STATE NMR, SOLUTION NMR | | 主引用文献 | Dynamics underlie the drug recognition mechanism by the efflux transporter EmrE.
Nat Commun, 15, 2024
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5M4X
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8E4H
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8E3R
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8E3K
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8E5Y
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8EE9
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5LXW
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8EBH
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8FTG
 | | Biophysical and Structural Characterization of an Anti-Caffeine VHH Antibody | | 分子名称: | 2-AMINO-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, Anti-Caffeine VHH Antibody, CAFFEINE, ... | | 著者 | Horn, J.R, Smith, C.A, Sonneson, G.J, Walter, R. | | 登録日 | 2023-01-12 | | 公開日 | 2023-06-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.13 Å) | | 主引用文献 | Molecular recognition requires dimerization of a VHH antibody.
Mabs, 15, 2023
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8FS2
 | | CamA Adenine Methyltransferase Complexed to Cognate Substrate DNA and Inhibitor 11b (YD907) | | 分子名称: | 1,2-ETHANEDIOL, 5'-S-{3-[N'-(cyclohexylmethyl)carbamimidamido]propyl}-N-(3-phenylpropyl)-5'-thioadenosine, DNA (5'-D(*TP*TP*CP*AP*AP*AP*AP*AP*GP*TP*CP*CP*CP*A)-3'), ... | | 著者 | Zhou, J, Horton, J.R, Cheng, X. | | 登録日 | 2023-01-09 | | 公開日 | 2023-05-10 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.59 Å) | | 主引用文献 | Comparative Study of Adenosine Analogs as Inhibitors of Protein Arginine Methyltransferases and a Clostridioides difficile- Specific DNA Adenine Methyltransferase.
Acs Chem.Biol., 18, 2023
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8DVW
 | | Structure of the Campylobacter concisus glycosyltransferase PglA R203Q | | 分子名称: | N, N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE | | 著者 | Vuksanovic, N, Clasman, J.R, Bernstein, H.M, Imperiali, B, Allen, K.N. | | 登録日 | 2022-07-30 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.29 Å) | | 主引用文献 | Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA.
Protein Sci., 33, 2024
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8DVZ
 | | Structure of the Campylobacter concisus glycosyltransferase PglA R282V variant | | 分子名称: | N, N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE | | 著者 | Vuksanovic, N, Clasman, J.R, Bernstein, H.M, Imperiali, B, Allen, K.N. | | 登録日 | 2022-07-30 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (2.27 Å) | | 主引用文献 | Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA.
Protein Sci., 33, 2024
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8DQD
 | | Structure of the Campylobacter concisus glycosyltransferase PglA | | 分子名称: | N, N'-diacetylbacillosaminyl-diphospho-undecaprenol alpha-1,3-N-acetylgalactosaminyltransferase, URIDINE-DIPHOSPHATE-N-ACETYLGALACTOSAMINE | | 著者 | Vuksanovic, N, Clasman, J.R, Bernstein, H.M, Imperiali, B, Allen, K.N. | | 登録日 | 2022-07-18 | | 公開日 | 2024-01-17 | | 実験手法 | X-RAY DIFFRACTION (1.78 Å) | | 主引用文献 | Specificity determinants revealed by the structure of glycosyltransferase Campylobacter concisus PglA.
Protein Sci., 33, 2024
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8EW3
 | | Cryo EM structure of Vibrio cholerae NQR | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, Na(+)-translocating NADH-quinone reductase subunit A, ... | | 著者 | Fuller, J.R, Juarez, O. | | 登録日 | 2022-10-21 | | 公開日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (2.65159 Å) | | 主引用文献 | Novel cofactor binding motifs, electron transfer and ion pumping mechanisms of the respiratory complex NQR
To Be Published
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2ZRO
 | | MsRecA ADP form IV | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, GLYCEROL, Protein recA | | 著者 | Prabu, J.R, Manjunath, G.P, Chandra, N.R, Muniyappa, K, Vijayan, M. | | 登録日 | 2008-08-27 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes
Acta Crystallogr.,Sect.D, 64, 2008
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2ZTD
 | | MtRuvA Form III | | 分子名称: | GLYCEROL, Holliday junction ATP-dependent DNA helicase ruvA | | 著者 | Prabu, J.R, Thamotharan, S, Khanduja, J.S, Chandra, N.R, Muniyappa, K, Vijayan, M. | | 登録日 | 2008-10-01 | | 公開日 | 2009-05-05 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (2.4 Å) | | 主引用文献 | Crystallographic and modelling studies on Mycobacterium tuberculosis RuvA Additional role of RuvB-binding domain and inter species variability
Biochim.Biophys.Acta, 1794, 2009
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2Z5D
 | | Human ubiquitin-conjugating enzyme E2 H | | 分子名称: | SODIUM ION, Ubiquitin-conjugating enzyme E2 H | | 著者 | Bochkarev, A, Cui, H, Walker, J.R, Newman, E.M, Mackenzie, F, Battaile, K.P, Sundstrom, M, Arrowsmith, C, Edwards, A, Dhe-Paganon, S, Structural Genomics Consortium (SGC) | | 登録日 | 2007-07-06 | | 公開日 | 2007-10-09 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | | 主引用文献 | A human ubiquitin conjugating enzyme (E2)-HECT E3 ligase structure-function screen.
MOL.CELL PROTEOMICS, 11, 2012
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8EVU
 | | Cryo EM structure of Vibrio cholerae NQR | | 分子名称: | FE2/S2 (INORGANIC) CLUSTER, FLAVIN MONONUCLEOTIDE, Na(+)-translocating NADH-quinone reductase subunit A, ... | | 著者 | Fuller, J.R, Juarez, O. | | 登録日 | 2022-10-20 | | 公開日 | 2022-11-16 | | 実験手法 | ELECTRON MICROSCOPY (2.5804 Å) | | 主引用文献 | Novel cofactor binding motifs, electron transfer and ion pumping mechanisms of the respiratory complex NQR
To Be Published
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2ZRD
 | | MsRecA Q196N ADP form IV | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, Protein recA | | 著者 | Prabu, J.R, Manjunath, G.P, Chandra, N.R, Muniyappa, K, Vijayan, M. | | 登録日 | 2008-08-27 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.1 Å) | | 主引用文献 | Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes
Acta Crystallogr.,Sect.D, 64, 2008
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2ZRL
 | | MsRecA Q196A dATP FORM II' | | 分子名称: | 2'-DEOXYADENOSINE 5'-TRIPHOSPHATE, Protein recA | | 著者 | Prabu, J.R, Manjunath, G.P, Chandra, N.R, Muniyappa, K, Vijayan, M. | | 登録日 | 2008-08-27 | | 公開日 | 2008-12-09 | | 最終更新日 | 2023-11-01 | | 実験手法 | X-RAY DIFFRACTION (3.7 Å) | | 主引用文献 | Functionally important movements in RecA molecules and filaments: studies involving mutation and environmental changes
Acta Crystallogr.,Sect.D, 64, 2008
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8EW6
 | | Anti-human CD8 VHH complex with CD8 alpha | | 分子名称: | Anti-CD8 alpha VHH, T-cell surface glycoprotein CD8 alpha chain | | 著者 | Kiefer, J.R, Williams, S, Davies, C.W, Koerber, J.T, Sriraman, S.K, Yin, Y.P. | | 登録日 | 2022-10-21 | | 公開日 | 2022-11-23 | | 最終更新日 | 2023-02-01 | | 実験手法 | X-RAY DIFFRACTION (1.904 Å) | | 主引用文献 | Development of an 18 F-labeled anti-human CD8 VHH for same-day immunoPET imaging.
Eur J Nucl Med Mol Imaging, 50, 2023
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5IZD
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8EXL
 | | Crystal structure of PI3K-alpha in complex with taselisib | | 分子名称: | 2-methyl-2-(4-{2-[3-methyl-1-(propan-2-yl)-1H-1,2,4-triazol-5-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-1H-pyrazol-1-yl)propanamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E. | | 登録日 | 2022-10-25 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (1.989 Å) | | 主引用文献 | Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
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8EXO
 | | Crystal structure of PI3K-alpha in complex with compound 19 | | 分子名称: | 1-{(4S,11aM)-2-[(4R)-2-oxo-4-(propan-2-yl)-1,3-oxazolidin-3-yl]-5,6-dihydroimidazo[1,2-d][1,4]benzoxazepin-9-yl}-L-prolinamide, Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform | | 著者 | Kiefer, J.R, Eigenbrot, C, Staben, S.T, Hanan, E.J, Wallweber, H.J.A, Ultsch, M, Braun, M.G, Friedman, L.S, Purkey, H.E. | | 登録日 | 2022-10-25 | | 公開日 | 2022-11-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | X-RAY DIFFRACTION (2.46 Å) | | 主引用文献 | Discovery of GDC-0077 (Inavolisib), a Highly Selective Inhibitor and Degrader of Mutant PI3K alpha.
J.Med.Chem., 65, 2022
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