3E6L
 
 | | Structure of murine INOS oxygenase domain with inhibitor AR-C132283 | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, ETHYL 4-[(4-CHLOROPYRIDIN-2-YL)AMINO]PIPERIDINE-1-CARBOXYLATE, Nitric oxide synthase, ... | | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2008-08-15 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
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7S65
 | | Compressed conformation of nighttime state KaiC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.2 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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7S66
 | | Extended conformation of nighttime state KaiC | | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, MAGNESIUM ION | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.8 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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7S67
 | | Extended conformation of daytime state KaiC | | 分子名称: | ADENOSINE-5'-DIPHOSPHATE, ADENOSINE-5'-TRIPHOSPHATE, Circadian clock protein kinase KaiC, ... | | 著者 | Sandate, C.R, Swan, J.A, Partch, C.L, Lander, G.C. | | 登録日 | 2021-09-13 | | 公開日 | 2021-09-22 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.8 Å) | | 主引用文献 | Coupling of distant ATPase domains in the circadian clock protein KaiC.
Nat.Struct.Mol.Biol., 29, 2022
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3E67
 | | Murine inos dimer with inhibitor 4-MAP bound | | 分子名称: | 4-METHYLPYRIDIN-2-AMINE, 5,6,7,8-TETRAHYDROBIOPTERIN, Nitric oxide synthase, ... | | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2008-08-14 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
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3E6T
 | | Structure of murine INOS oxygenase domain with inhibitor AR-C118901 | | 分子名称: | 5,6,7,8-TETRAHYDROBIOPTERIN, 5-(4'-AMINO-1'-ETHYL-5',8'-DIFLUORO-1'H-SPIRO[PIPERIDINE-4,2'-QUINAZOLINE]-1-YLCARBONYL)PICOLINONITRILE, Nitric oxide synthase, ... | | 著者 | Garcin, E.D, Arvai, A.S, Rosenfeld, R.J, Kroeger, M.D, Crane, B.R, Andersson, G, Andrews, G, Hamley, P.J, Mallinder, P.R, Nicholls, D.J, St-Gallay, S.A, Tinker, A.C, Gensmantel, N.P, Mete, A, Cheshire, D.R, Connolly, S, Stueh, D.J, Aberg, A, Wallace, A.V, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2008-08-15 | | 公開日 | 2008-10-07 | | 最終更新日 | 2024-02-21 | | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | | 主引用文献 | Anchored plasticity opens doors for selective inhibitor design in nitric oxide synthase.
Nat.Chem.Biol., 4, 2008
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1UZY
 | | Erythrina crystagalli lectin | | 分子名称: | 4-(2-HYDROXYETHYL)-1-PIPERAZINE ETHANESULFONIC ACID, CALCIUM ION, Lectin, ... | | 著者 | Turton, K, Natesh, R, Thiyagarajan, N, Chaddock, J.A, Acharya, K.R. | | 登録日 | 2004-03-19 | | 公開日 | 2004-06-22 | | 最終更新日 | 2023-12-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal structures of Erythrina cristagalli lectin with bound N-linked oligosaccharide and lactose.
Glycobiology, 14, 2004
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7RWL
 | | Envelope-associated Adeno-associated virus serotype 2 | | 分子名称: | Capsid protein VP1 | | 著者 | Hull, J.A, Mietzsch, M, Chipman, P, Strugatsky, D, McKenna, R. | | 登録日 | 2021-08-20 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (3.14 Å) | | 主引用文献 | Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology, 565, 2021
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7RWT
 | | Adeno-associated virus type 2 | | 分子名称: | Capsid protein VP1 | | 著者 | Hull, J.A, Mietzsch, M, Chipman, P, Strugatsky, D, McKenna, R. | | 登録日 | 2021-08-20 | | 公開日 | 2021-10-20 | | 最終更新日 | 2024-06-05 | | 実験手法 | ELECTRON MICROSCOPY (2.43 Å) | | 主引用文献 | Structural characterization of an envelope-associated adeno-associated virus type 2 capsid.
Virology, 565, 2021
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7S3N
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3DSD
 | | Crystal structure of P. furiosus Mre11-H85S bound to a branched DNA and manganese | | 分子名称: | DNA (5'-D(*DCP*DGP*DCP*DGP*DCP*DAP*DCP*DAP*DAP*DGP*DCP*DTP*DTP*DTP*DTP*DGP*DCP*DTP*DTP*DGP*DTP*DGP*DGP*DAP*DTP*DA)-3'), DNA double-strand break repair protein mre11, MANGANESE (II) ION | | 著者 | Williams, R.S, Moiani, D, Tainer, J.A. | | 登録日 | 2008-07-11 | | 公開日 | 2008-10-14 | | 最終更新日 | 2023-08-30 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Mre11 dimers coordinate DNA end bridging and nuclease processing in double-strand-break repair.
Cell(Cambridge,Mass.), 135, 2008
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3DU0
 | | E. coli dihydrodipicolinate synthase with first substrate, pyruvate, bound in active site | | 分子名称: | CHLORIDE ION, Dihydrodipicolinate synthase, GLYCEROL, ... | | 著者 | Dobson, R.C.J, Devenish, S.R.A, Gerrard, J.A, Jameson, G.B. | | 登録日 | 2008-07-16 | | 公開日 | 2008-11-18 | | 最終更新日 | 2019-12-18 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | The high-resolution structure of dihydrodipicolinate synthase from Escherichia coli bound to its first substrate, pyruvate.
Acta Crystallogr.,Sect.F, 64, 2008
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1VBY
 | | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, and Mn2+ bound | | 分子名称: | Hepatitis Delta virus ribozyme, MANGANESE (II) ION, SODIUM ION, ... | | 著者 | Ke, A, Zhou, K, Ding, F, Cate, J.H.D, Doudna, J.A. | | 登録日 | 2004-03-03 | | 公開日 | 2004-05-18 | | 最終更新日 | 2023-12-27 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | A Conformational Switch controls hepatitis delta virus ribozyme catalysis
NATURE, 429, 2004
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7S3M
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1V1K
 | | CDK2 IN COMPLEX WITH A DISUBSTITUTED 4, 6-BIS ANILINO PYRIMIDINE CDK4 INHIBITOR | | 分子名称: | (2R)-1-(DIMETHYLAMINO)-3-{4-[(6-{[2-FLUORO-5-(TRIFLUOROMETHYL)PHENYL]AMINO}PYRIMIDIN-4-YL)AMINO]PHENOXY}PROPAN-2-OL, CELL DIVISION PROTEIN KINASE 2 | | 著者 | Beattie, J.F, Breault, G.A, Ellston, R.P.A, Green, S, Jewsbury, P.J, Midgley, C.J, Naven, R.T, Minshull, C.A, Pauptit, R.A, Tucker, J.A, Pease, J.E. | | 登録日 | 2004-04-16 | | 公開日 | 2004-05-04 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (2.31 Å) | | 主引用文献 | Cyclin-Dependent Kinase 4 Inhibitors as a Treatment for Cancer. Part 1: Identification and Optimisation of Substituted 4,6-Bis Anilino Pyrimidines
Bioorg.Med.Chem.Lett., 13, 2003
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3DZ5
 | | Human AdoMetDC with covalently bound 5'-[(2-aminooxyethyl)methylamino]-5'-deoxy-8-methyladenosine | | 分子名称: | 1,4-DIAMINOBUTANE, 5'-{[2-(aminooxy)ethyl](methyl)amino}-5'-deoxy-8-methyladenosine, S-adenosylmethionine decarboxylase alpha chain, ... | | 著者 | Bale, S, McCloskey, D.E, Pegg, A.E, Secrist III, J.A, Guida, W.C, Ealick, S.E. | | 登録日 | 2008-07-29 | | 公開日 | 2009-03-10 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2.43 Å) | | 主引用文献 | New Insights into the Design of Inhibitors of Human S-Adenosylmethionine Decarboxylase: Studies of Adenine C8 Substitution in Structural Analogues of S-Adenosylmethionine
J.Med.Chem., 52, 2009
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1T9B
 | | Crystal structure of yeast acetohydroxyacid synthase in complex with a sulfonylurea herbicide, chlorsulfuron | | 分子名称: | 1-(2-CHLOROPHENYLSULFONYL)-3-(4-METHOXY-6-METHYL-L,3,5-TRIAZIN-2-YL)UREA, 2-{[(4-AMINO-2-METHYLPYRIMIDIN-5-YL)METHYL]AMINO}PROPANE-1-THIOL, 5-(AMINOMETHYL)-2-METHYLPYRIMIDIN-4-AMINE, ... | | 著者 | McCourt, J.A, Pang, S.S, Guddat, L.W, Duggleby, R.G. | | 登録日 | 2004-05-16 | | 公開日 | 2004-12-21 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | | 主引用文献 | Elucidating the specificity of binding of sulfonylurea herbicides to acetohydroxyacid synthase.
Biochemistry, 44, 2005
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1T6Q
 | | Nickel Superoxide Dismutase (NiSOD) CN-treated Apo Structure | | 分子名称: | Superoxide dismutase [Ni] | | 著者 | Barondeau, D.P, Kassmann, C.J, Bruns, C.K, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2004-05-07 | | 公開日 | 2004-07-13 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.05 Å) | | 主引用文献 | Nickel superoxide dismutase structure and mechanism.
Biochemistry, 43, 2004
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1TA2
 | | Crystal structure of thrombin in complex with compound 1 | | 分子名称: | 1-(2-AMINO-3,3-DIPHENYL-PROPIONYL)-PYRROLIDINE-3-CARBOXYLIC ACID 2,5-DICHLORO-BENZYLAMIDE, Hirudin, thrombin | | 著者 | Tucker, T.J, Brady, S.F, Lumma, W.C, Lewis, S.D, Gardel, S.J, Naylor-Olsen, A.M, Yan, Y, Sisko, J.T, Stauffer, K.J, Lucas, B.Y, Lynch, J.J, Cook, J.J, Stranieri, M.T, Holahan, M.A, Lyle, E.A, Baskin, E.P, Chen, I.-W, Dancheck, K.B, Krueger, J.A, Cooper, C.M, Vacca, J.P. | | 登録日 | 2004-05-19 | | 公開日 | 2004-06-08 | | 最終更新日 | 2017-10-11 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Design and synthesis of a series of potent and orally bioavailable
noncovalent thrombin inhibitors that utilize nonbasic groups in the P1 position
J.Med.Chem., 41, 1998
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1LIT
 | | HUMAN LITHOSTATHINE | | 分子名称: | LITHOSTATHINE | | 著者 | Bertrand, J.A, Pignol, D, Bernard, J.-P, Verdier, J.-M, Dagorn, J.-C, Fontacilla-Camps, J.C. | | 登録日 | 1996-01-17 | | 公開日 | 1997-01-11 | | 最終更新日 | 2011-07-13 | | 実験手法 | X-RAY DIFFRACTION (1.55 Å) | | 主引用文献 | Crystal structure of human lithostathine, the pancreatic inhibitor of stone formation.
EMBO J., 15, 1996
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1THK
 | | Effect of Shuttle Location and pH Environment on H+ Transfer in Human Carbonic Anhydrase II | | 分子名称: | Carbonic anhydrase II, ZINC ION | | 著者 | Fisher, Z, Hernandez Prada, J.A, Tu, C.K, Duda, D, Yoshioka, C, An, H, Govindasamy, L, Silverman, D.N, McKenna, R. | | 登録日 | 2004-06-01 | | 公開日 | 2005-01-25 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | | 主引用文献 | Structural and Kinetic Characterization of Active-Site Histidine as a Proton Shuttle in Catalysis by Human Carbonic Anhydrase II
Biochemistry, 44, 2005
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1TLL
 | | CRYSTAL STRUCTURE OF RAT NEURONAL NITRIC-OXIDE SYNTHASE REDUCTASE MODULE AT 2.3 A RESOLUTION. | | 分子名称: | FLAVIN MONONUCLEOTIDE, FLAVIN-ADENINE DINUCLEOTIDE, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ... | | 著者 | Garcin, E.D, Bruns, C.M, Lloyd, S.J, Hosfield, D.J, Tiso, M, Gachhui, R, Stuehr, D.J, Tainer, J.A, Getzoff, E.D. | | 登録日 | 2004-06-09 | | 公開日 | 2004-08-31 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural basis for isozyme-specific regulation of electron transfer in nitric-oxide synthase
J.Biol.Chem., 279, 2004
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1SRR
 | | CRYSTAL STRUCTURE OF A PHOSPHATASE RESISTANT MUTANT OF SPORULATION RESPONSE REGULATOR SPO0F FROM BACILLUS SUBTILIS | | 分子名称: | CALCIUM ION, SPORULATION RESPONSE REGULATORY PROTEIN | | 著者 | Madhusudan, Whiteley, J.M, Hoch, J.A, Zapf, J, Xuong, N.H, Varughese, K.I. | | 登録日 | 1996-04-10 | | 公開日 | 1997-04-21 | | 最終更新日 | 2024-02-14 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Crystal structure of a phosphatase-resistant mutant of sporulation response regulator Spo0F from Bacillus subtilis.
Structure, 4, 1996
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3GO3
 | | Interactions of an echinomycin-DNA complex with manganese(II) ions | | 分子名称: | 2-CARBOXYQUINOXALINE, 5'-D(*AP*CP*GP*TP*AP*CP*GP*T)-3', DI(HYDROXYETHYL)ETHER, ... | | 著者 | Pfoh, R, Cuesta-Seijo, J.A, Sheldrick, G.M. | | 登録日 | 2009-03-18 | | 公開日 | 2009-03-31 | | 最終更新日 | 2012-12-12 | | 実験手法 | X-RAY DIFFRACTION (1.1 Å) | | 主引用文献 | Interaction of an Echinomycin-DNA Complex with Manganese Ion
Acta Crystallogr.,Sect.F, 65, 2009
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7RXS
 | | Crystal of BRD4(D1) with 2-[(3S)-3-{5-[2-(3,5-dimethylphenoxy)pyrimidin-4-yl]-4-(4-iodophenyl)-1H-imidazol-1-yl}pyrrolidin-1-yl]ethan-1-amine | | 分子名称: | 1,2-ETHANEDIOL, 2-[(3S)-3-{5-[2-(3,5-dimethylphenoxy)pyrimidin-4-yl]-4-(4-iodophenyl)-1H-imidazol-1-yl}pyrrolidin-1-yl]ethan-1-amine, Bromodomain-containing protein 4 | | 著者 | Cui, H, Johnson, J.A, Shi, K, Aihara, H, Pomerantz, W.C.K. | | 登録日 | 2021-08-23 | | 公開日 | 2022-01-19 | | 最終更新日 | 2023-10-18 | | 実験手法 | X-RAY DIFFRACTION (1.43 Å) | | 主引用文献 | A Structure-based Design Approach for Generating High Affinity BRD4 D1-Selective Chemical Probes.
J.Med.Chem., 65, 2022
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