1SO6
 
 | | Crystal structure of E112Q/H136A double mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate | | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION | | 著者 | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | 登録日 | 2004-03-12 | | 公開日 | 2004-06-08 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.902 Å) | | 主引用文献 | Evolution of Enzymatic Activities in the Orotidine 5'-Monophosphate Decarboxylase Suprafamily: Crystallographic Evidence for a Proton Relay System in the Active Site of 3-Keto-l-gulonate 6-Phosphate Decarboxylase(,)
Biochemistry, 43, 2004
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3R4V
 | | Structure of the phage tubulin PhuZ-GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein | | 著者 | Agard, D.A, Pogliano, J, Kraemer, J.A, Erb, M.L, Waddling, C.A, Montabana, E.A, Wang, H, Nguyen, K, Pham, S. | | 登録日 | 2011-03-17 | | 公開日 | 2012-07-04 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (1.67 Å) | | 主引用文献 | A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell.
Cell(Cambridge,Mass.), 149, 2012
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4DFD
 | | Crystal structure of had family enzyme bt-2542 (target efi-501088) from bacteroides thetaiotaomicron, magnesium complex | | 分子名称: | CHLORIDE ION, MAGNESIUM ION, Putative haloacid dehalogenase-like hydrolase, ... | | 著者 | Patskovsky, Y, Toro, R, Bhosle, R, Hillerich, B, Seidel, R.D, Washington, E, Scott Glenn, A, Chowdhury, S, Evans, B, Hammonds, J, Zencheck, W.D, Imker, H.J, Gerlt, J.A, Allen, K, Dunaway-Mariano, D, Almo, S.C, Enzyme Function Initiative (EFI) | | 登録日 | 2012-01-23 | | 公開日 | 2012-02-01 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Crystal Structure of Protein Bt-2542 from Bacteroides Thetaiotaomicron (Target Efi-501088)
To be Published
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4DX6
 | | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop | | 分子名称: | Acriflavine resistance protein B, DARPIN, DODECYL-BETA-D-MALTOSIDE | | 著者 | Eicher, T, Cha, H, Seeger, M.A, Brandstaetter, L, El-Delik, J, Bohnert, J.A, Kern, W.V, Verrey, F, Gruetter, M.G, Diederichs, K, Pos, K.M. | | 登録日 | 2012-02-27 | | 公開日 | 2012-05-02 | | 最終更新日 | 2024-02-28 | | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | | 主引用文献 | Transport of drugs by the multidrug transporter AcrB involves an access and a deep binding pocket that are separated by a switch-loop.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1RVK
 | | Crystal structure of enolase AGR_L_2751 from Agrobacterium Tumefaciens | | 分子名称: | MAGNESIUM ION, isomerase/lactonizing enzyme | | 著者 | Fedorov, A.A, Fedorov, E.V, Thirumuruhan, R, Zencheck, W, Millikin, C, Gerlt, J.A, Almo, S.C, Burley, S.K, New York SGX Research Center for Structural Genomics (NYSGXRC) | | 登録日 | 2003-12-14 | | 公開日 | 2003-12-23 | | 最終更新日 | 2021-02-03 | | 実験手法 | X-RAY DIFFRACTION (1.7 Å) | | 主引用文献 | Evolution of enzymatic activites in the Enolase superfamily: 1.7 A crystal structure of the hypothetical protein MR.GI-17937161 from Agrobacterium tumefaciens
To be Published
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1RW5
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4DEY
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4DY0
 | | Crystal structure of native protease nexin-1 with heparin | | 分子名称: | 2-deoxy-6-O-sulfo-2-(sulfoamino)-alpha-D-glucopyranose-(1-4)-2-O-sulfo-alpha-L-idopyranuronic acid, GLYCEROL, Glia-derived nexin, ... | | 著者 | Huntington, J.A, Li, W. | | 登録日 | 2012-02-28 | | 公開日 | 2012-08-15 | | 最終更新日 | 2024-03-13 | | 実験手法 | X-RAY DIFFRACTION (2.35 Å) | | 主引用文献 | Crystal structures of protease nexin-1 in complex with heparin and thrombin suggest a 2-step recognition mechanism.
Blood, 120, 2012
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1RLP
 | | TWO BINDING ORIENTATIONS FOR PEPTIDES TO SRC SH3 DOMAIN: DEVELOPMENT OF A GENERAL MODEL FOR SH3-LIGAND INTERACTIONS | | 分子名称: | C-SRC TYROSINE KINASE SH3 DOMAIN, PROLINE-RICH LIGAND RLP2 (RALPPLPRY) | | 著者 | Feng, S, Chen, J.K, Yu, H, Simon, J.A, Schreiber, S.L. | | 登録日 | 1994-10-10 | | 公開日 | 1995-02-07 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Two binding orientations for peptides to the Src SH3 domain: development of a general model for SH3-ligand interactions.
Science, 266, 1994
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1RRB
 | | THE RAS-BINDING DOMAIN OF RAF-1 FROM RAT, NMR, 1 STRUCTURE | | 分子名称: | RAF PROTO-ONCOGENE SERINE/THREONINE-PROTEIN KINASE | | 著者 | Terada, T, Ito, Y, Shirouzu, M, Tateno, M, Hashimoto, K, Kigawa, T, Ebisuzaki, T, Takio, K, Shibata, T, Yokoyama, S, Smith, B.O, Laue, E.D, Cooper, J.A, RIKEN Structural Genomics/Proteomics Initiative (RSGI) | | 登録日 | 1998-03-26 | | 公開日 | 1999-03-30 | | 最終更新日 | 2024-05-22 | | 実験手法 | SOLUTION NMR | | 主引用文献 | Nuclear magnetic resonance and molecular dynamics studies on the interactions of the Ras-binding domain of Raf-1 with wild-type and mutant Ras proteins.
J.Mol.Biol., 286, 1999
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3ORZ
 | | PDK1 mutant bound to allosteric disulfide fragment activator 2A2 | | 分子名称: | 3-(1H-INDOL-3-YL)-4-{1-[2-(1-METHYLPYRROLIDIN-2-YL)ETHYL]-1H-INDOL-3-YL}-1H-PYRROLE-2,5-DIONE, 3-phosphoinositide-dependent protein kinase 1, 4-[4-(3-chlorophenyl)piperazin-1-yl]-4-oxobutane-1-thiol | | 著者 | Sadowsky, J.D, Wells, J.A. | | 登録日 | 2010-09-08 | | 公開日 | 2011-03-23 | | 最終更新日 | 2023-09-06 | | 実験手法 | X-RAY DIFFRACTION (1.9995 Å) | | 主引用文献 | Turning a protein kinase on or off from a single allosteric site via disulfide trapping.
Proc.Natl.Acad.Sci.USA, 108, 2011
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3OV6
 | | CD1c in complex with MPM (mannosyl-beta1-phosphomycoketide) | | 分子名称: | 1-O-[(S)-hydroxy{[(4S,8S,16S,20S)-4,8,12,16,20-pentamethylheptacosyl]oxy}phosphoryl]-beta-D-mannopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose, Beta-2-microglobulin, ... | | 著者 | Scharf, L, Li, N.S, Hawk, A.J, Garzon, D, Zhang, T, Kazen, A.R, Shah, S, Haddadian, E.J, Saghatelian, A, Faraldo-Gomez, J.D, Meredith, S.C, Piccirilli, J.A, Adams, E.J. | | 登録日 | 2010-09-15 | | 公開日 | 2011-01-19 | | 最終更新日 | 2020-07-29 | | 実験手法 | X-RAY DIFFRACTION (2.502 Å) | | 主引用文献 | The 2.5 A structure of CD1c in complex with a mycobacterial lipid reveals an open groove ideally suited for diverse antigen presentation
Immunity, 33, 2010
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1SO3
 | | Crystal structure of H136A mutant of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate | | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION | | 著者 | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | | 登録日 | 2004-03-12 | | 公開日 | 2004-06-08 | | 最終更新日 | 2021-10-27 | | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | | 主引用文献 | Evolution of Enzymatic Activities in the Orotidine 5'-Monophosphate Decarboxylase Suprafamily: Crystallographic Evidence for a Proton Relay System in the Active Site of 3-Keto-l-gulonate 6-Phosphate Decarboxylase(,)
Biochemistry, 43, 2004
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3P3F
 | | Crystal structure of the F36A mutant of the fluoroacetyl-CoA-specific thioesterase FlK | | 分子名称: | Fluoroacetyl coenzyme A thioesterase | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-04 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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3P2Q
 | | Crystal structure of the fluoroacetyl-CoA-specific thioesterase, FlK | | 分子名称: | Fluoroacetyl coenzyme A thioesterase | | 著者 | Weeks, A.M, Coyle, S.M, Jinek, M, Doudna, J.A, Chang, M.C.Y. | | 登録日 | 2010-10-03 | | 公開日 | 2010-10-20 | | 最終更新日 | 2011-11-16 | | 実験手法 | X-RAY DIFFRACTION (1.85 Å) | | 主引用文献 | Structural and biochemical studies of a fluoroacetyl-CoA-specific thioesterase reveal a molecular basis for fluorine selectivity.
Biochemistry, 49, 2010
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1S9B
 | | Crystal Structure Analysis of the B-DNA GAATTCG | | 分子名称: | 5'-D(*GP*AP*AP*TP*TP*CP*G)-3', NICKEL (II) ION | | 著者 | Valls, N, Uson, I, Gouyette, C, Subirana, J.A. | | 登録日 | 2004-02-04 | | 公開日 | 2004-09-07 | | 最終更新日 | 2024-04-03 | | 実験手法 | X-RAY DIFFRACTION (2.81 Å) | | 主引用文献 | A cubic arrangement of DNA double helices based on nickel-guanine interactions
J.Am.Chem.Soc., 126, 2004
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3RLV
 | | Crystal structure of the mutant Y206F of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with the inhibitor BMP | | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | | 著者 | Fedorov, A.A, Fedorov, E.V, Desai, B, Gerlt, J.A, Almo, S.C. | | 登録日 | 2011-04-20 | | 公開日 | 2012-04-25 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.421 Å) | | 主引用文献 | Conformational changes in orotidine 5'-monophosphate decarboxylase: a structure-based explanation for how the 5'-phosphate group activates the enzyme.
Biochemistry, 51, 2012
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1SJF
 | | Crystal Structure of the Hepatitis Delta Virus Gemonic Ribozyme Precursor, with C75U mutaion, in Cobalt Hexammine solution | | 分子名称: | COBALT HEXAMMINE(III), Hepatitis Delta virus ribozyme, U1 small nuclear ribonucleoprotein A | | 著者 | Ke, A, Zhou, K, Ding, F, Cate, J.H.D, Doudna, J.A. | | 登録日 | 2004-03-03 | | 公開日 | 2004-05-18 | | 最終更新日 | 2024-05-29 | | 実験手法 | X-RAY DIFFRACTION (2.75 Å) | | 主引用文献 | A conformational switch controls hepatitis delta virus ribozyme catalysis.
Nature, 429, 2004
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3R11
 | | Crystal structure of NYSGRC enolase target 200555, a putative dipeptide epimerase from Francisella philomiragia : Mg and Fumarate complex | | 分子名称: | Enzyme of enolase superfamily, FUMARIC ACID, GLYCEROL, ... | | 著者 | Vetting, M.W, Hillerich, B, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Gerlt, J.A, Almo, S.C, New York Structural Genomics Research Consortium (NYSGRC) | | 登録日 | 2011-03-09 | | 公開日 | 2011-04-20 | | 最終更新日 | 2023-11-15 | | 実験手法 | X-RAY DIFFRACTION (2 Å) | | 主引用文献 | Homology models guide discovery of diverse enzyme specificities among dipeptide epimerases in the enolase superfamily.
Proc.Natl.Acad.Sci.USA, 109, 2012
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1SNG
 | | Structure of a Thermophilic Serpin in the Native State | | 分子名称: | COG4826: Serine protease inhibitor, SULFATE ION | | 著者 | Fulton, K.F, Buckle, A.M, Cabrita, L.D, Irving, J.A, Butcher, R.E, Smith, I, Reeve, S, Lesk, A.M, Bottomley, S.P, Rossjohn, J, Whisstock, J.C. | | 登録日 | 2004-03-10 | | 公開日 | 2004-12-14 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.76 Å) | | 主引用文献 | The high resolution crystal structure of a native thermostable serpin reveals the complex mechanism underpinning the stressed to relaxed transition.
J.Biol.Chem., 280, 2005
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3RGU
 | | Structure of Fap-NRa at pH 5.0 | | 分子名称: | Fimbriae-associated protein Fap1, alpha-D-glucopyranose | | 著者 | Garnett, J.A, Matthews, S.J. | | 登録日 | 2011-04-09 | | 公開日 | 2011-12-28 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (3 Å) | | 主引用文献 | Structural insight into the role of Streptococcus parasanguinis Fap1 within oral biofilm formation.
Biochem.Biophys.Res.Commun., 417, 2012
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3RHG
 | | Crystal structure of amidohydrolase pmi1525 (target efi-500319) from proteus mirabilis hi4320 | | 分子名称: | BENZOIC ACID, CACODYLATE ION, Putative phophotriesterase, ... | | 著者 | Patskovsky, Y, Hillerich, B, Seidel, R.D, Zencheck, W.D, Toro, R, Imker, H.J, Raushel, F.M, Gerlt, J.A, Almo, S.C, Enzyme Function Initiative (EFI) | | 登録日 | 2011-04-11 | | 公開日 | 2011-04-27 | | 最終更新日 | 2023-09-13 | | 実験手法 | X-RAY DIFFRACTION (1.53 Å) | | 主引用文献 | Crystal Structure of Amidohydrolase Pmi1525 from Proteus Mirabilis Hi4320
To be Published
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1SJD
 | | x-ray structure of o-succinylbenzoate synthase complexed with n-succinyl phenylglycine | | 分子名称: | N-SUCCINYL PHENYLGLYCINE, N-acylamino acid racemase | | 著者 | Thoden, J.B, Taylor-Ringia, E.A, Garrett, J.B, Gerlt, J.A, Holden, H.M, Rayment, I. | | 登録日 | 2004-03-03 | | 公開日 | 2004-06-01 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (1.87 Å) | | 主引用文献 | Evolution of Enzymatic Activity in the Enolase Superfamily: Structural Studies of the Promiscuous o-Succinylbenzoate Synthase from Amycolatopsis
Biochemistry, 43, 2004
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1SH3
 | | Crystal Structure of Norwalk Virus Polymerase (MgSO4 crystal form) | | 分子名称: | MAGNESIUM ION, RNA Polymerase | | 著者 | Ng, K.K, Pendas-Franco, N, Rojo, J, Boga, J.A, Machin, A, Alonso, J.M, Parra, F. | | 登録日 | 2004-02-24 | | 公開日 | 2004-03-09 | | 最終更新日 | 2023-08-23 | | 実験手法 | X-RAY DIFFRACTION (2.95 Å) | | 主引用文献 | Crystal structure of norwalk virus polymerase reveals the carboxyl terminus in the active site cleft.
J.Biol.Chem., 279, 2004
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3RB8
 | | Structure of the phage tubulin PhuZ(SeMet)-GDP | | 分子名称: | GUANOSINE-5'-DIPHOSPHATE, MAGNESIUM ION, Putative uncharacterized protein | | 著者 | Agard, D.A, Pogliano, J, Kraemer, J.A, Erb, M.L, Waddling, C.A, Montabana, E.A, Wang, H, Nguyen, K, Pham, S. | | 登録日 | 2011-03-28 | | 公開日 | 2012-07-04 | | 最終更新日 | 2013-01-23 | | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | | 主引用文献 | A phage tubulin assembles dynamic filaments by an atypical mechanism to center viral DNA within the host cell.
Cell(Cambridge,Mass.), 149, 2012
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