4BL1
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![BU of 4bl1 by Molmil](/molmil-images/mine/4bl1) | Crystal structure of unphosphorylated Maternal Embryonic Leucine zipper Kinase (MELK) in complex with AMP-PNP | 分子名称: | MATERNAL EMBRYONIC LEUCINE ZIPPER KINASE, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER | 著者 | Canevari, G, Re-Depaolini, S, Cucchi, U, Forte, B, Carpinelli, P, Bertrand, J.A. | 登録日 | 2013-04-30 | 公開日 | 2013-05-08 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.6 Å) | 主引用文献 | Crystal Structure of Unphosphorylated Maternal Embryonic Leucine Zipper Kinase To be Published
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1PCI
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![BU of 1pci by Molmil](/molmil-images/mine/1pci) | PROCARICAIN | 分子名称: | PROCARICAIN | 著者 | Groves, M.R, Taylor, M.A.J, Scott, M, Cummings, N.J, Pickersgill, R.W, Jenkins, J.A. | 登録日 | 1996-06-28 | 公開日 | 1997-04-01 | 最終更新日 | 2023-08-09 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | The prosequence of procaricain forms an alpha-helical domain that prevents access to the substrate-binding cleft. Structure, 4, 1996
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4AYC
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![BU of 4ayc by Molmil](/molmil-images/mine/4ayc) | RNF8 RING domain structure | 分子名称: | CHLORIDE ION, E3 UBIQUITIN-PROTEIN LIGASE RNF8, GLYCEROL, ... | 著者 | Mattiroli, F, Vissers, J.H.A, Van Dijk, W.J, Ikpa, P, Citterio, E, Vermeulen, W, Marteijn, J.A, Sixma, T.K. | 登録日 | 2012-06-20 | 公開日 | 2012-09-26 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.9 Å) | 主引用文献 | Rnf168 Ubiquitinates K13-15 on H2A/H2Ax to Drive DNA Damage Signaling Cell(Cambridge,Mass.), 150, 2012
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4BBH
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![BU of 4bbh by Molmil](/molmil-images/mine/4bbh) | Plasmodium vivax N-myristoyltransferase with a bound benzothiophene inhibitor | 分子名称: | 2-oxopentadecyl-CoA, 3-methoxybenzyl 3-(piperidin-4-yloxy)-1-benzothiophene-2-carboxylate, CHLORIDE ION, ... | 著者 | Rackham, M.D, Brannigan, J.A, Moss, D.K, Yu, Z, Wilkinson, A.J, Holder, A.A, Tate, E.W, Leatherbarrow, R.J. | 登録日 | 2012-09-23 | 公開日 | 2012-12-05 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (1.63 Å) | 主引用文献 | Discovery of Novel and Ligand-Efficient Inhibitors of Plasmodium Falciparum and Plasmodium Vivax N-Myristoyltransferase. J.Med.Chem., 56, 2013
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4B23
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![BU of 4b23 by Molmil](/molmil-images/mine/4b23) | Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2 | 分子名称: | 5'-D(*CP*GP*AP*TP*TP*GP*GP*TP*AP*GP*CP)-3', 5'-D(*GP*CP*TP*AP*CP*(3DR)P*AP*AP*TP*CP*GP)-3', MAG2, ... | 著者 | Dalhus, B, Nilsen, L, Korvald, H, Huffman, J, Forstrom, R.J, McMurray, C.T, Alseth, I, Tainer, J.A, Bjoras, M. | 登録日 | 2012-07-12 | 公開日 | 2013-01-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Sculpting of DNA at Abasic Sites by DNA Glycosylase Homolog Mag2. Structure, 21, 2013
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4B24
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![BU of 4b24 by Molmil](/molmil-images/mine/4b24) | Unprecedented sculpting of DNA at abasic sites by DNA glycosylase homolog Mag2 | 分子名称: | 5'-D(*CP*GP*AP*TP*AP*GP*GP*TP*AP*GP)-3', 5'-D(*GP*CP*TP*AP*CP*3DRP*TP*AP*TP*CP*GP)-3', PROBABLE DNA-3-METHYLADENINE GLYCOSYLASE 2 | 著者 | Dalhus, B, Nilsen, L, Korvald, H, Huffman, J, Forstrom, R.J, McMurray, C.T, Alseth, I, Tainer, J.A, Bjoras, M. | 登録日 | 2012-07-12 | 公開日 | 2013-01-09 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Sculpting of DNA at Abasic Sites by DNA Glycosylase Homolog Mag2. Structure, 21, 2013
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3NQF
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![BU of 3nqf by Molmil](/molmil-images/mine/3nqf) | Crystal structure of the mutant L123S of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-06-29 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.312 Å) | 主引用文献 | Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site. Biochemistry, 50, 2011
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3O6I
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![BU of 3o6i by Molmil](/molmil-images/mine/3o6i) | Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator | 分子名称: | 2-[({3-tert-butyl-4-[(methylamino)methyl]-1H-pyrazol-1-yl}acetyl)amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, GLUTAMIC ACID, Glutamate receptor 2, ... | 著者 | Maclean, J.K.F, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Martin, F, Moir, E.M, Morrow, J.A, Pantling, J, Rankovic, Z, Smith, L. | 登録日 | 2010-07-29 | 公開日 | 2010-09-15 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | A novel series of positive modulators of the AMPA receptor: structure-based lead optimization. Bioorg.Med.Chem.Lett., 20, 2010
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1PM9
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![BU of 1pm9 by Molmil](/molmil-images/mine/1pm9) | |
3NQE
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![BU of 3nqe by Molmil](/molmil-images/mine/3nqe) | Crystal structure of the mutant L123N of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-06-29 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.421 Å) | 主引用文献 | Mechanism of the orotidine 5'-monophosphate decarboxylase-catalyzed reaction: importance of residues in the orotate binding site. Biochemistry, 50, 2011
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4A3R
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![BU of 4a3r by Molmil](/molmil-images/mine/4a3r) | Crystal structure of Enolase from Bacillus subtilis. | 分子名称: | CITRIC ACID, ENOLASE, SODIUM ION | 著者 | Newman, J.A, Hewitt, L, Rodrigues, C, Solovyova, A.S, Harwood, C.R, Lewis, R.J. | 登録日 | 2011-10-04 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Dissection of the Network of Interactions that Links RNA Processing with Glycolysis in the Bacillus Subtilis Degradosome. J.Mol.Biol., 416, 2012
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3NXW
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![BU of 3nxw by Molmil](/molmil-images/mine/3nxw) | Crystal structure of Staphylococcal nuclease variant Delta+PHS L125A at cryogenic temperature | 分子名称: | CALCIUM ION, THYMIDINE-3',5'-DIPHOSPHATE, Thermonuclease | 著者 | Caro, J.A, Schlessman, J.L, Garcia-Moreno, E.B, Heroux, A. | 登録日 | 2010-07-14 | 公開日 | 2011-07-20 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.65 Å) | 主引用文献 | Cavities determine the pressure unfolding of proteins. Proc.Natl.Acad.Sci.USA, 109, 2012
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4A3S
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![BU of 4a3s by Molmil](/molmil-images/mine/4a3s) | Crystal structure of PFK from Bacillus subtilis | 分子名称: | 6-PHOSPHOFRUCTOKINASE | 著者 | Newman, J.A, Hewitt, L, Rodrigues, C, Solovyova, A.S, Harwood, C.R, Lewis, R.J. | 登録日 | 2011-10-04 | 公開日 | 2012-08-15 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Dissection of the Network of Interactions that Links RNA Processing with Glycolysis in the Bacillus Subtilis Degradosome. J.Mol.Biol., 416, 2012
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3NQ7
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![BU of 3nq7 by Molmil](/molmil-images/mine/3nq7) | Crystal structure of the mutant F71A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP | 分子名称: | 6-HYDROXYURIDINE-5'-PHOSPHATE, GLYCEROL, Orotidine 5'-phosphate decarboxylase | 著者 | Fedorov, A.A, Fedorov, E.V, Wood, B.M, Gerlt, J.A, Almo, S.C. | 登録日 | 2010-06-29 | 公開日 | 2011-05-11 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (1.443 Å) | 主引用文献 | Crystal structure of the mutant F71A of orotidine 5'-monophosphate
decarboxylase from Methanobacterium thermoautotrophicum complexed with
inhibitor BMP To be Published
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4A31
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![BU of 4a31 by Molmil](/molmil-images/mine/4a31) | CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND | 分子名称: | 6-{[2-(4-METHYLPIPERAZIN-1-YL)ETHYL]AMINO}-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)PYRIDINE-3-SULFONAMIDE, GLYCEROL, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ... | 著者 | Robinson, D.A, Brand, S, Cleghorn, L.A.T, McElroy, S.P, Smith, V.C, Hallyburton, I, Harrison, J.R, Norcross, N.R, Norval, S, Spinks, D, Stojanovski, L, Torrie, L.S, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Read, K.D, Wyatt, P.G, Gilbert, I.H. | 登録日 | 2011-09-29 | 公開日 | 2011-12-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.09 Å) | 主引用文献 | Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012
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1QXT
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![BU of 1qxt by Molmil](/molmil-images/mine/1qxt) | Crystal structure of precyclized intermediate for the green fluorescent protein R96A variant (A) | 分子名称: | green-fluorescent protein | 著者 | Barondeau, D.P, Putnam, C.D, Kassmann, C.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2003-09-08 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures Proc.Natl.Acad.Sci.USA, 100
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1QY3
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![BU of 1qy3 by Molmil](/molmil-images/mine/1qy3) | Crystal structure of precyclized intermediate for the green fluorescent protein R96A variant (B) | 分子名称: | green-fluorescent protein | 著者 | Barondeau, D.P, Putnam, C.D, Kassmann, C.J, Tainer, J.A, Getzoff, E.D. | 登録日 | 2003-09-09 | 公開日 | 2003-09-23 | 最終更新日 | 2023-08-23 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Mechanism and energetics of green fluorescent protein chromophore synthesis revealed by trapped intermediate structures. Proc.Natl.Acad.Sci.Usa, 100, 2003
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1Q6L
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![BU of 1q6l by Molmil](/molmil-images/mine/1q6l) | Structure of 3-keto-L-gulonate 6-phosphate decarboxylase with bound L-threonohydroxamate 4-phosphate | 分子名称: | 3-keto-L-gulonate 6-phosphate decarboxylase, L-THREONOHYDROXAMATE 4-PHOSPHATE, MAGNESIUM ION | 著者 | Wise, E.L, Yew, W.S, Gerlt, J.A, Rayment, I. | 登録日 | 2003-08-13 | 公開日 | 2003-10-28 | 最終更新日 | 2019-07-24 | 実験手法 | X-RAY DIFFRACTION (1.8 Å) | 主引用文献 | Structural Evidence for a 1,2-Enediolate Intermediate in the Reaction Catalyzed by 3-Keto-l-Gulonate 6-Phosphate Decarboxylase, a Member of the Orotidine 5'-Monophosphate Decarboxylase Suprafamily Biochemistry, 42, 2003
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3O29
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![BU of 3o29 by Molmil](/molmil-images/mine/3o29) | Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator | 分子名称: | GLUTAMIC ACID, GLYCEROL, Glutamate receptor 2, ... | 著者 | Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. | 登録日 | 2010-07-22 | 公開日 | 2010-09-15 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2.02 Å) | 主引用文献 | A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
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4A32
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![BU of 4a32 by Molmil](/molmil-images/mine/4a32) | CRYSTAL STRUCTURE OF LEISHMANIA MAJOR N-MYRISTOYLTRANSFERASE (NMT) WITH BOUND MYRISTOYL-COA AND A PYRAZOLE SULPHONAMIDE LIGAND | 分子名称: | 3,5-DICHLORO-3'-[(DIETHYLAMINO)METHYL]-N-(1,3,5-TRIMETHYL-1H-PYRAZOL-4-YL)BIPHENYL-4-SULFONAMIDE, GLYCEROL, GLYCYLPEPTIDE N-TETRADECANOYLTRANSFERASE, ... | 著者 | Robinson, D.A, Brand, S, Cleghorn, L.A.T, McElroy, S.P, Smith, V.C, Hallyburton, I, Harrison, J.R, Norcross, N.R, Norval, S, Spinks, D, Stojanovski, L, Torrie, L.S, Frearson, J.A, Brenk, R, Fairlamb, A.H, Ferguson, M.A.J, Read, K.D, Wyatt, P.G, Gilbert, I.H. | 登録日 | 2011-09-29 | 公開日 | 2011-12-21 | 最終更新日 | 2023-12-20 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | Discovery of a novel class of orally active trypanocidal N-myristoyltransferase inhibitors. J. Med. Chem., 55, 2012
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1QGZ
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![BU of 1qgz by Molmil](/molmil-images/mine/1qgz) | FERREDOXIN:NADP+ REDUCTASE MUTANT WITH LEU 78 REPLACED BY ASP (L78D) | 分子名称: | FLAVIN-ADENINE DINUCLEOTIDE, PROTEIN (FERREDOXIN:NADP+ REDUCTASE), SULFATE ION | 著者 | Hermoso, J.A, Mayoral, T, Medina, M, Sanz-Aparicio, J, Gomez-Moreno, C. | 登録日 | 1999-05-10 | 公開日 | 2002-02-27 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Role of a cluster of hydrophobic residues near the FAD cofactor in Anabaena PCC 7119 ferredoxin-NADP+ reductase for optimal complex formation and electron transfer to ferredoxin. J.Biol.Chem., 276, 2001
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3O28
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![BU of 3o28 by Molmil](/molmil-images/mine/3o28) | Ligand-binding domain of GluA2 (flip) ionotropic glutamate receptor in complex with an allosteric modulator | 分子名称: | 2-({[3-(trifluoromethyl)-4,5,6,7-tetrahydro-1H-indazol-1-yl]acetyl}amino)-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxamide, DIMETHYL SULFOXIDE, GLUTAMIC ACID, ... | 著者 | Maclean, J.K.F, Basten, S, Campbell, R.A, Cumming, I.A, Gillen, K.J, Gillespie, J, Jamieson, C, Kazemier, B, Kiczun, M, Lamont, Y, Lyons, A.J, Moir, E.M, Morrow, J.A, Papakosta, M, Rankovic, Z, Smith, L. | 登録日 | 2010-07-22 | 公開日 | 2010-09-15 | 最終更新日 | 2017-08-09 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | A novel series of positive modulators of the AMPA receptor: discovery and structure based hit-to-lead studies. Bioorg.Med.Chem.Lett., 20, 2010
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1QMZ
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![BU of 1qmz by Molmil](/molmil-images/mine/1qmz) | PHOSPHORYLATED CDK2-CYCLYIN A-SUBSTRATE PEPTIDE COMPLEX | 分子名称: | ADENOSINE-5'-TRIPHOSPHATE, CELL DIVISION PROTEIN KINASE 2, G2/MITOTIC-SPECIFIC CYCLIN A, ... | 著者 | Brown, N.R, Noble, M.E.M, Endicott, J.A, Johnson, L.N. | 登録日 | 1999-10-11 | 公開日 | 1999-12-14 | 最終更新日 | 2024-05-01 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | The Structural Basis for Specificity of Substrate and Recruitment Peptides for Cyclin-Dependent Kinases Nat.Cell Biol., 1, 1999
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1QNM
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4AKL
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![BU of 4akl by Molmil](/molmil-images/mine/4akl) | Structure of the Crimean-Congo Haemorrhagic Fever Virus Nucleocapsid Protein | 分子名称: | NUCLEOCAPSID, TRIETHYLENE GLYCOL | 著者 | Carter, S.D, Walter, C.T, Surtees, R, Bergeron, E, Ariza, A, Albarino, C.G, Nichol, S.T, Hiscox, J.A, Edwards, T.A, Barr, J.N. | 登録日 | 2012-02-24 | 公開日 | 2012-08-22 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | Structure, Function, and Evolution of the Crimean-Congo Hemorrhagic Fever Virus Nucleocapsid Protein. J.Virol., 86, 2012
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