3JUH
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2PVR
| Crystal structure of the catalytic subunit of protein kinase CK2 (C-terminal deletion mutant 1-335) in complex with two sulfate ions | 分子名称: | Casein kinase II subunit alpha, catalytic subunit, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, ... | 著者 | Niefind, K, Yde, C.W, Ermakova, I, Issinger, O.-G. | 登録日 | 2007-05-10 | 公開日 | 2007-06-26 | 最終更新日 | 2023-08-30 | 実験手法 | X-RAY DIFFRACTION (1.605 Å) | 主引用文献 | Evolved to Be Active: Sulfate Ions Define Substrate Recognition Sites of CK2alpha and Emphasise its Exceptional Role within the CMGC Family of Eukaryotic Protein Kinases J.Mol.Biol., 370, 2007
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1PJK
| Crystal Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit | 分子名称: | CHLORIDE ION, Casein kinase II, alpha chain, ... | 著者 | Ermakova, I, Boldyreff, B, Issinger, O.-G, Niefind, K. | 登録日 | 2003-06-03 | 公開日 | 2003-06-24 | 最終更新日 | 2023-08-16 | 実験手法 | X-RAY DIFFRACTION (2.5 Å) | 主引用文献 | Crystal structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit J.Mol.Biol., 330, 2003
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4NH1
| Crystal structure of a heterotetrameric CK2 holoenzyme complex carrying the Andante-mutation in CK2beta and consistent with proposed models of autoinhibition and trans-autophosphorylation | 分子名称: | Casein kinase II subunit alpha, Casein kinase II subunit beta, GLYCEROL, ... | 著者 | Schnitzler, A, Issinger, O.-G, Niefind, K. | 登録日 | 2013-11-04 | 公開日 | 2014-03-12 | 最終更新日 | 2023-11-08 | 実験手法 | X-RAY DIFFRACTION (3.3 Å) | 主引用文献 | The Protein Kinase CK2(Andante) Holoenzyme Structure Supports Proposed Models of Autoregulation and Trans-Autophosphorylation J.Mol.Biol., 426, 2014
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3U87
| Structure of a chimeric construct of human CK2alpha and human CK2alpha' in complex with a non-hydrolysable ATP-analogue | 分子名称: | CHLORIDE ION, Casein kinase II subunit alpha, GLYCEROL, ... | 著者 | Niefind, K, Raaf, J, Issinger, O.-G, Olsen, B. | 登録日 | 2011-10-16 | 公開日 | 2012-05-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (2.9 Å) | 主引用文献 | Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias. Acta Crystallogr.,Sect.D, 68, 2012
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3EED
| Crystal structure of human protein kinase CK2 regulatory subunit (CK2beta; mutant 1-193) | 分子名称: | Casein kinase II subunit beta, SULFATE ION, ZINC ION | 著者 | Niefind, K, Raaf, J, Issinger, O.-G. | 登録日 | 2008-09-04 | 公開日 | 2008-09-16 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (2.8 Å) | 主引用文献 | The interaction of CK2{alpha} and CK2{beta}, the subunits of protein kinase CK2, requires CK2{beta} in a preformed conformation and is enthalpically driven Protein Sci., 17, 2008
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3H30
| Crystal structure of the catalytic subunit of human protein kinase CK2 with 5,6-dichloro-1-beta-D-ribofuranosylbenzimidazole | 分子名称: | 5,6-dichloro-1-beta-D-ribofuranosyl-1H-benzimidazole, CHLORIDE ION, Casein kinase II subunit alpha | 著者 | Niefind, K, Raaf, J, Issinger, O.-G. | 登録日 | 2009-04-15 | 公開日 | 2009-05-12 | 最終更新日 | 2024-03-20 | 実験手法 | X-RAY DIFFRACTION (1.56 Å) | 主引用文献 | The CK2alpha/CK2beta Interface of Human Protein Kinase CK2 Harbors a Binding Pocket for Small Molecules Chem.Biol., 15, 2008
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3OFM
| Structure of a human CK2alpha prime, the paralog isoform of the catalytic subunit of protein kinase CK2 from Homo sapiens | 分子名称: | 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION, Casein kinase II subunit alpha' | 著者 | Bischoff, N, Olsen, B, Raaf, J, Bretner, M, Issinger, O.-G, Niefind, K. | 登録日 | 2010-08-15 | 公開日 | 2011-01-19 | 最終更新日 | 2023-09-06 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Structural basis of the reduced affinity between the protein kinase CK2 subunits CK2alpha prime and CK2beta J.Mol.Biol., 407, 2011
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1LPU
| Low Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays | 分子名称: | BENZAMIDINE, Protein kinase CK2 | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | 登録日 | 2002-05-08 | 公開日 | 2002-05-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J.Mol.Biol., 347, 2005
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1LP4
| Crystal structure of a binary complex of the catalytic subunit of protein kinase CK2 with Mg-AMPPNP | 分子名称: | MAGNESIUM ION, PHOSPHOAMINOPHOSPHONIC ACID-ADENYLATE ESTER, Protein kinase CK2 | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | 登録日 | 2002-05-07 | 公開日 | 2002-05-29 | 最終更新日 | 2024-03-13 | 実験手法 | X-RAY DIFFRACTION (1.86 Å) | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J.Mol.Biol., 347, 2005
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1LR4
| Room Temperature Crystal Structure of the Apo-form of the catalytic subunit of protein kinase CK2 from Zea mays | 分子名称: | BENZAMIDINE, Protein kinase CK2 | 著者 | Niefind, K, Puetter, M, Guerra, B, Issinger, O.-G, Schomburg, D. | 登録日 | 2002-05-14 | 公開日 | 2002-05-29 | 最終更新日 | 2023-10-25 | 実験手法 | X-RAY DIFFRACTION (2 Å) | 主引用文献 | Inclining the purine base binding plane in protein kinase CK2 by exchanging the flanking side-chains generates a preference for ATP as a cosubstrate. J.Mol.Biol., 347, 2005
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4FBX
| Complex structure of human protein kinase CK2 catalytic subunit crystallized in the presence of a bisubstrate inhibitor | 分子名称: | CHLORIDE ION, Casein kinase II subunit alpha, bisubstrate inhibitor | 著者 | Enkvist, E, Viht, K, Bischoff, N, Vahter, J, Saaver, S, Raidaru, G, Issinger, O.-G, Niefind, K, Uri, A. | 登録日 | 2012-05-23 | 公開日 | 2012-10-17 | 最終更新日 | 2024-07-10 | 実験手法 | X-RAY DIFFRACTION (2.33 Å) | 主引用文献 | A subnanomolar fluorescent probe for protein kinase CK2 interaction studies. Org.Biomol.Chem., 10, 2012
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4IB5
| Structure of human protein kinase CK2 catalytic subunit in complex with a CK2beta-competitive cyclic peptide | 分子名称: | CHLORIDE ION, CK2beta-derived cyclic peptide, Casein kinase II subunit alpha, ... | 著者 | Raaf, J, Guerra, B, Neundorf, I, Bopp, B, Issinger, O.-G, Jose, J, Pietsch, M, Niefind, K. | 登録日 | 2012-12-08 | 公開日 | 2013-03-20 | 最終更新日 | 2013-06-05 | 実験手法 | X-RAY DIFFRACTION (2.2 Å) | 主引用文献 | First structure of protein kinase CK2 catalytic subunit with an effective CK2 beta-competitive ligand Acs Chem.Biol., 8, 2013
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3U9C
| Structure of a C-terminal deletion mutant of human protein kinase CK2 catalytic subunit with the ATP-competitive inhibitor resorufin | 分子名称: | 7-hydroxy-3H-phenoxazin-3-one, CHLORIDE ION, Casein kinase II subunit alpha, ... | 著者 | Klopffleisch, K, Issinger, O.-G, Niefind, K. | 登録日 | 2011-10-18 | 公開日 | 2012-05-30 | 最終更新日 | 2023-09-13 | 実験手法 | X-RAY DIFFRACTION (3.2 Å) | 主引用文献 | Low-density crystal packing of human protein kinase CK2 catalytic subunit in complex with resorufin or other ligands: a tool to study the unique hinge-region plasticity of the enzyme without packing bias. Acta Crystallogr.,Sect.D, 68, 2012
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3C13
| Low pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2 | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, CHLORIDE ION, Casein kinase II subunit alpha | 著者 | Niefind, K, Raaf, J, Issinger, O.-G. | 登録日 | 2008-01-22 | 公開日 | 2008-02-12 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.95 Å) | 主引用文献 | The Catalytic Subunit of Human Protein Kinase CK2 Structurally Deviates from Its Maize Homologue in Complex with the Nucleotide Competitive Inhibitor Emodin J.Mol.Biol., 377, 2008
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3BQC
| High pH-value crystal structure of emodin in complex with the catalytic subunit of protein kinase CK2 | 分子名称: | 3-METHYL-1,6,8-TRIHYDROXYANTHRAQUINONE, CHLORIDE ION, Casein kinase II subunit alpha | 著者 | Niefind, K, Raaf, J, Issinger, O.-G. | 登録日 | 2007-12-20 | 公開日 | 2008-01-15 | 最終更新日 | 2023-11-01 | 実験手法 | X-RAY DIFFRACTION (1.5 Å) | 主引用文献 | The Catalytic Subunit of Human Protein Kinase CK2 Structurally Deviates from Its Maize Homologue in Complex with the Nucleotide Competitive Inhibitor Emodin J.Mol.Biol., 377, 2008
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3RPS
| Structure of human CK2alpha in complex with the ATP-competitive inhibitor 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol | 分子名称: | 3-(4,5,6,7-tetrabromo-1H-benzotriazol-1-yl)propan-1-ol, CHLORIDE ION, Casein kinase II subunit alpha, ... | 著者 | Bischoff, N, Raaf, J, Olsen, B, Bretner, M, Issinger, O.-G, Niefind, K. | 登録日 | 2011-04-27 | 公開日 | 2011-06-08 | 最終更新日 | 2024-02-28 | 実験手法 | X-RAY DIFFRACTION (2.3 Å) | 主引用文献 | Enzymatic activity with an incomplete catalytic spine - insights from a comparative structural analysis of human CK2alpha and its paralogous isoform CK2alpha' Mol.Cell.Biochem., 356, 2011
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4UB7
| High-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) showing an extreme distortion of the ATP-binding loop combined with a pi-halogen bond | 分子名称: | 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, CHLORIDE ION, Casein kinase II subunit alpha | 著者 | Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G. | 登録日 | 2014-08-12 | 公開日 | 2015-07-01 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.1 Å) | 主引用文献 | A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures. Acs Chem.Biol., 10, 2015
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4UBA
| Low-salt structure of protein kinase CK2 catalytic subunit with 4'-carboxy-6,8-bromo-flavonol (FLC26) | 分子名称: | 4-(6,8-dibromo-3-hydroxy-4-oxo-4H-chromen-2-yl)benzoic acid, Casein kinase II subunit alpha | 著者 | Niefind, K, Bischoff, N, Guerra, B, Golub, A, Issinger, O.-G. | 登録日 | 2014-08-12 | 公開日 | 2015-07-01 | 最終更新日 | 2024-05-08 | 実験手法 | X-RAY DIFFRACTION (2.995 Å) | 主引用文献 | A Note of Caution on the Role of Halogen Bonds for Protein Kinase/Inhibitor Recognition Suggested by High- And Low-Salt CK2 alpha Complex Structures. Acs Chem.Biol., 10, 2015
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